Effects of supplementation with vitamin D on glucose metabolism during pregnancy:a systematic review and meta-analysis of randomized controlled trials
作者单位：Department of Obstetrics and GynecologyWenzhou people's Hospitalthe Third Clinical Institute Affiliated to Wenzhou Medical University Department of ObstetricsShanghai First Maternity and Infant HospitalTongji University School of Medicine Department of Wenzhou Key Laboratory of Gynecology and ObstetricsWenzhou People's HospitalThe Third Clinical Institute Affiliated to Wenzhou Medical University Department of Cardiovascular MedicineResearch Center for Translational MedicineShanghai East HospitalTongji University School of Medicine
会议名称：《2019浙江省妇产科医师大会及妇产科学学术年会》
会议日期：2019年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：vitamin D glucose metabolism pregnant women meta-analysis randomized controlled trial
摘 要：Background:Vitamin D has an important role in glucose metabolism and the associated hormones and metabolites in pregnant women,however its specific effect of vitamin D supplementation during pregnant time remains *** present meta-analysis describes the effect of varying doses of vitamin D supplementation on glucose metabolism in pregnant ***:A literature search was conducted using PubMed,EMBASE,Web of Science,and Cochrane *** revised Jadad’s scale was used to evaluate the quality of each *** reviewers independently performed a quality assessment of each study included.A random effects model was used to calculate the pooled ***:A total of 641 participants from 9 studies were pooled into our meta-analysis(intervention group:320,control group:321).Results from numerous populations(with and without GDM),suggest that vitamin D supplementation significantly reduced FPG,insulin,HOMA-IR,and HOMA-B in pregnant women with GDM [SMD=-0.87,-0.73,-0.68,-0.52,95%CI:(-1.32,-0.42),(-1.01,-0.44),(-1.08,-0.28),(-0.92,-0.13),z= 3.76,5.02,3.34,2.60,P= 0.00,0.00,0.00,0.01,respectively].Similarly,vitamin D supplementation significantly decreased insulin,HOMA-IR,and HOMA-B in pregnant women without GDM [SMD=-1.73,-2.52,-2.48,95%CI:(-2.80,-0.65),(-2.52,-0.66),(-2.48,-0.67),z= 3.15,3.34,3.42,P = 0.00,0.00,0.00,respectively].When vitamin D doses were varied,(low,moderate,high dosage group) the results fluctuated *** was no significant effect on glucose metabolism in the low dosage *** dosage of vitamin D supplementation significantly reduced FPG,insulin,HOMA-IR,and HOMA-B [SMD =-0.92,-0.97,-0.65,-0.48,95%CI :(-1.44,-0.41),(-1.62,-0.32),(-1.13,-0.18),(-0.95,-0.02),z= 3.49,2.91,2.68,2.02,P = 0.00,0.00,0.01,0.04,respectively].Similarly,high doses of vitamin D supplementation significantly reduced insulin,HOMA-IR,and HOMA-B [SMD=-1.13,-1.10,-1.09,95%CI:(-1.51,-0.74),(-1.53,-0.67),(-1.48,-0.71),z= 5.71,4.97,5.55,P = 0.00,0.00,0.