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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

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Frontiers of Medicine 2024年第2期18卷 258-284页

作者： Tianjing Sun Mo Li Qi Liu Anyong Yu Kun Cheng Jianxing Ma Sean Murphy Patrick Michael McNutt Yuanyuan Zhang Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Department of Nephrology Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Division of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Missouri-Kansas CityKansas CityMO64108USA Department of Biochemistry Wake Forest University School of MedicineWinston-SalemNC27157USA Wake Forest Institute of Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC27109USA

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing.This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond.Exosomes,small extracellular vesicles secreted by various stem cells,have emerged as potent mediators of intercellular communication and tissue repair.One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy,such as immune rejection or stem cells differentiating into unwanted cell types.However,further research is necessary to optimize exosome therapy,not only in the areas of exosome isolation,characterization,and engineering,but also in determining the optimal dose,timing,administration,and frequency of exosome therapy.Thus,optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer,ischemia,or inflammation.This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

关键词： exosomes stem cells therapeutic impact skin wound healing

A Deep Learning-Enabled skin-Inspired Pressure Sensor for Complicated Recognition Tasks with Ultralong Life

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Research 2024年第1期2023卷 443-454页

作者： Yingxi Xie Xiaohua Wu Xiangbao Huang Qinghua Liang Shiping Deng Zeji Wu Yunpeng Yao Longsheng Lu School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhouChina

Flexible full-textile pressure sensor is able to integrate with clothing directly,which has drawn extensive attention from scholars recently.But the realization of flexible full-textile pressure sensor with high sensitivity,wide detection range,and long working life remains challenge.Complex recognition tasks necessitate intricate sensor arrays that require extensive data processing and are susceptible to damage.The human skin is capable of interpreting tactile signals,such as sliding,by encoding pressure changes and performing complex perceptual tasks.Inspired by the skin,we have developed a simple dip-and-dry approach to fabricate a full-textile pressure sensor with signal transmission layers,protective layers,and sensing layers.The sensor achieves high sensitivity(2.16 kPa^(−1)),ultrawide detection range(0 to 155.485 kPa),impressive mechanical stability of 1 million loading/unloading cycles without fatigue,and low material cost.The signal transmission layers that collect local signals enable real-world complicated task recognition through one single sensor.We developed an artificial Internet of Things system utilizing a single sensor,which successfully achieved high accuracy in 4 tasks,including handwriting digit recognition and human activity recognition.The results demonstrate that skin-inspired full-textile sensor paves a promising route toward the development of electronic textiles with important potential in real-world applications,including human–machine interaction and human activity detection.

关键词： Deep skin utilizing

新一代皮肤再生:生物材料和生物工程的机遇和挑战

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Science Bulletin 2023年第16期68卷 1722-1725页

作者：彭雨姜玉峰付小兵 Key Laboratory of Tissue Repair and Regeneration PLA General HospitalBeijing 100037China School of Medicine Nankai UniversityTianjin 300071China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijing 100039China

skin regeneration is a critical area of focus in modern medicine due to its potential to repair or replace damaged skin tissue resulting from various causes,including trauma,burns,chronic wounds,and genetic disorders[1].The global burden of skin-related health issues is substantial,with an estimated 1.5 billion people worldwide suffering from chronic skin conditions,and a significant proportion of these individuals require advanced treatments for skin regeneration[2].In China,skin diseases account for approximately20%of all outpatient visits to hospitals[3].

关键词： replace 生物工程 skin

Personal Thermal Management by Radiative Cooling and Heating

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NANO-MICRO LETTERS 2024年第1期16卷 1-43页

作者： Xue, Shidong Huang, Guanghan Chen, Qing Wang, Xungai Fan, Jintu Shou, Dahua Hong Kong Polytech Univ Sch Fash & Text Hung Hom Kowloon Hong Kong 999077 Peoples R China Hong Kong Polytech Univ Future Intelligent Wear Ctr Hung Hom Kowloon Hong Kong 999077 Peoples R China Hong Kong Polytech Univ Res Ctr Text Future Fash Kowloon Hung Hom Hong Kong 999077 Peoples R China Hong Kong Polytech Univ Res Inst Smart Energy Hung Hom Kowloon Hong Kong 999077 Peoples R China Guangdong Univ Technol State Key Lab Precis Elect Mfg Technol & Equipment Guangzhou 510006 Peoples R China Donghua Univ Shanghai Int Fash Innovat Ctr Shanghai 200051 Peoples R China

