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Publication characteristics and visualized analysis of research about liver sinusoidal endothelial cells

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iliver 2024年第1期3卷 3-14页

作者： Shanshan Zhao Lan Zhang Junzhe Zhao Farah Tasnim Hanry Yu Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing Engineering Research Center for Nerve System DrugsBeijing Municipal Geriatric Medical Research CenterBeijing 100053China Department of Physiology The Institute for Digital Medicine(WisDM)Yong Loo Lin School of MedicineMD9-04-112 Medical DriveSingapore 117593Singapore Duke-NUS Medical School 8 College RoadSingapore 169857Singapore Biomedical Sciences Industry Partnership Office(BMSIPO) A*STAR31 Biopolis WaySingapore 138669Singapore CAMP Singapore-MIT Alliance for Research and Technology1 CREATE WayLevel 4 Enterprise WingSingapore 138602Singapore Mechanobiology Institute National University of SingaporeT-Lab#05-015A Engineering Drive 1Singapore 117411Singapore

Background and aims:Through visual analysis of related literature,the main research direction and hot spots of liver sinusoidal endothelial cells(LSECs)in recent 24 years were ***:This study used bibliometric analysis with CiteSpace,VOSviewer,Biblioshiny and online analytic tool *** to provide a quantitative analysis,hot spot mining,and commentary of articles published in the field of LSECs *** relevant literature in the Web of Science Core Collection(WOSCC)was searched from 2000 to *** publications with topics or titles or keywords containing LSECs were included into this *** countries,organizations,journals,authors,and keywords of the publications were summarized and ***:This study included 3,747 publications from 14,132 authors belonging to 389 institutions in 61 countries/regions and published in 150 journals,with 156,309 *** United States contributed most(1,150)to the *** most productive institution was the University of *** accounts for the most output(293,7.8%),European authors had a widespread *** most productive author was Adam DH with 68 *** function of LSECs is research hot ***:This study highlights key trends based on a large dataset of the most influential publications about LSECs research over a 24-year *** provides important clues and ideas for researchers focusing in this area and facilitates future liver disease mechanism,understanding,and treatment.

关键词： Bibliometrics liver sinusoidal endothelial cells CiteSpace VOSviewer

Induction of liver sinusoidal endothelial cells immune activation by HBeAg during HBV infection

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Induction of liver sinusoidal endothelial cells immune activ...

Amygdalin Ameliorates liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling

第十二届全国免疫学学术大会

作者： Yu Qing Luo Jinzhuo Wang Qin Yang Shangqing Yang Dongliang Liu Jia Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and Technology

Backgrounds & Aims:liver sinusoidal endothelial cells(LSECs) play a crucial role in maintaining the homeostasis of the hepatic microenvironment through induction of Ag-specific T cell *** has been shown that some viruses infection or TLRs stimulation can induce the maturation of LSECs,which reverts their suppressive properties to induce T cell ***,little is known about whether and how the function of LSECs in regulating T cell immunity is regulated during HBV ***,we investigated the function and mechanism of LSECs regulating CD8 T cell immunity during HBV ***:Mice were hydrodynamic injected with pAAV/HBV1.2 or pSM2,and their LSECs were freshly isolated at different time points post injection and co-cultured with polyclonal TCR-activated T *** freshly isolated from naive mice were stimulated by recombinant HBV antigen protein and co-cultured with polyclonal TCR-activated T *** phenotype and function of LSECs were characterized by flow cytometry,quantitative PCR,and functional ***:Compared to LSECs of naive mice or HI control mice,LSECs separated from HBV HI mice at 14 dpi reverted their suppressive properties to enhance T cell *** analysis demonstrated HBeAg stimulation could induce the maturation of naive LSECs and enable them to promote IFN-γ production by TCR-activated CD8 T *** separated from HBeAg-deficiency HBV HI mice were less capable of promoting T cell immunity compared to those separated from wild type HBV HI *** contrast,replenishing HBeAg expression in HBeAg-deficiency HBV HI mice resulted in better LSEC activation and led to accelerated HBV *** LSECs separated from HBV HI mice and HBeAg stimulated LSECs showed increased TNF-α ***:HBV replication can revert LSECs suppressive properties to promote T cell immunity,which is probably mediated by HBeAg induced LSECs TNF-α production.

