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sesquiterpenes from the soft coral Paralemnalia thyrsoides and their biogenetic correlation

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Chinese Science Bulletin 1995年第3期40卷 213-216页

作者：曾陇梅钟永利苏镜娱赵迪 Department of Chemistry Zhongshan University Guangzhou 510275 China Department of Chemistry Zhongshan University Guangzhou 510275 ChinaDepartment of Chemistry Zhongshan University Guangzhou 510275 China South China Sea Institute of Oceanology Guangzhou 510275 China

Terpenoids are the important secondary metabolites of soft coral. In the investigation of soft corals collected from South China Sea, we have found many cembranoid diterpenes with bioactivity and two rare unique biscembranoid tetraterpenes, i.e. methyl sartortuoate and methyl isosartortuoate. We have suggested a plausible biogenesis pathway for these two tetraterpenoids in the soft coral Sarcophyton tortuosum.Recently, B. F. Bowden et al. obtained one more tetraterpenoid with the similar structure from the same species Australian soft coral. Besides, they isolated one of the probably

关键词： sesquiterpenes biogenetic synthesis soft coral structural determination biological activity.

Toxicity Assessment of Cadinene sesquiterpenes from Eupatorium adenophorum in Mice

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Natural Products and Bioprospecting 2015年第1期5卷 29-36页

作者： Can-Bin Ouyang Xiao-Man Liu Qi Liu Jie Bai Hou-Yong Li Yuan Li Qiu-Xia Wang Dong-Dong Yan Lian-Gang Mao Aocheng Cao Mei-Xia Guo Department of Pesticides Institute of Plant ProtectionChinese Academy of Agricultural SciencesMinistry of Agricultureand State Key Laboratory for Biology of Plant Diseases and Insect PestsBeijing 100193People’s Republic of China National Engineering Laboratory for Crop Efficient Water Use and Disaster Mitigation and Key Laboratory of Dryland AgricultureMinistry of AgricultureInstitute of Environment and Sustainable Development in AgricultureChinese Academy of Agricultural SciencesBeijing 100081People’s Republic of China

This study evaluated toxic efficacy of Eupatorium adenophorum extracts,against the Kunming mice.In acute study,we firstly tested median lethal dose(LD50)in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-oxoageraphorone(DAOA),9-oxo-agerophorone(OA)and 9-oxo-10,11-dehydro-agerophorone(ODA)from Eupatorium adenophorum(Ea).DAOA(215–4640 mg/kg BW,given orally)showed lowest LD50 at 926 mg/kg BW for male mice in contrast with OA(1470 mg/kg BW)and ODA(1470 mg/kg BW).In sub-acute study,repeated doses(75–300 mg/kg BW,for 7 days)of DAOA/OA increased blood parameters,liver and spleen index in dose dependent relationship,along with decrease in thymus index.The blood biochemical and histopathological examination showed that DAOA/OA dose 300 mg/kg BW significantly causes pathological changes of hepatic lobules and hepatocytes,which are consistent with cholestasis and hepatic injury.75 mg/kg dose of DAOA/OA was found to be approximately/totally safe over the span of 7 days treatment showing no change in all above described parameters.Cadinene sesquiterpenes guarantee low risk to environment as a type of low toxic botanical components,which may find potential application in biopesticides development field.

关键词： Eupatorium adenophorum sesquiterpenes Histopathology Environmental toxicity Biopesticide

Steroids and sesquiterpenes From Cultures of the Fungus Phellinus igniarius

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Natural Products and Bioprospecting 2015年第1期5卷 17-22页

作者： Rong-Hua Yin Zhen-Zhu Zhao Xu Ji Ze-Jun Dong Zheng-Hui Li Tao Feng Ji-Kai Liu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Two new steroids,3a,17a,19,20-tetrahydroxy-4a-methylpregn-8-ene(1)and 3a,12a,17a,20-tetrahydroxy-4amethylpregn-8-ene(2)and three new sesquiterpenoids,12-hydroxy-a-cadinol(3),3a,12-dihydroxy-d-cadinol(4),and 3a,6a-dihydroxyspiroax-4-ene(5),have been isolated from cultures of the fungus Phellinus igniarius.Their structures were characterized based on extensive spectroscopic data.In preliminary in vitro assays,compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0%and 7.0%at 3910-4 M,respectively.

关键词： Pregnene steroids sesquiterpenes Phellinus igniarius Cytotoxicity Vascular-activities

Antiparasitic sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment

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Natural Products and Bioprospecting 2017年第3期7卷 235-247页

作者： Kennedy D.Nyongbela Fidele Ntie-Kang Thomas R.Hoye Simon M.N.Efange Pharmacochemistry Research Group Department of ChemistryUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry University of Minnesota207 Pleasant StreetSEMinneapolisMNUSA Chemical and Bioactivity Information Centre Department of ChemistryUniversity of BueaP.O.Box 63BueaCameroon

We are grateful for financial support from the International Cooperative Biodiversity Groups(ICBG),a program of the Fogarty International Centre of the National Institutes of Health(NIH),USA through grant(no TW00327)awarded to Professor S.M.N.Efange and Medicines for Malaria Venture(MMV),Geneva,Switzerland.The US Fulbright Council for International Exchange of Scholars(CIES)is acknowledged for grant to Kennedy D.Nyongbela to carry-out research at the University of Minnesota.We wish to thank M.Campbell and A.Powell from the Centre for Drug Candidate Optimisation(CDCO),Monash University for the DMPK data.Fidele Ntie-Kang is currently a Georg Forster fellow of the Alexander von Humboldt Foundation,Germany.We are equally grateful to Schro¨dinger Inc.for the academic license to use the QikProp software.

