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ExosomalmicroRNA let-7c-5p enhances cell malignant characteristics by inhibiting TAGLN in oral cancer

Oncology Research 2024年第10期32卷 1623-1635页

作者： YI LI TIANYI WANG HAORAN DING SHIYONG ZHUANG XIAOBO DAI BING YAN State Key Laboratory of oral Diseases&National Center for Stomatology&National Clinical Research Center for oral Diseases&Department of Head and Neck Oncology Surgery West China Hospital of StomatologySichuan UniversityChengdu610041China Frontier Innovation Center for Dental Medicine Plus Chengdu610041China

Background:oral cancer,a malignancy that is prevalent worldwide,is often diagnosed at an advanced ***(miRNAs)in circulating exosomes have emerged as promising cancer *** role of miRNA let-7c-5p in oral cancer remains underexplored,and its potential involvement in tumorigenesis warrants comprehensive ***:Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA *** of the exosomes was confirmed through transmission electron *** PCR was used to assess the miRNA *** effects of let-7c-5p and TAGLN overexpression on oral cancer cell viability,migration,and invasion were analyzed via CCK-8 and Transwell ***,we conducted mRNA sequencing of exosomal RNA from exosomes overexpressing let-7c-5p to delineate the gene expression profile and identify potential let-7c-5p target ***:let-7c-5p was upregulated in serumderived exosomes of patients with oral *** of let-7c-5p in the TCA8113 and CAL-27 cell lines enhanced their proliferative,migratory,and invasive capacities,and overexpression of let-7c-5p cell-derived exosomes promoted oral cancer cell *** mRNA sequencing revealed 2,551 differentially expressed genes between control cell-derived exosomes and overexpressed let-7c-5p cell-derived *** further identified TAGLN as a direct target of let-7c-5p,which has been implicated in modulating the oncogenic potential of oral cancer *** of TAGLN reverses the promoting role of let-7c-5p on oral cancer ***:Our findings highlight the role of exosomal let-7c-5p in enhancing oral cancer cell aggressiveness by downregulating TAGLN expression,highlighting its potential as a diagnostic and therapeutic strategy.

关键词： oral cancer Exosomal microRNA let-7c-5p Tumorigenesis biomarkers Gene expression profiling TAGLN

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Research Progress on the Application of Nanomaterials in the Treatment of oral cancer

Expert Review of Chinese Medical

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Expert Review of Chinese Medical 2024年第2期2卷 48-53页

作者： Xiandu Huang Baojiang Du Stomatology Department of Weifang Medical College

oral cancer is a complex pathological process caused by a combination of exogenous factors represented by oncoviruses and endogenous factors represented by immune damage,individual DNA damage,and *** treatment for oral cancer is based on the perspective of molecular genetics,which can not only reduce toxicity and increase efficacy,but also improve the quality of life of *** is the bottleneck that clinical oral cancer treatment needs to break through the *** can exhibit a unique large molecular surface area,with relatively high surface reactivity and multiple surface active centers,resulting in strong adsorption capacity in molecular *** is a certain foundation in its application in the field of biology,but it has good tumor cytotoxicity and inhibition of proliferation in the treatment of oral *** study reviews the application of nanomaterials in tumor prevention,treatment,and other fields,providing new ideas for the future treatment of this disease.

关键词： nano oral cancer treatment application

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Paclitaxel induces human KOSC3 oral cancer cell apoptosis through caspase pathways

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BIOCELL 2024年第7期48卷 1047-1054页

作者： YU-YAN LAN TSUN-CHIH CHENG YI-PING LEE CHIA-YIH WANG BU-MIIN HUANG School of Medicine College of MedicineI-Shou UniversityKaohsiung82445Taiwan Department of Otolaryngology An Nan HospitalChina Medical UniversityTainan70965Taiwan Department of Cell Biology and Anatomy College of MedicineNational Cheng Kung UniversityTainan70101Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

