检索结果-南通市图书馆

Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/nf-κb signaling pathway

引用

World Journal of Gastrointestinal Surgery 2024年第4期16卷 1149-1154页

作者： Li Han Kun Tang Xiao-Li Fang Jing-Xi Xu Xi-Yun Mao Ming Li Department of Anorectal Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui HospitalHefei 230001Anhui ProvinceChina Anorectal Center The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230001Anhui ProvinceChina Department of Spleen and Stomach Diseases Department of GastroenterologyAffiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese MedicineWuhu 241000Anhui ProvinceChina

bACKGROUND Ulcer colitis(UC)is a chronic,nonspecific,and noninfectious inflammatory bowel ***,Toll-like receptors(TLRs)have been found to be closely associated with clinical inflammatory *** complete remission in patients with intermittent periods of activity followed by dormancy is ***,no study has explored the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** This prospective clinical study included patients who met the exclusion criteria in 2020 and *** patients with UC were divided into two groups(control and experimental).The peripheral blood of the experimental and control groups were collected under aseptic *** expression of TLR4 protein,nf-κb,IL-6,and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the *** co rrelation analysis was used to analyze the relationship between the expression level of TLR4 protein and the expression levels of downstream signal nf-κb and inflammatory factors IL-6 and IL-17,and Pbetween the control and experimental *** results showed that the expression levels of TLR4 and nf-κb in the experimental group were significantly lower than those in the control group(Pnf-κb and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-

关键词： Ulcerative colitis TLR4 nf-κb signaling pathway Kuicolong-yu enema

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Downregulation of MUC1 Inhibits Proliferation and Promotes Apoptosis by Inactivating nf-κb signaling pathway in Human Nasopharyngeal Carcinoma

引用

生物化学与生物物理进展 2024年第9期51卷 2182-2193页

作者： WU Shou-Wu LIN Shao-Kun NIAN Zhong-Zhu WANG Xin-Wen LIN Wei-Nian ZHUANG Li-Ming WU Zhi-Sheng HUANG Zhi-Wei WANG A-Min GAO Ni-Li CHEN Jia-Wen YUAN Wen-Ting LU Kai-Xian LIAO Jun Department of Otolaryngology Quanzhou First HospitalQuanzhou 362001China Department of Otolaryngology Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362001China Department of Ultrasound Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362001China Department of Orthopaedics Dongguan City People’s HospitalDongguan 523016China

Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory *** The 60 NPC and paired para-cancer normal tissues were collected from October 2020 to July 2021 in Quanzhou First *** expression of MUC1 was measured by real-time quantitative PCR(qPCR)in the patients with *** 5-8F and HNE1 cells were transfected with siRNA control(si-control)or siRNA targeting MUC1(si-MUC1).Cell proliferation was analyzed by cell counting kit-8 and colony formation assay,and apoptosis was analyzed by flow cytometry analysis in the 5-8F and HNE1 *** qPCR and ELISA were executed to analyze the levels of Tnf-αand *** blot was performed to measure the expression of MUC1,nfкb and apoptosis-related proteins(bax and bcl-2).Results The expression of MUC1 was up-regulated in the NPC tissues,and NPC patients with the high MUC1 expression were inclined to EbV infection,growth and metastasis of *** of MUC1 restrained malignant features,including the proliferation and apoptosis,downregulated the expression of p-Iкb、p-P65 and bcl-2 and upregulated the expression of bax in the NPC *** Downregulation of MUC1 restrained biological characteristics of malignancy,including cell proliferation and apoptosis,by inactivating nf-κb signaling pathway in NPC.

关键词： mucin 1 nasopharyngeal carcinoma nf-κb signaling pathway proliferation apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aszonapyrone A Isolated from Neosartorya spinosa IFM 47025 Inhibits the nf-κb signaling pathway Activated by Expression of the Ependymoma-Causing Fusion Protein ZFTA-RELA

引用

Advances in Microbiology 2024年第9期14卷 448-467页

作者： Kazuki Ishikawa Nao Kamiya Masaki Ishii Takashi Yaguchi Koji Ichinose Shinya Ohata Faculty of Pharmaceutical Sciences Teikyo Heisei University Nakano Tokyo Japan Research Institute of Pharmaceutical Sciences Faculty of Pharmacy Musashino University Nishitokyo-Shi Tokyo Japan Medical Mycology Research Center Chiba University Inohana Chiba Japan

