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non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer

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World Journal of Gastroenterology 2006年第44期12卷 7172-7178页

作者： Antonio Rollan Catterina Ferreccio Alessandra Gederlini Carolina Serrano Javiera Torres Paul Harris Department of Gastroenterology Faculty ofMedicine Pontificia Universidad Católica de Chile Marcoleta367 Santiago 6510260 Chile Department of Public Health Faculty of Medicine Pontificia Universidad Católica de Chile Marcoleta 367 Santiago 6510260 Chile Department of Pediatrics Faculty of Medicine Pontificia Universidad Católica de Chile Marcoleta 367 Santiago 6510260 Chile Department of Pathology Faculty of Medicine Pontificia Universidad Católica de Chile Marcoleta 367 Santiago 6510260 Chile

AIM: To validate a non-invasive method to detect gastric mucosal atrophy in a Chilean population with high prevalence of gastric cancer and a poor survival rate. METHODS: We first determined the optimal cut-off level of serum pepsinogen (PG)-1, PG-1/PG-2 ratio and 17-gastrin in 31 voluntary symptomatic patients (mean age: 66.1 years), of them 61% had histologically confirmed gastric atrophy. Then, in a population-based sample of 536 healthy individuals (209 residents in counties with higher relative risk and 327 residents in counties with lower relative risk for gastric cancer), we measured serum anti-H pylori antibodies, PG and 17-gastrin and estimated their risk of gastric cancer. RESULTS: We found that serum PG-1 13.3 pmol/L had a high specificity (91%-100%) and a fair sensitivity (56%-78%) to detect corpus-predominant atrophy. Based on low serum PG-1 and PG-1/PG-2 ratio together as diagnostic criteria, 12.5% of the asymptomatic subjects had corpus-predominant atrophy (0% of those under 25 years and 20.2% over 65 years old). The frequency of gastric atrophy was similar (12% vs 13%) but H pylori infection rate was slightly higher (77% vs 71%) in the high-risk compared to the low-risk counties. Based on their estimated gastric cancer risk, individuals were classified as: low-risk group (no H pylori infection and no atrophy; n = 115; 21.4%); moderate-risk group(H pylori infection but no atrophy; n = 354, 66.0%); and high-risk group (gastric atrophy, with or without H pylori infection; n = 67, 12.5%). The high-risk group was significantly older (mean age: 61.9 ± 13.3 years), more frequently men and less educated as compared with the low-risk group. CONCLUSION: We propose to concentrate on an upper gastrointestinal endoscopy for detection of early gastric cancer in the high-risk group. This intervention model could improve the poor prognosis of gastric cancer in Chile.

关键词： Gastric cancer H pylori Gastric atrophy non-invasive diagnosis Pepsinogen Gastrin

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Variability in fecal metabolome depending on age, PFBS pollutant, and fecal transplantation in zebrafish: A non-invasive diagnosis of health

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Journal of Environmental Sciences 2023年第5期127卷 530-540页

作者： Baili Sun Mengyuan Liu Lizhu Tang Xiangzhen Zhou Chenyan Hu Lianguo Chen State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430072China

To protect the wellbeing of research animals,certain non-invasive measures are in increasing need to facilitate an early diagnosis of health and *** this study,feces specimen was collected from adult zebrafish to profile the metabolome *** in fecal metabolite composition was also distinguished as a result of aging,perfluorobutanesulfonate(PFBS)toxicant,and fecal *** results showed that zebrafish feces was very rich in a diversity of metabolites that belonged to several major classes,including lipid,amino acid,carbohydrate,vitamin,steroid hormone,and *** metabolites had functional implications to multiple physiological activities,which were characterized by the enrichment of digestion,absorption,endocrine,and neurotransmission *** high richness and functional involvement of fecal metabolites pinpointed feces as an abundant source of diagnostic *** comparison between young and aged zebrafish,fundamental modifications of fecal metabolomes were caused by aging progression,centering on the neuroactive ligand-receptor interaction *** of aged zebrafish to PFBS pollutant also significantly disrupted the metabolomic structure in *** special concern were the changes in fecal hormone intermediates after PFBS exposure,which was concordant with the in vivo endocrine disrupting effects of ***,itwas intriguing that transplantation of young zebrafish feces efficientlymitigated the metabolic perturbation of PFBS in aged recipients,highlighting the health benefits of therapeutic strategies based on gut microbiota *** summary,the present study provides preliminary clues to evidence the non-invasive advantage of fecal metabolomics in the early diagnosis and prediction of physiology and toxicology.

