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Effect of Traditional Chinese Medicine combined with Western Medicine on blood lipid levels and inflammatory factors in patients with angina pectoris in coronary heart disease identified as intermingled phlegm and blood stasis syndrome:a network Meta-anal

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中医杂志:英文版 2023年第4期43卷 640-649页

作者： WANG Chao WU Qiong LI Ping WANG Zhigang LOU Xusheng LI Yuanyuan ZHANG Lin Postdoctoral Mobile Station of Chinese Academy of Traditional Chinese medicine Beijing 100700China China Academy of Chinese Medical Sciences Beijing 100700China Zang-xiang Teaching and Research Department the Institute of Basic Theory for Chinese MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Cardiovascular Medicine Beijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029China Shandong College of Traditional Chinese Medicine Yantai 264199China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China

OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network ***:randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December *** was screened and literature bias risk was assessed by RevMan5.4 *** overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 ***:Totally,26 RCTs were included,involving 2098 *** were 6 TCM formulas with the effects of dispelling phlegm and removing blood *** conventional Western Medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,*** sequence of TC improvement from high to low was MZXGD,MED,DT,and *** of improving TG from high to low was MED,MZXGD,MGXBD,and *** LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and *** regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and

关键词： coronary disease angina pectoris phlegm and blood stasis interaction blood lipid inflammatory factors medicine traditional Chinese network Meta-analysis randomized controlled trial

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Avanafil for male erectile dysfunction： a systematic review and meta-analysis

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Asian Journal of Andrology 2014年第3期16卷 472-477页

作者： Yuan-Shan Cui Nan Li Huan-Tao Zong Hui-Lei Yan Yong Zhang Department of Urology Beijing Tian-Tan Hospital Capital Medical University Beijing China

Avanafil, a potent new selective phosphodiesterase type 5 （PDE5） inhibitor, has been developed for the treatment of erectile dysfunction （ED）. We carried out a systematic review and meta-analysis to assess the efficacy and safety of this drug for the treatment of ED. A literature review was performed to identify all published randomized, double-blind, placebo-controlled trials of avanafil for the treatment of ED. The search included the following databases： MEDLINE, EMBASE and the Cochrane controlled trials Register. The reference lists of the retrieved studies were also investigated. Four publications, involving a total of 1381 patients, were used in the analysis, including four randomized controlled trials （RCTs） that compared avanafU with a placebo. Among the co-primary efficacy end points indicating that avanafil 100 mg was more effective than a placebo were successful vaginal penetration （SEP2）（the odds ratio （OR） =5.06, 95% confidence interval （CI） =3.29-7.78, P〈 0.00001） and successful intercourse （SEP3）（OR = 3.99, 95% CI = 2.80-5.67, P 〈 0.00001）. Men randomized to receive avanafil were less likely than those receiving the placebo to drop out due to an adverse event （AE）（OR = 1.48, 95% CI = 0.54-4.08, P = 0.44）. Specific AEs with avanafil included headache and flushing, which were significantly less likely to occur with placebo. This meta-analysis indicates that avanafil 100 or 200 mg is an effective and well-tolerated treatment for ED. Compared with avanafil 100 mg, patients who take avanafil 200 mg are more likely to experience headaches.

关键词： avanafil erectile dysfunction meta-analysis randomized controlled trial

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Efficacy and safety of blood pricking and cupping for treating nonspecific low back pain: a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2022年第6期42卷 869-876页

作者： XIE Chaoju SUN Zhangyin JI Changchun YANG Jinsheng Shaanxi University of Traditional Chinese Medicine College of AcupunctureMoxibustion and TuinaXianyang 712046China Department of Acupuncture and Moxibustion Shaanxi Provincial Hospital of Traditional Chinese MedicineXi'an 710003China Institute of Basic Theory of Traditional Chinese Medicine Chinese Academy of Traditional Chinese MedicineBeijing 100700China