This review delves into the intricate relationship between thermal models, function-oriented design principles, and practical applications in personal radiative thermal management (PRTM).It provides an in-depth discussion on design strategies for radiative cooling, heating, and dual-mode modulating textiles, offering practical insights for application.It offers a thorough examination of the prospects and challenges of PRTM textiles, proposing potential solutions and future directions for the field. Maintaining thermal comfort within the human body is crucial for optimal health and overall well-being. By merely broadening the set-point of indoor temperatures, we could significantly slash energy usage in building heating, ventilation, and air-conditioning systems. In recent years, there has been a surge in advancements in personal thermal management (PTM), aiming to regulate heat and moisture transfer within our immediate surroundings, clothing, and skin. The advent of PTM is driven by the rapid development in nano/micro-materials and energy science and engineering. An emerging research area in PTM is personal radiative thermal management (PRTM), which demonstrates immense potential with its high radiative heat transfer efficiency and ease of regulation. However, it is less taken into account in traditional textiles, and there currently lies a gap in our knowledge and understanding of PRTM. In this review, we aim to present a thorough analysis of advanced textile materials and technologies for PRTM. Specifically, we will introduce and discuss the underlying radiation heat transfer mechanisms, fabrication methods of textiles, and various indoor/outdoor applications in light of their different regulation functionalities, including radiative cooling, radiative heating, and dual-mode thermoregulation. Furthermore, we will shine a light on the current hurdles, propose potential strategies, and delve into future technology trends for PRTM with an emphasis on functionalities and applications.

关键词： Personal thermal management Radiative cooling and heating Thermal comfort Dynamic thermoregulation INFRARED RADIATION TEMPERATURE EFFICIENT REFLECTION MEMBRANE TEXTILES DESIGN ENERGY skin GARMENTS

Deep-skin third-harmonic generation(THG)imaging in vivo excited at the 2200 nm window

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创新光学健康科学杂志(英文) 2023年第4期16卷 58-65页

作者： Xinlin Chen Yi Pan Ping Qiu Ke Wang Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060P.R.China

The skin is heterogeneous and exerts strong scattering and aberration onto excitation light in multiphoton microscopy(MPM).Shifting to longer excitation wavelengths may help reduce skin scattering and aberration,potentially enabling larger imaging depths.However,previous demonstrations of skin MPM employ excitation wavelengths only up to the 1700 nm window,leaving an open question as to whether longer excitation wavelengths are suitable for deep-skin MPM.Here,in order to explore the longer-wavelength territory,first,we demonstrate characterization of the broadband transmittance of excised mouse skin,revealing a high transmittance window at 2200nm.Then,we demonstrate third-harmonic generation(THG)imaging in mouse skin in vivo excited at this window.With 9mW optical power on the skin surface operating at 1MHz repetition rate,we can get THG signals of 250m below the skin surface.Comparative THG imaging excited at the 1700nm window shows that as imaging depth increases,THG signals decay even faster than those excited at 2200 nm.Our results thus uncover the 2200 nm window as a new,promising excitation window potential for deep-skin MPM.

关键词： Third-harmonic generation 2200 nm 1700 nm skin

Advances in spray products for skin regeneration

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Bioactive Materials 2022年第10期7卷 187-203页

作者： Paula Pleguezuelos-Beltran Patricia Galvez-Martín Daniel Nieto-Garcí Juan Antonio Marchal Elena Lopez-Ruiz Biopathology and Regenerative Medicine Institute(IBIMER) Centre for Biomedical Research(CIBM)University of GranadaGranadaSpain Department of Human Anatomy and Embryology Faculty of MedicineUniversity of GranadaGranadaSpain BioFab i3D Lab-Biofabrication and 3D(bio)printing Laboratory GranadaSpain Excellence Research Unit“Modeling Nature”(MNat) University of GranadaGranadaSpain Biosanitary Research Institute of Granada(ibs.GRANADA) University Hospitals of Granada-University of GranadaGranadaSpain R&D Human Health Bioib´erica S.A.UBarcelonaSpain Department of Pharmacy and Pharmaceutical Technology Faculty of PharmacyUniversity of GranadaGranadaSpain Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineUniversiteitssingel 406229ER Maastrichtthe Netherlands Department of Health Sciences University of Ja´enJa´enSpain