关键词： Fecal metabolome Aging microbiota Perfluorobutanesulfonate(PFBS) Fecal transplantation non-invasive diagnosis Zebrafish

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non-invasive Early diagnosis of Obstructive Lung Diseases Leveraging Machine Learning Algorithms

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Computers, Materials & Continua 2022年第9期72卷 5681-5697页

作者： Mujeeb Ur Rehman Maha Driss Abdukodir Khakimov Sohail Khalid Department of Electrical Engineering Riphah International UniversityIslamabad44000Pakistan Security Engineering Lab Prince Sultan UniversityRiyadh12435Saudi Arabia RIADI Laboratory National School of Computer ScienceUniversity of ManoubaManouba2010Tunisia Peoples’Friendship University of Russia(RUDN University) Moscow117198Russia

Lungs are a vital human body organ,and different Obstructive Lung Diseases(OLD)such as asthma,bronchitis,or lung cancer are caused by shortcomings within the ***,early diagnosis of OLD is crucial for such patients suffering from OLD since,after early diagnosis,breathing exercises and medical precautions can effectively improve their health state.A secure non-invasive early diagnosis of OLD is a primordial need,and in this context,digital image processing supported by Artificial Intelligence(AI)techniques is reliable and widely used in the medical field,especially for improving early disease ***,this article presents an AIbased non-invasive and secured diagnosis for OLD using physiological and iris *** research work implements different machine-learning-based techniques which classify various subjects,which are healthy and effective *** iris features include gray-level run-length matrix-based features,gray-level co-occurrence matrix,and statistical *** features are extracted from iris ***,ten different classifiers and voting techniques,including hard and soft voting,are implemented and tested,and their performances are evaluated using several parameters,which are precision,accuracy,specificity,F-score,and *** on the statistical analysis,it is concluded that the proposed approach offers promising techniques for the non-invasive early diagnosis of OLD with an accuracy of 97.6%.

关键词： Obstructive lung disease non-invasive diagnosis machine learning physiological features voting techniques

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Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis

Combined serum biomarkers in non-invasive diagnosis of non-a...

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第九届全国生物医学体视学学术会议、第十二届全军军事病理学学术会议、第八届全军定量病理学学术会议

作者： Mei Yang DongPing Xu Yuan Liu Xiaodong Guo Wenshu Li Chaonan Guo Hongping Zhang Yinjie Gao Yuanli Mao Jingmin Zhao Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital 中国人民解放军第三O二医院病现研究与诊断中心

Backgroud&Aims:non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis and even hepatocellular carcinoma(HCC).Seeking non-invasive biomarkers in diagnosing NASH is a worldwide heated *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1Ra),pigment epithelium-derived factor(PEDF) and osteoprotegerin(OPG) in diagnosing NAFLD and ***:A large-cohort prospective study was conducted on 242 patients with biopsy-proven NAFLD,randomly divided into NAFLD training group(n=179) and validation group(n=63),and 91 ageand gender-matched healthy subjects as *** biomarker levels were measured by enzyme-linked immunosorbent ***:Serum levels of CK-18-M30,FGF-21,IL-IRa and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(P respectively in validation ***:Stepwise combination of CK-18-M30,FGF-21,IL-IRa,PEDF and OPG can greatly improve the accuracy in diagnosing NASH compared to single biomarker,which is worth clinical application.

关键词： non-alcoholic Steatohepatitis non-invasive diagnosis Combined serum biomarker Accuracy

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Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis——Combined biomarkers in NASH non-invasive diagnosis

Combined serum biomarkers in non-invasive diagnosis of non-a...

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第十四届中国体视学与图像分析学术会议

作者： Yang Mei Xu Dongping Liu Yuan Guo Xiaodong Li Wenshu Guo Chaonan Zhang Hongping Gao Yinjie Mao Yuanli Zhao Jingmin Department of Pathology and Hepatology Beijing 302 Hospital Institute of Infectious Diseases/Liver Failure Medical Center Beijing 302 Hospital Center for Clinical Trial Beijing 302 Hospital Center for Clinical Laboratory Beijing 302 Hospital