OBJECTIVE: To systematically evaluate the efficacy and safety of blood pricking and cupping in the treatment of nonspecific low back pain(NLBP).METHODS:The China National Knowledge Infrastructure Database(CNKI), Wanfang Med Online Database(Wanfang), China Science and Technology Journal Database(VIP), Pub Med, Web of Science,EMBase, and Cochrane Library databases were searched from inception to October 31, 2021, for randomized controlled trials(RCTs) of the treatment of NLBP by blood pricking and cupping. The quality of each included study was evaluated according to the Cochrane Systematic Assessor’s Manual evaluation criteria, while the Meta-analysis was performed using RevMan ***: A total of 13 thirteen RCTs included a total of 1088 subjects. The visual analogue scale scores indicated that blood pricking and cupping was superior to the other treatments at relieving NLBP pain [mean difference(MD) =-1.43;95% confidence interval(CI):-2.31 to 0.54;Z = 3.15;P = 0.002). The Oswestry Disability Index score of blood pricking and cupping was superior to that of the control group in terms of improving NLBP dysfunction(MD =-6.25;95%CI:-8.37 to-4.31);Z = 5.77;P < 0.000 01). 7 RCTs mentioned no adverse reactions, while one study reported mild syncope [7%(n = 3), all in the 17-30 years group] that was gradually relieved after rest. CONCLUSIONS: Blood pricking and cupping therapy can safely and effectively reduce pain and improve functional impairment in patients with NLBP. However, this study included limited high-grade studies with a small overall sample size;therefore, further high-quality large-sample RCTs are needed to improve clinical evidence.

关键词： low back pain blood pricking cupping therapy Meta-analysis systematic review randomized controlled trial

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Effects of supplementation with vitamin D on glucose metabolism during pregnancy:a systematic review and meta-analysis of randomized controlled trials

Effects of supplementation with vitamin D on glucose metabol...

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2019浙江省妇产科医师大会及妇产科学学术年会

作者： Jianqiong Zheng Hongping Zhang HaiYing Chen Bingbing Zheng Zhenzhen Zheng Jie Yang Congcong Sun Liang Zheng Hao Ying Department of Obstetrics and Gynecology Wenzhou people's Hospitalthe Third Clinical Institute Affiliated to Wenzhou Medical University Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of Medicine Department of Wenzhou Key Laboratory of Gynecology and Obstetrics Wenzhou People's HospitalThe Third Clinical Institute Affiliated to Wenzhou Medical University Department of Cardiovascular Medicine Research Center for Translational MedicineShanghai East HospitalTongji University School of Medicine

Background:Vitamin D has an important role in glucose metabolism and the associated hormones and metabolites in pregnant women,however its specific effect of vitamin D supplementation during pregnant time remains *** present meta-analysis describes the effect of varying doses of vitamin D supplementation on glucose metabolism in pregnant ***:A literature search was conducted using PubMed,EMBASE,Web of Science,and Cochrane *** revised Jadad’s scale was used to evaluate the quality of each *** reviewers independently performed a quality assessment of each study included.A random effects model was used to calculate the pooled ***:A total of 641 participants from 9 studies were pooled into our meta-analysis(intervention group:320,control group:321).Results from numerous populations(with and without GDM),suggest that vitamin D supplementation significantly reduced FPG,insulin,HOMA-IR,and HOMA-B in pregnant women with GDM [SMD=-0.87,-0.73,-0.68,-0.52,95%CI:(-1.32,-0.42),(-1.01,-0.44),(-1.08,-0.28),(-0.92,-0.13),z= 3.76,5.02,3.34,2.60,P= 0.00,0.00,0.00,0.01,respectively].Similarly,vitamin D supplementation significantly decreased insulin,HOMA-IR,and HOMA-B in pregnant women without GDM [SMD=-1.73,-2.52,-2.48,95%CI:(-2.80,-0.65),(-2.52,-0.66),(-2.48,-0.67),z= 3.15,3.34,3.42,P = 0.00,0.00,0.00,respectively].When vitamin D doses were varied,(low,moderate,high dosage group) the results fluctuated *** was no significant effect on glucose metabolism in the low dosage *** dosage of vitamin D supplementation significantly reduced FPG,insulin,HOMA-IR,and HOMA-B [SMD =-0.92,-0.97,-0.65,-0.48,95%CI :(-1.44,-0.41),(-1.62,-0.32),(-1.13,-0.18),(-0.95,-0.02),z= 3.49,2.91,2.68,2.02,P = 0.00,0.00,0.01,0.04,respectively].Similarly,high doses of vitamin D supplementation significantly reduced insulin,HOMA-IR,and HOMA-B [SMD=-1.13,-1.10,-1.09,95%CI:(-1.51,-0.74),(-1.53,-0.67),(-1.48,-0.71),z= 5.71,4.97,5.55,P = 0.00,0.00,0.

关键词： vitamin D glucose metabolism pregnant women meta-analysis randomized controlled trial

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Effects of supplementation with vitamin D on glucose metabolism during pregnancy: a systematic review and meta-analysis of randomized controlled trials

Effects of supplementation with vitamin D on glucose metabol...

