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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Frontiers of Medicine 2024年第2期18卷 258-284页

作者： Tianjing Sun Mo Li Qi Liu Anyong Yu Kun Cheng Jianxing Ma Sean Murphy Patrick Michael McNutt Yuanyuan Zhang Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Department of Nephrology Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Division of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Missouri-Kansas CityKansas CityMO64108USA Department of Biochemistry Wake Forest University School of MedicineWinston-SalemNC27157USA Wake Forest Institute of Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC27109USA

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing.This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond.Exosomes,small extracellular vesicles secreted by various stem cells,have emerged as potent mediators of intercellular communication and tissue repair.One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy,such as immune rejection or stem cells differentiating into unwanted cell types.However,further research is necessary to optimize exosome therapy,not only in the areas of exosome isolation,characterization,and engineering,but also in determining the optimal dose,timing,administration,and frequency of exosome therapy.Thus,optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer,ischemia,or inflammation.This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

关键词： exosomes stem cells therapeutic impact skin wound healing

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skin neuropathy and immunomodulation in diseases

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Fundamental Research 2024年第2期4卷 218-225页

作者： Manze Zhang Tingting Liu Jing Yang Department of Biology Stanford UniversityStanfordCA 94305USA Department of Biochemistry Weill Cornell Medical CollegeNew YorkNY 10065USA IDG/McGovern Institute for Brain Research Center for Life SciencesSchool of Life SciencesPeking UniversityBeijing 100871China Peking University Third Hospital Cancer Center Beijing 100191China

skin is a vital barrier tissue of the body.Immune responses in the skin must be precisely controlled,which would otherwise cause severe disease conditions such as psoriasis,atopic dermatitis,or pathogenic infection.Research evidence has increasingly demonstrated the essential roles of neural innervations,i.e.,sensory and sympathetic signals,in modulating skin immunity.Notably,neuropathic changes of such neural structures have been observed in skin disease conditions,implicating their direct involvement in various pathological processes.An in-depth understanding of the mechanism underlying skin neuropathy and its immunomodulatory effects could help reveal novel entry points for therapeutic interventions.Here,we summarize the neuroimmune interactions between neuropathic events and skin immunity,highlighting the current knowledge and future perspectives of this emerging research frontier.

关键词： skin Neuropathy Neuroimmune Psoriasis Atopic dermatitis Pathogenic infection

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A Deep Learning-Enabled skin-Inspired Pressure Sensor for Complicated Recognition Tasks with Ultralong Life

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Research 2024年第1期2023卷 443-454页

作者： Yingxi Xie Xiaohua Wu Xiangbao Huang Qinghua Liang Shiping Deng Zeji Wu Yunpeng Yao Longsheng Lu School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhouChina

Flexible full-textile pressure sensor is able to integrate with clothing directly,which has drawn extensive attention from scholars recently.But the realization of flexible full-textile pressure sensor with high sensitivity,wide detection range,and long working life remains challenge.Complex recognition tasks necessitate intricate sensor arrays that require extensive data processing and are susceptible to damage.The human skin is capable of interpreting tactile signals,such as sliding,by encoding pressure changes and performing complex perceptual tasks.Inspired by the skin,we have developed a simple dip-and-dry approach to fabricate a full-textile pressure sensor with signal transmission layers,protective layers,and sensing layers.The sensor achieves high sensitivity(2.16 kPa^(−1)),ultrawide detection range(0 to 155.485 kPa),impressive mechanical stability of 1 million loading/unloading cycles without fatigue,and low material cost.The signal transmission layers that collect local signals enable real-world complicated task recognition through one single sensor.We developed an artificial Internet of Things system utilizing a single sensor,which successfully achieved high accuracy in 4 tasks,including handwriting digit recognition and human activity recognition.The results demonstrate that skin-inspired full-textile sensor paves a promising route toward the development of electronic textiles with important potential in real-world applications,including human–machine interaction and human activity detection.

关键词： Deep skin utilizing

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Atmospheric Particulate Matter 2.5(PM_(2.5))Induces Cell Damage and Pruritus in Human skin

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Biomedical and Environmental Sciences 2024年第2期37卷 216-220页

作者： HE Qiao XUE Wan Ting LI Li YI Fan LING Xiao GUO Miao Miao College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China China Light Industry Cosmetics Key Laboratory Beijing Technology and Business UniversityBeijing 100048China Beijing Lan Divine Technology Co.LTD Beijing 100872China

With the accelerated rate of urbanization in recent years,air pollution has become an environmental problem that requires urgent resolution,almost all of the world’s population exposed to pollution on a daily basis.A... 详细信息

关键词： pollution skin Human

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Comparison of the pathological characteristics of uninjured skin tissues of diabetic rodents and diabetic patients

