Fluorescent Silicon Nanorods-Based Nanotheranostic Agents for Multimodal Imaging-Guided Photothermal Therapy

作     者：Mingyue Cui Sangmo Liu Bin Song Daoxia Guo Jinhua Wang Guyue Hu Yuanyuan Su Yao He 

作者机构：Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano&Soft Materials(FUNSOM)and Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow University199 Ren’ai RoadSuzhou 215123JiangsuPeople’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2019年第11卷第4期

页      面：293-307页

核心收录：

学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0817[工学-化学工程与技术] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：financial support from the National Basic Research Program of China(973 Program,2013CB934400) the National Natural Science Foundation of China(21825402,31400860,21575096,and 21605109) the Natural Science Foundation of Jiangsu Province of China(BK20170061) Collaborative Innovation Center of Suzhou Nano Science and Technology,and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD) the 111 Project Joint International Research Laboratory of Carbon-Based Functional Materials and Devices 

主　　题：Gold nanoparticle Fluorescent silicon nanorods Nanotheranostic Multimodal imaging Photothermal therapy Tumor target 

摘      要：The utilization of diagnosis to guide/aid therapy procedures has shown great prospects in the era of personalized medicine along with the recognition of tumor heterogeneity and ***,a kind of multifunctional silicon-based nanostructure,i.e.,gold nanoparticles-decorated fluorescent silicon nanorods(Au@SiNRs),is fabricated and exploited for tumor-targeted multimodal imaging-guided photothermal *** particular,the prepared Au@SiNRs feature high photothermal conversion efficiency(~43.9%)and strong photothermal stability(photothermal performance stays constant after five-cycle NIR laser irradiation),making them high-performance agents for simultaneously photoacoustic and infrared thermal *** Au@SiNRs are readily modified with targeting peptide ligands,enabling an enhanced tumor accumulation with a high value of^8.74%ID g?*** advantages of these unique merits,the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal ***,all the mice treated with the Au@SiNRs remain alive,and no distinct tumor recurrence is observed during 60-day investigation.