Significance of 125I radioactive seed implantation on growth differentiation factor and programmed death receptor-1 during treatment of oral cancer

作     者：Gang Xue Yao Feng Jia-Bin Li 

作者机构：Department II of ProsthodonticsThe Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department I of EndodonticsThe Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department II of Oral and Maxillofacial SurgeryThe Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第5期

页      面：874-886页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Heilongjiang Provincial Health and Family Planning Commission Research Project No.2017-413 

主　　题：125I radioactive seeds Oral cancer Growth differentiation factor 11 Programmed death receptor-1 Prognosis Recurrence 

摘      要：BACKGROUND Oral cancer(OC)is the most common malignant tumor in the oral cavity,and is mainly seen in middle-aged and elderly *** present,OC is mainly treated clinically by surgery or combined with radiotherapy and chemotherapy;but recently,more and more studies have shown that the stress trauma caused by surgery and the side effects of radiotherapy and chemotherapy seriously affect the prognosis of *** To determine the significance of 125I radioactive seed implantation on growth differentiation factor 11(GDF11)and programmed death receptor-1(PD-1)during treatment of *** A total of 184 OC patients admitted to The Second Affiliated Hospital of Jiamusi University from May 2015 to May 2017 were selected as the research subjects for prospective *** these patients,89 who received 125I radioactive seed implantation therapy were regarded as the research group(RG)and 95 patients who received surgical treatment were regarded as the control group(CG).The clinical efficacy,incidence of adverse reactions and changes in GDF11 and PD-1 before treatment(T0),2 wk after treatment(T1),4 wk after treatment(T2)and 6 wk after treatment(T3)were compared between the two *** The efficacy and recurrence rate in the RG were better than those in the CG(P0.05),while the incidence of adverse reactions and survival rate were not *** was no difference in GDF11 and PD-1 between the two groups at T0 and T1,but these factors were lower in the RG than in the CG at T2 and T3(P0.05).Using receiver operating characteristic(ROC)curve analysis,GDF11 and PD-1 had good predictive value for efficacy and recurrence(P0.001).CONCLUSION 125I radioactive seed implantation has clinical efficacy and can reduce the recurrence rate in patients with *** therapy has marked potential in clinical *** detection of GDF11 and PD-1 in patients during treatment showed good predictive value for treatment efficacy and recurrence in OC patients,and may be poten