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Effects of special brain area regional cerebral blood flow abnormal perfusion on learning and memory function and its molecular mechanism in rats

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Frontiers in Biology 2008年第2期3卷 147-153页

作者： Lingbin KONG Zhiyin YANG Rui AN Shouhua DING Jining Medical College Shandong Institute of Behavioral Medical ScienceJining 272000China Department of Nuclear Medicine Union HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China

To study the effect of special brain area regional cerebral blood flow(rCBF)abnormal perfusion on learning and memory function and its molecular mechanism,64 adult male healthy Sprague-Dawley(SD)rats were randomly divided into two groups,the false operation group(control group)and the operation group(model group).After surgical operation,the operation group undertook bilateral common carotid artery permanent ligation,while the other group did *** and memory function were measured by Y-maze at 4 h,8 h,24 h and 3 d after surgical operation,*** rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry,and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method *** showed that the rCBF of the right frontal lobe and hippocampus in the operation group was significantly lower than that in the false operation group(P,0.05).The learning indexes,error number(EN),day of reach standard and total reaction time(TRT)in the operation group,were significantly higher than that in the false operation group(P,0.05).However,the initiative evasion rate in the operation group was significantly lower than that in the false operation *** study also found that the rCBF was relatively more,the indexes(EN,the day of reach standard and TRT)relatively fewer,but the initiative evasion rate and the memory keeping rate were relatively *** positive expression and the average absorbency of Fos and Jun in the operation group were significantly higher than that in the false operation group(P<0.05).Furthermore,Bax and Bcl-2 positive cells were all increased over time in the operation group,and the expression ratio of Bax/Bcl-2 in the operation group was significantly higher than that in the false operation group(P<0.01).In conclusion,rCBF decrease can impair the learning and memory function in rats,which may be related to the increase of the expression

关键词： rCBF learning memory function correlation frontal lobe hippocampus molecular mechanism

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Boswellic acids: a review on its pharmacological properties, molecular mechanism and bioavailability

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Traditional Medicine Research 2024年第10期9卷 64-74页

作者： Na Cui Ming-Jie Li Yi-Wen Wang Qian Meng Ya-Jun Shi Yi Ding Department of Pharmacy 3201 HospitalHanzhong 723000China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Pharmacy Shaanxi University of Traditional Chinese medicineXianyang 712046China

Boswellic acids is a general term for a series of pentacyclic triterpenoid compounds that are isolated from the oleogin resin of the Boswellia genus and serve as the main active *** exhibits a wide range of biological activities,such as anti-inflammatory,anti-cancer,antibacterial,antiviral,hepatoprotective,neuroprotective,anti-diabetic,and anti-thrombotic *** a result,it has gained significant recognition among practitioners of traditional Chinese and Indian *** biological effects may be associated with multiple molecular targets and signal transduction ***,the poor pharmacokinetic properties of the substance lead to lower bioavailability,which affects its *** address this issue,scientists have proposed a number of strategies,such as solid dispersions,phytosome®technologies,and novel drug delivery *** article aims to provide a comprehensive overview for boswellic acids on the phytochemistry,molecular mechanisms,potential therapeutic applications,and strategies to improve bioavailability.

关键词： boswellic acids molecular mechanism pharmacological properties bioavailability

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molecular mechanism of peritoneal dissemination in gastric cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 451-458页

作者： Qing-Jiang Hu Shuhei Ito Kazuyoshi Yanagihara Koshi Mimori Department of Surgery Kyushu University Beppu HospitalBeppu 874-0838Japan Department of Surgery and Science Kyushu University HospitalFukuoka 812-8582Japan Division of Biomarker Discovery Exploratory Oncology Research&Clinical Trial CenterNational Cancer CenterKashiwa 277-8577Japan

Peritoneal dissemination(PD)is the most common cause of metastasis in gastric cancer(GC).Because there are no standard treatments for PD,it is associated with a poor *** clinicians have performed intraperitoneal chemotherapy for GC with PD,the outcome remains ***,the development of novel treatments and diagnostic tools for PD is expected to improve the prognosis of GC patients with ***,it is essential to elucidate the molecular mechanisms involved in the development of PD in *** this review,the molecular mechanisms of PD(three steps:detachment from the primary tumor,adaptation to the microenvironment of the peritoneal cavity,and attachment to peritoneal mesothelial cells)and new topics in GC are highlighted.

