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Potential role of an athlete-focused echocardiogram in sports eligibility

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World Journal of Cardiology 2021年第8期13卷 271-297页

作者： Stefano Palermi Alessandro Serio Marco Vecchiato Felice Sirico Francesco Gambardella Fabrizio Ricci Franco Iodice Juri Radmilovic Vincenzo Russo Antonello D'Andrea Department University of Naples Federico IINaples 80131Italy Sport and Exercise Medicine Division Department of MedicineUniversity Hospital of PadovaPadova 35128Italy Department of Neuroscience Imaging and Clinical Sciences“G.d’Annunzio”University of Chieti-PescaraChieti 66100Italy Department of Clinical Sciences Faculty of MedicineLund UniversityClinical Research CenterMalmö21428Sweden Casa di Cura Villa Serena Pescara 65013Italy Unit of Cardiology Department of Translational Medical SciencesUniversity of Campania“Luigi Vanvitelli”Monaldi HospitalNaples 80131Italy Unit of Cardiology and Intensive Coronary Care “Umberto I”HospitalNocera Inferiore 84014Italy

sudden cardiac death(SCD)of an athlete is a rare but tragic event and sport activity might play a trigger role in athletes with underlying structural or electrical heart *** screenings(PPs)have been conceived for the potential to prevent SCD in young athletes by early identification of cardiac *** European Society of Cardiology protocol for PPs includes history collection,physical examination and baseline electrocardiogram,while further examinations are reserved to individuals with abnormalities at first-line ***,transthoracic echocardiography has been hypothesized to have a primary role in the *** review aims to describe how to approach an athlete-focused echocardiogram,highlighting what is crucial to focus on for the different diseases(cardiomyopathies,valvulopathies,congenital heart disease,myocarditis and pericarditis)and when is needed to pay attention to overlap diagnostic zone(“grey zone”)with the athlete's *** properly tested,focused echocardiography by sports medicine physicians may become standard practice in larger screening practices,potentially available during first-line evaluation.

关键词： Echocardiogram Athletes Sport eligibility Pre-participation screening sudden cardiac death Sport cardiology

Genetic basis of atrial fibrillation

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Genes & Diseases 2016年第4期3卷 257-262页

作者： Oscar Campuzano Alexandra Perez-Serra Anna Iglesias Ramon Brugada Cardiovascular Genetics Center University of GironaIDIBGISpain Department of Medical Sciences School of MedicineUniversity of GironaSpain Cardiomyopathies Unit Hospital Josep TruetaGironaSpain

Atrial fibrillation is the most common sustained arrhythmia and remains as one of main challenges in current clinical *** disease may be induced secondary to other diseases such as hypertension,valvular heart disease,and heart failure,conferring an increased risk of stroke and sudden *** studies have provided evidence that genetic factors play an important role and up to 30%of clinically diagnosed patients may have a family history of atrial *** date,several rare variants have been identified in a wide range of genes associated with ionic channels,calcium handling protein,fibrosis,conduction and *** advances in clinical,genetic and molecular basis have been performed over the last decade,improving diagnosis and ***,the genetics of atrial fibrillation is complex and pathophysiological data remains still unraveling.A better understanding of the genetic basis will induce accurate risk stratification and personalized clinical *** this review,we have focused on current genetics basis of atrial fibrillation.

关键词： Arrhythmia Atrial fibrillation Genetics Heart failure sudden cardiac death

Mutations of Desmoglein‑2 in sudden Unexplained death in the Chinese Han Population

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Journal of Forensic Science and Medicine 2019年第2期5卷 61-64页

作者： Junyi Lin Yulei Yang Ziqin Zhao Yiwen Shen Kaijun Ma Mingchang Zhang Department of Forensic Medicine School of Basic Medical SciencesFudan UniversityShanghaiChina2Shangha Key

sudden unexplained death(SUD)remains a puzzle in forensic ***‑2(DSG2)has been linked to arrhythmogenic right ventricular cardiomyopathy which may cause life‑threatening ventricular arrhythmias and sudden *** arrhythmias resulting in sudden death also occur in the absence of morphologic cardiac abnormalities at *** hypothesized that DSG2 mutations may be responsible for certain Chinese SUD *** sequenced all 15 exons of DSG2 in DNA extracted from postmortem heart tissues of 25 Chinese patients dying from *** primers were designed using the Primer Express 3.0 *** sequencing for both sense and antisense strands was performed with a BigDye Terminator DNA sequencing kit on a 3130 Xl Genetic *** damage prediction was made using Mutation Taster,PolyPhen,and SIFT *** 2 of 25 cases of Chinese SUD samples,two DSG2 heterozygous mutations(p.P927 L and p.T1070M)were identified,and one is probably *** concluded that DSG2 mutations may be related to the occurrence of part of SUD cases in the Chinese Han population.

