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Food Science and Human Wellness 2023年第6期12卷 1948-1960页

作者： Dengtai Wen Yiling Chen Xu Tian Wenqi Hou Department of physical Education Ludong UniversityYantai 264025China College of physical Education Yichun UniversityYichun 336000China School of exercise and Health Shanghai University of SportShanghai 200438China

Aging decreases muscle mass,strength,and functional ***-salt stress seems to promote muscle aging and decrease ***,exercise delays muscle aging and increases longevity,and it may protect muscle from rapid aging induced by high-salt intake(HSI),but the molecular mechanisms are poorly *** this study,the flies were fed a high-salt diet and trained to *** CG2196(salt)gene and dSir2 gene were over-expressed by building mef2-gal4/UAS *** results showed that both physical exercise and muscle dSir2 gene overexpression prevented HSI-induced and muscle salt overexpression-induced accelerated age-related decline of climbing index,climbing endurance,muscle NAD^(+)level,SOD activity level,dSir2 expression,and dFOXO expression,and they also prevented HSI-induced and muscle salt overexpression-induced accelerated age-related increase in muscle ROS level,MDA level,and salt gene *** exercise improved lifespan decrease induced by HSI and muscle salt ***,current results indicated that high-salt stress accelerated muscle aging by decreasing muscular NAD^(+)/dSir2/dFOXO pathway activity and increasing oxidative *** exercise protected muscle from accelerated aging induced by high-salt stress through activating muscle NAD^(+)/dSir2/dFOXO pathway and enhancing muscle oxidation *** combination of exercise and muscle dSir2 overexpression had the best protective effect on muscle aging and lifespan in flies.

关键词： physical exercise high-salt intake muscle aging NAD^(+)/dSir2

physical exercise suppresses hepatocellular carcinoma progression by alleviating hypoxia and attenuating cancer stemness through the Akt/GSK-3β/β-catenin pathway

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Journal of Integrative Medicine 2023年第2期21卷 184-193页

作者： Chu-lan Xiao Zhi-peng Zhong Can Lü Bing-jie Guo Jiao-jiao Chen Tong Zhao Zi-fei Yin Bai Li Department of Rehabilitation Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Traditional Chinese Medicine The 920th Hospital of Joint Logistics Support ForceKunming 650000Yunnan ProvinceChina Second Team Graduate SchoolNaval Medical UniversityShanghai 200433China College of Integrated Traditional Chinese and Western Medicine Nanjing University of Traditional Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Military Traditional Chinese Medicine Faculty of Traditional Chinese MedicineNaval Medical UniversityShanghai 200433China

Objective:physical exercise,a common non-drug intervention,is an important strategy in cancer treatment,including hepatocellular carcinoma(HCC).However,the mechanism remains largely *** to the importance of hypoxia and cancer stemness in the development of HCC,the present study investigated whether the anti-HCC effect of physical exercise is related to its suppression on hypoxia and cancer ***:A physical exercise intervention of swimming(30 min/d,5 d/week,for 4 weeks)was administered to BALB/c nude mice bearing subcutaneous human HCC *** anti-HCC effect of swimming was assessed in vivo by tumor weight monitoring,hematoxylin and eosin(HE)staining,and immunohistochemistry(IHC)detection of proliferating cell nuclear antigen(PCNA)and *** expression of stemness transcription factors,including Nanog homeobox(NANOG),octamer-binding transcription factor 4(OCT-4),v-Myc avian myelocytomatosis viral oncogene homolog(C-MYC)and hypoxia-inducible factor-1a(HIF-1a),was detected using real-time reverse transcription polymerase chain reaction.A hypoxia probe was used to explore the intratumoral hypoxia *** blot was used to detect the expression of HIF-1a and proteins related to protein kinase B(Akt)/glycogen synthase kinase-3β(GSK-3β)/β-catenin signaling *** IHC analysis of platelet endothelial cell adhesion molecule-1(CD31),and the immunofluorescence co-location of CD31 and desmin were used to analyze tumor blood ***-7721 cells were treated with nude mice *** inhibition effect on cancer stemness in vitro was detected using suspension sphere experiments and the expression of stemness transcription *** hypoxia status was inferred by measuring the protein and mRNA levels of ***,the expression of proteins related to Akt/GSK-3β/β-catenin signaling pathway was ***:Swimming significantly reduced the body weight and tumor weight in nude mice bearing HCC *** staining and IHC results show

