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A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants

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Bioactive Materials 2023年第9期27卷 488-504页

作者： Zhenbao Zhang Aobo Liu Jiadong Fan Menglin Wang Jiabao Dai Xiang Jin Huanze Deng Xuan Wang Yijie Liang Haixia Li Yantao Zhao Peng Wen Yanfeng Li Department of Stomatology the Fourth Medical Center of PLA General HospitalBeijing100048China State Key Laboratory of Tribology in Advanced Equipment Beijing100084China Medical School of Chinese PLA Beijing100039China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Senior Department of Orthopedics the Fourth Medical Center of PLA General HospitalBeijing100048China Beijing Engineering Research Center of Orthopedics Implants Beijing100048China Institute of Process Engineering Chinese Academy of SciencesBeijing100190China

Zinc(Zn)alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions,having a great application potential for repairing bone *** this work,a hydroxyapatite(HA)/polydopamine(PDA)composite coating was constructed on the surface of Zn-1Mg porous scaffolds fabricated by laser powder bed fusion,and was loaded with a bioactive factor BMP2 and an antibacterial drug *** microstructure,degradation behavior,biocompatibility,antibacterial performance and osteogenic activities were systematically *** with as-built Zn-1Mg scaffolds,the rapid increase of Zn2+,which resulted to the deteriorated cell viability and osteogenic differentiation,was inhibited due to the physical barrier of the composite *** vitro cellular and bacterial assay indicated that the loaded BMP2 and vancomycin considerably enhanced the cytocompatibility and antibacterial *** improved osteogenic and antibacterial functions were also observed according to in vivo implantation in the lateral femoral condyle of *** design,influence and mechanism of the composite coating were discussed *** was concluded that the additively manufactured Zn-1Mg porous scaffolds together with the composite coating could modulate biodegradable performance and contribute to effective promotion of bone recovery and antibacterial function.

关键词： Additive manufacturing Biodegradable metal Zn-Mg alloy porous scaffold Composite coating Bone repair

Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications:Process optimization,in vitro and in vivo investigation

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Bioactive Materials 2022年第10期7卷 301-319页

作者： Jinge Liu Bingchun Liu Shuyuan Min Bangzhao Yin Bo Peng Zishi Yu Caimei Wang Xiaolin Ma Peng Wen Yun Tian Yufeng Zheng The State Key Laboratory of Tribology Tsinghua UniversityBeijing100084China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Department of Orthopaedics Peking University Third HospitalBeijing100191China School of Materials Science and Engineering Peking UniversityBeijing100871China Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijing100191China Beijing AKEC Medical Co. Ltd.Beijing102200China

Laser powder bed fusion(L-PBF)of magnesium(Mg)alloy porous scaffolds is expected to solve the dual challenges from customized structures and biodegradable functions required for repairing bone ***,one of the key technical difficulties lies in the poor L-PBF process performance of Mg,contributed by the high susceptibility to oxidation,vaporization,thermal expansion,and powder attachment *** work investigated the influence of L-PBF energy input and scanning strategy on the formation quality of porous scaffolds by using WE43 powder,and characterized the microstructure,mechanical properties,biocompatibility,biodegradation and osteogenic effect of the as-built WE43 porous *** the customized energy input and scanning strategy,the relative density of struts reached over 99.5%,and the geometrical error between the designed and the fabricated porosity declined to below 10%.Massive secondary phases including intermetallic precipitates and oxides were *** compressive strength(4.37-23.49 MPa)and elastic modulus(154.40-873.02 MPa)were comparable to those of cancellous *** biocompatibility was observed by in vitro cell viability and in vivo *** biodegradation of as-built porous scaffolds promoted the osteogenic effect,but the structural integrity devastated after 12 h by the immersion tests in Hank’s solution and after 4 weeks by the implantation in rabbits’femur,indicating an excessively rapid degradation rate.

关键词： Additive manufacturing Biodegradable metal Laser powder bed fusion Magnesium alloy porous scaffold WE43

Fabrication of Highly Anisotropic and Interconnected porous scaffolds to Promote Preosteoblast Proliferation for Bone Tissue Engineering

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Chinese Journal of Polymer Science 2021年第9期39卷 1191-1199页

作者： Ya-Hui Liu Wei Liu Zi-Li Zheng Xin Wei Nouman Ali Shah Hao Lin Bai-Song Zhao Shi-Shu Huang Jia-Zhuang Xu Zhong-Ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Department of Anesthesiology Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Orthopaedic Surgery West China HospitalSichuan UniversityChengdu 610065China

Mimicking the complex structure of natural bone remains a challenge for bone tissue *** this study,a novel processing strategy was developed to prepare the bone-like scaffolds that are featured by highly oriented and fully interconnected *** type of biomimetic scaffolds was evolved from solid phase stretching of immiscible polycaprolactone(PCL)/poly(ethylene oxide)(PEO)blends with cocontinuous structure and the pore morphology was inherited from selective extraction of water soluble PEO *** pore anisotropy was readily tuned by varying the stretching strain without loss of *** promotion in preosteoblast proliferation,alkaline phosphatase activity and osteogenic gene expression was observed in the oriented porous scaffolds compared to the isotropic porous *** oriented architecture provided a topographical cue for aligned growth of preosteoblasts,which activated the Wnt/β-catenin signaling *** proposed strategy enriches the toolbox for the scaffold design and fabrication for bone tissue engineering.

关键词： porous scaffold Pore anisotropy Polymer blend Co-continuous structure Tissue engineering

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Engineering 2022年第6期8卷 31-45页

作者： Jingming Gao Xiaoye Yu Xinlei Wang Yingning He Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

An appropriate cell microenvironment is key to tissue engineering and regenerative *** the factors that influence the cell microenvironment is a fundamental research topic in the fields of cell biology,biomaterials,tissue engineering,and regenerative *** cell microenvironment consists of not only its surrounding cells and soluble factors,but also its extracellular matrix(ECM)or nearby external biomaterials in tissue engineering and *** review focuses on six aspects of bioma-terial-related cell microenvironments:①chemical composition of materials,②material dimensions and architecture,③material-controlled cell geometry,④effects of material charges on cells,⑤matrix stiff-ness and biomechanical microenvironment,and⑥surface modification of *** present chal-lenges in tissue engineering are also mentioned,and eight perspectives are predicted.

关键词： Tissue engineering Regenerative medicine Biomaterials Cell microenvironment porous scaffold Surface patterning Cell-material interactions

Extrusion-based additive manufacturing of Mg-Zn alloy scaffolds

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Journal of Magnesium and Alloys 2022年第9期10卷 2491-2509页

作者： J.Dong N.Tümer M.A.Leeflang P.Taheri L.E.Fratila-Apachitei J.M.C.Mol A.A.Zadpoor J.Zhou Department of Biomechanical Engineering Delft University of TechnologyDelft 2628 CDthe Netherlands Department of Materials Science and Engineering Delft University of TechnologyDelft 2628 CDthe Netherlands

porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone *** recent progress in additive manufacturing(AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous *** AM,followed by debinding and sintering,has been recently demonstrated as a powerful approach to fabricating such Mg scaffolds,which can avoid some crucial problems encountered when applying powder bed fusion AM ***,such pure Mg scaffolds exhibit a too high rate of in vitro *** the present research,alloying through a pre-alloyed Mg-Zn powder was ultilized to enhance the corrosion resistance and mechanical properties of AM geometrically ordered Mg-Zn scaffolds *** in vitro biodegradation behavior,mechanical properties,and electrochemical response of the fabricated Mg-Zn scaffolds were ***,the response of preosteoblasts to these scaffolds was systematically evaluated and compared with their response to pure Mg *** Mg-Zn scaffolds with a porosity of 50.3% and strut density of 93.1% were composed of the Mg matrix and MgZn2second phase *** in vitro biodegradation rate of the Mg-Zn scaffolds decreased by 81% at day 1,as compared to pure Mg *** 28 days of static immersion in modified simulated body fluid,the corrosion rate of the Mg-Zn scaffolds decreased from 2.3± 0.9 mm/y to 0.7±0.1 mm/*** yield strength and Young’s modulus of the Mg-Zn scaffolds were about 3 times as high as those of pure Mg scaffolds and remained within the range of those of trabecular bone throughout the biodegradation *** culture of MC3T3-E1 preosteoblasts in Mg-Zn extracts indicated favorable *** direct cell culture,some cells could spread and form filopodia on the surface of the Mg-Zn ***,this study demonstrates the great potential of the extrusion-based AM Mg-Zn scaffolds to be further develo

关键词： Additive manufacturing Material extrusion Magnesium-zinc alloy porous scaffold Biodegradation

Additively manufactured metallic biomaterials

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Bioactive Materials 2022年第9期7卷 214-249页

作者： Elham Davoodi Hossein Montazerian Anooshe Sadat Mirhakimi Masoud Zhianmanesh Osezua Ibhadode Shahriar Imani Shahabad Reza Esmaeilizadeh Einollah Sarikhani Sahar Toorandaz Shima ASarabi Rohollah Nasiri Yangzhi Zhu Javad Kadkhodapour Bingbing Li Ali Khademhosseini Ehsan Toyserkan Multi-Scale Additive Manufacturing(MSAM)Laboratory Mechanical and Mechatronics Engineering DepartmentUniversity of WaterlooWaterlooOntario N2L 3G1Canada Department of Bioengineering University of CaliforniaLos AngelesCalifornia 90095United States California NanoSystems Institute(CNSI) University of CaliforniaLos AngelesCalifornia 90095United States Terasaki Institute for Biomedical Innovation Los AngelesCalifornia 90024United States Department of Mechanical Engineering Isfahan University of TechnologyIsfahanIsfahan 84156-83111Iran School of Biomedical Engineering University of SydneySydneyNew South Wales 2006Australia Department of Nanoengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoCalifornia 92093United States Mechanical and Aerospace Engineering Department University of CaliforniaLos AngelesCalifornia 90095United States Department of Mechanical Engineering Shahid Rajaee Teacher Training UniversityTehranTehran 16785-163Iran Institute for Materials Testing Materials Science and Strength of MaterialsUniversity of StuttgartStuttgart 70569Germany Department of Manufacturing Systems Engineering and Management California State UniversityNorthridgeCalifornia 91330United States

