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Energy metabolism disorders and potential therapeutic drugs in heart failure

Acta Pharmaceutica Sinica B 2021年第5期11卷 1098-1116页

作者： Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine ResourcesChengdu University of Traditional Chinese MedicineChengdu 611137China Jiangxi University of Traditional Chinese Medicine Nanchang 330004China The College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China

Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy *** deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of *** HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the *** aimed at cardiac energy metabolism have not yet been *** this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy ***,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF.

关键词： Heart failure Energy deficit Cardiac dysfunction Energy metabolism Substrate metabolism Hormones Natural products synthetic drugs

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Challenges and opportunities in the treatment of ulcerative colitis

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World Journal of Pharmacology 2015年第2期4卷 219-226页

作者： Sunil Ashokrao Nirmal Sunil Shivaji Gangurde Pratiksha Shankar Dumbre Subodh Chandra Pal Subhash Chandra Mandal Department of Pharmacognosy Pravara Rural College of Pharmacy Biotechnology Centre Post Graduate InstituteDr. PDKVMaharashtra 413736India Sarswati Vidyabhavan College of Pharmacy Department of Pharmacognosy NDMVP’s College of Pharmacy Pharmacognosy and Phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur University

Ulcerative colitis(UC) is an inflammatory destructive disease of the large intestine occurred usually in the rectum and lower part of the colon as well as the entire colon. Drug therapy is not the only choice for UC treatment and medical management should be as a comprehensive whole. Many synthetic drugs are available for the treatment of UC like 5-aminosalicylic acid, oral or systemic corticosteroids, immunomodulator, etc. but these drugs are associated with many serious side effects after long term use or have certain disadvantage or not suitable for the use in some patients. In short synthetic drugs have many disadvantages and for this reason effective and safe alternative drug treatment for the UC is the challenge. Herbal drugs are found to be very promising results of the treatment of UC and enzymatic level. Researchers explored many herbal drugs for the treatment and even many more may found effective in the treatment of UC. At this point we feel herbal medicine is the better alternative for the treatment of UC.

关键词： Ulcerative colitis Herbal drugs synthetic drugs

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