Ependymoma is a rare and chemotherapy-resistant brain tumor, which has resulted in a delay in the development of drugs to treat it. A subclass of supratentorial ependymomas (ST-EPN), designated ST-EPN-zinc finger-translocation-associated (ZFTA, ST-EPN-ZFTA), exhibits the expression of a fusion protein comprising ZFTA and v-rel reticuloendotheliosis viral oncogene homolog A (RELA), an effector transcription factor of the nuclear factor-kappa b (nf-κb) pathway (ZFTA-RELA). The expression of ZFTA-RELA results in the hyperactivation of the oncogenic nf-κb signaling pathway, which ultimately leads to the development of ST-EPN-ZFTA. To identify inhibitors of the nf-κb signaling pathway activated by the expression of ZFTA-RELA, we used a doxycycline-inducible ZFTA-RELA-expressing nf-κb reporter cell line and found that extracts of the fungus Neosartorya spinosa IFM 47025 exhibited nf-κb inhibitory activity. We identified eight compounds [aszonapyrone A (2), sartorypyrone A (3), epiheveadride (4), acetylaszonalenin (5), (R)-benzodiazepinedione (6), aszonalenin (7), sartorypyrone E (8) and (Z, Z)-N,N’-(1,2-bis[(4-methoxyphenyl)methylene]-1,2-ethanediyl)bis-formamide (9)] from N. spinosa IFM 47025 culture extract using a variety of chromatographic techniques. The structures of these compounds were identified through the analysis of various instrumental data (1D, 2D-NMR, MS, and optical rotation). The nf-κb responsive reporter assay indicated that compounds 2, 3, 5, 7, and 9 exhibited inhibitory activity. We further evaluated the inhibitory activity of these compounds against the expression of endogenous nf-κb responsive genes (CCND1, L1CAM, ICAM1, and Tnf) and found that compound 2 showed significant inhibitory activity. Further studies are required to elucidate the mechanism of action of compound 2, which may serve as a lead compound for the development of a novel therapy for ST-EPN-ZFTA.

关键词： Aszonapyrone A Neosartorya spinosa nf-κb signaling pathway Ependymoma ZFTA-RELA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the nf-κb signaling pathway

引用

Virologica Sinica 2023年第1期38卷 119-127页

作者： Chaoxiang Lv Yuanguo Li Tiecheng Wang Qiqi Zhang Jing Qi Mingwei Sima Entao Li Tian Qin Zhuangzhuang Shi Fangxu Li Xuefeng Wang Weiyang Sun Na Feng Songtao Yang Xianzhu Xia Ningyi Jin Yifa Zhou Yuwei Gao College of Life Sciences Northeast Normal UniversityChangchunJilin130021China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences.Changchun130122China College of Animal Medicine Jilin UniversityChangchun130000China College of basic Medicine Changchun University of Chinese MedicineChangchun130117China College of Animal Science and Technology Jilin Agricultural UniversityChangchun130033China College of Life Sciences Shandong Normal UniversityJinan250014China

Taurolidine(TRD),a derivative of taurine,has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls,endotoxins and exotoxins to inhibit the adhesion of ***,its application in antiviral therapy is seldom ***,we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration(EC_(50))of 34.45μg/***,the drug inhibited the amplification of the cytokine storm effect and improved the survival rate of mice lethal challenged with H5N1(protection rate was 86%).Moreover,TRD attenuated virus-induced lung damage and reduced virus titers in mice *** of TRD reduced the number of neutrophils and increased the number of lymphocytes in the blood of H5N1 virus-infected ***,the drug regulated the nf-κb signaling pathway by inhibiting the separation of nf-κb and Iκba,thereby reducing the expression of inflammatory *** conclusion,our findings suggested that TRD could act as a potential anti-influenza drug candidate in further clinical studies.

关键词： Influenza viruses H5N1 Taurolidine(TRD) Cytokine storms Inflammatory response nf-κb signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Substrate stiffness modulates bone marrow-derived macrophage polarization through nf-κb signaling pathway

引用

bioactive Materials 2020年第4期5卷 880-890页

作者： Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu bin Li Xuesong Zhu Qin Shi Department of Orthopedics The First Affiliated Hospital of Soochow UniversityOrthopedic InstituteMedical CollegeSoochow University188 Shizi RoadSuzhouJiangsu215006PR China Key Laboratory of Stem Cells and biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology 199 Renai RoadSuzhou215123PR China

The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular ***,the mechanical characteristics of ECM affecting cell differentiation are still under ***,we aimed to study the effect of ECM substrate stiffness on macrophage *** prepared polyacrylamide hydrogels with different substrate stiffness,*** the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(bMMs)from mice were incubated on the *** simulated by the low substrate stiffness,bMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand Tnf-αin the *** the contrary,stressed by the medium stiffness,bMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness *** addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated Iκb(pi-Iκb)were significantly increased after stimulation with low stiffness in *** together,these findings demonstrated that substrate stiffness could affect macrophages *** substrate stiffness promoted bMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated nf-κb ***,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary.