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2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Jianqiong Zheng Hongping Zhang HaiYing Chen Bingbing Zheng Zhenzhen Zheng Jie Yang Congcong Sun Liang Zheng Hao Ying Department of Obstetrics and Gynecology Wenzhou people's Hospital the Third Clinical Institute Affiliated to Wenzhou Medical University Department of Obstetrics Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Department of Wenzhou Key Laboratory of Gynecology and Obstetrics Wenzhou People's Hospital The Third Clinical Institute Affiliated to Wenzhou Medical University Department of Cardiovascular Medicine Research Center for Translational Medicine Shanghai East HospitalTongji University School of Medicine

Background: Vitamin D has an important role in glucose metabolism and the associated hormones and metabolites in pregnant women, however its specific effect of vitamin D supplementation during pregnant time remains unclear. The present meta-analysis describes the effect of varying doses of vitamin D supplementation on glucose metabolism in pregnant ***: A literature search was conducted using PubMed, EMBASE, Web of Science, and Cochrane databases. The revised Jadad’s scale was used to evaluate the quality of each trial. Two reviewers independently performed a quality assessment of each study included. A random effects model was used to calculate the pooled ***: A total of 641 participants from 9 studies were pooled into our meta-analysis(intervention group: 320, control group: 321). Results from numerous populations(with and without GDM), suggest that vitamin D supplementation significantly reduced FPG, insulin, HOMA-IR, and HOMA-B in pregnant women with GDM [SMD=-0.87,-0.73,-0.68,-0.52, 95%CI:(-1.32,-0.42),(-1.01,-0.44),(-1.08,-0.28),(-0.92,-0.13), z= 3.76, 5.02, 3.34, 2.60, P= 0.00, 0.00, 0.00, 0.01, respectively]. Similarly, vitamin D supplementation significantly decreased insulin, HOMA-IR, and HOMA-B in pregnant women without GDM [SMD=-1.73,-2.52,-2.48, 95%CI:(-2.80,-0.65),(-2.52,-0.66),(-2.48,-0.67), z= 3.15, 3.34, 3.42, P = 0.00, 0.00, 0.00, respectively]. When vitamin D doses were varied,(low, moderate, high dosage group) the results fluctuated accordingly. There was no significant effect on glucose metabolism in the low dosage group. Moderate dosage of vitamin D supplementation significantly reduced FPG, insulin, HOMA-IR, and HOMA-B [SMD =-0.92,-0.97,-0.65,-0.48, 95%CI :(-1.44,-0.41),(-1.62,-0.32),(-1.13,-0.18),(-0.95,-0.02), z= 3.49, 2.91, 2.68, 2.02, P = 0.00, 0.00, 0.01, 0.04, respectively]. Similarly, high doses of vitamin D supplementation significantly reduced insulin, HOMA-IR, and HOMA-B [SMD=-1.13,-1.10,-1.09, 95%CI:(-1.51,-0.74

关键词： vitamin D glucose metabolism pregnant women meta-analysis randomized controlled trial

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One hundred and ninety-two weeks treatment of entecavir maleate for Chinese chronic hepatitis B predominantly genotyped B or C

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World Journal of Clinical Cases 2022年第28期10卷 10085-10096页

作者： Jing-Hang Xu Sa Wang Da-Zhi Zhang Yan-Yan Yu Chong-Wen Si Zheng Zeng Zhong-Nan Xu Jun Li Qing Mao Hong Tang Ji-Fang Sheng Xin-Yue Chen Qin Ning Guang-Feng Shi Qing Xie Xi-Quan Zhang Jun Dai Department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100094China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Infectious Diseases The Second Affiliated Hospital with Chongqing Medical UniversityChongqing 400010China Jiangsu Chia-tai Tianqing Pharmaceutical Co. LtdNanjing 222006Jiangsu ProvinceChina Department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Infectious Diseases Southwest China HospitalChongqing 400038China Department of Infectious Diseases West China HospitalChengdu 610041Sichuan ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310010Zhejiang ProvinceChina Department of International Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department and Institute of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of Infectious Diseases Ruijin HospitalJiaotong University School of MedicineShanghai 200025China

