Exploration of the molecular mechanism of Indigo Naturalis in the treatment of myelodysplastic syndromes through integrated pharmacological study
作者机构：Technology DepartmentXiamen Bencao Zhenyuan Pharmaceutical Technology Co.LtdXiamen China General Medicine DepartmentRizhao People's HospitalRizhao China Department of Traditional Chinese MedicineRizhao People's HospitalRizhao China Technology DepartmentAnguo Yaodu Traditional Chinese Medicine Museum Co.LtdAnguoHebei ProvinceChina Integrated Traditional Chinese and Western Medicine DepartmentThe Fifth People's Hospital of Weifang CityWeifang China
出 版 物：《TMR Theory and Hypothesis》 (TMR理论与假说)
年 卷 期：2021年第4卷第3期
页 面：518-532页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Indigo Naturalis Myelodysplastic Syndromes Molecular Mechanism Integrated Pharmacological Study
摘 要：Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fully elucidated and needs to be further ***:By searching the traditional Chinese medicine system and analyzing platforms(TCMSP),bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine(BATMAN-TCM),and Swiss Target Prediction network database,the main active components and potential targets of IN were *** on this,a component-target network was established by Cytoscape 3.6.1 *** expressed genes(DGEs)in MDS were obtained from three GEO(Gene Expression Omnibus)gene ***,the protein-protein interaction(PPI)network of DGEs was constructed and analyzed by STRING database and Cytoscape 3.6.1 *** addition,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)biological enrichment analysis were carried out using REVIGO and KEGG Orthology Based Annotation System(KOBAS)on DGEs,*** of IN-MDS compound targets was performed by matching potential targets of active components with disease-related *** results of KEGG pathway enrichment analysis were combined with compound targets to screen key *** the end,molecular docking was performed by SYBYL-X2.1 to verify the key ***:Nine active components of IN and 439 potential targets of IN were identified by analyzing TCMSP,BATMAN-TCM,and Swiss Target Prediction network *** MDS disease-related gene microarray chips were obtained from the GEO databases:GSE4619,GSE19429,and *** this analysis,87 DEGs were finally obtained using the Venn diagram.A PPI network of DEGs was then constructed,in which 18 genes were upregulated and 69 genes were *** the GO enrichment results were de-redundant,the representative GO terms were obtained by using REVIGO
维普期刊数据库