关键词： Hepatitis B liver sinusoidal endothelial cells T cell immunity

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Chinese Journal of Integrative Medicine 2023年第4期29卷 316-324页

作者： XIAO Zhun JI Qiang FU Ya-dong GAO Si-qi HU Yong-hong LIU Wei CHEN Gao-feng MU Yong-ping CHEN Jia-mei LIU Ping Institute of liver Diseases Key Laboratory of Liver and Kidney Diseases(Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China E-Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China

Objective:To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model,and the underlying mechanisms were partly dissected in vivo and in ***:Thirty-two male mice were randomly divided into 4 groups,including control,model,low-and high-dose amygdalin-treated groups,8 mice in each *** the control group,mice in the other groups were injected intraperitoneally with 10%carbon tetrachloride(CCl4)-olive oil solution 3 times a week for 6 weeks to induce liver *** the first 3 weeks,amygdalin(1.35 and 2.7 mg/kg body weight)were administered by gavage once a *** in the control group received equal quantities of subcutaneous olive oil and intragastric water from the fourth *** the end of 6 weeks,liver tissue samples were harvested to detect the content of hydroxyproline(Hyp).Hematoxylin and eosin and Sirius red staining were used to observe the inflammation and fibrosis of liver *** expressions of collagenⅠ(Col-Ⅰ),alpha-smooth muscle actin(α-SMA),CD31 and transforming growth factorβ(TGF-β)/Smad signaling pathway were detected by immunohistochemistry,quantitative real-time polymerase chain reaction and Western blot,*** activation models of hepatic stellate cells,JS-1and LX-2 cells induced by TGF-β1 were used in vitro with or without different concentrations of amygdalin(0.1,1,10μmol/L).The effect of different concentrations of amygdalin on the expressions of liver sinusoidal endothelial cells(LSECs)dedifferentiation markers CD31 and CD44 were ***:High-dose of amygdalin significantly reduced the Hyp content and percentage of collagen positive area,and decreased the mRNA and protein expressions of Col-Ι,α-SMA,CD31 and p-Smad2/3 in liver tissues of mice compared to the model group(Pcells,and TGFβR1,TGFβR2 and p-Smad2/3 in LX-2 cells compared to the model group(P<0.05 or P<0.01).Moreover,1 and 10μmol/L amygdal

关键词： amygdalin liver fibrosis hepatic stellate cells liver sinusoidal endothelial cells TGF-β/Smad signalingpathway

Structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis

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World Journal of Gastroenterology 2005年第33期11卷 5095-5102页

作者： Katrien Vekemans Filip Braet Centre of Experimental Surgery and Anaesthesia Abdominal Transplant Surgery Department Catholic University of Leuven (KUL)Herestraat 49 3000 Leuven Belgium Australian Key Centre for Microscopy and Microanalysis Electron Microscopy Unit The University of SydneySydney 2006NSWAustralia

Nowadays, liver metastasis remains difficult to cure. When tumor cells escape and arrive in the liver sinusoids, they encounter the local defense mechanism specific to the liver. The sinusoidal cells have been widely described in physiologic conditions and in relation to metastasis during the past 30 years. This paper provides an “overview” of how these cells function in health and in diseases such as

关键词： Metastasis liver Colon carcinoma sinusoidalcells Kupffer cells liver sinusoidal endothelial cells Hepatic NK cells

Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats

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World Journal of Gastroenterology 2012年第36期18卷 5034-5041页

作者： Ling Fu Tsuneo Kitamura Kazuhisa Iwabuchi Syozo Ichinose Mitsuaki Yanagida Hideoki Ogawa Sumio Watanabe Toshihide Maruyama Masafumi Suyama Kenji Takamori Institute for Environmental and Gender Specific Medicine Juntendo University Graduate School of Medicine Urayasu 279-0021 Japan Department of Gastroenterology Juntendo University Urayasu Hospital Urayasu 279-0021 Japan Department of Gastroenterology Juntendo University School of Medicine Tokyo 113-8421 Japan