关键词： Desmoglein‑2 desmosomal mutation sudden cardiac death sudden unexplained death

Athletes ECG Stress Characteristics in Division Ⅱ College Athletes:A Preliminary Analysis

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Journal of Science in Sport and Exercise 2020年第2期2卷 183-187页

作者： Ludmila Cosio-Lima Lauren Adlof Jeffrey Simpson Amy Crawley Youngil Lee University of West Florida 11000 University Parkway#72/220PensacolaFL 32514USA

Purpose Two-thirds of sudden cardiac deaths are attributable to underlying cardiovascular conditions in young collegiate athletes.A 12-lead exercise stress test is a screening tool that can detect these abnormalities that may predispose collegiate athletes to sudden cardiac death,and can ensure athletes meet the physical demands of training and *** pur-pose of this study was to evaluate the electrocardiographic(ECG)characteristics of DivisionⅡcollegiate athletes using the Seattle *** Fifty two athletes(males=26;females=26)of various ethnicities(Caucasian=65%,Latino/Hispanic=20%,and African American=15%);from soccer(27%),tennis(17%),basketball(15%),softball(14%),cross country(9%),volleyball(6%),football(6%),and swimming(6%)completed cardiovascular screening with resting and exercise 12-lead ECG *** abnormalities and anthropometrics were compared across race,gender,and sports using an ***-square analysis was used to test for differences in the frequency of ECG findings across gender,race,and *** Although sport was not a predictor for an abnormal ECG,73%of the athletes presented with athletes'heart con-figuration,which was significantly higher in males than females(P=0.02).The highest occurrence of these adaptations was observed in 100%of Latino/Hispanic athletes,compared to 75%of African American and 64%of Caucasian *** With newer and more sensitive ECG screening criteria,the prevalence of false-positive tests is *** research should focus on advancing the sensitivity and specificity of ECG interpretation in more diverse athletic populations regarding race and *** increasing incidence of sudden cardiac death in collegiate athletes warrants future research that evaluates the impact of implementing the 12-lead ECG as a standard screening tool for collegiate athletes.

关键词： sudden cardiac death 12-Lead ECG Athlete's heart

Comparative Analysis of CT Virtual Autopsy and Traditional Autopsy:A report of 3 Cases

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Journal of Forensic Science and Medicine 2020年第4期6卷 148-151页

作者： Longda Ma Rong Liang Yuluo Liu Qing Shi Xiangyang Xu Lian Yang Yiwu Zhou Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Radiology Tianjin Medical University Cancer Institute and HospitalTianjinChina Department of Radiology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

The objective of the study is to compare the results of virtual autopsy and traditional autopsy and then to analyze the advantages and disadvantages of *** cases with postmortem computed tomography(CT)examination and autopsy were *** CT images were sent to radiologists for interpretation and were compared with autopsy *** the cases of death in traffic accidents,the two examination conclusions are relatively consistent;in the cases of sudden cardiac death,the information provided by virtual autopsy is limited;virtual autopsy has more strength on showing some lesions such as pneumatosis and *** autopsy has high application value in traffic accident cases,while its application in some sudden death cases remains to be improved.

关键词： Computed tomography forensic pathology sudden cardiac death traffic accident virtual autopsy

Assessment of cardiac Autonomic Function by Using Heart Rate Turbulence in Behcet’s Disease

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World Journal of Cardiovascular Surgery 2014年第11期4卷 193-199页

作者： Onder Akci Mustafa Aldemir Fatma Yaman Ozlem Solak Sadik Volkan Emren Ersel Onrat Alaeddin Avsar Cardiology Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiovascular Surgery Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Physical Medicine and Rehabilitation Department School of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiology Department Afyon State HospitalAfyonkarahisarTurkey

Behcet’s disease (BD) is a chronic inflammatory disorder that can affect many systems in the body. cardiac involvement increases the risk of cardiovascular mortality and occurs in 1%-5% of patients with BD. Ventricular arrythmias are believed to be the cause of this increased risk of cardiovascular mortality and it is also thought to be related with cardiac autonomic dysfunction. Heart rate turbulence (HRT) is a new predictor of cardiac autonomic activity. HRT is an independent and powerful predictor of mortality. In this study, we investigated the cardiac autonomic activity which can be determined by HRT in patients with BD. Forty patients with BD (20 men, mean age: 40 ± 9 years, range: 27-55 years) were diagnosed according to the International Study Group Criteria (ISGC) and gender and age matched healthy volunteers (20 men, mean age: 39 ± 8 years, range: 26-56 years) were included in this study. All of the participants (patients and controls) underwent 24 hours Holter electrocardiogram. HRT parameters, turbulence onset (TO) and turbulence slope (TS) were calculated with HRT (View Version 0.60-0.1 of Software Program). There were no significant differences in TO and TS values between patients with BD and control subject (TO-BD: 0.014 ± 0.03, TO-Control: 0.011 ± 0.04;TS-BD: 7.88 ± 4.9, TS-Control: 9.42 ± 6.7 respectively). Although increased cardiovascular mortality rates in BD have been shown in many studies, HRT values—detecting the risk of sudden death—do not seem to be altered in this disease.

关键词： Behcet’s Disease Heart Rate Turbulence sudden cardiac death cardiac Autonomic Activity

NYHA Class II or III Heart Failure: Who Will Need an Implantable Cardioverter Defibrillator (ICD)?

