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Chemical Research in Chinese Universities 2015年第6期31卷 958-963页

作者： MA Junjie HU Gang XIE Lijun CHEN Lei XU Boxuan GONG Ping Key Laboratory of Structure-based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 P. R. China Fujian Institute of Microbiology Fuzhou 350007 P. R. China

A series of novel benzothiazole derivatives bearing semicarbazone as a linker was designed and synthe- sized, and their in vitro antitumor activities were evaluated against four cancer cell lines（HT29, H460, A549 and MDA-MB-231）. Most of them showed moderate to excellent activity against all the tested cell lines. Among them, compounds 12a--12i with fluoro-substituted benzyl-1H-indole moiety displayed more potent activity than those with phenyl moiety. The most promising compound 12d exhibited excellent antitumor activity with IC50 values of 0.015, 0.28, 1.53 and 0.68 ***/L against the four tested cell lines respectively.

关键词： Benzothiazole semicarbazone Antitumor activity

Synthesis and Crystal Structure of a Zinc(II) Complex Salt with the Schiff Base of Picolinaldehyde N-oxide and semicarbazone

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1271-1275页

作者： YU Qing ZHU Li-Gang BIAN He-Dong DENG Ji-Hua YANG Xiao-E GUO Gui-Quan LIANG Hong College of Chemistry and Chemical Engineering Guangxi Normal University Guilin Guangxi 541004 China

The title zinc（Ⅱ） complex salt [Zn（H2O）6]（ClO4）2-（PNOS）4, where PNOS is derived from picolinaldehyde N-oxide with semicarbazone, has been prepared and structurally characterized by X-ray single-crystal analysis. It crystallizes in triclinic, space group PI with a = 7.529（3）, b = 10.206（4）, c = 14.678（6）A, a = 86.293（6）, β= 87.686（7）, γ= 81.382（6）°, C28H44Cl2N16O22Zn, Mr = 1093.06, V = 1112.3（8） ,A^3 Z = 1, Dc = 1.632 g/cm^3, S = 1.089, μ（MoKa） = 0.773 mm^-1, F（000） = 564, the final R = 0.0438 and wR = 0.1076 for 3888 independent reflections with Rint = 0.0224. The crystal structure possesses a [Zn（H2O）6]^2＋ cation, two ClO4^- anions and four PNOSs. In the crystal structure, Zn^2＋ cation is located at the symcenter and coordinated by six water molecules. In [Zn（H2O）6]^2＋, an elongate octahedral complex cation, the average Zn-O bond length is 2.087（2） A. There exist a lot of H bonds in the structure, linking the cation [Zn（H2O）6]^2＋, anion ClO4^- and PNOS to form a 3D network.

关键词： zinc(Ⅱ) complex salt picolinaldehyde N-oxide semicarbazone crystal structure,Schiff base

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Synthesis and characterization of semicarbazone metal complexes of Sn(IV) and Zr(IV)

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Chinese Journal of Chemistry 2000年第3期18卷 364-367页

作者：尹冬冬王志文单璐 Department of Chemistry Beijing Normal University Beijing 100875 China Pharmaceutical School Beijing Medical University Beijing 100083 China

Three semicarbazonyl ligands were synthesized and used to form six novel organometallic complexes with Ph2SnCl2 and Cp2ZrCl2. All these complexes were characterized by IR 1H NMR MS and elemental analysis.

关键词： semicarbazone PS2SnCl2 Cp2ZrCl2 organometallic complexes

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Synthesis,Crystal Structure and Interaction with DNA of a Novel Chromium(Ⅲ) Complex Containing Salicylaldehyde semicarbazone

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Chinese Journal of Structural Chemistry 2009年第7期28卷 789-796页

作者：岳蕾周荫庄刘金丽屠淑洁肖岭梅 Department of Chemistry Capital Normal University

The novel chromium（Ⅲ） complex with salicylaldehyde semicarbazone was synthesized and characterized by IR spectra and single-crystal X-ray diffraction analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 8.9849（13）, b = 12.0475（16）, c = 34.522（5）A, V = 3736.9（9）A3, Z = 8, C16H18C1CrN6O5, Mr= 461.81, De= 1.642 g/cm^3, F（000） = 1896,A（MoKα） = 0.799 mm^-1, the final R = 0.0370 and wR = 0.0827 for 2908 observed reflections with I 〉 2σ（I）. The interaction between the chromium（Ⅲ） complex with calf thymus DNA （Ct-DNA） has been investigated by absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The results indicated that the complex was bonded to Ct-DNA through a non-classical intercalative mode.

关键词： chromium(Ⅲ) complex semicarbazone crystal structure calf thymus DNA

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Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 105-110页

作者： Farhadul Islam Shaikh Mohummad Mohsin Ali Jahan Ara Khanam Department of Biochemistry and Molecular Biology Rajshahi University Applied Chemistry and Chemical Technology Rajshahi University

Objective:To determine the hepatoprotective effect of acetone semicarbazone(ASC)in vivo in normal and Ehrlich ascites carcinoma(EAC)bearing male Swiss albino ***:Druginduced changes in biochemical and behavioral parameters at dose of 2.0 mg/kg body weight for14 d and nullifying the toxicity induced by EAC cells were *** histopathology studies of the protective effects of ASC on vital organs were also ***:The administration of ASC made insignificant changes in body weight and behavioral(salivation,diarrhea,muscular numbness)changes during treatment period due to minor toxicity were minimized after the treatment in normal *** biochemical parameters,including serum glutamate pyruvate transaminase,glutamate oxaloactate transaminase,alkaline phosphatase,serum glucose,cholesterol,urea,triglyceride and billirubin changed modestly in normal mice receiving *** the treatment continued,these values gradually decreased to normal level after the *** EAC bearing mice,the toxic effects due to EAC cells in all cases were nullified by treatment with the *** abnormalities were not detected in histology of the various organs of the normal mice treated with ***:ASC can,therefore,be considered safe in formulating novel anticancer drug,as it exhibits strong protective effect against EAC cell bearing mice.