关键词： sesquiterpenes Pharmacokinetics Drug metabolism Scleria striatinux

Two New sesquiterpenes from Ligularia Duciformis

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Chemical Research in Chinese Universities 1999年第1期15卷 72-74页

作者： GAO Kun JIA Zhong-jian Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

ＡｐｒｅｖｉｏｕｓｐｈｙｔｏｃｈｅｍｉｃａｌｓｔｕｄｙｏｆＬｉｇｕｌａｒｉａｄｕｃｉｆｏｒｍｉｓｄｅａｌｔｗｉｔｈｔｈｅｉｓｏｌａｔｉｏｎｏｆｃｏｎｉｆｅｒｙｌａｌｃｏｈｏｌｄｅｒｉｖａｔｉｖｅｓ［１，２］．Ｉｎｏｒ... 详细信息

ＡｐｒｅｖｉｏｕｓｐｈｙｔｏｃｈｅｍｉｃａｌｓｔｕｄｙｏｆＬｉｇｕｌａｒｉａｄｕｃｉｆｏｒｍｉｓｄｅａｌｔｗｉｔｈｔｈｅｉｓｏｌａｔｉｏｎｏｆｃｏｎｉｆｅｒｙｌａｌｃｏｈｏｌｄｅｒｉｖａｔｉｖｅｓ［１，２］．Ｉｎｏｒｄｅｒｔｏｆｉｎｄｓｅｓｑｕｉｔｅ...

关键词： Ligularia duciformis Roots sesquiterpenes Liguducin A Liguducin B 2D NMR

Two New sesquiterpenes from Euonymus phellomana Loes.

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Chinese Chemical Letters 2000年第4期11卷 331-332页

作者： Hong WANG Xuan TIAN Li YANG Yao Zu CHEN (National laboratory of Applied Organic Chemistry, Lanzhou University. Lanzhou 730000) Natl. Lab. of Appl. Organ. Chemistry Lanzhou University Lanzhou 730000 China

Two new beta-dihydroagarofuran sesquiterpenes were isolated from Euonymus phellomana Loes. and their structures were established on the basis of spectral analysis.

关键词： Euonymus phellomana Loes. beta-dihydroagarofuran sesquiterpenes

Activity of dihydroartemisinin against Leishmania donovani both in vitro and vivo

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Chinese Medical Journal 2004年第8期117卷 1271-1273页

作者：马莹芦殿梅陆小军廖琳胡孝素 Department of Parasitology School of Preclinical and Forensic Medicine Sichuan UniversityChengdu610041China Department of Laboratory Medicine Huaxi Hospital Sichuan UniversityChengdu610041China

Visceral leishmaniasis (VL), also known as kala-azar, is a vector-borne disease caused by protozoa of the Leishmania donovani complex. It is usually fatal if untreated. Pentavalent antimonials have been the mainstay of treatment for more than 60 years, but these drugs have serious side effects and progressive antimonial resistance.1 Other proven therapeutics such as amphotericin B, pentamidine, and paromomycin are costly without oral formulation and unpleasant side effects.2 Thus, new chemotherapeutic drugs are required to supplement or replace currently available drugs.

关键词： Animals Artemisinins Cricetinae Leishmania donovani Male Mesocricetus sesquiterpenes

5-Hydroxytryptamine-inhibiting property of Feverfew: role of parthenolide content

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Acta Pharmacologica Sinica 2000年第12期21卷 51-59页

作者： Shivani MTTTRA Aniruddha DATTA S K SINGH Amarjit SINGH India P O Lalru 140501 Panacea Biotec Limited Punjab Research and Development

AIM: To study the mechanism of antimigraine activity of Tanacetum parthenium ( Feverfew), its extracts and parthenolide, a component of Feverfew, by observing their effect on 5-HT storage and release, and stimulation of 5-HT2B and 5-HT2A receptors. Also to standardize a dosage form of Feverfew with respect to its parthenolide content. METHODS: Isometric responses to 5-HT and an indirect acting serotonergic, d-fenfluramine, were obtained on rat fundus and ileum. In one set of experiments the effect of dichloromethane extract of Feverfew and parthenolide was observed on the above. The extract was then thermally degraded upto 10 %, 23 %, and 33 % with respect to its parthenolide content by keeping at 60℃ and 75 % relative humidity and the experiments were repeated. In another set of experiments rats were fed with 20 mg/kg Feverfew powder (equivalent to a human dose of 500 μg parthenolide per day) for 30 d or were ip injected with parthenolide (23.4 μg/day) for 7 d. In the same set of experiments one gro

关键词： Tanacetum parthenium Feverfew parthenolide sesquiterpenes lactones stomach fundus ileum serotonin antagonist migraine

Two Cytotoxic Eremophilanolides from Senecio tsoongianus

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Chinese Chemical Letters 2005年第3期16卷 362-364页

作者： QiJunZHANG HuiDOU ChangXinZHOU ZhaoJunXU HuaPENG YuZHAO DepartmentofTraditionalChineseMedicineandNaturalDrugResearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031 KunmingInstituteofBotany ChineseAcademyofSciencesKunming650204

Two new cremophilanolidcs, tsoongianolide E and F, were isolated from Senecio tsoongianus. Their structures were elucidated on the basis of NMR and MS spectra. Both of these two compounds showed in vitro cytotoxicity ... 详细信息

关键词： sesquiterpenes eremophilanolide Seneciotsoongianus.