Background:Paclitaxel is a compound derived from Paciﬁc yew bark that induces various cancer cell ***,whether it also has anticancer activities in KOSC3 cells,an oral cancer cell line,is ***:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide,ﬂow cytometry,and western blotting assays were carried out to assess cell viability,subG1 phase of the cell cycle,and apoptosis-related protein expression,***:Ourﬁndings indicate that paclitaxel could inhibit cell viability and increase the expression of apoptotic markers,including plasma membrane blebbing and the cleavage of poly ADP-ribose polymerase in KOSC3 ***,the treatment with paclitaxel remarkably elevated the percentage of the subG1 phase in KOSC3 *** addition,treatment with a pan-caspase inhibitor could recover paclitaxel-inhibited cell ***,caspase-8,caspase-9,caspase-7,and BH3 interacting domain death agonist(Bid)were activated in paclitaxel-treated KOSC3 ***:Paclitaxel induced apoptosis through caspase cascade in KOSC3 cells.

关键词： Paclitaxel oral cancer KOSC3 cells Apoptosis Caspase pathways

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Unraveling the therapeutic mechanisms of myristic acid and luteolin 7-rutinoside in oral cancer: insights from network pharmacology and molecular docking analysis

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Pharmacology Discovery 2024年第2期4卷 1-9页

作者： Ansari Vikhar Danish Ahmad Misba Ruhi Syed Ayaz Ali Qazi Yasar Mohd.Mukhtar Khan Subur W Khan Mohammed Imran Anees Y.B.Chavan College of Pharmacy Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India Maulana Azad College Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431001India

Background:The compound Luteolin-7-rutinoside(L7R)is a flavone derivative of luteolin,predominantly identified in plant species belonging to the families ***,Myristic acid is characterized by its structure as a 14-carbon,unsaturated fatty *** this investigation,we endeavor to elucidate the putative mechanisms underlying the therapeutic effects of Myristic Acid and Luteolin 7-rutinoside in the context of oral cancer treatment,employing network pharmacology coupled with molecular docking ***:The protein targets of Myristic Acid and Luteolin 7-rutinoside were identified through a search on the Swiss Target ***,a compound-target network was constructed using Cytoscape *** associated with OC were retrieved from the OMIM and GeneCards *** overlap between compound targets and OC-related targets was determined,and the resulting shared targets were subjected to protein-protein interaction(PPI)network analysis using the STRING ***,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were conducted on the identified *** docking were performed to investigate the interactions between the core target and the active ***:The component target network comprises 103 nodes and 102 *** the proteins in the protein-protein interaction(PPI)network,those with higher degrees are TNF,PPARG,and *** through Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways indicates that the treatment of OC with Myristic Acid and Luteolin 7-rutinoside primarily involves the regulation of miRNA transcription and inflammatory *** identified signaling pathways include Pathways in cancer,PPAR signaling pathway,EGFR signaling pathway,and TNF signaling *** docking studies reveal that Luteolin 7-rutinoside and Myristic acid exhibit higher affinity towards TNF,PPARG,TP53,and ***:This study

关键词： myristic acid luteolin 7-rutinoside network pharmacology oral cancer molecular docking

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oral cancer incidence and mortality in China, 2011

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Chinese Journal of cancer Research 2015年第1期27卷 44-51页

作者： Shao-Kai Zhang Rongshou Zheng Qiong Chen Siwei Zhang Xibin Sun Wanqing Chen Department of cancer Epidemiology Henan Cancer Hospital/Institute Affiliated cancer Hospital of Zhengzhou University National Central cancer Registry National Cancer Center

