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sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis

Neural Regeneration Research 2022年第12期17卷 2702-2709页

作者： Yi-Xin Chen Talifu Zuliyaer Bin Liu Shuang Guo De-Gang Yang Feng Gao Yan Yu Ming-Liang Yang Liang-Jie Du Jian-Jun Li School of Rehabilitation Medicine Capital Medical UniversityBeijingChina China Rehabilitation Science Institute BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Department of Spinal and Neural Functional Reconstruction China Rehabilitation Research CenterBeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina Department of Rehabilitation Medicine Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Spine Surgery Hunan Provincial People’s Hospital(The First Affiliated Hospital of Hunan Normal University)ChangshaHunan ProvinceChina

Ferroptosis is a recently discovered form of iron-dependent cell death,which occurs during the pathological process of various central nervous system diseases or injuries,including secondary spinal cord *** has been shown to promote neurological function recovery after cerebral hemorrhage by inhibiting ***,whether selenium can promote neurological function recovery after spinal cord injury as well as the underlying mechanism remain poorly *** this study,we injected sodium selenite(3μL,2.5μM)into the injury site of a rat model of T10 vertebral contusion injury 10 minutes after spinal cord injury *** found that sodium selenite treatment greatly decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and ***,sodium selenite increased the protein and mRNA expression of specificity protein 1 and glutathione peroxidase 4,promoted the survival of neurons and oligodendrocytes,inhibited the proliferation of astrocytes,and promoted the recovery of locomotive function of rats with spinal cord *** findings suggest that sodium selenite can improve the locomotive function of rats with spinal cord injury possibly through the inhibition of ferroptosis via the specificity protein 1/glutathione peroxidase 4 pathway.

关键词： ferroptosis glutathione peroxidase 4 glutathione iron lipid peroxidation neural regeneration secondary injury sodium selenite specificity protein 1 spinal cord injury

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sodium selenite ameliorates dextran sulfate sodiuminduced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses

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World Journal of Gastroenterology 2017年第21期23卷 3850-3863页

作者： Li-Xuan Sang Bing Chang Jun-Feng Zhu Fang-Li Yang Yan Li Xue-Feng Jiang Da-Nan Wang Chang-Long Lu Xun Sun Department of Immunology China Medical University Department of Geriatrics First Affiliated HospitalChina Medical University Department of Gastroenterology First Affiliated HospitalChina Medical University

AIM To assess the effect of sodium selenite on the severity of dextran sulfate sodium(DSS)-induced colitis in C57BL/6 *** Mice were randomly divided into four groups(n = 10/group): normal group, selenium(Se) group, chronic colitis group, and Se + chronic colitis group. The mice were sacrificed on day 26. Survival rates, clinical symptoms, colon length, and histological changes were determined. The percentages and absolute numbers of immune system cells in the lamina propria lymphocytes(LPL) of the colon, the expression of m RNA in colon tissue, and the concentrations of Th1, Th17, and Treg cytokines in LPL from the large intestine, were *** Se significantly ameliorated the symptoms of colitis and histological injury(P < 0.05 each), increasing the proportions of neutrophils and CD4+ CD25+ T cells(P < 0.05 each) and decreasing the proportions of γδT cells, CD4+, CD4+CD44+, and CD4+ CD69+ T cells in LPL(P < 0.05 each). Moreover, Se reduced the expression of IL-6, IFN-γ, IL-17 A, IL-21, T-bet, and RORγt(P < 0.05 each), but enhanced the expression of IL-10 and Foxp3(P < 0.05 each). CONCLUSION These results suggest that Se protects against DSSinduced chronic colitis perhaps by increasing the number of CD4(+)CD25(+) Tregs that suppress the secretion of proinflammatory cytokines and populations of Th1, Th17, and γδT cells.

