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Efficacy of Alzer<sup>®</sup>and Diamel, nutritional supplements, in the Prevention of Severe Diabetic Macular Edema

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Open Journal of Ophthalmology 2020年第4期10卷 307-322页

作者： Juana Elvira Maciques Rodríguez Maria Emoé Pérez Muñoz Eduardo Cabrera Rode Laura Rosa Redondo Piño Raísa Beltrán Sainz Teresa González Calero Manuel Licea Puig Juan Lence Anta Rosaralis Paneca Santiesteban Yordanka Marrero Álvarez Eduardo Sanz Navares Instituto Nacional de Endocrinología Havana Cuba Hospital Universitario Salvador Allende Havana Cuba Instituto Nacional de Oncologia Havana Cuba Catalysis SL. Madrid Spain

Introduction: Macular edema is the main cause of low vision in diabetic patients. Laser photocoagulation continues to be the treatment of choice in conjunction with the use of steroids and anti-angiogenics, but these treatments include possible ocular complications. The nutritional supplement Alzer (whose primary active ingredient is Ginkgo biloba, a powerful antioxidant that acts on vascular factors and oxidative damage, which are two of the mechanisms implicated in the pathogenesis of diabetic macular edema), which has been used on other non-diabetic macular conditions, along with the Diamel nutritional supplement has been shown to be effective on glycemic control and could represent a treatment alternative for mild to moderate macular edema by reducing the thickness of the macular retina and preventing the progression of other more advanced clinical presentations that are harder to treat. Objective: Identify the effect of Alzer along with Diamel in reduction of the thickness of the macular retina among patients with mild to moderate diabetic macular edema. Materials and Methods: A phase II double-blind clinical trial was conducted in 64 patients with non-severe diabetic macular edema over the course of non-proliferative diabetic retinopathy, who attended the ophthalmology service of the Institute of Endocrinology of Havana from January 2016 to December 2016. The treatment was randomly assigned to two groups: one received Alzer plus Diamel (n

关键词： Alzer Diamel Ginkgo Biloba Macular Edema Macular Thickness nutritional supplement

Antioxidant,nutritional and anti-nutritional composition of Garcinia kola and Chrysophyllum albidum from rainforest ecosystem of Ondo State,Nigeria

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Journal of Forestry Research 2015年第2期26卷 417-424页

作者： Jonathan C.Onyekwelu Olufunmilayo Oyewale Bernd Stimm Reinhard Mosandl Department of Forestry and Wood Technology Federal University of Technology Institute of Silviculture Technische Universit?t Muenchen

Tropical forests contain many tree species that have supplied edible fruits for *** fruits have contributed to human diets due to their richness in nutrients,vitamins,minerals,antioxidants and their low antinutrients *** investigated the antioxidant,nutritional and anti-nutritional composition of Garcinia kola and Chrysophyllum albidum fruit *** nutritional,anti-nutritional and antioxidant compositions differed depending on the fruit *** of fruit part,moisture content was high（72–93 %）.While the edible part（fruit pulp） of *** proved a better source of protein（4）,fibre（17 %） and fat（2 %）,the seed kernel was a better source of ash（2 %） and carbohydrate（15 %）.Carbohydrate（22 %）,protein（2 %）,fat（1 %） and fibre（3 %） were higher in *** seed kernel（edible part） than in the pulp and ***-nutrient content in *** and *** fruits was low,indicating that their consumption would not pose nutritional or health *** antioxidant compositions（especially phenolic content（10–21 mg g-1） and DPPH（1,1-diphenyl–2 picrylhydrazyl）（26–55 %）） of *** fruit pulp and *** seed kernel were high,implying that they could be good sources of natural antioxidants and could be used as supplements in food manufacturing.

关键词： Forest food trees Livelihood Antioxidant nutritional supplement Tropical forests Garcinia kola Chrysophyllum albidum Nigeria

Effect of perioperative branched chain amino acids supplementationin liver cancer patients undergoing surgical intervention: Asystematic review

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2596-2618页

作者： Kwan Yi Yap HongHui Chi Sherryl Ng Doris HL Ng Vishal G Shelat Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 636921Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

performed independently by authors(Yap KY,Chi H,Ng S)identified 50 studies for full-text ***,12 prospective RCTs and 4 non-randomised studies(1 non-randomised trial and 3 observational studies)were included.A detailed PRISMA diagram is shown in Figure *** studies included were assessed for risk of bias,with a summary of the assessment shown in Figure 2 and Table 1 for trials and non-interventional studies,*** PRISMA checklist is appended in supplementary Figure 1.

