Roles of physical exercise in neurodegeneration:reversal of epigenetic clock

作     者：Miao Xu JiaYi Zhu Xian‑Dong Liu Ming‑Ying Luo Nan‑Jie Xu Miao Xu;JiaYi Zhu;Xian-Dong Liu;Ming-Ying Luo;Nan-Jie Xu

作者机构：Department of AnatomyHistology and EmbryologyKunming Medi‑cal UniversityKunming 650500China Collaborative Innovation Center for Brain ScienceDepartment of Anatomy and PhysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurology and Institute of NeurologyRui Jin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Reproductive MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Cell Diferentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University School of MedicineShanghai 200025China Present Address:Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoONCanada 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2021年第10卷第3期

页      面：385-399页

核心收录：

学科分类：0710[理学-生物学] 0402[教育学-心理学(可授教育学、理学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100204[医学-神经病学] 1009[医学-特种医学] 10[医学] 

基　　金：This research was supported by the National Natural Science Foundation of China(31671062 and 81870820 to N.-J.X.31900796 to X.-D.L),Shanghai Brain-Intelligence Project from the Science and Technology Commission of Shanghai Municipality(16JC1420500 and 18JC1420302) the Innovative Research Team of High-level Local Universities in Shanghai 

主　　题：Physical exercise DNA methylation Neural mechanism Neurodegeneration Motor defcits 

摘      要：The epigenetic clock is defned by the DNA methylation(DNAm)level and has been extensively applied to distinguish biological age from chronological ***-related neurodegeneration is associated with epigenetic alteration,which determines the status of *** recent years,extensive research has shown that physical exercise(PE)can afect the DNAm level,implying a reversal of the epigenetic clock in *** also regulates brain plas‑ticity,neuroinfammation,and molecular signaling cascades associated with *** review summarizes the efects of PE on neurodegenerative diseases via both general and disease-specifc DNAm mechanisms,and discusses epigenetic modifcations that alleviate the pathological symptoms of these *** may lead to probing of the underpinnings of neurodegenerative disorders and provide valuable therapeutic references for cognitive and motor dysfunction.