Nonlinear optical microscopy for skin in vivo:Basics,development and applications

作     者：Jianhua Zhao Yuan Zhao Zhenguo Wu Yunxian Tian Haishan Zeng 

作者机构：Integrative Oncology Department–Imaging Unit BC Cancer Research InstituteVancouverBCCanada Department of Dermatology and Skin Science University of British Columbia and Vancouver Coastal Health Research Institute VancouverBCCanada 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2023年第16卷第1期

页      面：95-113页

核心收录：

学科分类：070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：supported partially by the Canadian Institutes of Health Research and the Canadian Dermatology Foundation 

主　　题：Nonlinear microscopy multiphoton microscopy coherent anti-Stokes Raman scattering microscopy skin skin cancer multiphoton therapy 

摘      要：Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noninvasive in vrito biomedical *** paper provides a detailed discussion of the basics,development and applications of these technologies for in vrivo skin research,covering the following topics:The principle and advantage of MPM and CARS,instrumentation development for in vino applications,MPM and CARS of normal skin,application of MPM and CARS in skin cancer and disease diagnosis;application of MPM in skin disease intervention,ie.,imaging guided two-photon photothermolysis.