Diagnostic challenges in non-cirrhotic portal hypertension-porto sinusoidal vascular disease

作     者：Oana Nicoara-Farcau Ioana Rusu Horia Stefanescu Marcel Tanțau Radu Ion Badea Bogdan Procopet 

作者机构：University of Medicine and Pharmacy“Iuliu Hatieganu”Cluj-Napoca 400000Romania Gastroenterology DepartmentRegional Institute of Gastroenterology and Hepatology“O.Fodor”Cluj-Napoca 400000Romania Pathology DepartmentRegional Institute of Gastroenterology and Hepatology“O.Fodor”Cluj-Napoca 400000Romania Imagistic DepartmentRegional Institute of Gastroenterology and Hepatology“O.Fodor”Cluj-Napoca 400000Romania 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第22期

页      面：3000-3011页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by UEFISCDI Ministry of Education of Romania No.PNIII-P1-1.1-PD-2016-0689 

主　　题：Porto-sinusoidal vascular disease Extrahepatic portal vein obstruction Noncirrhotic portal hypertension Non-invasive diagnosis Idiopathic portal hypertension Cirrhosis 

摘      要：Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and,clinical *** of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD),are misdiagnosed as having liver cirrhosis and thus raising difficulties in their *** most challenging differentiation to be considered is between PSVD and cirrhosis and,although not pathognomonic,liver biopsy is still the standard of *** they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising *** issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40%of patients suffering from PSVD develop portal vein *** this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current ***,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been clear so far in particular *** this review we highlighted the diagnostic challenges regarding the PSVD,as well as the current techniques used in the evaluation of these patients.