AIM： To elucidate the role of neuropilin-1 （Nrp-1） and semaphorin 3A （Sema3A） in sinusoidal remodeling dur- ing liver regeneration in rats. METHODS： Male Wistar/ST rats at 7 wk of age, weigh- ing about 200 g, were used for all animal experiments. In vivo, at 24, 48, 72, 96, 144 and 192 h after two- thirds partial hepatectomy （PHx）, the remnant livers were removed. liver tissues were immunohistochemi- cally stained for Nrp-1, Sema3A and SE-1, a liver sinu- soidal endothelial cell （SEC） marker. Total RNA of the liver tissue was extracted and reversely transcribed into cDNA. The mRNA expression of Sema3A was ana- lyzed by quantitative real-time polymerase chain reac- tion and normalized to that of ribosomal protein $18. In vitro, SECs were isolated from rat liver and cultured in endothelial growth medium containing 20 ng/mL vascular endothelial cell growth factor. Migration of SECs in primary culture was assessed by cell transwell assay with or without recombinant Sema3A. Apoptotic cells were determined by a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling method. RESULTS： In vitro, immunohistochemistry study re- vealed that Sema3A and Nrp-1 were constitutively ex- pressed in hepatocytes and SECs, respectively, in normal rat liver tissues. Nrp-1 expression in SECs was quantified by the percentage of immunostained area with anti- Nrp-1 antibody in relation to the area stained with SE-1. Between 24 h and 96 h following resection of liver, Nrp-1 expression in SECs was transiently increased. Compared with the baseline （5.2% ± 0.1%）, Nrp-1 expression in SECs significantly increased at 24 h （17.3% ± 0.7%, P 〈 0.05）, 48 h （39.1% ± 0.6%, P 〈 0.01）, 72 h （46.9% ± 4.5%, P 〈 0.01） and 96 h （29.9% ±3.8%, P 〈 0.01） after PHx, then returned to the basal level at termination of liver regeneration. Interestingly, the expression of Sema3A was inversely associated with that of Nrp-1 in liver after PHx. Sema3A mRNA expres- sion was significantly

关键词： Neuropilin-1 Semaphorin 3A sinusoidal re-modeling liver regeneration Two-thirds partial hepa-tectomy Angiogenesis liver sinusoidal endothelial cells

Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2171-2182页

作者： Guofeng Ji Lushun Ma Haochen Yao Sheng Ma Xinghui Si Yalin Wang Xin Bao Lili Ma Fangfang Chen Chong Ma Leaf Huang Xuedong Fang Wantong Song Department of Gastrointestinal and Colorectal Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of PharmacyUniversity of North Carolina at Chapel HillChapel HillNC 27599USA Key Laboratory of Zoonosis Chinese Ministry of EducationCollege of Basic Medical ScienceJilin UniversityChangchun 130021China Second Hospital of Shandong University Jinan 250000China Second Hospital of Jilin University Changchun 130041China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

Primary bile acids were reported to augment secretion of chemokine(C-X-C motif)ligand16(CXCL16)from liver sinusoidal endothelial cells(LSECs)and trigger natural killer T(NKT)cellbased immunotherapy for liver ***,abundant expression of receptors for primary bile acids across the gastrointestinal tract overwhelms the possibility of using agonists against these receptors for liver cancer *** advantage of the intrinsic property of LSECs in capturing circulating nanoparticles in the circulation,we proposed a strategy using nanoemulsion-loaded obeticholic acid(OCA),a clinically approved selective farnesoid X receptor(FXR)agonist,for precisely manipulating LSECs for triggering NKT cell-mediated liver cancer *** OCA-nanoemulsion(OCA-NE)was prepared via ultrasonic emulsification method,with a diameter of 184 nm and good *** vivo biodistribution studies confirmed that the injected OCA-NE mainly accumulated in the liver and especially in LSECs and Kupffer *** a result,OCA-NE treatment significantly suppressed hepatic tumor growth in a murine orthotopic H22 tumor model,which performed much better than oral medication of free *** analysis revealed that the OCA-NE resulted in augmented secretion of CXCL16 and IFN-g,as well as increased NKT cell populations inside the ***,our research provides a new evidence for the antitumor effect of receptors for primary bile acids,and should inspire using nanotechnology for precisely manipulating LSECs for liver cancer therapy.

关键词： Obeticholic acid Farnesoid X receptor Nanoemulsion liver sinusoidal endothelial cells liver cancer

Neuropilin-1: A feasible link between liver pathologies and COVID-19

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World Journal of Gastroenterology 2021年第24期27卷 3516-3529页

作者： Aitor Benedicto Iñigo García-Kamiruaga Beatriz Arteta Department of Cellular Biology and Histology School of Medicine and NursingUniversity of the Basque CountryLeioa 48940BizkaiaSpain Department of Gastroenterology and Hepatology San Eloy HospitalBarakaldo 48902Spain

