Energy metabolism disorders and potential therapeutic drugs in heart failure

作     者：Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang Yanan He;Wei Huang;Chen Zhang;Lumeng Chen;Runchun Xu;Nan Li;Fang Wang;Li Han;Ming Yang;Dingkun Zhang

作者机构：State Key Laboratory Breeding Base of Systematic ResearchDevelopment and Utilization of Chinese Medicine ResourcesChengdu University of Traditional Chinese MedicineChengdu 611137China Jiangxi University of Traditional Chinese MedicineNanchang 330004China The College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第5期

页      面：1098-1116页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：support of National Key Research and Development Program(2018YFC1707205,China) Sichuan Provincial Administration of Traditional Chinese Medicine Research Project(2018NQ008,China) 

主　　题：Heart failure Energy deficit Cardiac dysfunction Energy metabolism Substrate metabolism Hormones Natural products Synthetic drugs 

摘      要：Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy *** deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of *** HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the *** aimed at cardiac energy metabolism have not yet been *** this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy ***,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF.