Extrusion-based additive manufacturing of Mg-Zn alloy scaffolds

作     者：J.Dong N.Tümer M.A.Leeflang P.Taheri L.E.Fratila-Apachitei J.M.C.Mol A.A.Zadpoor J.Zhou 

作者机构：Department of Biomechanical EngineeringDelft University of TechnologyDelft 2628 CDthe Netherlands Department of Materials Science and EngineeringDelft University of TechnologyDelft 2628 CDthe Netherlands 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2022年第10卷第9期

页      面：2491-2509页

核心收录：

学科分类：080503[工学-材料加工工程] 0806[工学-冶金工程] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0801[工学-力学（可授工学、理学学位）] 080201[工学-机械制造及其自动化] 

基　　金：China Scholarship Council (CSC) for financial support 

主　　题：Additive manufacturing Material extrusion Magnesium-zinc alloy Porous scaffold Biodegradation 

摘      要：Porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone *** recent progress in additive manufacturing(AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous *** AM,followed by debinding and sintering,has been recently demonstrated as a powerful approach to fabricating such Mg scaffolds,which can avoid some crucial problems encountered when applying powder bed fusion AM ***,such pure Mg scaffolds exhibit a too high rate of in vitro *** the present research,alloying through a pre-alloyed Mg-Zn powder was ultilized to enhance the corrosion resistance and mechanical properties of AM geometrically ordered Mg-Zn scaffolds *** in vitro biodegradation behavior,mechanical properties,and electrochemical response of the fabricated Mg-Zn scaffolds were ***,the response of preosteoblasts to these scaffolds was systematically evaluated and compared with their response to pure Mg *** Mg-Zn scaffolds with a porosity of 50.3% and strut density of 93.1% were composed of the Mg matrix and MgZn2second phase *** in vitro biodegradation rate of the Mg-Zn scaffolds decreased by 81% at day 1,as compared to pure Mg *** 28 days of static immersion in modified simulated body fluid,the corrosion rate of the Mg-Zn scaffolds decreased from 2.3± 0.9 mm/y to 0.7±0.1 mm/*** yield strength and Young’s modulus of the Mg-Zn scaffolds were about 3 times as high as those of pure Mg scaffolds and remained within the range of those of trabecular bone throughout the biodegradation *** culture of MC3T3-E1 preosteoblasts in Mg-Zn extracts indicated favorable *** direct cell culture,some cells could spread and form filopodia on the surface of the Mg-Zn ***,this study demonstrates the great potential of the extrusion-based AM Mg-Zn scaffolds to be further develo