BACKGROUND Entecavir(ETV)is a potent and selective nucleotide analog with significant activity against hepatitis B virus(HBV).ETV maleate is a derivative compound of ETV and was reported to have an efficacy and safety profile that is comparable to ETV(Baraclude)when used in Chinese patients with chronic hepatitis B(CHB)in phase III clinical trials(Clinical *** number,NCT-01926288)at weeks 48,96,and *** To investigate the antiviral potency and safety of ETV maleate at week 192 in Chinese CHB patients predominantly genotyped B or *** In this double-blind study,we randomly assigned patients to receive 0.5 mg/d ETV(Group A)or ETV maleate(Group B)(ratio,1:1),each with a placebo tablet for 48 ***,all patients received open-label treatment with 0.5 mg/d ETV maleate starting at week *** primary efficacy endpoint was the reduction in HBV DNA levels from *** endpoints included the proportion of patients with undetectable HBV DNA(0.05),viral suppression with HBV DNA0.05)and HBe Ag seroconversion(28.77%vs 20.00%,P>0.05)occurred similarly between Groups A and B at week ***,there was a significant difference in the proportion of patients with normal ALT levels(91.14%vs 78.38%,P0.05),percentages of patients who achieved undetectable HBV DNA(100%vs 100%,P>0.05)and rates of ALT normal

关键词： Chronic hepatitis B Entecavir maleate randomized controlled trial Treatment outcome Mutation Genotype

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Effectiveness of nonsteroidal anti-inflammatory drugs in prevention of post-ERCP pancreatitis:A meta-analysis

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World Journal of Gastroenterology 2014年第34期20卷 12322-12329页

作者： Xiao Li Li-ping Tao Chun-hui Wang Department of Gastroenterology West China Hospital of Sichuan University

AIM: To investigate the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). METHODS: Two independent reviewers searched Pub Med (1966 to October 2013), Embase (1984 to October 2013) and the Cochrane Central Register of controlled trials (CENTRAL; Issue 4, 2013) for relevant randomized controlled trials (RCTs) studying the effectiveness of prophylactic NSAID administration in the prevention of PEP. Using the Cochrane Collaboration Handbook, meta-analyses were conducted to evaluate the overall effect of NSAIDs in preventing the incidences of PEP and moderate to severe pancreatitis. RESULTS: Eight RCTs were identified from the literature search and included 1883 patients that underwent ERCP, with 971 patients in the NSAID group and 912 patients in the placebo group. Sixty-nine out of 971 (7.11%) patients developed PEP in the NSAID group in comparison to 143 out of 912 (15.68%) patients in the placebo group. The pooled RR of PEP incidence with prophylactic NSAID administration was 0.43 (95%CI: 0.33-0.56), which demonstrates that NSAID administration after ERCP significantly reduced the incidence of PEP when compared to the placebo group (P < 0.0001). Subgroup analysis was performed and revealed that the presence (NSAID group) or absence (placebo group) of NSAIDs had no significant effect on the development of moderate to severe pancreatitis (RR = 0.79, 95%CI: 0.52-1.18). Moreover, the administration of NSAIDs as a rectal suppository (RR = 0.35, 95%CI: 0.26-0.48; P < 0.0001) was more effective than oral administration (RR = 0.97, 95%CI: 0.53-1.80) or through infusion (RR = 0.43, 95%CI: 0.12-1.54). CONCLUSION: NSAIDs effectively reduce the incidence of PEP but not of moderate to severe pancreatitis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Nonsteroidal anti-inflammatory drugs Post-endoscopic retrograde cholangiopancreatography pancreatitis randomized controlled trial Meta-analysis

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Extent of lymphadenectomy and perioperative therapies:two open issues in gastric cancer

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World Journal of Gastroenterology 2014年第14期20卷 3889-3904页

作者： Andrea Giuliani Michelangelo Miccini Luigi Basso Department of Surgery "Pietro Valdoni" "Sapienza" University of RomeMedical School

Gastric cancer is one of the leading causes of death for cancer worldwide,although geographical variations in incidence *** the last decades,its incidence and mortality have gradually decreased in Western countries,while these have increased,or remained stable,in the other world *** cancer is often diagnosed at an advanced stage,with the only notable exception of Japan,where nationwide screening programs are enforced,due to local high *** surgery(i.e.,gastrectomy,total or partial,and lymphadenectomy)remains the cornerstone of treatment of gastric *** has been debated about the extent of lymph node dissection and,although it is a valuable contribution to staging and cure,operative treatment only represents one aspect of overall effective management,as the risk of both locoregional and distant recurrences are high,and bear a poor *** a matter of fact,surgery,as a single modality treatment,has probably achieved its maximum efficacy for local control and survival,while other accompanying nonsurgical treatment modalities have to be taken into account,although their role is still the subject of considerable *** authors in this review present an update on the outcome of treatment of gastric cancer in relation to the extent of lymphadenectomy and of various nonsurgical preoperative,intraoperative,and postoperative strategies.