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中华内分泌外科杂志（中英文） 2024年第3期18卷 339-345页

作者： Du Juan Liu Ying Zhu Anfeng Song Dongming Qu Shiguang Yuan Zhixin Emergency Critical and Translational Medicine LaboratoryJilin Province People’s HospitalChangchun 130021China Emergency Medicine Department of General Hospital of Northern Theater Command Laboratory of Rescue Center of Severe Wound and Trauma PLAShenyang 110016China Department of Pathology the Centre Hospital of ChangchunChangchun 130021China Department of Emergency Surgery Jilin Province People’s HospitalChangchun 130021China

Objective To study uninjured diabetic skin structure and compare the pathological characteristics of skin tissue from mouse and rat models of diabetes mellitus(DM)and humans with DM.Methods Establishing the DM C57BL/6J mice skin tissue models and db/db mice skin tissue models,as well as DM rat skin tissue models.skin tissues were collected from the animal models and DM patients.The biopsy specimens were stained with hematoxylin and eosin(HE)staining,Masson trichrome staining and periodic acid-Schiff(PAS)staining.Results(1)skin from mice with streptozotocin(STZ)-induced DM was thinner and had less hair than skin from control mice.The epidermis had abnormal keratinization and dermal collagen and elastin fibers were dense and significantly atrophied.(2)Compared with the control group,skin tissue from db/db mice was thinner and had less hair.There was no aberrant keratinization in the epidermis,and dermal collagen and elastin fibres were loose.(3)skin tissue from rats with STZ-induced DM was significantly thinner than control skin.The epidermis had mildly abnormal keratinization,and the dermis layer was atrophied and partly loose.Some focal lipofuscin was deposited.(4)Whole skin tissue from patients with diabetes was significantly thinner than skin from subjects without DM.The epidermis had mild hyper keratinization,and the dermal elastin fibers were atrophied,loose,irregular,and showed focal mucoid degeneration.Conclusions Uninjured DM skin tissues were thinner and more irregular than normal skin.Structural changes in rat DM skin were most like those seen in the skin of patients with DM.

关键词： Diabetes mellitus skin Human Mouse Rat

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你我风采秀

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英语角 2024年第5期 44-47页

I love sking(滑雪)!When it snows,I put on my warm coat,gloves,and boots.Then I go sking with my family.I put on my skis(滑雪板)and ski down the mountain.It feels like I'm flying!Sometimes I fall down,but I always get up and try again.My favourite part is making snowmen and having snowball fights with my friends.After sking,we drink hot soup.sking is so much fun because I get to play in the snow and I feel like a winter superhero.I can't wait for the next time to go sking again!

关键词： winter skin 滑雪板

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Nonlinear optical microscopy for skin in vivo:Basics,development and applications

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 95-113页

作者： Jianhua Zhao Yuan Zhao Zhenguo Wu Yunxian Tian Haishan Zeng Integrative Oncology Department–Imaging Unit BC Cancer Research Institute VancouverBCCanada Department of Dermatology and Skin Science University of British Columbia and Vancouver Coastal Health Research Institute VancouverBCCanada

Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noninvasive in vrito biomedical applications.This paper provides a detailed discussion of the basics,development and applications of these technologies for in vrivo skin research,covering the following topics:The principle and advantage of MPM and CARS,instrumentation development for in vino applications,MPM and CARS of normal skin,application of MPM and CARS in skin cancer and disease diagnosis;application of MPM in skin disease intervention,ie.,imaging guided two-photon photothermolysis.

关键词： Nonlinear microscopy multiphoton microscopy coherent anti-Stokes Raman scattering microscopy skin skin cancer multiphoton therapy

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Attenuated niacin-induced skin flush response in individuals with clinical high risk for psychosis

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General Psychiatry 2022年第2期35卷 92-100页

作者： Ranpiao Gan Yanyan Wei Guisen Wu Jiahui Zeng Yegang Hu Lihua Xu Xiaochen Tang Xiaohua Liu Haichun Liu Tao Chen Jijun Wang Tianhong Zhang Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Automation Shanghai Jiao Tong UniversityShanghaiChina Big Data Research Lab University of WaterlooWaterlooOntarioCanada Center for Excellence in Brain Science and Itelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina

