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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and Liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic dysfunction.Although the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been determined.AIM To compare the changes in the microbiota,inflammatory factor levels,and Liver function before and after probiotic treatment in HBC patients.METHODS This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December 2020.Patients were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment only.Fecal samples were collected at the onset and conclusion of the 12-wk intervention period.The structure of the intestinal microbiota and the levels of serological indicators,such as Liver function and inflammatory factors,were assessed.RESULTS Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(PLiver function indices and significantly lower levels of inflammatory factors(PLiver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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Influence of Liver function after laparoscopy-assisted vs totally laparoscopic gastrectomy

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 859-870页

作者： Fan Xiao Xing-Feng Qiu Cai-Wen You Fu-Ping Xie Yao-Yuan Cai The School of Clinical Medicine Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastrointestinal Surgery Zhongshan HospitalXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND Previously,some studies have proposed that total laparoscopic gastrectomy(TLG)is superior to laparoscopic-assisted gastrectomy(LAG)in terms of safety and feasibility based on the related intraoperative operative parameters and incidence of postoperative complications.However,there are still few studies on the changes in postoperative Liver function in patients undergoing LG.The present study compared the postoperative Liver function of patients with TLG and LAG,aiming to explore whether there is a difference in the influence of TLG and LAG on the Liver function of patients.AIM To investigate whether there is a difference in the influence of TLG and LAG on the Liver function of patients.METHODS The present study collected 80 patients who underwent LG from 2020 to 2021 at the Digestive Center(including the Department of Gastrointestinal Surgery and the Department of General Surgery)of Zhongshan Hospital affiliated with Xiamen University,including 40 patients who underwent TLG and 40 patients who underwent LAG.Alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),γ-glutamyltransferase(GGLT),total bilirubin(TBIL),direct bilirubin(DBIL)and indirect bilirubin(IBIL),and other Liver function-related test indices were compared between the 2 groups before surgery and on the 1^(st),3^(rd),and 5^(th) d after surgery.RESULTS The levels of ALT and AST in the 2 groups were significantly increased on the 1st to 2nd postoperative days compared with those before the operation.The levels of ALT and AST in the TLG group were within the normal range,while the levels of ALT and AST in the LAG group were twice as high as those in the TLG group(P<0.05).The levels of ALT and AST in the 2 groups showed a downward trend at 3-4 d and 5-7 d after the operation and gradually decreased to the normal range(P<0.05).The GGLT level in the LAG group was higher than that in the TLG group on postoperative days 1-2,the ALP level in the TLG group was higher than that in the LAG group on postoperative days 3-

关键词： Totally laparoscopic gastrectomy Laparoscopy-assisted gastrectomy Liver function Alanine aminotransferase Aspartate aminotransferase

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Dynamic changes in Liver function after transjugular intrahepatic portosystemic shunt in patients with cirrhosis

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Journal of Interventional Medicine 2022年第4期5卷 207-212页

作者： Chaoyang Wang Jinghong Yao Huanzhang Niu Chongtu Yang Jiacheng Liu Yaowei Bai Shuguang Ju Bin Xiong Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan430022China Department of Infectious Disease Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Interventional Radiology The First Affiliated Hospital of Henan University of Science and TechnologyLuoyang471000China Department of Interventional Radiology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510000China

Purpose:To evaluate the dynamic changes in Liver function after transjugular intrahepatic portosystemic shunt(TIPS)creation in patients with cirrhosis and to explore its association with clinical outcomes.Methods:This retrospective study included patients who underwent TIPS between August 2016 and December2020.Liver function was primarily evaluated using the model for end-stage liver disease(MELD)score,which was analyzed at baseline,1 week,1 month,3 months,6 months,and 12 months using one-way repeated measures ANOVA.The Kaplan-Meier method,log-rank test,and multivariate analysis were used as appropriate.Results:In total,235 patients were included in this study.The MELD score was significantly higher at 1 week(11.8±3.1 vs 13.5±3.5,p0.05).At 12 months,the MELD score was higher than the baseline level(11.8±3.1 vs 12.4±3.2,pLiver function after TIPS creation showed a trend of deterioration at first,followed by recovery.Recovery of Liver function at three months was associated with reduced overt and severe HE.