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World Journal of Cardiovascular Diseases 2016年第10期6卷 372-381页

作者： Irtiza Hasan Muhammad Tofazzal Hossain Md. Harun Ur Rashid Bhuiyan Cardiology Canterbury Christ Church University Canterbury UK Internal Medicine The University of Edinburgh Edinburgh UK Cardiology Universal Medical College Dhaka Bangladesh Clinical & Interventional Cardiology Z.H. Sikder Cardiac Care & Research Centre Dhaka Bangladesh

sudden cardiac death (SCD) is one of the most debilitating and life-threatening complications of heart failure (HF) which has challenged medical care for long. Current guidelines suggest the use of Implantable Cardioverter Defibrillator (ICD) in primary prevention of SCD in both New York Heart Association (NYHA) class II and class III heart failure. This paper critically evaluated the evidence underlying the guideline recommendation. In contrast to recent guidelines, the majority of the intervention trials conducted on the topic till date found a promising role of ICD only in the prevention of SCD in NYHA class II HF. One of the trials which found a significant role of ICD in type III heart failure was underpowered. Thus, further trials are needed to validate the use of ICD in the prevention of SCD in type III HF.

关键词： Heart Failure sudden cardiac death Implantable Cardioverter Defibrillator ICD NYHA ESC

The Impact of High-Intensity Interval Training on CAMR-RyR complex in cardiomyocyte in CAMR1A transgenic mice

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The Impact of High-Intensity Interval Training on CAMR-RyR c...

Comprehensive Analysis,Discussion and Suggestion on the Current Situation of Cardiopulmonary Resuscitation and Automatic External Defibrillator in General Public in China

2015年中国生理学会运动生理学专业委员会会议暨“运动与心血管保护”学术研讨会

作者： Rui Feng Zhongguang Li Jing Cui Juncai Lv Xin Zhou Yingfeng Gao Liyang Wang Ronghua Yang Xiaofei Zhang Rongrong Wang Yazhuo Xue Juan Chen Xuehong Xu The Laboratory of Cell Genetics and Developmental Biology(CGDB) Shannxi Normal University College of Medicine

Arrhythmias and heart failure are common cause of sudden *** arrhythmia is closely associated with cardiac dysfunction,its cellular genetic mechanism on molecular biology is related to abnormal cardiac calcium *** receptors(RyR) are cardiac sarcoplasmic reticulum(SR) Ca release *** RyR,exhibiting enhanced Caleak has been implicated in arrhythmogenesis and heart failure(HF).Both CAMR1 and CAMR2 were found to be associated with calcium release channel ryanodine receptors(RyR).Although CAMR1 and CAMR2 both express in cardiomyocytes,CAMR1 is highly expressed in *** its function in the heart is largely ***1-deficient mice are emyonic lethal due to abnormal cardiac *** study demonstrates CAMR1 is a key regulator for cardiac voltage-gated sodium channel,the dysregulation of Imediated by CAMR1 plays an important role in the pathological process,may be one mechanism of *** this study,we generated CAMR1 overexpressing transgenic(MyHC-CAMR1) mice,based on finding of that the whole-heart cardiac overexpression of CAMR1 A gene driven by MHC promoter resulted in atrium enlargement leading to cardiac *** 4 wk high intensity exercise,we analyzed the effects of exercise on the cellular genetic mechanism of the atrium-enlargement caused atrial fibrillation and enhance the understanding on molecular cell biology of the SCD related to CAMR-RyR complex in cardiomyocyte by utilizing CAMR1 A transgenic mouse.A total of 32 transgenic mice and wild-type mice(C57) were randomly divided into 4 *** documented ECGs and BP,exercise animals were placed on a treadmill and acclimated to exercise for 1 *** treadmill running was conducted for 1 h/day for 5 consecutive days,including 10 min of warm-up at 40-50%VO2 max and 50 min of interval *** interval consisted of 4 min of high-intensity(85-90%VO2 max) running and 2 min of low intensity(50-60%VO2 max) *** showe

关键词： Arrhythmia sudden cardiac death Atrioventricular conduction block CAMR1 CAMR2

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Journal of Advances in Medicine Science 2021年第1期4卷 16-18页

作者： Yuheng Jiang Chenxu Yang Xuchen Deng Zhilu Li Saijia Li Hainan Medical University HaikouHainan570100China

The number of sudden cardiac death(SCD)has increased year by year,which has become one of the main causes of death in *** cardiopulmonary resuscitation(CPR)and timely and accurate use of automatic external defibrillator(AED)can greatly improve the survival rate of patients with sudden cardiac *** the large probability of sudden cardiac death occurs outside the hospital,it is very important for the general public to master first aid *** paper will mine all kinds of data from multi-dimensional and multi-angle,analyze the mastery of public first aid skills in China,and provide practical suggestions and ideas for popularizing first aid skills in the future.

关键词： sudden cardiac death cardiac arrest Cardiopulmonary resuscitation Automatic external defibrillator Pre-hospital first aid