Attenuated niacin-induced skin flush response in individuals with clinical high risk for psychosis

作     者：Ranpiao Gan Yanyan Wei Guisen Wu Jiahui Zeng Yegang Hu Lihua Xu Xiaochen Tang Xiaohua Liu Haichun Liu Tao Chen Jijun Wang Tianhong Zhang Ranpiao Gan;Yanyan Wei;Guisen Wu;Jiahui Zeng;Yegang Hu;Lihua Xu;Xiaochen Tang;Xiaohua Liu;Haichun Liu;Tao Chen;Jijun Wang;Tianhong Zhang

作者机构：Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research CenterShanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of AutomationShanghai Jiao Tong UniversityShanghaiChina Big Data Research LabUniversity of WaterlooWaterlooOntarioCanada Center for Excellence in Brain Science and Itelligence Technology(CEBSIT)Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research CenterShanghai Jiao Tong UniversityShanghaiChina 

出 版 物：《General Psychiatry》 (综合精神医学（英文）)

年 卷 期：2022年第35卷第2期

页      面：92-100页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This study was supported by the National Natural Science Foundation of China(82171544,81971251,81671329,82001406 and 81871050) Science and Technology Comission of Shanghai Municipality(19441907800,16ZR1430500,19ZR1445200,19ZR1445100,17411953100,21S31903100,2018SHZDZX01,19410710800,19411969100,19411950800) Shanghai Clinical Research Center for Mental Health(19MC1911100) The Clinical Research Center at Shanghai Mental Health Center(CRC2018Z001,CRC2018ZD04) Project of the Key Discipline Construction,Shanghai 3-Year Public Health Action Plan(GWV-10.1-XK18) Clinical Research Center at Shanghai Jiao Tong University School of Medicine(DLY201817,20190102) Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01,2018SHZDZX05) ZJLab.Foundation of Shanghai Mental Health Center(2020-FX-02) 

主　　题：Skin high shorter 

摘      要：Background Im paired sesitwity of he soin Mlush response bo miacin is one of the most rpicated findngs in patents with schizoprenia *** studies have usaly focused on postonset psychusis,and ll is knowm about the dinical high-risk(CHR)phase of niacin senstity in psychosis Aims To proftle and compare the miacin flush responsge among CHR individuals(converters and non-coverters)patients with frstepso schinophrenia(FES)and healty controls(HCs).Methods Sensivily 1o ftour concentralions (0.1-0001M)of aqueous methylnicotinate was tested in 105 CHR individuals,57 patients with FES and 52 *** individuals were further grouped as converters and non converters according to the 2-year follow-up *** flush response scores were rated on a 4-point *** Of the 105 CHR individuals,21 individuals were lost during the study,leaving 84 CHR individuals;16(19.0%)converted to full psychosis at 2 years of *** response scores identifed in the CHR samples were characterised as modest degree levels,intermediate between those of HC individuals and patients with *** flush responses in the CHR group mimicked the responses observed in the FES group at higher concentrations(0.01 M,0.1 M)and longer time points(15 min,20min);however,these became comparable vith the responses in the HC group at the shorter time points and at lower concentr *** converters exhibited lower mean flush response scores than the *** Attenuated niacin-induced flushing emerged during the early phase of *** devices should be developed and verified for objective quantification of skin responses in the CHR population.