Objective： To descript the incidence and mortality rates of oral cancer among Chinese population in 2011, and provide valuable data for oral cancer prevention and research. Methods： Data from 177 population-based cancer registries distributed in 28 provinces were accepted for this study after evaluation based on quality control criteria, covering a total of 175,310,169 populations and accounting for 13.01% of the overall national population in 2011. Incidence and mortality rates were calculated by area, gender and age groups. The numbers of new cases and deaths were estimated using the 5-year age-specific cancer incidence/mortality rates and the corresponding populations. The Chinese population in 2000 and World Segi＇s population were used for age-standardized rates. Results： The estimate of new cases diagnosed with oral cancer was 39,450 including 26,160 males and 13,290 females. The overall crude incidence rate for oral cancer was 2.93/100,000. The age-standardized rates by China （ASRcN） population and by World population （ASRwld） were 2.22/100,000 and 2.17/100,000, respectively. Among subjects aged 0-74 years, the cumulative incidence rate was 0.25%. The estimated number of oral cancer deaths of China in 2011 was 16,933, including 11,794 males and 5,139 females. The overall crude mortality rate was 1.26/I00,000, accounting for 0.80% of all cancer deaths. The ASRcN and ASP^Id for mortality were 0.90/100,000 and 0.89/100,000, respectively. Among subjects aged 0-74 years, the cumulative mortality rate was 0.10%. The incidence and mortality rates of oral cancer were much higher in males and urban areas than in females and rural areas. In addition, the incidence and mortality rates were increased by the raising of ages. Conclusions： Results in the study may have important roles for oral cancer prevention and research. Although oral cancer burden of China is not high, we must pay attention to this malignancy as well. In addition, further researches need to be done for

关键词： Incidence mortality oral cancer China

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NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics

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Nano Research 2022年第7期15卷 6288-6296页

作者： Mingjian Ling Rui Sun Guang Li Madiha Zahra Syeda Wen Ma Ziyi Mai Longquan Shao Longguang Tang Zhiqiang Yu School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510632China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Department of Obstetrics and Gynecology The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510632China Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital Zhejiang University School of MedicineKey Laboratory of Respiratory Disease of Zhejiang ProvinceHangzhou 310009China The Fourth Affiliated Hospital International Institutes of MedicineZhejiang University School of MedicinJinhua 322000China

oral cancer is a common malignant tumor of the head and neck,and surgery combined with radiotherapy and chemotherapy is the primary treatment ***,a positive resection margin that may lead to recurrence after surgery has always been a critical issue to ***,radiotherapy and chemotherapy also have shortcomings such as resistance to chemotherapy and radiation,lack of targeting,and severe side ***,exploring new methods of tumor surgical navigation and tumor treatment is of great significance for oral ***,the emerging near-infrared II(NIR-II,1,000–1,700 nm)region fluorescent imaging has revolutionized surgical navigation,a high tumor-targeting fluorescent probe remains ***,while emerging photothermal therapy(PTT)can overcome chemoradiotherapy’s shortcomings and achieve precise treatment of tumors,its clinical application is still limited by the lack of high photothermal conversion efficiency,high photothermal stability,and highly penetrating ***,a NIR-II dye SQ890 is developed for tumor imaging and PTT of oral *** assembling into nanoparticles(NPs)and being modified with epithelial growth factor receptor(EGFR)-targeting peptides GE11,SQ890 NPs-Pep can specifically accumulate in tumor sites via active targeting,and realize photoacoustic/NIR-II fluorescence dual-modality imaging-guided PTT of oral cancer.

关键词： near-infrared(NIR-II)imaging oral cancer theranostics epithelial growth factor receptor(EGFR) photothermal therapy

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Hyperparameter Tuning Bidirectional Gated Recurrent Unit Model for oral cancer Classification

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Computers, Materials & Continua 2022年第12期73卷 4541-4557页