关键词： Transjugular intrahepatic portosystemic shunt Liver function Cirrhosis Model for end-stage liver disease

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Assessing Liver function by T1 Maps on Gd-EOB-DTPA- Enhanced MRI for up to 50 Min in Rat Models of liver Fibrosis: A Longer Hepatobiliary Time Period may Help

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Chinese Medical Sciences Journal 2021年第2期36卷 110-119页

作者： Jia Xu Xuan Wang Zhengyu Jin Qin Wang Yan You Shitian Wang Tianyi Qian Huadan Xue Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Siemens Healthcare Ltd. Beijing 100102China

Objectives To investigate whether a longer time period of gadolinium ethoxybenzyl diethylenetriaminepen-taacetic add(Gd-EOB-DTPA)-enhanced T1 mapping scanning,as well as dynamic contrast-enhanced(DCE)and multiple hepatobiliary phase magnetic resonance imaging(MRI)have the potential to provide information about Liver function in rats with liver fibrosis.Methods Forty rats were divided into the carbon tetrachloride-induced hepatic injury groups[carbon tetrachloride for four(n=14),eight(n=8),or twelve(n=8)weeks]and the control group(n=10).Gd-EOB-DTPA-enhanced MRI was performed including T1-mapping(delayed to 50 min),DCE,and multiple hepatobiliary phases.Indocyanine green retention rate at 15 min(ICG-R15)was determined.Parameters such as T1 reduction rate(△T1),elimination half-life of △T1(T_(△T1 1/2)),relative enhancement(RE),time to maximum RE(T_(max)),and perfusion parameters were calculated.Pearson correlation analysis was used for correlation analysis between ICG-R15 and each MRI indices.Results △T1 at 30,40,and 50 min showed significant positive correlations with ICG-R15(r=0.784,0.653,0.757,P=0.007,0.041,0.030).T_(△T1 1/2) showed a significant positive correlation with ICG-R15(r=0.685,P=0.029).showed a significant positive correlation with ICG-R15(r=0.532,P=0.019).Conclusions △T1 in the late hepatobiliary phase and T_(△T1 1/2) exhibited moderate correlations with Liver function.The longer time period of Gd-EOB-DTPA-enhanced Tl mapping scanning,as well as DCE and multiple hepatobiliary phases,may be of some value for estimating Liver function in rats with liver fibrosis.

关键词： Liver function T1 mapping Gd-EOB-DTPA magnetic resonance imaging

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Impact of intra-operative cholangiography and parenchymal resection to donor Liver function in living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 259-263页

作者： Feng Gao Xiao Xu Yang-Bo Zhu Qiang Wei Bin Zhou Xiao-Yong Shen Qi Ling Hai-Yang Xie Jian Wu Wei-Lin Wang Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgery Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University School of Medicine Department of General Surgery The Second Hospital of Ningbo City Department of Radiology Zhejiang University School of Medicine Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthFirst Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND: Living donor liver transplantation(LDLT)has been widely accepted over the past decade, and hepatic dysfunction often occurs in the donor in the early stage after liver donation. The present study aimed to evaluate the effect of intraoperative cholangiography(IOC) and parenchymal resection on Liver function of donors in LDLT, and to assess the role of IOC in influencing the biliary complications and improving the overall outcome.METHODS: Data from 40 patients who had donated their right lobes for LDLT were analyzed. Total bilirubin(TB), alanine aminotransferase(ALT), aspartate aminotransferase(AST),alkaline phosphatase(ALP) and γ-glutamyl transpeptidase(GGT)at different time points were compared, and the follow-up data and the biliary complications were also analyzed.RESULTS: The ALT and AST values were significantly increased after IOC(P0.05) or parenchymal resection(P>0.05). The biochemical changes caused by IOC or parenchymal resection were not correlated with the degree of post-operative liver injury or the recovery of Liver function. The Liver functions of the donors after operation were stable, and none of the donors suffered from biliary stenosis or leakage during the follow-up.CONCLUSIONS: IOC and parenchymal resection may induce a transient increase in liver enzymes of donors in LDLT, but do not affect the recovery of Liver function after operation. Moreover,the routine IOC is helpful to clarify the division line of the hepatic duct, thus reducing the biliary complication rate.