关键词： Substrate stiffness Macrophage polarization nf-κb signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low-temperature Plasma Promotes Fibroblast Proliferation in Wound Healing by ROS-activated nf-κb signaling pathway

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 107-114页

作者： Xing-min SHI Gui-min XU Guan-jun ZHANG Jin-ren LIU Yue-ming WU Ling-ge GAO Yang YANG Zheng-shi CHANG Cong-wei YAO Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationSchool of Public HealthXi'an Jiaotong UniversityXi'an 710061China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'an 710049China

Low-temperature plasma(LTP)has shown great promise in wound healing,although the underlying mechanism remains poorly *** the present study,an argon atmospheric pressure plasma jet was employed to treat L929 murine fibroblasts cultured in vitro and skin wounds in bALb/c *** in vitro analysis revealed that treatment of fibroblasts with LTP for 15 s resulted in a significant increase in cell proliferation,secretion of epidermal growth factor(EGF)and transforming growth factor-β1(TGF-β1),production of intracellular reactive oxygen species(ROS),and the percentage of cells in S phase,protein expression of phosphorylated p65(P-p65)and cyclin D1,but a noted decrease in the protein expression of inhibitor kappa b(Iκb).The in vivo experiments demonstrated that 30-s LTP treatment enhanced the number of fibroblasts and the ability of collagen synthesis,while 50-s treatment led to the opposite *** results suggested that LTP treatment promotes the fibroblast proliferation in wound healing by inducing the generation of ROS,upregulating the expression of P-p65,downregulating the expression of Iκb,and activating the nf-κb signaling pathway and consequently altering cell cycle progression(increased DNA synthesis in S phage).

关键词： low-temperature plasma fibroblast proliferation nf-κb signaling pathway cell cycle reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new lignan and active compounds inhibiting nf-κb signaling pathway from Caulis Trachelospermi

引用

Acta Pharmaceutica Sinica b 2013年第2期3卷 109-112页

作者： Chencheng Zhu LingJing Nengjiang Yu Xuedong Yang Yimin Zhao School of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300193China Institute of Pharmacology and Toxicology Academy of Military Medical SciencesBeijing 100850China

A new dibenzylbutyrolactone lignan named matairesinol 4'-O-β-D-cellobioside(1),together with a known compound(7R,85)-dihydrodehydrodiconiferyl alcohol(2)was isolated from Caulis *** extract of Caulis Trachelospermi,which was separated by 80% alcohol extraction and subsequent HP-20 macroporous resin column chromatography,and its main components trachelogenin(3),nortrachelogenin(4),matairesinol(5)showed moderate inhibiting activities on nf-κb signaling pathway induced by Tnfα,with the IC_(50) values of 17.7μg/mL,17.9μM,49.4μM and 29.1μM,respectively.

关键词： Caulis Trachelospermi Matairesinol 4'-O-β-D-cellobioside Dibenzylbutyrolactone lignan nf-κb signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long non-coding RNA Tug 1 regulates inflammation in microglia and in status epilepticus rats through the nf-κb signaling pathway

引用

Acta Epileptologica 2022年第2期5卷 88-96页

作者： Ming Wang Yangmei Xie Yiye Shao Yinghui Chen Department of Neurology Huashan HospitalFudan UniversityShang-hai 200040China Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China.

background:Inflammation plays an important role in the pathogenesis of status epilepticus(SE).The long non-cod-ing RNA(lncRNA)taurine up-regulated gene1(Tug1)plays a well-defned role in inflammatory ***,the molecular mechanism of Tug1 in SE progression remains *** present study,we investigated whether Tug1 is involved in microglial inflammation in SE ***:The SE rat model was established via intraperitoneal injection of lithium chloride ***-binding protein immunoprecipitation(RIP)and RIP sequencing were carried out in rat microglia(RM).Tug1 cloned into the adenovirus was overexpressed in the *** of Tug1 was performed via siRNA *** level of Tug1 and inflammatory factors IL-1βand Tnf-αwas examined by real-time polymerase chain reaction(RT-PCR)and western *** levels of p65,P-p65,p-IKba and Ikba were assessed by western ***:The RIP-seq result showed 14 lncRNAs that bound to the nf-κb p65 protein in *** lncRNA Tug1 directly interacted with *** level of declined Tug1 was decreased in the hippocampus of SE *** ofTug1 reduced the LPS-induced inflammation and M1/M2 polarization of microglia,while knockdown of Tug1 aggravated the inflammatory response in ***,the protein levels of p-p65/p65 and p-Ikba/Ikba were reduced in the Tug1-overexpression microglia and elevated in the Tug1-knockdown ***:These findings indicate that Tug1 modulates the inflammation in microglia through the nf-κb signal pathway,and the Tug1/P65 axis are like to play a signifcant role in the inflammatory processes,providing a valid target for the therapy of SE.

