Synthesis,Crystal Structure and Interaction with DNA of a Novel Chromium(Ⅲ) Complex Containing Salicylaldehyde Semicarbazone

作     者：岳蕾 周荫庄 刘金丽 屠淑洁 肖岭梅 

作者机构：Department of Chemistry Capital Normal University 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2009年第28卷第7期

页      面：789-796页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the Scientific Research Common Program of Beijing Municipal Commission of Education  PRC (KM200510028005) 

主　　题：chromium(Ⅲ) complex semicarbazone crystal structure calf thymus DNA 

摘      要：The novel chromium（Ⅲ） complex with salicylaldehyde semicarbazone was synthesized and characterized by IR spectra and single-crystal X-ray diffraction analysis. The crystal belongs to the orthorhombic system, space group Pbca with a = 8.9849（13）, b = 12.0475（16）, c = 34.522（5）A, V = 3736.9（9）A3, Z = 8, C16H18C1CrN6O5, Mr= 461.81, De= 1.642 g/cm^3, F（000） = 1896,A（MoKα） = 0.799 mm^-1, the final R = 0.0370 and wR = 0.0827 for 2908 observed reflections with I 〉 2σ（I）. The interaction between the chromium（Ⅲ） complex with calf thymus DNA （Ct-DNA） has been investigated by absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. The results indicated that the complex was bonded to Ct-DNA through a non-classical intercalative mode.