关键词： Gastric cancer Adenocarcinoma Postoperative Preoperative Chemoradiotherapy Chemotherapy Radiotherapy Intraperitoneal randomized controlled trial Meta-analysis

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Combining of chemotherapy with targeted therapy for advanced biliary tract cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2061-2076页

作者： Xue-Song Bai Sheng-Nan Zhou Yi-Qun Jin Xiao-Dong He Department of General Surgery Peking Union Medical College HospitalChina Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Affiliated Hangzhou First People’s Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Targeted therapy(TT)has resulted in controversial efficacy as first-line treatment for biliary tract cancer(BTC).More efficacy comparisons are required to clarify the overall effects of chemotherapy(CT)combined with TT and CT alone on advanced *** To conduct a meta-analysis of the available evidence on the efficacy of CT combined with TT for advanced *** The PubMed,EMBASE,Clinicaltrials,Scopus and Cochrane Library databases were systematically searched for relevant studies published from inception to August *** randomized clinical trials(RCTs)including comparisons between the combination of gemcitabine-based CT with TT and CT alone as firstline treatment for advanced BTC were eligible(PROSPERO-CRD42022313001).The odds ratios(ORs)for the objective response rate(ORR)and hazard ratios(HRs)for both progression-free survival(PFS)and overall survival(OS)were calculated and *** analyses based on different targeted agents,CT regimens and tumor locations were *** Nine RCTs with a total of 1361 individuals were included and *** overall analysis showed a significant improvement in ORR in patients treated with CT+TT compared to those treated with CT alone(OR=1.43,95%CI:1.11-1.86,P=0.007)but no difference in PFS or *** trends were observed in the subgroup treated with agents targeting epidermal growth factor receptor(OR=1.67,95%CI:1.17-2.37,P=0.004)but not in the subgroups treated with agents targeting vascular endothelial growth factor receptor or mesenchymal-epithelial transition ***,patients who received a CT regimen of gemcitabine+oxaliplatin in the CT+TT arm had both a higher ORR(OR=1.75,95%CI:1.20-2.56,P=0.004)and longer PFS(HR=0.83,95%CI:0.70-0.99,P=0.03)than those in the CT-only ***,patients with cholangiocarcinoma treated with CT+TT had significantly increased ORR and PFS(ORR,OR=2.06,95%CI:1.27-3.35,PFS,HR=0.79,95%CI:0.66-0.94).CONCLUSION CT+TT is a potential first-line treat

关键词： Advanced biliary tract cancer Targeted therapy Chemotherapy Meta-analysis randomized controlled trial First-line treatment

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Is endoscopic papillary balloon dilatation really a risk factor for post-ERCP pancreatitis?

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World Journal of Gastroenterology 2016年第26期22卷 5909-5916页

作者： Toshio Fujisawa Koichi Kagawa Kantaro Hisatomi Kensuke Kubota Atsushi Nakajima Nobuyuki Matsuhashi Department of Gastroenterology NTT Medical Center Tokyo Department of Gastroenterology and Hepatology Yokohama City University School of Medicine

Endoscopic papillary balloon dilatation(EPBD) is useful for decreasing early complications of endoscopic retrograde cholangio-pancreatography(ERCP), including bleeding, biliary infection, and perforation, but it is generally avoided in Western countries because of a relatively high reported incidence of post-ERCP pancreatitis(PEP). However, as the efficacy of endoscopic papillary largeballoon dilatation(EPLBD) becomes widely recognized, EPBD is attracting attention. Here we investigate whether EPBD is truly a risk factor for PEP, and seek safer and more effective EPBD procedures by reviewing past studies. We reviewed thirteen randomised control trials comparing EPBD and endoscopic sphincterotomy(EST) and ten studies comparing direct EPLBD and EST. Three randomized controlled trials of EPBD showed significantly higher incidence of PEP than EST, but no study of EPLBD did. Careful analysis of these studies suggested that longer and higher-pressure inflation of balloons might decrease PEP incidence. The paradoxical result that EPBD with small-calibre balloons increases PEP incidence while EPLBD does not may be due to insufficient papillary dilatation in the former. Insufficient dilatation could cause the high incidence of PEP through the use of mechanical lithotripsy and stress on the papilla at the time of stone removal. Sufficient dilation of the papilla may be useful in preventing PEP.

关键词： Endoscopic papillary balloon dilatation Post-endoscopic retrograde cholangio-pancreatography pancreatitis Endoscopic papillary large-balloon dilatation Endoscopic sphincterotomy randomized controlled trial

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