Background non-alcoholic steatoheaptitis(NASH),the critical stage of non-alcoholic fatty liver disease(NAFLD),is of chronic progression and can develop cirrhosis even hepatocellular carcinoma(HCC).However,non-invasive biomarkers for NASH diagnosis remain poorly applied in clinical *** study aims at testing the accuracy of the combination of cytokeratin-18 M30 fragment(CK-18-M30),fibroblast growth factor 21(FGF-21),interleukin 1 receptor antagonist(IL-1 Ra),pigment epithelium-derived factor(PEDF)and osteoprotegerin(OPG)in diagnosing NAFLD and *** 179 patients with biopsy-proven NAFLD were enrolled as training group,91 ageand gender-matched healthy subjects were recruited at the same time as controls.63 otherNAFLD patients were separately collected as validation group.45 alcoholic fatty liver disease(AFLD)patients,50hepatitis B virus(HBV)patients,52 hepatitis C virus(HCV)patients were also *** biomarker levels were measured by enzyme-linked immunosorbent *** Serum levels of CK-18-M30,FGF-21,IL-1Ra and PEDF increased,while OPG decreased in a stepwise fashion in controls,non-NASH NAFLD patients and NASH patients(P<0.01).The area under receiver-operating characteristics curve to diagnose NASH was 0.86 for CK-18-M30,O.89 for},0.89 for IL-1Ra,0.89 for PEDF and 0.89 for ***-18-M30 had 70%negative predictive value(NPV)and 79%positive predictive value(PPV)to diagnose NASH.A 5-step approach measuring CK-18-M30 followed by FGF21,IL-1Ra,PEDF and OPG gradually improved the NPV to 76%and PPV to 85%,which reached80%and 76%respectively in the validation *** Compared to single biomarker,stepwise combination of CK-18-M30,FGF-21,IL-1 Ra,PEDF and OPG can further improve the accuracy in diagnosing NASH.

关键词： non-alcoholic steatohepatitis non-invasive diagnosis Combined serum biomarker Accuracy

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Current biomarkers for the detection of endometriosis

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Chinese Medical Journal 2020年第19期133卷 2346-2352页

作者： Zhao Tian Xiao-Hong Chang Yan Zhao Hong-Lan Zhu Department of Obstetrics and Gynecology People’s HospitalPeking UniversityBeijing 100044China.

A clinically reliable non-invasive test for endometriosis is expected to reduce the diagnostic *** varieties of biomarkers have been investigated for decades,and cancer antigen-125,cancer antigen-199,interleukin-6,and urocortin were the most studied ones among hundreds of biomarkers,no clinically reliable biomarkers have been confirmed so *** emerging technologies including“omics”technologies,molecular imaging techniques,and microRNAs are promising in solving these challenges,but their utility to detect endometriosis has yet to be *** combinations of researched indicators or other non-invasive methods and further exploration of the emerging technologies may be new targets and future research hotspots for non-invasive diagnosis of *** conclusion,researches of biomarkers for the detection of endometriosis are still ongoing and may benefit from novel molecular biology,bioinformatics methods and a combination of more diverse monitoring *** it will be a daunting task,the identification of a specific set of diagnostic biomarkers will undoubtedly improve the status of endometriosis.

关键词： Biomarkers Endometriosis non-invasive diagnosis

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Outstanding Humidity Chemiresistors Based on Imine-Linked Covalent Organic Framework Films for Human Respiration Monitoring

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Nano-Micro Letters 2023年第9期15卷 368-383页

作者： Xiyu Chen Lingwei Kong Jaafar Abdul-Aziz Mehrez Chao Fan Wenjing Quan Yongwei Zhang Min Zeng Jianhua Yang Nantao Hu Yanjie Su Hao Wei Zhi Yang Key Laboratory of Thin Film and Microfabrication(Ministry of Education) Department of Micro/Nano ElectronicsSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Human metabolite moisture detection is important in health monitoring and non-invasive ***,ultra-sensitive quantitative extraction of respiration information in real-time remains a great ***,chemiresistors based on imine-linked covalent organic framework(COF)films with dual-active sites are fabricated to address this issue,which demonstrates an amplified humidity-sensing signal *** regulation of monomers and functional groups,these COF films can be pre-engineered to achieve high response,wide detection range,fast response,and recovery *** the condition of relative humidity ranging from 13 to 98%,the COFTAPB-DHTA film-based humidity sensor exhibits outstanding humidity sensing perfor-mance with an expanded response value of 390 ***,the response values of the COF film-based sensor are highly linear to the relative humidity in the range below 60%,reflecting a quantitative sensing mechanism at the molecular *** on the dual-site adsorption of the(-C=N-)and(C-N)stretching vibrations,the revers-ible tautomerism induced by hydrogen bonding with water molecules is demonstrated to be the main intrinsic mechanism for this effective humidity *** addition,the synthesized COF films can be further exploited to effectively detect human nasal and oral breathing as well as fabric permeability,which will inspire novel designs for effective humidity-detection devices.