作者： K.Shankar E.Laxmi Lydia Sachin Kumar Ali S.Abosinne Ahmed alkhayyat A.H.Abbas Sarmad Nozad Mahmood Department of Computer Science South Ural State UniversityChelyabinsk454080Russia Department of Computer Science and Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Computer Technical Engineering Department College of Technical Engineeringthe Islamic UniversityNajaf54001Iraq College of Technical Engineering the Islamic UniversityNajafIraq College of Information Technology Imam Ja’afar Al-Sadiq UniversityAl-Muthanna66002Iraq Computer Technology Engineering College of Engineering TechnologyAl-Kitab UniversityIraq

oral Squamous Cell Carcinoma(OSCC)is a type of Head and Neck Squamous Cell Carcinoma(HNSCC)and it should be diagnosed at early stages to accomplish efficient treatment,increase the survival rate,and reduce death *** imaging is a wide-spread standard used for OSCC ***,it is a cumbersome process and demands expert’s ***,there is a need exists for automated detection ofOSCC using Artificial Intelligence(AI)and Computer Vision(CV)*** this background,the current research article introduces Improved Slime Mould Algorithm with Artificial Intelligence Driven oral cancer Classification(ISMA-AIOCC)model on Histopathological images(HIs).The presented ISMA-AIOCC model is aimed at identification and categorization of oral cancer using *** the initial stage,linear smoothing filter is applied to eradicate the noise from ***,MobileNet model is employed to generate a useful set of feature ***,Bidirectional Gated Recurrent Unit(BGRU)model is exploited for classification *** the end,ISMA algorithm is utilized to fine tune the parameters involved in BGRU ***,ISMA algorithm is created by integrating traditional SMA and ChaoticOppositional Based Learning(COBL).The proposed ISMA-AIOCC model was validated for performance using benchmark dataset and the results pointed out the supremacy of ISMA-AIOCC model over other recent approaches.

关键词： Computer aided diagnosis deep learning BGRU biomedical imaging oral cancer histopathological images

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Phototheranostic Nanoagents for Imaging-Guided Treatment of oral cancer

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中国化学:英文版 2023年第13期41卷 1624-1636页

作者： Jisen Li Yufan Zhang Jiafei Qu Jing Gao Dan Ding Jing Shen Central Laboratory of Tianjin Stomatological Hospital Tianjin Key Laboratory of Oral and Maxillofacial Function ReconstructionTianjin Stomatological HospitalThe Affiliated Stomatological Hospital of Nankai UniversityTianjin300041 China Key Laboratory of Bioactive Materials Ministry of Educationand College of Life SciencesNankai UniversityTianjin300071 China

Phototherapy showed almost a lack of drug resistance and,depending on the therapeutic effects of non-invasive light-stimulating *** side effects of phototherapy were greatly reduced compared to their traditional *** nanoagents had new properties in drug delivery,biocompatibility,targeting and response,in which traditional phototheranostic drugs can not ***,a large number of relevant studies have demonstrated that photodynamic therapy(PDT)in combination with other agents and image-guided multifunctional photothermal therapy(PTT)were well suited for the treatment of oral *** the design of the nanoagents,researchers have discovered various applications for phototherapy,such as targeted release of co-packaged drugs,multifunctional imaging for diagnosis and treatment combination,accurate targeting caused by nanocarriers,and synergistic chemotherapy with *** this paper,we first reviewed the research related to phototheranostic nanoagents for image-guided treatment of oral *** tried to introduce the design concept and the treatment effect by three parts of components of phototheranostic nanoagents,categories of phototheranostic nanoagents and application of phototheranostic *** also provided a reference for nanomaterial development and clinical applications in research of oral cancer treatment.

