Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet containing Aflatoxin B1
作者单位：Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan ProvinceCollege of Veterinary MedicineSichuan Agricultural University
会议名称：《第七届中国畜牧科技论坛》
会议日期：2016年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
关 键 词：Aflatoxin B1 Sodium Selenite Pathological Observation Ultrastructural Observation Renal Function Broiler
摘 要：To evaluate the renal toxicity of dietary aflatoxin B(AFB) and ameliorating effects of added dietary sodium selenite in broiler,renal histopathological changes,ultrastructural changes and renal function parameters were monitored at 7,14,and 21 days of *** hundred one-day-old healthy male Avian broilers were divided into four groups,namely control group,AFB group(0.3 mg/kg AFB),+Se group(0.4 mg/kg Se) and AFB +Se group(0.3 mg/kg AFB +0.4 mg/kg Se).Compared with that of the control group,the relative weight of kidney was increased in the AFB *** were no significant differences between the AFB +Se group and the control *** histopathological observation,the renal epithelia were swelling and necrosis at 7 and 21 days of ***,the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the *** mitochondria with degenerated cristae were observed in the+Se *** with the control group,the contents of serum creatinine and serum uric acid in the AFBgroup were increased,while the activity of renal Na-K ATPase was *** 0.4mg/kg selenium was added into the diet containing 0.3 mg/kg AFB,there were no obvious histological changes in the AFB +Se group,and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na-K ATPase were close to those in the control *** conclusion,sodium selenite exhibited protective effects on AFB-induced kidney toxicity in broilers.