Metal additive manufacturing(AM)has led to an evolution in the design and fabrication of hard tissue substitutes,enabling personalized implants to address each patient’s specific *** addition,internal pore architectures integrated within additively manufactured scaffolds,have provided an opportunity to further develop and engineer functional implants for better tissue integration,and long-term *** this review,the latest advances in different aspects of the design and manufacturing of additively manufactured metallic biomaterials are *** introducing metal AM processes,biocompatible metals adapted for integration with AM machines are ***,we elaborate on the tools and approaches undertaken for the design of porous scaffold with engineered internal architecture including,topology optimization techniques,as well as unit cell patterns based on lattice networks,and triply periodic minimal ***,the new possibilities brought by the functionally gradient porous structures to meet the conflicting scaffold design requirements are thoroughly ***,the design constraints and physical characteristics of the additively manufactured constructs are reviewed in terms of input parameters such as design features and AM processing *** assess the proposed applications of additively manufactured implants for regeneration of different tissue types and the efforts made towards their clinical ***,we conclude the review with the emerging directions and perspectives for further development of AM in the medical industry.

关键词： Additive manufacturing Metal implant porous scaffold Tissue engineering Biomaterials

Engineered chitosan for improved 3D tissue growth through Paxillin-FAK-ERK activation

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Regenerative Biomaterials 2020年第2期7卷 141-151页

作者： Md Abdul Kafi Khudishta Aktar Mitsugu Todo Ravinder Dahiya BEST Group School of EngineeringUniversity of GlasgowGlasgow G128QQUK Department of Microbiology and Hygiene Bangladesh Agricultural UniversityMymensingh 2202Bangladesh Research Institute for Applied Mechanics Kyushu UniversityKasugaFukuokaJapan

scaffold engineering has attracted significant attention for three-dimensional(3D)growth,prolifer-ation and differentiation of stem cells in *** available scaffolds suffer from issues such as poor ability for cell adhesion,migration and *** paper addresses these issues with 3D porous chitosan scaffold,fabricated and functionalized with cysteine-terminated Arg-Gly-Asp(Cys-RGD)tri-peptide on their *** study reveals that the compressive moduli of the scaffold is independent to RGD functionalization but shows dependence on the applied freezing temperature(TM)during the fabrication *** low freezing TM(-80℃)produces scaffold with high compressive moduli(14.64±1.38 kPa)and high TM(-30℃)produces scaffold with low compressive moduli(5.6±0.38 kPa).The Cys-RGD functionalized scaffolds lead to significant improvements in adhesion(150%)and proliferation(300%)of human mesenchymal stem cell(hMSC).The RGD-integrin coupling activates the focal adhesion signaling(Paxillin-FAK ERK)path-ways,as confirmed by the expression of p-Paxillin,p-FAK and p-ERK protein,and results in the observed improvement of cell adhesion and *** proliferation of hMSC on RGD func-tionalized surface was evaluated with scanning electron microscopy imaging and distribution though pore was confirmed by histochemistry of transversely sectioned *** hMSC adhe-sion and proliferation in scaffold with high compressive moduli showed a constant enhancement(with a slope value 9.97)of compressive strength throughout the experimental period of 28 *** improved cell adhesion and proliferation with RGD functionalized chitosan scaffold,together with their mechanical stability,will enable new interesting avenues for 3D cell growth and differen-tiation in numerous applications including regenerative tissue implants.

关键词： adhesion signaling chitosan hMSC porous scaffold proliferation Cys-RGD tssue engineering

Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites:In vitro and in vivo studies

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Bioactive Materials 2021年第11期6卷 3999-4013页

作者： Zechuan Zhang Bo Jia Hongtao Yang Yu Han Qiang Wu Kerong Dai Yufeng Zheng School of Materials Science and Engineering Peking UniversityBeijing100871China Department of Orthopedic Surgery Shanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200011China Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China School of Medical Science and Engineering Beihang UniversityBeijing100191China

A novel biodegradable metal system,ZnLiCa ternary alloys,were systematically investigated both in vitro and in *** ultimate tensile strength(UTS)of Zn0.8Li0.1Ca alloy reached 567.60±9.56 MPa,which is comparable to pure Ti,one of the most common material used in *** elongation of Zn0.8Li0.1Ca is 27.82±18.35%,which is the highest among the ZnLiCa *** in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid(SBF)showed significant acceleration than that of pure ***-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good ***-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes(ALP,COL-1,OCN and Runx-2),especially the *** in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks,aiming to treat the bone *** Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti ***0.8Li0.1Ca alloy showed great potential to be applied in orthopedics,especially in the load-bearing sites.

关键词： ZnLiCa alloys Biodegradable metal Critical-sized bone defect Orthopedics porous scaffold In vivo

Degradation and osteogenic potential of a novel PLA/nano-sized β-TCPscaffolds

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Degradation and osteogenic potential of a novel PLA/nano-siz...