关键词： Phototheranostic Nanoagents Sensors Bioimaging oral cancer cancer treatment

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Sailfish Optimization with Deep Learning Based oral cancer Classification Model

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Computer Systems Science & Engineering 2023年第4期45卷 753-767页

作者： Mesfer Al Duhayyim Areej A.Malibari Sami Dhahbi Mohamed K.Nour Isra Al-Turaiki Marwa Obayya Abdullah Mohamed Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Department of Industrial and Systems Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversityAbha62529Saudi Arabia Department of Computer Science College of Computing and Information SystemUmm Al-Qura UniversityMecca24382Saudi Arabia Department of Information Technology College of Computer and Information SciencesKing Saud UniversityRiyadh4545Saudi Arabia Department of Biomedical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Research Centre Future University in EgyptNew Cairo11845Egypt

Recently,computer aided diagnosis(CAD)model becomes an effective tool for decision making in healthcare *** advances in computer vision and artificial intelligence(AI)techniques have resulted in the effective design of CAD models,which enables to detection of the existence of diseases using various imaging *** cancer(OC)has commonly occurred in head and neck *** identification of OC enables to improve survival rate and reduce mortality ***,the design of CAD model for OC detection and classification becomes ***,this study introduces a novel Computer Aided Diagnosis for OC using Sailfish Optimization with Fusion based Classification(CADOC-SFOFC)*** proposed CADOC-SFOFC model determines the existence of OC on the medical *** accomplish this,a fusion based feature extraction process is carried out by the use of VGGNet-16 and Residual Network(ResNet)***,feature vectors are fused and passed into the extreme learning machine(ELM)model for classification ***,SFO algorithm is utilized for effective parameter selection of the ELM model,consequently resulting in enhanced *** experimental analysis of the CADOC-SFOFC model was tested on Kaggle dataset and the results reported the betterment of the CADOC-SFOFC model over the compared methods with maximum accuracy of 98.11%.Therefore,the CADOC-SFOFC model has maximum potential as an inexpensive and non-invasive tool which supports screening process and enhances the detection efficiency.

关键词： oral cancer computer aided diagnosis deep learning fusion model seagull optimization classification

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Significance of 125I radioactive seed implantation on growth differentiation factor and programmed death receptor-1 during treatment of oral cancer

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World Journal of Clinical Cases 2020年第5期8卷 874-886页

作者： Gang Xue Yao Feng Jia-Bin Li Department II of Prosthodontics The Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department I of Endodontics The Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department II of oral and Maxillofacial Surgery The Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina

BACKGROUND oral cancer(OC)is the most common malignant tumor in the oral cavity,and is mainly seen in middle-aged and elderly *** present,OC is mainly treated clinically by surgery or combined with radiotherapy and chemotherapy;but recently,more and more studies have shown that the stress trauma caused by surgery and the side effects of radiotherapy and chemotherapy seriously affect the prognosis of *** To determine the significance of 125I radioactive seed implantation on growth differentiation factor 11(GDF11)and programmed death receptor-1(PD-1)during treatment of *** A total of 184 OC patients admitted to The Second Affiliated Hospital of Jiamusi University from May 2015 to May 2017 were selected as the research subjects for prospective *** these patients,89 who received 125I radioactive seed implantation therapy were regarded as the research group(RG)and 95 patients who received surgical treatment were regarded as the control group(CG).The clinical efficacy,incidence of adverse reactions and changes in GDF11 and PD-1 before treatment(T0),2 wk after treatment(T1),4 wk after treatment(T2)and 6 wk after treatment(T3)were compared between the two *** The efficacy and recurrence rate in the RG were better than those in the CG(P<0.05),while the incidence of adverse reactions and survival rate were not *** was no difference in GDF11 and PD-1 between the two groups at T0 and T1,but these factors were lower in the RG than in the CG at T2 and T3(P<0.05).Using receiver operating characteristic(ROC)curve analysis,GDF11 and PD-1 had good predictive value for efficacy and recurrence(P<0.001).CONCLUSION 125I radioactive seed implantation has clinical efficacy and can reduce the recurrence rate in patients with *** therapy has marked potential in clinical *** detection of GDF11 and PD-1 in patients during treatment showed good predictive value for treatment efficacy and recurrence in OC patients,and may be poten

关键词： 125I radioactive seeds oral cancer Growth differentiation factor 11 Programmed death receptor-1 Prognosis Recurrence

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