关键词： sodium selenite Dextran sulfate sodium Chronic colitis

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Hydrogen selenide,a vital metabolite of sodium selenite,uncouples the sulfilimine bond and promotes the reversal of liver fibrosis

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Science China(Life Sciences) 2021年第3期64卷 443-451页

作者： Dongrui Luan Zengteng Zhao Dandan Xia Qiuling Zheng Xiaonan Gao Kehua Xu Bo Tang College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano ProbesMinistry of EducationInstitute of Molecular and Nano ScienceShandong Normal UniversityJinan 250014China Department of Pharmaceutical Analysis School of PharmacyState Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China

sodium selenite has alleviating effects on liver fibrosis;however,its therapeutic molecular mechanism remains ***,hydrogen selenide,a major metabolite of Na_(2)SeO_(3),was tested to uncouple the sulfilimine bond in collagen IV,the biomarker of liver fibrosis.A mouse model of liver fibrosis was constructed via a CCl_(4)-induced method,followed by the administration of 0.2 mg kg−1 Na_(2)SeO_(3)via gavage three times per week for 4 *** in H2Se,NADPH,and H_(2)O_(2)levels were monitored in real time by using NIR-H2Se,DCI-MQ-NADPH,and H_(2)O_(2)probes in vivo,respectively.H_(2)Se continuously accumulated in the liver throughout the Na_(2)SeO_(3)treatment period,but the levels of NADPH and H_(2)O_(2)*** expression of collagen IV was analyzed through Western blot and liquid chromatography-mass *** confirmed that the sulfilimine bond of collagen IV in the fibrotic mouse livers could be broken by H2Se with the Na_(2)SeO_(3)***,the therapeutic effect of Na_(2)SeO_(3)on liver fibrosis could be mainly attributed to H_(2)Se that uncoupled the sulfilimine bond to induce collagen IV *** study provided a reasonable explanation for the molecular mechanism of the in vivo function of Na_(2)SeO_(3)and the prevention of liver fibrosis by administering inorganic selenium.

关键词： hydrogen selenide sodium selenite sulfilimine bond liver fibrosis reversal collagen IV

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sodium selenite may be not the optimal speciation as an effective therapy for arsenic-induced anxiety-/depression-like behavior

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World Journal of Psychiatry 2022年第9期12卷 1255-1257页

作者： Xiao-Hua Ren Xiao-Xuan Wang Lian-Ping He School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

Major depressive disorder is a serious and prevalent neuropsychiatric disorder,affecting more than 350 million people ***,sodium selenite(SS)was selected as the selenite supplement to improve the behavior in a mouse model of depression induced by *** may be not the optimal speciation for selenite supplementation and the source of the SS used in the study was not *** are many mouse models of depression and anxiety;however,in the current study,a classical mouse model of depression was not ***,several questions still need to be further *** together,the results indicate that SS may be not the optimal speciation as an effective therapy for As-induced anxiety-/depression-like behavior.

关键词： Depression Arsenic Major depressive disorder sodium selenite Optimal speciation

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Change of choline compounds in sodium selenite-induced apoptosis of rats used as quantitative analysis by in vitro 9.4T MR spectroscopy

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World Journal of Gastroenterology 2008年第24期14卷 3891-3896页

作者： Zhen Cao Lin-Ping Wu Yun-Xia Li Yu-Bo Guo Yao-Wen Chen Ren-Hua Wu Departmen't of Medical Imaging The S'econdAffiliated Hospital Shantou University Medical CollegeShantou 515041 Guangdong Province China Multidisciplinary Research Center ShantouUniversity Shantou 515041 Guangdong Province China

AIM: To study liver cell apoptosis caused by the toxicity of selenium and observe the alteration of choline compounds using in vitro 9.4T high resolution magnetic resonance spectroscopy. METHODS: Twenty male Wistar rats were randomly divided into two groups. The rats in the treatment group were intraperitoneally injected with sodium selenite and the control group with distilled water. All rats were sacrifi ced and the livers were dissected. 1H-MRS data were collected using in vitro 9.4T high resolution magnetic resonance spectrometer. Spectra were processed using XWINNMR and MestRe-c 4.3. HE and TUNEL staining was employed to detect and confi rm the change of liver cells. RESULTS: Good 1H-MR spectra of perchloric acid extract from liver tissue of rats were obtained. The conventional metabolites were detected and assigned. Concentrations of different ingredient choline compounds in treatment group vs control group were as follows: total choline compounds,5.08 ± 0.97 mmol/L vs 3.81 ± 1.16 mmol/L (P = 0.05); and free choline,1.07 ± 0.23 mmol/L vs 0.65 ± 0.20 mmol/L (P = 0.00). However,there was no statistical signif icance between the two groups. The hepatic sinus and cellular structure of hepatic cells in treatmentgroup were abnormal. Apoptosis of hepatic cells was confi rmed by TUNEL assay. CONCLUSION: High dose selenium compounds can cause the rat liver lesion and induce cell apoptosis in vivo. High resolution 1H-MRS in vitro can detect diversified metabolism. The changing trend for different ingredient of choline compounds is not completely the same at early period of apoptosis.