关键词： Gastric cancer peritoneal dissemination molecular mechanism

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molecular mechanism of different viruses associated with autoimmunity

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Life Research 2022年第1期5卷 9-19页

作者： Arslan Habib Zeeshan Ashraf Irfan Ullah Khan Amjad Ali Dominic Kwesi Quainoo Sajjad Ahmad Qamar Umutumwa Eric Principe Dur E Maknoon Razia Laboratory of molecular Immunology School of Life SciencesFudan UniversityShanghaiChina Department of Fisheries and Aquaculture University of Veterinary&Animal SciencesLahorePakistan Centre of Biotechnology and Microbiology Faculty of Life SciencesUniversity of PeshawarPakistan Department of Biotechnology Faculty of BiosciencesUniversity for Development StudiesGhana Department of Zoology University of OkaraOkaraPakistan School of Biotechnology East China University of Science&TechnologyShanghaiChina Department of Biochemistry Government College University FaisalabadPakistan

Different kinds of human chronic diseases may develop the mechanism of autoimmune *** a group of disorders,in the Western world autoimmunity possess as the third most prevalent morbidity and ***,the mechanism of most autoimmune diseases is still under *** infection is the principal factor involved in the induction of autoimmune diseases other than genetic factors and cytokine *** mechanisms have been proposed by which viral infection might interrupt tolerance to self and induce autoimmune cascade which eventually leads to the destruction of a specific type of cell or a whole-body *** autoimmune attack can be understood through the different immune systems and other possible mechanisms such as molecular mimicry,bystander activation and epitope *** addition to genetic and viral factors,other environmental factors are also involved including bacterial,parasitic and fungal ***,different animal models have been studied which provide strong evidence that viruses induced AIDs as well as accelerated and increased lesions in conditions where self-tolerance is *** the current review,we discussed the virus-induced autoimmunity and the molecular mechanism which is associated with this *** we also discussed the different viruses such as rubella virus,enteroviruses,measles virus,human T-lymphotropic virus type1,human cytomegalovirus,human herpes virus-6,Epstein-Barr virus,rotavirus and some other viruses which modulate the development of AIDs.

关键词： autoimmunity viruses immune tolerance molecular mechanism

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molecular mechanism of KDM5B Development in Hepatocellular Carcinoma

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Journal of Cancer Therapy 2024年第1期15卷 1-12页

作者： Shijian Fu Min Guo Dean’s Office The Fourth People’s Hospital of Haikou Haikou China

Objective: To investigate the mechanism of cell cyclin-dependent kinase (KDM5B), a key enzyme driving all cell cycle transitions, promoting HCC progression and metastasis. Methods: The expression of KDM5B in normal liver, HCC and its adjacent tissues was analyzed by RT-PCR and IHC. Lentivirus transfection method was used to construct stable cell lines with KDM5B overexpression and down-regulation, and the role of KDM5B in HCC migration and invasion was detected at cell level and animal level. Western blotting and Transwell experiments were performed to verify the effect of KDM5B and/or CCR2 inhibitors on HCC progression and metastasis by using liver orthotopic transplantation tumor model and immunofluorescence methods. Results: RT-PCR showed that the expression level of KDM5B in HCC was significantly higher than that in adjacent tissues, and the increase of KDM5B was relatively significant. Upregulation of KDM5B in nude mouse liver orthotopic transplantation tumor model can promote the incidence of lung metastasis and shorten the survival time of nude mice, whereas upregulation of KDM5B can reduce the incidence of lung metastasis and prolong the survival time of nude mice. Conclusion: This study clarified the expression of KDM5B in HCC and its function in promoting HCC migration, invasion and metastasis. The molecular mechanism of KDM5B promoting HCC metastasis was revealed, providing a potential therapeutic target for HCC.

关键词： Liver Cancer Cyclin-Dependent Kinase (KDM5B) Pathology molecular mechanism

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molecular mechanism of mulberry response to drought stress revealed by complementary transcriptomic and iTRAQ analyses

Molecular mechanism of mulberry response to drought stress r...