关键词： Inflammation Microglia Status epilepticus lncRNA nf-κb signaling pathway Tug1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of warming yang and supplementing kidney moxibustion therapy on the nf-κb signaling pathway of vascular dementia rats

引用

World Journal of Acupuncture-Moxibustion 2018年第1期28卷 44-49,I0006,I0007页

作者： Wanli ZHU Kun YANG Shengchao CAI Ying WANG Xiaoge SONG Anhui University of Chinese Medidne Hefei 230038 Anhui Province China Second Affiliated Hospital of Anhui University of Chinese Medicine Hefei 230061 Anhui Province China Research Institute of Acupuncture-Moxibustion and Meridians-Collaterals Anhui University of Chinese Medicine Hefei 230038 Anhui Province China

Objective： To observe the effect of warming yang and supplementing kidney moxibustion therapy on the behavioristics and the expression levels of hippocampal IL-1β, Tnf-α and nf-κb related genes and proteins of vascular dementia（VD） rats, and to explore the mechanism of warming yang and supplementing kidney moxibustion therapy in inhibiting VD inflammatory response. Methods Seventy-eight SD rats, except 10 rats as sham operation group（group A）, were established into VD models by applying the ischemia reperfusion method in bilateral common carotid arteries. 30 models were successful and were randomly divided into model group（group b）, moxibustion group（group C） and western medication group（group D）, with 10 rats in each group. After modeling, suspended moxibustion was conducted at ＂Dàzhuī（大椎GV 14）＂,＂Mìngmén（命门GV 4）＂ and ＂Guānyuán（关元CV 4）＂ of the rats in group C for15 min/time. The intervention was performed for once a day, and intervention for 4 consecutive weeks was needed. Intragastric administration with nimodipine（2 mgkg-1d-1） was carried out in the rats in group D for 4 consecutive weeks. Morris water maze test was adopted for behavioral test in the rats in each group. HE staining was conducted in order to observe the pathological changes. RT-qPCR method and Western blot method were used for detecting the expression levels of hippocampal IL-1β, Tnf-αand nf-κb related genes and ***： After modeling, the Morris water maze escape latency of rats in operation groups was obviously longer than that in group A（P〈0.05）. According to HE staining results, the arrangement of neurons in group b was incompact, the cell membranes were undefined, the cytoplasm was heterogeneous, karyopyknosis was found, the amount of necrosis increased, and the number of inflammatory cells significantly increased. Compared with group b, the number of inflammatory cells significantly reduced in group C and group D, and the amount of neuron necrosis also reduced. After intervention, c

关键词： Moxibustion Vascular dementia rats Inflammatory response nf-κb signaling pathway Hippocampal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

引用

Journal of Environmental Sciences 2024年第3期137卷 53-64页

作者： Chao Shen Xiaoyan Ding Jinpeng Ruan Fengkai Ruan Weiping Hu Jiyi Huang Chengyong He Yi Yu Zhenghong Zuo Department of Nephrology State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesFujian Clinical Research Center for Chronic Glomerular DiseaseThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

As an ultrasmall derivative of black phosphorus(bP)sheets,bP quantum dots(bP-QDs)have been effectively used in many ***,information on the cardiotoxicity induced by bP-QDs remains *** aimed to evaluate bP-QD-induced cardiac toxicity in *** examination of heart tissue sections was *** sequencing,real-time quantitative PCR(RT–qPCR),western blotting,and enzyme-linked immunosorbent assay(ELISA)assays were used to detect the m RNA and/or protein expression of proinfammatory cytokines,nuclear factor kappa b(nf-κb),phosphatidylinositol3 kinase-protein kinase b(PI3K-AKT),peroxisome proliferator-activated receptor gamma(PPARγ),and glucose/lipid metabolism pathway-related *** found that heart weight and heart/body weight index(HbI)were significantly reduced in mice after intragastric administration of 0.1 or 1 mg/kg bP-QDs for 28 *** addition,obvious infammatory cell infiltration and increased cardiomyocyte diameter were observed in the bP-QD-treated *** expression of proinfammatory cytokines and genes related to the nf-κb signaling pathway further confirmed that bP-QD exposure induced infammatory *** addition,bP-QD treatment also affected the PI3K-AKT,PPARγ,thermogenesis,oxidative phosphorylation,and cardiac muscle contraction signaling *** expression of genes related to glucose/lipid metabolism signaling pathways was dramatically affected by bP-QD exposure,and the effect was primarily mediated by the PPAR signaling *** study provides new insights into the toxicity of bP-QDs to human health.

关键词： bP-QDs Cardiac toxicity Infammatory responses nf-κb signaling pathway PPARγsignaling pathway Glucose/lipid metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：