Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites:In vitro and in vivo studies

作     者：Zechuan Zhang Bo Jia Hongtao Yang Yu Han Qiang Wu Kerong Dai Yufeng Zheng 

作者机构：School of Materials Science and EngineeringPeking UniversityBeijing100871China Department of Orthopedic SurgeryShanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai200011China Department of OrthopedicsShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China School of Medical Science and EngineeringBeihang UniversityBeijing100191China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第11期

页      面：3999-4013页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 

基　　金：National Natural Science Foundation of China(Grant No.51931001) International Cooperation and Exchange project between NSFC(China)and CNR(Italy)(NSFC-CNR Grant No.52011530392) 

主　　题：ZnLiCa alloys Biodegradable metal Critical-sized bone defect Orthopedics Porous scaffold In vivo 

摘      要：A novel biodegradable metal system,ZnLiCa ternary alloys,were systematically investigated both in vitro and in *** ultimate tensile strength(UTS)of Zn0.8Li0.1Ca alloy reached 567.60±9.56 MPa,which is comparable to pure Ti,one of the most common material used in *** elongation of Zn0.8Li0.1Ca is 27.82±18.35%,which is the highest among the ZnLiCa *** in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid(SBF)showed significant acceleration than that of pure ***-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good ***-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes(ALP,COL-1,OCN and Runx-2),especially the *** in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks,aiming to treat the bone *** Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti ***0.8Li0.1Ca alloy showed great potential to be applied in orthopedics,especially in the load-bearing sites.