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中国蚕学会2021年学术年会

作者： Li Ruixue Su Xueqiang Zhang Yuping Wang Taichu Sericultural Research Institute Anhui Academy of Agricultural Sciences

With the continuous improvement of mulberry(Morus alba) resources development and utilization,people’s use of mulberry leaves has long been not limited to raising silkworms,and various mulberry leaf extension products have emerged one after *** requirements of the mulberry industry for the quality and yield of mulberry leaves are gradually ***,the fresh leaves of mulberry trees have a strong period of time for picking and are susceptible to adverse factors such as drought and high *** them,drought stress is the most harmful,drought stress will not only reduce the yield of mulberry leaves per unit area,but also cause premature aging,shrinkage,and insufficient nutrient supply of mulberry leaves,which greatly damages the quality of mulberry ***,exploring the molecular mechanism of mulberry trees resisting drought stress and clarifying the regulation network of mulberry drought response is the focus of current *** this study,mulberry grafted seedlings were subjected to natural drought treatment,and 9 day drought treatment(DS9) materials were collected and the control samples were compared for transcriptome and proteome analysis(CK ***9),aiming to clarify the molecular mechanism of mulberry drought stress *** transcriptome and proteome sequencing,we identified 23,358 DEGs and 1,893 DEPs,enriched them in the stress-responsive GO functional categories such as signal transducer activity,antioxidant activity,and transcription regulator *** Encyclopedia of Genes and Genomes(KEGG) differential enrichment analysis shows that a large number of DEGs and DEPs are enriched in flavonoid biosynthesis pathways,hormone signaling pathways(ABA,gibberellin,salicylic acid,etc.),lignin metabolism and other pathways *** subsequent cooperation analysis,we identified 818 co-differentially expressed genes in the CK ***9 comparison group,including:Peroxidase(PRX),Superoxide dismutase(SOD),Aldehyde dehydrogen

关键词： Mulberry Drought stress Transcriptomic iTRAQ molecular mechanism

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Anti-senescence effect and molecular mechanism of the major royal jelly proteins on human embryonic lung fibroblast(HFL-I) cell line

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第12期19卷 960-972页

作者： Chen-min JIANG Xin LIU Chun-xue LI Hao-cheng QIAN Di CHEN Chao-qiang LAI Li-rong SHEN College of Biosystems Engineering and Food Science Zhejiang University/Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs/Zhejiang Key Laboratory for Agri-Food ProcessingHangzhou 310058China USDA ARS Nutritional Genomics Laboratory JM-USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonMassachusetts 02111the United States

Royal jelly (R J)from honeybee has been widely used as a health promotion *** major royal jelly proteins (MRJPs)have been identified as the functional component of ***,the question of whether MRJPs have anti-senescence activity for human cells *** embryonic lung fibroblast (HFL-I)cells were cultured in media containing no MRJPs (A),MRJPs at 0.1mg/ml (B),0.2mg/ml (C),or 0.3mg/ml (D),or bovine serum albumin (BSA)at 0.2mg/ml (E).The mean population doubling levels of cells in media B,C,D,and E were increased by 12.4%,31.2%,24.0%,and 10.4%,respectively,compared with that in medium *** cells in medium C also exhibited the highest relative proliferation activity,the lowest senescence,and the longest ***, MRJPs up-regulated the expression of superoxide dismutase-1(SOD1)and down-regulated the expression of mammalian target of rapamycin (MTOR),catenin beta like-1(CTNNB1),and tumor protein p53(TP53).Raman spectra analysis showed that there were two unique bands related to DNA synthesis materials,amide carbonyl group vibrations and aromatic *** results suggest that MRJPs possess anti-senescence activity for the HFL-I cell line,and provide new knowledge illustrating the molecular mechanism of MRJPs as anti-senescence factors.

关键词： Major royal jelly protein Human embryonic lung flbroblast (HFL-I)cell line Anti-senescence Relative proliferation activity Telomere length molecular mechanism

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Study on molecular mechanism of Liver Yang Ascending Syndrome in Hypertension

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Chinese Journal of Integrative Medicine 2000年第4期6卷 244-249页

作者：金益强胡随瑜鄢东红刘爱平唐发清肖纯谌兵来王勇华 Institute of Integrated Traditional Chinese and Western Medicine