关键词： physical exercise Swimming Hepatocellular carcinoma Liver cancer Blood perfusion Hypoxia Cancer stemness Akt/GSK-3β/β-catenin

physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

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Neural Regeneration Research 2024年第8期19卷 1768-1771页

作者： Federica Azzolini Ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari Unit of Neurology IRCCS NeuromedPozzilliItaly Department of System Medicine University of Tor VergataRomeItaly Synaptic Immunopathology Lab Department of Systems MedicineTor Vergata UniversityRomeItaly

In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying *** r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple *** evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully ***,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and *** humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal *** present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.

关键词： disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis neuroplasticity neuroprotection physical exercise synaptopathy

physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer

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Military Medical Research 2024年第4期11卷 616-619页

作者： Zhi-Wen Luo Ya-Ying Sun Wei Xia Jun-Ying Xu Dong-Jing Xie Chun-Meng Jiao Ji-Ze Dong Hui Chen Ren-Wen Wan Shi-Yi Chen Jie Mei Wen-Jun Mao Department of Sports Medicine Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalShanghai 200080China Department of Critical Care Medicine the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Department of Oncology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina Guangdong Pharmaceutical University Guangzhou 510006China Institute of Acupuncture Research Institutes of Integrative MedicineFudan UniversityShanghai 200433China Department of Cardiothoracic Surgery the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023JiangsuChina

Dear Editor,physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are *** regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.

关键词： physical exercise Non-small cell lung cancer(NSCLC) Squalene epoxidase(SQLE) Tumor immune microenvironment(TIME)

physical exercise and COVID-19 pandemic in PubMed:Two months of dynamics and one year of original scientific production

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Sports Medicine and Health Science 2021年第2期3卷 80-92页

作者： Rodrigo L.Vancini Marília S.Andrade Ricardo B.Viana Pantelis T.Nikolaidis Beat Knechtle Cassia R.V.Campanharo Alexandre A.de Almeida Paulo Gentil Claudio A.B.de Lira Centro de Educaçao Física e Desportos(CEFD) Universidade Federal do Espírito Santo(UFES)Espírito Santo(ES)Brazil Departamento de Fisiologia Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo(SP)Brazil Setor de Fisiologia Humana e do Exercício Faculdade de Educaçao Física e DançaUniversidade Federal de Goias(UFG)GoianiaGoias(GO)Brazil School of Health and Caring Sciences University of West AtticaGreece Medbase St.Gallen Am Vadianplatz St.Gallen and Institute of Primary CareUniversity of ZurichZurichSwitzerland Escola Paulista de Enfermagem(EPE) UNIFESPSao Paulo(SP)Brazil Instituto Federal de Educaçao Ciencia e Tecnologia do Tocantins(IFTO Araguatins)Campus Araguatins.Povoado Santa TerezaKm 05 S/N Zona RuralAraguatinsTocantins(TO)Brazil

Our aim was to conduct a narrative review about physical exercise and Corona Virus Disease 2019(COVID-19).A literature search was completed crossing the keywords“COVID-19”and“physical exercise”,for a narrative re-view,and physical activity(PA),physical exercise,physical training,sport,physical fitness,for a systematic re-view;search strategy(Randomized Controlled Trial,in the last 1 year,English).The first search date was closed on 04/26/2020 and 06/26/*** strategy was chosen to assess the dynamics of scientific information production for the *** two months,an increase of 76%,from 12(19.4%)to 50(80.64%)COVID-19 articles(n=62,100%)was *** main types of articles published were editorial articles(16.13%,n=10 of 62 articles)and commentary(9.68%,n=6 of 62 articles).The most frequent country of origin of the scientific production was the United States(12.90%,n=8 of 62 articles),the United Kingdom(12.90%,n=8 of 62 arti-cles),and Brazil(11.29%,n=7 of 62 articles).However,in 2020,there were only 2 relevant randomized controlled trials on the COVID-19 topic in the context of physical *** information production shows the concern of the PA science community to bring a solution to the increase in physical inactivity generated by the COVID-19 *** findings show the dynamics of scientific production on the COVID-19,in a situation so unique such as a pandemic,denotes that the practice of PA is essential to improve and/or maintain physical and mental health.

