Assessment of Cardiac Autonomic Function by Using Heart Rate Turbulence in Behcet’s Disease

作     者：Onder Akci Mustafa Aldemir Fatma Yaman Ozlem Solak Sadik Volkan Emren Ersel Onrat Alaeddin Avsar 

作者机构：Cardiology DepartmentSchool of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiovascular Surgery DepartmentSchool of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Physical Medicine and Rehabilitation DepartmentSchool of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey Cardiology DepartmentAfyon State HospitalAfyonkarahisarTurkey 

出 版 物：《World Journal of Cardiovascular Surgery》 (心血管外科国际期刊（英文）)

年 卷 期：2014年第4卷第11期

页      面：193-199页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Behcet’s Disease Heart Rate Turbulence Sudden Cardiac Death Cardiac Autonomic Activity 

摘      要：Behcet’s disease (BD) is a chronic inflammatory disorder that can affect many systems in the body. Cardiac involvement increases the risk of cardiovascular mortality and occurs in 1%-5% of patients with BD. Ventricular arrythmias are believed to be the cause of this increased risk of cardiovascular mortality and it is also thought to be related with cardiac autonomic dysfunction. Heart rate turbulence (HRT) is a new predictor of cardiac autonomic activity. HRT is an independent and powerful predictor of mortality. In this study, we investigated the cardiac autonomic activity which can be determined by HRT in patients with BD. Forty patients with BD (20 men, mean age: 40 ± 9 years, range: 27-55 years) were diagnosed according to the International Study Group Criteria (ISGC) and gender and age matched healthy volunteers (20 men, mean age: 39 ± 8 years, range: 26-56 years) were included in this study. All of the participants (patients and controls) underwent 24 hours Holter electrocardiogram. HRT parameters, turbulence onset (TO) and turbulence slope (TS) were calculated with HRT (View Version 0.60-0.1 of Software Program). There were no significant differences in TO and TS values between patients with BD and control subject (TO-BD: 0.014 ± 0.03, TO-Control: 0.011 ± 0.04;TS-BD: 7.88 ± 4.9, TS-Control: 9.42 ± 6.7 respectively). Although increased cardiovascular mortality rates in BD have been shown in many studies, HRT values—detecting the risk of sudden death—do not seem to be altered in this disease.