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Fluorescent Silicon Nanorods-Based nanotheranostic Agents for Multimodal Imaging-Guided Photothermal Therapy

Nano-Micro Letters 2019年第4期11卷 293-307页

作者： Mingyue Cui Sangmo Liu Bin Song Daoxia Guo Jinhua Wang Guyue Hu Yuanyuan Su Yao He Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano&Soft Materials(FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow University199 Ren’ai RoadSuzhou 215123JiangsuPeople’s Republic of China

The utilization of diagnosis to guide/aid therapy procedures has shown great prospects in the era of personalized medicine along with the recognition of tumor heterogeneity and ***,a kind of multifunctional silicon-based nanostructure,i.e.,gold nanoparticles-decorated fluorescent silicon nanorods(Au@SiNRs),is fabricated and exploited for tumor-targeted multimodal imaging-guided photothermal *** particular,the prepared Au@SiNRs feature high photothermal conversion efficiency(~43.9%)and strong photothermal stability(photothermal performance stays constant after five-cycle NIR laser irradiation),making them high-performance agents for simultaneously photoacoustic and infrared thermal *** Au@SiNRs are readily modified with targeting peptide ligands,enabling an enhanced tumor accumulation with a high value of^8.74%ID g?*** advantages of these unique merits,the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal ***,all the mice treated with the Au@SiNRs remain alive,and no distinct tumor recurrence is observed during 60-day investigation.

关键词： Gold nanoparticle Fluorescent silicon nanorods nanotheranostic Multimodal imaging Photothermal therapy Tumor target

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Engineering nanotheranostic strategies for liver cancer

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1213-1228页

作者： Lei Cao Yu-Qin Zhu Zhi-Xian Wu Gao-Xiong Wang Hong-Wei Cheng Department of Pathology Quanzhou Women's and Children's HospitalQuanzhou 362000Fujian ProvinceChina Department of Hepatobiliary Disease The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina School of Public Health Xiamen UniversityXiamen 361002Fujian ProvinceChina

The incidence and mortality of hepatocellular carcinoma have continued to increase over the last few years,and the medicine-based outlook of patients is *** great ideas from the development of nanotechnology in medicine,especially the advantages in the treatments of liver *** engineering nanoparticles with active targeting,ligand modification,and passive targeting capacity achieve efficient drug delivery to tumor *** addition,the behavior of drug release is also applied to the drug loading nanosystem based on the tumor *** clinical use of local treatment of liver cancer,in situ drug delivery of nanogels is also fully studied in orthotopic chemotherapy,radiotherapy,and ablation ***,novel therapies including gene therapy,phototherapy,and immunotherapy are also applied as combined therapy for liver *** nonviral polymers to function as gene delivery vectors with increased efficiency and specificity,and strategies of co-delivery of therapeutic genes and drugs show great therapeutic effect against liver tumors,including drug-resistant *** is also applied in surgical procedures,chemotherapy,and *** strategies significantly enhance therapeutic effects and decrease side ***,the application of nanotechnology could bring a revolutionary change to the current treatment of liver cancer.

关键词： Liver cancer Poor prognosis nanotheranostic Drug delivery Gene delivery Combination therapy

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nanotheranostics:A powerful next-generation solution to tackle hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第2期28卷 176-187页

作者： Rusdina Bte Ladju Zulvikar Syambani Ulhaq Gita Vita Soraya Department of Anatomic Pathology Faculty of MedicineHasanuddin UniversityMakassar 90245Indonesia Department of Biochemistry Faculty of Medicine and Health SciencesMaulana Malik Ibrahim Islamic State UniversityMalang 65151Indonesia National Research and Innovation Agency Central Jakarta 10340Indonesia Department of Biochemistry Faculty of MedicineHasanuddin UniversityMakassar 90245Indonesia Department of Neurology Faculty of MedicineHasanuddin UniversityMakassar 90245Indonesia

Hepatocellular carcinoma(HCC)is an epidemic burden and remains highly prevalent *** significant mortality rates of HCC are largely due to the tendency of late diagnosis and the multifaceted,complex nature of ***,current therapeutic modalities such as liver resection and transplantation are only effective for resolving early-stage ***,alt-ernative approaches are required to improve detection and enhance the efficacy of current treatment *** platforms,which utilize biocompatible nanoparticles to perform both diagnostics and targeted delivery,has been considered a potential approach for cancer management in the past few *** of nanomaterials and biomedical engineering techniques has led to rapid expansion of the nanotheranostics field,allowing for more sensitive and specific diagnosis,real-time monitoring of drug delivery,and enhanced treatment efficacies across various *** focus of this review is on the applications of nanotheranostics for *** review first explores the current epidemiology and the commonly encountered obstacles in HCC diagnosis and *** then presents the current technological and functional advancements in nanotheranostic technology for cancer in general,and then specifically explores the use of nanotheranostic modalities as a promising option to address the key challenges present in HCC management.

关键词： Hepatocellular carcinoma Hepatic cancer nanotheranostic Nanoplatform Personalized medicine Future therapy

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Multi-responsive nanotheranostics with enhanced tumor penetration and oxygen self-producing capacities for multimodal synergistic cancer therapy

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Acta Pharmaceutica Sinica B 2022年第1期12卷 406-423页

作者： Shuangquan Gou Nanxi Chen Xiaoai Wu Menghang Zu Shixiong Yi Binwu Ying Fangyin Dai Bowen Ke Bo Xiao Laboratory of Anesthesiology&Critical Care Medicine Department of AnesthesiologyWest China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing School of Materials and EnergySouthwest UniversityChongqing 400715China Department of Nuclear Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China

Incorporation of multiple functions into one nanoplatform can improve cancer diagnostic efficacy and enhance anti-cancer outcomes. Here, we constructed doxorubicin(DOX)-loaded silk fibroinbased nanoparticles(NPs) with surface functionalization by photosensitizer(N770). The obtained nanotheranostics(N770-DOX@NPs) had desirable particle size(157 nm) and negative surface charge(-25 m V). These NPs presented excellent oxygen-generating capacity and responded to a quadruple of stimuli(acidic solution, reactive oxygen species, glutathione, and hyperthermia). Surface functionalization of DOX@NPs with N770 could endow them with active internalization by cancerous cell lines, but not by normal cells. Furthermore, the intracellular NPs were found to be preferentially retained in mitochondria, which were also efficient for near-infrared(NIR) fluorescence imaging, photothermal imaging,and photoacoustic imaging. Meanwhile, DOX could spontaneously accumulate in the nucleus. Importantly, a mouse test group treated with N770-DOX@NPs plus NIR irradiation achieved the best tumorretardation effect among all treatment groups based on tumor-bearing mouse models and a patientderived xenograft model, demonstrating the unprecedented therapeutic effects of trimodal imagingguided mitochondrial phototherapy(photothermal therapy and photodynamic therapy) and ***, the present study brings new insight into the exploitation of an easy-to-use, versatile, and robust nanoplatform for programmable targeting, imaging, and applying synergistic therapy to tumors.

关键词： Quadruple responsibility Silk fiborin nanotheranostic Oxygen self-generation Mitochondrial targeting Phototherapy Chemotherapy Cancer

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