关键词： Coronavirus Pandemic COVID-19 Social isolation Quarantine physical exercise physical activity Sport

Effects of physical exercise on the developmental expression of hippocampal zinc transporter 1 and glutamate receptor subunit 2, and on cognitive function in a rat model of recurrent neonatal seizure

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Neural Regeneration Research 2009年第1期4卷 20-25页

作者： Hong Ni Yuwu Jiang Weiming Jiang Zhedong Wang Xiru Wu Institute of Pediatrics Children's Hospital Soochow University Suzhou 215003 Jiangsu Province China Department of Pediatric Neurology First Hospital Peking University Beijing 100034 China

BACKGROUND： Developmental seizures are pathologically characterized by regenerative sprouting of hippocampal mossy fibers rich in Zn^2＋. Zn^2＋ metabolism in the mossy fiber pathway, and Zn^2＋ accumulation in presynaptic membrane vesicles, are dependent on zinc transporter 1 （ZnT1） and glutamate receptor subunit 2 （GluR2）. OBJECTIVE： To investigate the effects of long-term recurrent neonatal seizure, in the presence and absence of physical exercise, on the developmental expression of hippocampal zinc transporter 1 （ZnT1） and GluR2, and on cognitive function in rats. DESIGN, TIME AND SETTING： Based on behavioral examination and molecular biological research, a randomized, controlled animal experiment was performed at the Department of Neurobiology, Medical College of Soochow University, between January 2007 and April 2008. MATERIALS： Twenty-one 6-day-old Sprague Dawley rats of either gender were employed in this study. ZnT1 mRNA in situ hybridization kit was provided by Tianjin Haoyang Biological Manufacture Co.,Ltd., China. Rabbit anti-GluR2 was purchased from Santa Cruz Biotech, Inc, USA. METHODS： Rats were randomly divided into a recurrent seizure group （n = 11） and a control group （n = 10）. In the recurrent seizure group, 30-minute seizure was induced by flurothyl gas inhalation for a total of 6 consecutive days. Rats from the control group underwent experimental procedures similar to the recurrent seizure group, with the exception of flurothyl gas inhalation. Thirty minutes of treadmill exercise was performed daily by all rats at postnatal days 51–56. MAIN OUTCOME MEASURES： At postnatal day 82, rat hippocampal tissue was harvested for analysis of hippocampal ZnT1 and GluR2 expression by in situ hybridization and immunohistochemistry, respectively. Rat learning and memory capabilities were examined using the Y-maze test. RESULTS： In the recurrent seizure group, the gray scale value of ZnT1 in situ hybridization positive neurons in the hippocampal CA3 r

关键词： seizure Y-maze physical exercise zinc transporter 1 glutamate receptor subunit 2

Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?

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Neural Regeneration Research 2015年第1期10卷 7-9页

作者： Suk Yu Yau Ang Li Aimin Xu Kwok-fai So State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong Division of Medical Sciences University of Victoria BCCanada Department of Anatomy The University of Hong Kong Department of Medicine The University of Hong Kong Department of Pharmacology and Pharmacy The University of Hong Kong Research Centre of Heart BrainHormone and Healthy AgeingThe University of Hong Kong State Key Laboratory of Pharmaceutical Biotechnology Li Ka Shing Faculty of MedicineThe University of Hong Kong Department of Ophthalmology The University of Hong Kong Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan University Guangdong Key Laboratory of Brain Function and Diseases Jinan University

Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. physical exercise has been long recog- nized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neuro- genesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counter- acting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.