关键词： Apoptosis of liver cell Choline compounds sodium selenite In vitro ^1H-MRS Quantitative analysis

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Redifferentiation of Human Gastric Cancer Cells Induced by Ascorbic Acid and sodium selenite

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Biomedical and Environmental Sciences 2002年第3期15卷 223-232页

作者： ZHENGQIU－SHENG SUNXI－LING 等 Departmentofbiochemistry YantaiUniversity HospitalofYantaiUniversity YantaiUniversityYantai264005

Objective To explore the effects and mechanisms of ascorbic acid (AA) and sodium selenite (SS) on growth inhibition and redifferentiation in human gastric cancer cells. Methods In the present study, trypan blue dye exclusion method was used to determine the cell growth curve and mitotic index, cell electrophoresis and colonogenic potential were used as the indexes of redifferentiation. In order to find out the mechanisms of redifferentiation, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) were assayed, the content of malondialdehyde (MDA), reduced glutathione (GSH) and H2O2 were evaluated. Results After treatment with AA 3 mol/L + SS 2μmol/L, the growth rate and mitotic index of human gastric cancer cells (MGc-803) decreased remarkably. The indexes related with cell malignancy were alleviated. For example, cell surface charge was obviously decreased, the electrophoresis rate was dropped from 2.21 to 1.15μm·s-1·V-1·cm-1. The indexes related with cell redifferentiation were promoted. For example, the colonogenic potential was decreased to 93.5%. These results indicated that redifferentiation of human gastric cancer cells was successfully induced by AA + SS. The activities of SOD and GPX were significantly higher, while the activity of CAT was slower in treated group than that in the control. The content of MDA was slightly decreased, GSH was sharply decreased, and H2O2 content was dramatically increased. Conclusion These results indicated that combination of ascorbic acid and sodium selenite may induce the redifferentiation of human gastric cancer cells and inhibit cell growth by virtue of enhancing the activities of antioxidative enzymes and inducing the formation of H2O2, and altering the cell redox status. Combination of ascorbic acid and sodium selenite may be a potent anticancer agent for human gastric cancer.

关键词： Ascorbic acid sodium selenite Gastric cancer Malondialdehyde Catalase Superoxide dismutase

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Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 499-506页

作者： Irfan Ergen Burak Turgut Nevin Ilhan Diskapi YildirimBeyazit Training and Research Hospital Eye Diseases Clinic Ankara 06330 Turkey Department of Ophthalmology Faculty of Medicine Firat University Elazig 23119 Turkey Department of Biochemistry Faculty of Medicine Firat University Elazig 23119 Turkey

AIM：To compare the potential protective effects of epigallocatechin gallate（EGCG） and ellagic acid（EA） in an experimental cataract model.●METHODS：Twenty-eight Spraque-Dawley rat pups were assigned into four *** the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th *** in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/（kg·d） saline solution,50 mg/（kg·d） EGCG and 200 mg/（kg·d） EA,*** reduced glutathione（GSH） and malondialdehyde（MDA） levels,total antioxidant status（TAS） and total oxidant status（TOS） in lens supernatants were ***：The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group（P〈0.001）.The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group（P〈0.001）.CONCLUSION：EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress.

关键词： sodium selenite experimental cataract epigallocatechin gallate ellagic acid total oxidant status totalanti-oxidant status.