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has a tremendous impact on the health of millions of people ***,those suffering from previous pathological conditions are more vulnerable and tend to develop more severe disease upon infection with the new *** coronavirus interacts with the angiotensin-converting enzyme 2 receptor to invade the ***,another receptor,neuropilin-1(NRP-1),has been reported to amplify the viral ***,NRP-1 is expressed in nonparenchymal liver cells and is related to and upregulated in a wide variety of liver-related *** has been observed that SARS-CoV-2 infection promotes liver injury through several pathways that may be influenced by the previous pathological status of the patient and liver expression of ***,coronavirus disease 2019 causes an inflammatory cascade called cytokine storm in patients with severe *** cytokine storm may influence liver sinusoidal-cell phenotype,facilitating viral *** this review,the shreds of evidence linking NRP-1 with liver pathologies such as hepatocellular carcinoma,liver fibrosis,nonalcoholic fatty liver disease and inflammatory disorders are discussed in the context of SARS-CoV-2 *** addition,the involvement of the infection-related cytokine storm in NRP-1 overexpression and the subsequent increased risk of SARS-CoV-2 infection are also *** review aims to shed some light on the involvement of liver NRP-1 during SARSCoV-2 infection and emphasizes the possible involvement this receptor with the observed liver damage.

关键词： liver liver sinusoidal endothelial cells Hepatic stellate cells SARS-CoV-2 COVID-19 Pathology

The role of the Notch signaling pathway in liver injury and repair

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Journal of Bio-X Research 2018年第2期1卷 95-104页

作者： Zhen-Sheng Yue Bai Ruan Juan-Li Duan Hua Han Lin Wang Department of Hepatobiliary Surgery Xijing Hospital Aerospace Clinical Medical Center School of Aerospace Medicine State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’anShaanxi ProvinceChina

This review aims to compile recent advances regarding the significance of Notch signaling in different types of intrahepatic cells during liver injury and *** functions of Notch signaling in regulating cell development,fate decisions,and organ homeostasis have been widely *** is also expressed and activated in hepatocytes,macrophages,liver sinusoidal endothelial cells,endothelial progenitor cells,and hepatic progenitor cells during the process of development,injury,inflammation,fibrosis,and *** acute/chronic liver injury,Notch interacts with many signaling pathways that are involved in liver *** research,including ours,has confirmed the crucial role of Notch signaling in modulating the function of diverse intrahepatic cells during liver injury and ***,Notch signaling may serve as a potential therapeutic target for liver diseases.

关键词： hepatocytes liver injury liver sinusoidal endothelial cells macrophages Notch signaling

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Effect of Qishen decoction on dedifferentiation of sinusoidal endothelial cells by autophagy

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Journal of Hainan Medical University 2020年第16期26卷 21-25页

作者： Xu Mao Xing-Xing Yuan Lei Yang Dan-Dan Li Bing-Yu Wang Heilongjiang University of traditional Chinese medicine JiamusiHeilongjiang Province154000 Nangang Branch of Heilongjiang Academy of traditional Chinese medicine HarbinHeilongjiang1500001

Objective:To observe the effect of Qishen decoction on dedifferentiation and autophagy of liver sinusoid endothelial cells(LSEC);Methods:LSEC were randomly divided into the control group,model group,Qishen Decoction low,medium,high dose group,and inhibitor *** model was induced by 100μg/ml oxidized low-density lipoprotein(oxLDL)for 24 hours,and the corresponding drugs or medicated serum were given for *** expression levels of VEGFR2 and ET1 were detected by RT-qPCR and immunofluorescence staining,the ultrastructure of LSEC was detected by transmission electron microscopy,the content of NO was detected by ELISA,the expression levels of autophagy related proteins(LC3BI,LC3BⅡand p62)and endothelial function related proteins(eNOS and p-eNOS)were detected by western blot;Results:The results of transmission electron microscopy showed that Qishen decoction medicated serum could increase the number of fenestra and autophagy in LSEC cells,and inhibit the formation of basement membrane under *** with the model group,Qishen decoction medicated serum could significantly up-regulate the expression level of VEGFR2 mRNA and protein in LSEC,down regulate the expression level of ET1 mRNA and protein,the difference was statistically significant(P<0.05).In addition,Qishen decoction medicated serum could significantly increase the expression of LC3BII,p-eNOS,eNOS protein and the ratio of LC3BII/LC3BI,p-eNOS/eNOS,and reduce the expression of LC3BI and p62 protein in LSEC,which is statistically significant compared with the model group(P<0.05).Conclusion:Qishen decoction can inhibit the dedifferentiation of LSEC by promoting the autophagy level of LSEC,and then play an anti-fibrosis role.

关键词： Qishen decoction liver sinusoidal endothelial cells Autophagy Dedifferentiation Medicated serum