关键词： Covalent organic frameworks Humidity sensors Reversible tautomerism non-invasive diagnosis Health monitoring

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Application of Stool-PCR test for diagnosis of Helicobacter pylori infection in children

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World Journal of Gastroenterology 2009年第4期15卷 484-488页

作者： Tahereh Falsafi Raha Favaedi Fatemeh Mahjoub Mehri Najafi Department of Biology Alzahra University Department of Gastroenterology and Pathology Medical Center for Children

AIM： To evaluate the usefulness of stooI-PCR test for diagnosis of Helicobacter pylori （H pylon） infection in pediatric populations. METHODS： Based on endoscopic features （including nodular gastritis, erosive duodenitis and ulcer） and/or a positive rapid urease test （RUT） obtained during endoscopy, 28 children from a group of children admitted to the Children＇s Medical Center of Tehran for persistent upper gastrointestinal problems were selected to compare biopsy-based tests with stool- PCR. Their gastric activity and bacterial density were graded by the updated Sydney system, and their first stool after endoscopy was stored at -70℃. Biopsies were cultured on modified campy-blood agar plates and identified by gram-staining, biochemical tests, and PCR. Two methods of phenol-chloroform and boiling were used for DNA extraction from H pylori isolates. Isolation of DNA from stool was performed using a stool DNA extraction kit （Bioneer Inc, Korea）. PCR was performed using primers for detection of vacA, cagA, and 16srRNA genes in both isolates and stool. RESULTS： Sixteen out of 28 child patients （57%） were classified as H pylori positive by biopsy-based tests, of which 11 （39%） were also positive by stool- PCR. Sensitivity and specificity of stool-PCR was 62.5% and 92.3% respectively. H pylori was observed in histological sections for 10 out of 11 stool-positive patients. Association was observed between higher score of H pylori in histology and positivity of stool- PCR. Also association was observed between the more severe form of gastritis and a positive stool-PCR. CONCLUSION： Association between higher score of H pylori in histology and a positive stool-PCR make it a very useful test for detection of H pylori active infection in children. We also suggest that a simple stool-PCR method can be a useful test for detection of Hpylori virulence genes in stool.

关键词： Helicobacter pylori non-invasive diagnosis Stool-PCR Histology Score Children Iran

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Study of detection times for liver stiffness evaluation by shear wave elastography

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World Journal of Gastroenterology 2014年第28期20卷 9578-9584页

作者： Ze-Ping Huang Xin-Ling Zhang Jie Zeng Jian Zheng Ping Wang Rong-Qin Zheng Department of Medical Ultrasonics the Third Affiliated Hospital of Sun Yat-sen University

AIM: To investigate enough valid measurements (VMs) to assess liver fibrosis in chronic hepatitis B patients (CHB).

关键词： Liver stiffness measurement Elastography Shear wave elastography non-invasive diagnosis Liver fibrosis

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Diagnostic challenges in non-cirrhotic portal hypertension-porto sinusoidal vascular disease

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World Journal of Gastroenterology 2020年第22期26卷 3000-3011页

作者： Oana Nicoara-Farcau Ioana Rusu Horia Stefanescu Marcel Tanțau Radu Ion Badea Bogdan Procopet University of Medicine and Pharmacy“Iuliu Hatieganu” Cluj-Napoca 400000Romania Gastroenterology Department Regional Institute of Gastroenterology and Hepatology“O.Fodor”Cluj-Napoca 400000Romania Pathology Department Regional Institute of Gastroenterology and Hepatology“O.Fodor”Cluj-Napoca 400000Romania Imagistic Department Regional Institute of Gastroenterology and Hepatology“O.Fodor”Cluj-Napoca 400000Romania

non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and,clinical *** of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD),are misdiagnosed as having liver cirrhosis and thus raising difficulties in their *** most challenging differentiation to be considered is between PSVD and cirrhosis and,although not pathognomonic,liver biopsy is still the standard of *** they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising *** issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40%of patients suffering from PSVD develop portal vein *** this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current ***,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been clear so far in particular *** this review we highlighted the diagnostic challenges regarding the PSVD,as well as the current techniques used in the evaluation of these patients.

关键词： Porto-sinusoidal vascular disease Extrahepatic portal vein obstruction noncirrhotic portal hypertension non-invasive diagnosis Idiopathic portal hypertension Cirrhosis

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