To date,skin wounds are still an issue for healthcare professionals.Although numerous approaches have been developed over the years for skin regeneration,recent advances in regenerative medicine offer very promising strategies for the fabrication of artificial skin substitutes,including 3D bioprinting,electrospinning or spraying,among others.In particular,skin sprays are an innovative technique still under clinical evaluation that show great potential for the delivery of cells and hydrogels to treat acute and chronic wounds.skin sprays present significant advantages compared to conventional treatments for wound healing,such as the facility of application,the possibility to treat large wound areas,or the homogeneous distribution of the sprayed material.In this article,we review the latest advances in this technology,giving a detailed description of investigational and currently commercially available acellular and cellular skin spray products,used for a variety of diseases and applying different experimental materials.Moreover,as skin sprays products are subjected to different classifications,we also explain the regulatory pathways for their commercialization and include the main clinical trials for different skin diseases and their treatment conditions.Finally,we argue and suggest possible future trends for the biotechnology of skin sprays for a better use in clinical dermatology.

关键词： skin Spray Tissue engineering Fibrin Hydrogel

Attenuated niacin-induced skin flush response in individuals with clinical high risk for psychosis

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General Psychiatry 2022年第2期35卷 92-100页

作者： Ranpiao Gan Yanyan Wei Guisen Wu Jiahui Zeng Yegang Hu Lihua Xu Xiaochen Tang Xiaohua Liu Haichun Liu Tao Chen Jijun Wang Tianhong Zhang Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Automation Shanghai Jiao Tong UniversityShanghaiChina Big Data Research Lab University of WaterlooWaterlooOntarioCanada Center for Excellence in Brain Science and Itelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina

Background Im paired sesitwity of he soin Mlush response bo miacin is one of the most rpicated findngs in patents with schizoprenia Howewer.prior studies have usaly focused on postonset psychusis,and ll is knowm about the dinical high-risk(CHR)phase of niacin senstity in psychosis Aims To proftle and compare the miacin flush responsge among CHR individuals(converters and non-coverters)patients with frstepso schinophrenia(FES)and healty controls(HCs).Methods Sensivily 1o ftour concentralions (0.1-0001M)of aqueous methylnicotinate was tested in 105 CHR individuals,57 patients with FES and 52 HCs.CHR individuals were further grouped as converters and non converters according to the 2-year follow-up outcomes.skin flush response scores were rated on a 4-point scale.Results Of the 105 CHR individuals,21 individuals were lost during the study,leaving 84 CHR individuals;16(19.0%)converted to full psychosis at 2 years of fllow-up.Flush response scores identifed in the CHR samples were characterised as modest degree levels,intermediate between those of HC individuals and patients with FES.The flush responses in the CHR group mimicked the responses observed in the FES group at higher concentrations(0.01 M,0.1 M)and longer time points(15 min,20min);however,these became comparable vith the responses in the HC group at the shorter time points and at lower concentr ations.The converters exhibited lower mean flush response scores than the non-converters.Conclusions Attenuated niacin-induced flushing emerged during the early phase of psychosis.New devices should be developed and verified for objective quantification of skin responses in the CHR population.

关键词： skin high shorter

skin inflammation and psoriasis may be linked to exposure of ultrafine carbon particles

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Journal of Environmental Sciences 2020年第10期32卷 206-208页

作者： Huyan Xiao Hongquan Zhang Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of AlbertaEdmonton T6G 2G3Canada

Air pollution has become the largest environmental risk to human health,estimated to kill seven million people worldwide every year.Data from the World Health Organization (WHO)showed that 91%of the world population w... 详细信息

关键词： inflammation skin pollution

High luminescent polymers for stretchable displays

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National Science Review 2023年第1期10卷 11-13页

作者： Zhitao Zhang Zhenan Bao Department of Chemical Engineering Stanford University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University

Displays severing as the human-machine interface are playing indispensable roles in our daily lives.The machine displays information visually to allow the user to respond directly.However,traditional bulky and rigid displays cannot meet the requirements of the fast-developing wearable electronics,considering skin compatibility,portability and durability under exercise [1].

关键词： LIGHT-EMITTING DEVICES skin