Objective: To investigate the molecular mechanism of Liver Yang Ascending Syndrome (LYAS) in hypertension. Methods: The plasma norepinephrine (NE), epinephrine (E) contents in patients with LYAS or Liver and Kidney Yin Deficiency Syndrome (LKYDS) of hypertension and normal controls were determined by high performance liquid chromatography-electrochemical detector (HPLC-ECD). The polymorphism of tyrosine hydroxylase (TH) gene in the three groups were analysed by Southern Blot assay. The polymorphism of TH and monoamine oxidation A(MAO-A), monoamine oxidation B(MAO-B) gene microsatellite in these groups were analysed by polymerase chain reaction (PCR)-SSCP. At the same time, the LYAS model was established by administering Aconitum preparation (AP) to spontaneous hypertension rats (SHR). The adrenal gland medulla of the experimental animal was examined for their TH expression at the protein level after ABC immuno-histochemical staining with the TH monoclonal antibody (McAb). The adrenal TH gene mRNA expression was demonstrated by in situ hybridization with the synthetized TH oligonucleic acid probe. The results of immuno-histochemistry and in situ hybridization were analyzed with the image analysis system (IAS). Results: The plasma NE and E contents in patients with LYAS were more obviously increased than those in LKYDS and normal controls. The TH gene amplified and the type A1 TH microsatellite D11S4046 was markedly higher in the LYAS group than those in the other groups. The TH mRNA protein expression in the adrenal tissue of the AP induced LYAS model in SHR elevated. Conclusion: The LYAS of hypertension has the characters as amplified TH gene and increased TH mRNA and protein expression, which suggested that the overexpression of TH is probably the mechanism of LYAS in hypertension.

关键词： hypertension Liver Yang Ascending Syndrome Liver and Kidney Yin Deficiency Syndrome tyrosine hydroxylase molecular mechanism

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Research Progress in molecular mechanism of Broad-spectrum Disease Resistance in Rice

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Agricultural Biotechnology 2021年第4期10卷 4-10,15页

作者： Jing SU Jinqi FENG Kailing CHEN Shen CHEN Xiaoyuan ZHU Plant Protection Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of High Technology for Plant ProtectionGuangzhou 510640China

Yield loss caused by crop diseases seriously restricts global food *** disease-resistant varieties with resistance(R)genes is acknowledged as the most economical and effective way to control ***,exploring broad-spectrum resistance(BSR)genes to pathogens and clarifying the underlying mechanism are the basis for effective utilization of BSR resources and finding new approaches for disease *** the past 20 years,significant progress has also been made in plant immune mechanism and remarkable achievements have been made in researches on broad-spectrum disease resistance of major grain crops,and the potential molecular mechanisms of some BSR have been ***,the advances of broad-spectrum disease resistance in rice(including the representative cloned BSR genes and their molecular mechanisms)were *** addition,the problems,opportunities and challenges encountered by BSR were analyzed,and the development of BSR research and its application in rice production were prospected.

关键词： Rice Disease Broad-spectrum resistance molecular mechanism

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Exploration of the molecular mechanism of Indigo Naturalis in the treatment of myelodysplastic syndromes through integrated pharmacological study

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TMR Theory and Hypothesis 2021年第3期4卷 518-532页

作者： Qin-Shuai Zhang Li-Li Sha Hao Zhang Yuan-Long Liu Min Liu Technology Department Xiamen Bencao Zhenyuan Pharmaceutical Technology Co.LtdXiamen China General Medicine Department Rizhao People's HospitalRizhao China Department of Traditional Chinese Medicine Rizhao People's HospitalRizhao China Technology Department Anguo Yaodu Traditional Chinese Medicine Museum Co.LtdAnguoHebei ProvinceChina Integrated Traditional Chinese and Western Medicine Department The Fifth People's Hospital of Weifang CityWeifang China

Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fully elucidated and needs to be further ***:By searching the traditional Chinese medicine system and analyzing platforms(TCMSP),bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine(BATMAN-TCM),and Swiss Target Prediction network database,the main active components and potential targets of IN were *** on this,a component-target network was established by Cytoscape 3.6.1 *** expressed genes(DGEs)in MDS were obtained from three GEO(Gene Expression Omnibus)gene ***,the protein-protein interaction(PPI)network of DGEs was constructed and analyzed by STRING database and Cytoscape 3.6.1 *** addition,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)biological enrichment analysis were carried out using REVIGO and KEGG Orthology Based Annotation System(KOBAS)on DGEs,*** of IN-MDS compound targets was performed by matching potential targets of active components with disease-related *** results of KEGG pathway enrichment analysis were combined with compound targets to screen key *** the end,molecular docking was performed by SYBYL-X2.1 to verify the key ***:Nine active components of IN and 439 potential targets of IN were identified by analyzing TCMSP,BATMAN-TCM,and Swiss Target Prediction network *** MDS disease-related gene microarray chips were obtained from the GEO databases:GSE4619,GSE19429,and *** this analysis,87 DEGs were finally obtained using the Venn diagram.A PPI network of DEGs was then constructed,in which 18 genes were upregulated and 69 genes were *** the GO enrichment results were de-redundant,the representative GO terms were obtained by using REVIGO

关键词： Indigo Naturalis Myelodysplastic Syndromes molecular mechanism Integrated Pharmacological Study

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