关键词： Branched-chain amino acid Liver cancer Liver surgery nutritional supplement Perioperative supplementation

Pharmaceutical and nutraceutical potential of natural bioactive pigment:astaxanthin

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Natural Products and Bioprospecting 2022年第1期12卷 367-392页

作者： Apurva D.Patil Pramod J.Kasabe Padma B.Dandge Department of Biochemistry Shivaji UniversityKolhapur 416004Maha-rashtraIndia School of Nanoscience and Biotechnology Shivaji UniversityKolhapurMaharashtraIndia

Astaxanthin(3,3′-dihydroxy-β,β-carotene-4,4′-dione)is an orange-red,lipophilic keto-carotenoid *** is majorly found in marine ecosystems particularly in aquatic animals such as salmon,shrimp,trout,krill,crayfish,and so *** is also synthesized in microalgae Heamatococcus pluvialis,Chlorococcum,Chlorella zofingiensis,red yeast Phaffia rhodozyma and bacterium Paracoccus *** aquatic and terrestrial creatures regarded as a primary and secondary sources of the astaxanthin producing and accumulating it through their metabolic ***-anthin is the powerful antioxidant,nutritional supplement as well as promising therapeutic compound,observed to have activities against different ravaging diseases and *** have reported remarkable bioactivities of astaxanthin against major non-communicable chronic diseases such as cardiovascular diseases,cancer,diabetes,neurodegenerative,and immune *** current review discusses some structural aspects of *** fur-ther elaborates its multiple potencies such as antioxidant,anti-inflammatory,anti-proliferative,anti-cancer,anti-obese,anti-diabetic,anti-ageing,anti-TB,anti-viral,anti-COVID 19,neuro-protective,nephro-protective,and fertility-enhanc-ing *** potencies make it a more precious entity in the preventions as well as treatments of prevalent systematic diseases and/or ***,the review is acknowledging and documenting its powerful bioactivities in relation with the pharmaceutical as well as nutraceutical applicability.

关键词： Astaxanthin nutritional supplement Therapeutic compound Chronic diseases Fertility enhancer

Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C

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World Journal of Gastroenterology 2010年第21期16卷 2638-2647页

作者： Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian Department of Hepatology National Institute of GastroenterologyHavana 10400Cuba Department of Gastroenterology National Institute of GastroenterologyHavana 10400Cuba Department of Immunology National Institute of GastroenterologyHavana 10400Cuba Department of Oxidative Stress National Genetic CenterHavana 10400Cuba Department of Biostatistics National Institute of GastroenterologyHavana 10400Cuba Department of Pathology Institute of GastroenterologyHavana 10400Cuba

AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis ***:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 *** primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well ***:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C.

关键词： Antioxidant therapy Chronic hepatitis C Cytokines Immunomodulatory therapy nutritional supplement Oxidative stress

Drug-Seeking Behavior Is Significantly Attenuated in nutritionally supplemented Cocaine Withdrawn Sprague-Dawley Rats

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Journal of Behavioral and Brain Science 2021年第7期11卷 143-156页

作者： Lauriann Young Annice Webber-Waugh Karen Thaxter Physiology Section Department of Basic Medical Sciences The University of the West Indies (UWI) Mona Jamaica

Aim: The effect of patented nutritional supplementation on drug-seeking behavior in cocaine addicted rats during acute drug withdrawal was investigated using a biased Conditioned Place Preference (CPP) paradigm. Method: Twenty-four (24) male Sprague-Dawley rats with pre-conditioned preference for the black chamber of the CPP box were randomly divided into Cocaine (COC) or Saline (SAL) treated groups. Rats (n = 12) treated with cocaine hydrochloride 20 mg/kg/ml, i.p. (COC group) were confined individually to the white chamber on days 1, 3, 5 and 7. On alternate days, they were given 1 ml saline vehicle, i.p. and confined to the black chamber. Control rats (SAL group, n = 12) received only vehicle on all 8 days and were confined on alternate days to the white or black chamber. Positive place preference was confirmed for COC rats, which subsequently received 6 increasing daily doses of cocaine. CPP performances of both COC and SAL rats were recorded following an acute 3-day withdrawal period. All animals were then randomly assigned to rats fed either chow reconstituted with the nutritional supplement (COC-S and SAL-S) or standard rat chow (COC-N and SAL-N) for 8 weeks, followed by final CPP performances. Results: Following supplementation, COC-S rats made significantly less entries and time spent in the white chamber (p Conclusion: Drug-seeking behavior that persisted during cocaine withdrawal was significantly diminished in the nutritionally supplemented.

关键词： Cocaine Conditioned Place Preference nutritional supplement Addiction Drug-Seeking Behavior

White Mulberry （Morus alba） Foliage as a Feeding supplement for Growing Calves

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Journal of Agricultural Science and Technology(A) 2016年第1期6卷 59-63页

作者： Amalia Cabrera Nunez Iliana Del Carmen Daniel Renteria Miguel Angel Lammoglia Villagomez Cesar Enrique Martinez Sanchez Sara Aida Alarcon Pulido Rebeca Rojas-Ronquillo School of Biological and Agricultural Science University of Veracruz Tuxpan Veracruz 92860 Mexico

The aim of this study was to evaluate the feed consumption and weight gain in calves fed with a nutritional block made of white mulberry （Morus alba） for a 90-day-period, involving dry season months （March-May） in Tuxpan, Veracruz, Mexico. A total of 45 growing Zebu x Swiss calves with an average weight of 200 kg were assigned randomly in three groups of 15 animals, and the following treatments of nutritional block were offered to each group： grazing animals （To）, grazing animals plus nutritious block with white mulberry （T1）, and grazing animals plus nutritious block without white mulberry （T2）. A consumption of 0.545 kg/d from block in treatment T1 was observed, significantly improving calves growing and showing a weight gain of 0.933 kg/d. Use of white mulberry in nutritional blocks is a good alternative for growing calves, as a feeding strategy given the seasonality of pasture production in the tropics.

关键词： White mulberry nutritional supplement calves.