The role of the Notch signaling pathway in liver injury and repair

作     者：Zhen-Sheng Yue Bai Ruan Juan-Li Duan Hua Han Lin Wang 

作者机构：Department of Hepatobiliary SurgeryXijing Hospital Aerospace Clinical Medical CenterSchool of Aerospace Medicine State Key Laboratory of Cancer BiologyDepartment of Biochemistry and Molecular BiologyFourth Military Medical UniversityXi’anShaanxi ProvinceChina 

出 版 物：《Journal of Bio-X Research》 (生物组学研究杂志（英文）)

年 卷 期：2018年第1卷第2期

页      面：95-104页

学科分类：12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 08[工学] 

基　　金：MOST(2016YFA0102100[The National Key Research and Development Program of China:Stem Cell and Translational Research],2015CB553702) the National Natural Science Foundation of China(81401940,81370512,81770560,81800533,81870430,31730041,31370769,81200707,31301194) 

主　　题：hepatocytes liver injury liver sinusoidal endothelial cells macrophages Notch signaling 

摘      要：This review aims to compile recent advances regarding the significance of Notch signaling in different types of intrahepatic cells during liver injury and *** functions of Notch signaling in regulating cell development,fate decisions,and organ homeostasis have been widely *** is also expressed and activated in hepatocytes,macrophages,liver sinusoidal endothelial cells,endothelial progenitor cells,and hepatic progenitor cells during the process of development,injury,inflammation,fibrosis,and *** acute/chronic liver injury,Notch interacts with many signaling pathways that are involved in liver *** research,including ours,has confirmed the crucial role of Notch signaling in modulating the function of diverse intrahepatic cells during liver injury and ***,Notch signaling may serve as a potential therapeutic target for liver diseases.