关键词： living donor liver transplantation intra-operative liver imaging Liver function hepatectomy

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Effects of Bivalirudin and Unfractionated Heparin on liver and Renal function in Chinese Patients with Coronary Artery Disease Undergoing Coronary Angiography with/without Percutaneous Coronary Intervention

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 477-483页

作者： Qiaowei Jia Jia Hu Wenfeng Ji Liansheng Wang Enzhi Jia Department of Cardiovascular Medicine First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Cardiovascular Medicine Liyang People’s HospitalLiyangJiangsuChina

Background and Aims:Unfractionated heparin(UFH)and bivalirudin are widely used as anticoagulants in cardiovascular medicine,including for thrombosis prevention during coronary angiography(CAG)and percutaneous coronary intervention(PCI).Little is known of the effects of UFH and bivalirudin on liver and kidney function in patients subjected to these procedures.This study compared the effects of bivalirudin and UFH on liver/renal function in patients with coronary artery disease who underwent CAG,with or without PCI.Methods:The study comprised 134 consecutive patients(40–89 years-old),who underwent CAG(or CAG and PCI);among them,66 and 68 patients were subject to,respectively,bivalirudin or UFH.The following indicators of liver/renal function were measured before and after the procedures:plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood urea nitrogen,estimated glomerular filtration rate(eGFR),creatinine clearance,and serum creatinine.Patients were further stratified by severity of chronic kidney disease(CKD),based on original eGFR.Results:Relative to baseline,in the bivalirudin group,ALT and AST were higher after CAG(p=0.005,0.025),while blood urea nitrogen and serum creatinine were lower(p=0.049,function.Conclusions:Relative to UFH,bivalirudin may better safeguard the renal function of patients with coronary artery disease who undergo CAG,especially patients with moderate-to-severe renal insufficiency.UFH may cause less liver damage than bivalirudin.

关键词： Bivalirudin Unfractionated heparin Coronary artery disease Coro-nary angiography Percutaneous coronary intervention Liver function

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Dynamic monitoring of serum Liver function indexes in patients with COVID-19

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World Journal of Clinical Cases 2021年第7期9卷 1554-1562页

作者： Hao Lin Ling-Jie Wu Shun-Qi Guo Rui-Lie Chen Jing-Ru Fan Bin Ke Ze-Qun Pan Department of Gastroenterology Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Infectious Disease Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Emergency Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Ultrasonography Shantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Pediatrics Shantou Central HospitalShantou 515000Guangdong ProvinceChina

BACKGROUND Some patients with the novel 2019 coronavirus disease(COVID-19)display elevated liver enzymes.Some antiviral drugs that can be used against COVID-19 are associated with a risk of hepatotoxicity.AIM To analyze the clinical significance of the dynamic monitoring of the Liver function of patients with COVID-19.METHODS This was a retrospective study of patients diagnosed with COVID-19 in January and February 2020 at the Department of Infection,Shantou Central Hospital.The exclusion criteria for all patients were:(1)History of chronic liver disease;(2)History of kidney disease;(3)History of coronary heart disease;(4)History of malignancy;or(5)History of diabetes.The serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyltransferase,and total bilirubin of patients with COVID-19 were measured on days 1,3,7 and 14 after admission,and compared to non-COVID-19 patents.RESULTS Twelve patients with COVID-19(seven men and five women)and twelve controls(eight men and four women)were included.There were one,two,and nine patients with severe,mild,and moderate COVID-19,respectively.There were no differences in age and sex between the two groups(both P>0.05).No significant differences were found in albumin,ALT,AST,γ-glutamyltransferase,or total bilirubin between the controls and the patients with COVID-19 on day 1 of hospitalization(all P>0.05).Serum albumin showed a decreasing trend from days 0 to 7 of hospitalization,reaching the lowest level on day 7.Total bilirubin was higher on day 3 than on day 7.ALT,AST,andγ-glutamyltransferase did not change significantly over time.The severe patient was observed to have ALT levels of 67 U/L and AST levels of 75 U/L on day 7,ALT of 71 U/L and AST of 35 U/L on day 14,and ALT of 210 U/L and AST of 123 U/L on day 21.CONCLUSION Changes in serum Liver function indicators are not obvious in the early stage of COVID-19,but clinically significant changes might be observed in severe COVID-19.