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Protective Role of C-Phycocyanin Against Secondary Changes During sodium selenite Mediated Cataractogenesis

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Natural Products and Bioprospecting 2014年第2期4卷 81-89页

作者： Rasiah Pratheepa Kumari Kumarasamy Anbarasu Department of Marine Biotechnology Bharathidasan UniversityTiruchirappalli 620024Tamil NaduIndia

Age related cataract is the leading cause of blindness associated with accumulation of oxidative stress in the eye *** present investigation reveals the rational of the beneficial effects of the natural compound C-phycocyanin(CPC)is beneficial when administered to rat pups to protect against the secondary effects of sodium selenite induced cataractogenesis.A single subcutaneous dose of sodium selenite(19 lmol/kg body weight)on the 10th day of postpartum is adequate to induce cataract in rat *** biochemical parameters,such as the level of electrolytes,mean activities of anti-oxidant enzymes *** dismutase,catalase and reduced glutathione were observed to be significantly altered during selenite induced cataractogenic *** examination revealed signs of degradation of normal cell architecture in the liver,kidney and eye ***,the deleterious effects of sodium selenite toxicity were restored with the simultaneous treatment with *** results suggest that an administration of 200 mg/kg body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to sodium *** results complement the beneficial role of C-PC of cyanobacterial origin as a efficacious anti-cataractogenic agent against sodium selenite toxicity.

关键词： Cyanobacteria C-phycocyanin Cataract sodium selenite Cataractogenesis

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Effect of sodium selenite-Chitosan Compound Preservative on Storability of Kumquats

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Asian Agricultural Research 2021年第4期13卷 43-47页

作者： Dongdi XIE Jun YUE Yankun LU Department of Chemical and Biological Engineer Hezhou University Hezhou 542899 China Library of Hezhou University Hezhou 542899 China

[Objectives]To explore the effect of sodium selenite-chitosan compound preservative on storability of kumquats.[Methods]Under the condition of room temperature,fresh kumquats were coated with different concentrations of sodium selenite-chitosan compound preservative,respectively.[Results]sodium selenite-chitosan compound preservative reduced the weight loss rate,delayed the decline of vitamin C,soluble solids,titratable acid and GSH contents,slowed down the accumulation of MDA,inhibited the increase of PPO activity,and increased to a certain extent the activity of SOD in fresh kumquats.[Conclusions]sodium selenite-chitosan compound preservative maintained the quality and prolonged the shelf life of *** preservation effect of compound preservative composed of 4 mg/L sodium selenite and 8 g/L chitosan was the best.

关键词： Kumquat sodium selenite Chitosan Storage quality

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Effect of sodium selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet containing Aflatoxin B1

Effect of Sodium Selenite on Pathological Changes and Renal ...

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第七届中国畜牧科技论坛

作者： Liang na Wang fengyuan Peng xi Fang jing Cui hengmin Chen zhengli Lai weimin Zhou yi Geng yi Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province College of Veterinary MedicineSichuan Agricultural University

To evaluate the renal toxicity of dietary aflatoxin B(AFB) and ameliorating effects of added dietary sodium selenite in broiler,renal histopathological changes,ultrastructural changes and renal function parameters were monitored at 7,14,and 21 days of *** hundred one-day-old healthy male Avian broilers were divided into four groups,namely control group,AFB group(0.3 mg/kg AFB),+Se group(0.4 mg/kg Se) and AFB +Se group(0.3 mg/kg AFB +0.4 mg/kg Se).Compared with that of the control group,the relative weight of kidney was increased in the AFB *** were no significant differences between the AFB +Se group and the control *** histopathological observation,the renal epithelia were swelling and necrosis at 7 and 21 days of ***,the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the *** mitochondria with degenerated cristae were observed in the+Se *** with the control group,the contents of serum creatinine and serum uric acid in the AFBgroup were increased,while the activity of renal Na-K ATPase was *** 0.4mg/kg selenium was added into the diet containing 0.3 mg/kg AFB,there were no obvious histological changes in the AFB +Se group,and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na-K ATPase were close to those in the control *** conclusion,sodium selenite exhibited protective effects on AFB-induced kidney toxicity in broilers.

关键词： Aflatoxin B1 sodium selenite Pathological Observation Ultrastructural Observation Renal Function Broiler

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