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natural polyphenols effects on protein aggregates in Alzheimer＇s and Parkinson＇s prion-like diseases

Neural Regeneration Research 2018年第6期13卷 955-961页

作者： aline freyssin guylène page bernard fauconneau agnès rioux bilan University of Poitiers EA380-8 NEUVACOD (Neurovascular Unit and Cognitive Disorders) Pole Biologie Sante Poitiers France

Alzheimer＇s and Parkinson＇s diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer＇s disease, α-synuclein and synphilin-1 for Parkinson＇s disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer＇s and Parkinson＇s diseases.

关键词： natural polyphenols protein aggregates Alzheimer's disease amyloid peptide amyloid plaques hyperphosphorylated tau Parkinson's disease a-synuclein synphilin-I

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Liquid metal compartmented by polyphenol-mediated nanointerfaces enables high-performance thermal management on electronic devices

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InfoMat 2024年第1期6卷 83-95页

作者： Chaojun Zhang Yang Tang Tianyu Guo Yizhou Sang Ding Li Xiaoling Wang Orlando J.Rojas Junling Guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengduSichuanthe People's Republic of China Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBritish ColumbiaCanada Institute of Development Studies Southwestern University of Finance and EconomicsChengduSichuanthe People's Republic of China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengduSichuanthe People's Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengduSichuanthe People's Republic of China

The exponentially increasing heat generation in electronic devices,induced by high power density and miniaturization,has become a dominant issue that affects carbon footprint,cost,performance,reliability,and *** metals(LMs)with high thermal conductivity are promising candidates for effective thermal management yet are facing pump-out and surface-spreading *** in the form of metallic particles can address these problems,but apparent alloying processes elevate the LM melting point,leading to severely deteriorated ***,we propose a facile and sustainable approach to address these challenges by using a biogenic supramolecular network as an effective diffusion barrier at copper particle-LM(EGaIn/Cu@TA)interfaces to achieve superior thermal *** supramolecular network promotes LM stability by reducing unfavorable alloying and fluidity *** EGaIn/Cu@TA exhibits a record-high metallic-mediated thermal conductivity(66.1 W m^(-1) K^(-1))and fluidic ***,mechanistic studies suggest the enhanced heat flow path after the incorporation of copper particles,generating heat dissipation suitable for computer central processing units,exceeding that of commercial *** results highlight the prospects of renewable macromolecules isolated from biomass for the rational design of nanointerfaces based on metallic particles and LM,paving a new and sustainable avenue for high-performance thermal management.

关键词： Electronic devices High thermal conductivity Liquid metals natural polyphenols Thermal management

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Effects of green iron nanoparticles on iron changes and phytoavailability in a calcareous soil

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Pedosphere 2021年第5期31卷 761-770页

作者： Akbar SOLIEMANZADEH Majid FEKRI Department of Soil Science College of AgricultureShahid Bahonar University of KermanKerman ***(Iran)

Green iron nanoparticles(Fe NPs)can be a practical solution to combat iron(Fe)deficiency in calcareous agricultural *** main aim of the present work was to assess the effects of green Fe NPs on Fe availability in calcareous *** this purpose,green Fe NPs were synthesized using green tea(G-Fe NPs),Shirazi thyme(T-Fe NPs),walnut green hull(W-Fe NPs),and pistachio green hull(P-Fe NPs)extracts and applied as a source of Fe fertilizer to sorghum(Sorghum bicolor ***)*** of X-ray diffraction(XRD),scanning electron microscopy(SEM),and dynamic light scattering(DLS)indicated that the green Fe NPs were amorphous in nature and the polyphenols obtained from plant-part extracts acted as both capping and reducing *** to the behavior of Fe-ethylenediamine-N,N-bis(2-hydroxyphenyl)acetic acid(Fe-EDDHA)in calcareous soils,G-Fe NPs,T-Fe NPs,W-Fe NPs,and P-Fe NPs increased Fe release compared with the control and FeSO_(4) *** Fe release data fitted well to the power function,intra-particle diffusion,and Elovich kinetic *** to the pot experiment,the increment in soil Fe availability upon Fe-EDDHA and Fe NPs application led to an increase in Fe uptake,growth,and photosynthetic pigment contents of the sorghum *** further research is needed to evaluate the residual effect and environmental impact of green Fe NPs,they may be an appropriate substitute for traditional Fe fertilizers in calcareous soils.

关键词： chlorophyll content Fe fertilizer Fe release green chemistry natural polyphenols sorghum

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