关键词： COVID-19 Liver function Dynamic monitoring Disease severity Kidney disease Index

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Measurement of Liver function for patients with cirrhosis by ^13C-methacetin breath test compared with Child-Pugh score and routine Liver function tests

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Chinese Medical Journal 2006年第18期119卷 1563-1566页

作者： LIU Yun-xiang HUANG Liu-ye WU Cheng-rong CUI Jun Department of Gastroenterology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai 264000 China

^13C-methacetin breath test was used for the evaluation of Liver function, as for quantitative data could be achieved using this method, it had the characteristics of safety, quantification, and repetition and got recognition gradually through the world. We began this ^13C- methacetin test to assess Liver function of patients with cirrhosis from January 2002. The aim of this study was to explore the characteristic of this test for Liver function evaluation and explore the correlation of this method with some clinical liver biochemical parameters and Child-Pugh score.

关键词： ^13 C-methacetin breath test cirrhosis Liver function

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Effect of donor age on graft function and longterm survival of recipients undergoing living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 50-55页

作者： Kai Wang Wen-Tao Jiang Yong-Lin Deng Cheng Pan Zhong-Yang Shen Department of Transplant Surgery Tianjin First Center Hospital Key Laboratory of Organ Transplantation of Tianjin

BACKGROUND： Donor shortage is the biggest obstacle in organ transplantation. Living donor liver transplantation（LDLT） has been considered as a valuable approach to shortening waiting time. The objectives of this study were to investigate the feasibility of utilizing donors older than 50 years in LDLT and to evaluate the graft function and recipient survival.METHODS： All LDLT cases（n=159） were divided into the older（donor age ≥50 years, n=10） and younger（donor age 〈50 years,n=149） donor groups. Donor graft and recipient condition pre-,intra- and post-operation were compared between the two groups.In particular, graft functions and recipient survivals were analyzed.RESULTS： The median donor age was 58.5（52.5-60.0） years in the older donor group and 25.0（23.0-32.0） in the younger donor group. There was no significant difference in cold ischemic time, anhepatic phase and operation time between the older and younger donor groups（P〉0.05）. However, the volume of red blood cell transfused in operation was greater in the older donor group than in the younger donor group（1900 vs 1200 m L, P=0.023）. The 1-, 3- and 5-year graft survival rates were 90%, 80% and 80% for the older donor group, and 92%, 87% and 87% for the younger donor group, respectively（P=0.459）.The 1-, 3- and 5-year survival rates were 100%, 90% and 90% for recipients with older grafts, and 93%, 87% and 87% for those with younger grafts, respectively（P=0.811）.CONCLUSION： It is safe for a LDLT recipient to receive liver from donors older than 50 years, and there is no significant adverse effect on graft function and long-term patients’ survival.

关键词： living donor liver transplantation donor age graft Liver function long-term survival

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Effect of Compound Danshen Injection Combined with Labetalol on Liver function and Placental Growth Factor in Patients with Eclampsia

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Journal of Hainan Medical University 2020年第5期26卷 34-37页

作者： Lin Qi Hong Li Li-Sha Wang Cui Yang Cong Li Yu-Jiao Cui Yue-Yang Shao Li-Yun Sun Xi Wang Clinical laboratory The Fourth Hospital Shijiazhuang City Clinical laboratory Luquan District Maternal and Child Health HospitalShijiazhuang City The First Hospital of Hebei Medical University Genetic Service The Maternal and Child Health Hospital Shijiazhuang

Objective: To explore the effect of Compound Danshen Injection combined with Labetalol on Liver function and placental growth factor in patients with eclampsia. Methods: Seventy patients with eclampsia who were treated in the Hospital from February 2017 to February 2019 were enrolled. The patients were divided into two groups according to the random number table, with 35 cases in each group. The Observation group was treated with Labetalol, and the combined therapy group was treated with Compound Danshen Injection combined with Labetalol. The Liver function [alanine aminotransferase, aspartate aminotransferase, total protein, and albumin], hemorheology indicators, placental growth factor and serum insulin-like growth factor-1 and clinical indicators in the two groups were analyzed. Results: After treatment, the levels of alanine aminotransferase and aspartate aminotransferase in the combined therapy group were significantly lower than those in the Observation group. The levels of total protein and albumin in the combined therapy group were significantly higher than those in the Observation group (PLiver function and placental growth factor sta

关键词： Compound Danshen Injection Labetalol Patients with Eclampsia Liver function Placental Growth Factor

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