关键词： EAC cell Host toxicity Acetone semicarbazone Schiff bases Histopathology Subacute toxicity

The Synthesis and Structure of Tris-nitrato-Aqua-(2,6-Diacetyl-Pyridine) Bis ( semicarbazone )lanthanum(III )

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Chemical Research in Chinese Universities 1988年第1期 1-8页

作者： Yao Xinkan, Wang Honggen and Wang Ruji (Central Laboratoty, Nankai University, Tianjin) Pan Xiangyang, Yan Sniping and Wang Genglin (Department of Chemistry, Nankai University, Tianjin)

The complex of (La(DAPSC)(NO3)3 H2O) · H2O was prepared. Its crystal data are: triclinic, space group P- , a =8.736(1), b = 12.108(3), c =12.412(3)(A) , α=110.35(2)°, β =94.88(1)°, γ = 95.35(2)°, v =1215.78(A)3 , Z =*** was found that two arms of the ligand DAPSC can be opened to accept the La(Ⅲ). This is obviously different from the complex of Sm(Ⅲ) with DAPSC. DAPSC can be expanded easily, but it is hard to be compressed.

关键词： La lanthanum semicarbazone The Synthesis and Structure of Tris-nitrato-Aqua III

Syntheses and Structures of Rare Earth Nitrate Complexes with 2.6-Diacetylpyridinebis(semicarbazone)

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高等学校化学学报(英文版) 1988年第2期 45-53页

作者： Pan Xiangyang, Yan Shiping, Wang Genglin (Department of Chemistry, Nankai University, Tianjin) Wang Honggen, Wang Ruji and Yao Xinkan (Test center, Nankai University, Tianjin)

Six rare earth nitrate complexes of 2, 6-diacetylpyridinebis (semicarbazone) (DAPSC) were synthesized and characterized by elemental analysis, IR spectra and electrical conductance. Molecular and crystal structures of complex [Sm(DAPSC)(NO3)2(EtOH)]NO3 were determined by X-ray diffraction method. C13H21N10O12 Sm crystallized in the monoclinic apace group C2/c with the following unit-cell constants, a=16.674(2)A, b = 10. 715(2)A, c = 25.242(4)A . β = 100.077(11)°; z=8, the final R factor is 0.025. The coordination number of Sm3+ is ten.

关键词： nitrate constants monoclinic conductance crystallized complexes semicarbazone neutral EtOH titration

Synthesis and Crystal Structure ofp-tert-Butylcalix[4]arene 1,3-Distal and Monosubstituted semicarbazones and Thiosemicarbazones

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Chemical Research in Chinese Universities 2014年第3期30卷 415-419页

作者： LIU Zhenming LIU Dongmei WANG Jinxiang SUN Jing YAN Chaoguo Analysis and Test Center College of Chemistry & Chemical Engineering Yangzhou University Yangzhou 225002 P. R. China

A series of p-tert-butylcalix[4]arene 1,3-distal and monosubstituted semicarbazones and thiosemicarbazones was preparedd by acid catalyzed condensation reaction of active calixarene aldehydes with semi- carbazide and thiocarbazide in methanol. One representative single crystal was determined by X-ray dirraction method, which shows that calixarene exists in cone configuration and intramolecular hydrogen-bands exist in the crystal.

关键词： Calixarene Semicarbazide semicarbazone Thiosemicarbazone Schiffbase Crystal structure

Synthesis, Spectral Characterization and Crystal Structure of 2-((3-Aminophenyl)(phenyl)methylene) hydrazinecarboxamide

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Journal of Crystallization Process and Technology 2013年第2期3卷 64-68页

作者： Yi-Chen Chan Abdussalam Salhin Mohamed Ali Melati Khairuddean Ching-Kheng Quah School of Chemical Sciences Universiti Sains Malaysia Penang Malaysia X-ray Crystallography Unit School of Physics Universiti Sains Malaysia Penang Malaysia

A benzophenone substituted semicarbazone, 2-((3-aminophenyl)(phenyl)methylene)hydrazinecarboxamide (APHC) had been synthesized in good yield by the condensation of 3-aminobenzophenone and semicarbazide hydrochloride. The title compound was elucidated by elemental analysis (CHN), FTIR, 1H and 13C-NMR, 1H-1H COSY, TGA and single crystal X-ray diffraction. The compound crystallized in the orthorhombic crystal system with space group of Pccn, Z = 32, V = 10375.1 (2) ?3, and lattice constants a = 12.3855 (1) ?, b = 34.5746 (5) ?, c = 24.2283 (3) ??and γ = β = α = 90°. The molecular view shows that APHC contains four molecules of each species in the asymmetric unit, with similar geometries. However, there is no intramolecular hydrogen bond found in the crystal structure of the synthesized compound. X-ray diffraction also reveals that the molecule of the semicarbazone exists as a Z isomer with respect to the C=N.

关键词： semicarbazone Aminobenzophenone Benzophenone Hydrazone