Background Im paired sesitwity of he soin Mlush response bo miacin is one of the most rpicated findngs in patents with schizoprenia Howewer.prior studies have usaly focused on postonset psychusis,and ll is knowm about the dinical high-risk(CHR)phase of niacin senstity in psychosis Aims To proftle and compare the miacin flush responsge among CHR individuals(converters and non-coverters)patients with frstepso schinophrenia(FES)and healty controls(HCs).Methods Sensivily 1o ftour concentralions (0.1-0001M)of aqueous methylnicotinate was tested in 105 CHR individuals,57 patients with FES and 52 HCs.CHR individuals were further grouped as converters and non converters according to the 2-year follow-up outcomes.skin flush response scores were rated on a 4-point scale.Results Of the 105 CHR individuals,21 individuals were lost during the study,leaving 84 CHR individuals;16(19.0%)converted to full psychosis at 2 years of fllow-up.Flush response scores identifed in the CHR samples were characterised as modest degree levels,intermediate between those of HC individuals and patients with FES.The flush responses in the CHR group mimicked the responses observed in the FES group at higher concentrations(0.01 M,0.1 M)and longer time points(15 min,20min);however,these became comparable vith the responses in the HC group at the shorter time points and at lower concentr ations.The converters exhibited lower mean flush response scores than the non-converters.Conclusions Attenuated niacin-induced flushing emerged during the early phase of psychosis.New devices should be developed and verified for objective quantification of skin responses in the CHR population.

关键词： skin high shorter

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Advances in spray products for skin regeneration

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Bioactive Materials 2022年第10期7卷 187-203页

作者： Paula Pleguezuelos-Beltran Patricia Galvez-Martín Daniel Nieto-Garcí Juan Antonio Marchal Elena Lopez-Ruiz Biopathology and Regenerative Medicine Institute(IBIMER) Centre for Biomedical Research(CIBM)University of GranadaGranadaSpain Department of Human Anatomy and Embryology Faculty of MedicineUniversity of GranadaGranadaSpain BioFab i3D Lab-Biofabrication and 3D(bio)printing Laboratory GranadaSpain Excellence Research Unit“Modeling Nature”(MNat) University of GranadaGranadaSpain Biosanitary Research Institute of Granada(ibs.GRANADA) University Hospitals of Granada-University of GranadaGranadaSpain R&D Human Health Bioib´erica S.A.UBarcelonaSpain Department of Pharmacy and Pharmaceutical Technology Faculty of PharmacyUniversity of GranadaGranadaSpain Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineUniversiteitssingel 406229ER Maastrichtthe Netherlands Department of Health Sciences University of Ja´enJa´enSpain

To date,skin wounds are still an issue for healthcare professionals.Although numerous approaches have been developed over the years for skin regeneration,recent advances in regenerative medicine offer very promising strategies for the fabrication of artificial skin substitutes,including 3D bioprinting,electrospinning or spraying,among others.In particular,skin sprays are an innovative technique still under clinical evaluation that show great potential for the delivery of cells and hydrogels to treat acute and chronic wounds.skin sprays present significant advantages compared to conventional treatments for wound healing,such as the facility of application,the possibility to treat large wound areas,or the homogeneous distribution of the sprayed material.In this article,we review the latest advances in this technology,giving a detailed description of investigational and currently commercially available acellular and cellular skin spray products,used for a variety of diseases and applying different experimental materials.Moreover,as skin sprays products are subjected to different classifications,we also explain the regulatory pathways for their commercialization and include the main clinical trials for different skin diseases and their treatment conditions.Finally,we argue and suggest possible future trends for the biotechnology of skin sprays for a better use in clinical dermatology.

关键词： skin Spray Tissue engineering Fibrin Hydrogel

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Deep-skin third-harmonic generation(THG)imaging in vivo excited at the 2200 nm window

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创新光学健康科学杂志(英文) 2023年第4期16卷 58-65页

作者： Xinlin Chen Yi Pan Ping Qiu Ke Wang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060P.R.China

The skin is heterogeneous and exerts strong scattering and aberration onto excitation light in multiphoton microscopy(MPM).Shifting to longer excitation wavelengths may help reduce skin scattering and aberration,potentially enabling larger imaging depths.However,previous demonstrations of skin MPM employ excitation wavelengths only up to the 1700 nm window,leaving an open question as to whether longer excitation wavelengths are suitable for deep-skin MPM.Here,in order to explore the longer-wavelength territory,first,we demonstrate characterization of the broadband transmittance of excised mouse skin,revealing a high transmittance window at 2200nm.Then,we demonstrate third-harmonic generation(THG)imaging in mouse skin in vivo excited at this window.With 9mW optical power on the skin surface operating at 1MHz repetition rate,we can get THG signals of 250m below the skin surface.Comparative THG imaging excited at the 1700nm window shows that as imaging depth increases,THG signals decay even faster than those excited at 2200 nm.Our results thus uncover the 2200 nm window as a new,promising excitation window potential for deep-skin MPM.

关键词： Third-harmonic generation 2200 nm 1700 nm skin

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