关键词： hippocampus adult neurogenesis physical exercise voluntary wheel running depression neural progenitor cell adipocyte adiponectin adiponectin receptor AMP-activated protein kinase

Roles of physical exercise in neurodegeneration:reversal of epigenetic clock

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Translational Neurodegeneration 2021年第3期10卷 385-399页

作者： Miao Xu JiaYi Zhu Xian‑Dong Liu Ming‑Ying Luo Nan‑Jie Xu Department of Anatomy Histology and EmbryologyKunming Medi‑cal UniversityKunming 650500China Collaborative Innovation Center for Brain Science Department of Anatomy and PhysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurology and Institute of Neurology Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Cell Diferentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of MedicineShanghai 200025China Present Address:Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada

The epigenetic clock is defned by the DNA methylation(DNAm)level and has been extensively applied to distinguish biological age from chronological ***-related neurodegeneration is associated with epigenetic alteration,which determines the status of *** recent years,extensive research has shown that physical exercise(PE)can afect the DNAm level,implying a reversal of the epigenetic clock in *** also regulates brain plas‑ticity,neuroinfammation,and molecular signaling cascades associated with *** review summarizes the efects of PE on neurodegenerative diseases via both general and disease-specifc DNAm mechanisms,and discusses epigenetic modifcations that alleviate the pathological symptoms of these *** may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction.

关键词： physical exercise DNA methylation Neural mechanism Neurodegeneration Motor defcits

Updated overview on interplay between physical exercise,neurotrophins,and cognitive function in humans

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Journal of Sport and Health Science 2020年第1期9卷 74-81页

作者： Giuseppe Lippi Camilla Mattiuzzi Fabian Sanchis-Gomar Section of Clinical Biochemistry University of VeronaVerona 37129Italy Service of Clinical Governance Provincial Agency for Social and.Sanitary ServicesTrento 38123Italy Department of Physiology Faculty of MedicineUniversity of Valencia and INCLIVA Biomedical Research InstituteValencia 46010Spain

The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, recent evidence attests that neurotrophin receptor signalingmay have an important role, because the activation of this pathway leads to growth and differentiation of new neurons and synapses, supportsaxonal and dendritic growth, fosters synaptic plasticity, and preserves survival of existing neurons. In this review of published evidence, we highlightthat a positive relationship exists between physical exercise and circulating brain-derived neurotrophic factor levels and that the postexercisevariation of this molecule is associated with improvement of neurocognitive functioning. Less clear evidence has instead been published forother neurotrophins, such as nerve growth factor, neurotrophin-3, and neurotrophin-4. Overall, promotion of adequate volumes and intensities ofphysical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2—3 sessions/week lasting not less than 30 min)may hence be regarded as an inexpensive and safe strategy for boosting brain-derived neurotrophic factor release, thus preserving or restoringcognitive functions.

关键词： Cognitive function Neurotrophins physical exercise Sport

Who Benefits More from physical exercise?On the Relations between Personality,physical exercise,and Well-Being

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International Journal of Mental Health Promotion 2023年第10期25卷 1147-1157页

作者： Jialing Miao Wei Liao Baoguo Xie School of Entrepreneurship Wuhan University of TechnologyWuhan430070China School of Management Wuhan University of BioengineeringWuhan430415China School of Management Wuhan University of TechnologyWuhan430070China

Although employers believe that encouraging and supporting physical exercise activities by purchasing fitness equipment and building sports venues can improve employees’well-being,the utilization rate is rather *** most of the evidence of the well-being promotion in the workplace concentrated on the perspectives of organizational factors and psychosocial factors and focused on the reduction of the negative affect of well-being,it is still an open question whether physical exercise has benefits on both negative and positive affect of well-being and who benefits more from physical ***,the purpose of this study is to investigate the impact of physical exercise on occupational well-being(job burnout and work engagement)and examine whether effectiveness depends on personality *** questionnaires were *** sample included 671 participants from different enterprises in *** showed that the effectiveness of physical exercise was also applicable to well-being in the *** exercise was negatively correlated with job burnout and positively correlated with work *** effectiveness was different among employees with different personality *** to our expectation,individuals with neuroticism were more likely to improve their work engagement through physical *** and conscientiousness weakened the benefits of physical ***,differences of effectiveness among different personality traits emphasize the need for a more personalized strategy in physical exercise interventions.

关键词： physical exercise job burnout work engagement personal traits