Impact of intra-operative cholangiography and parenchymal resection to donor liver function in living donor liver transplantation

作     者：Feng Gao Xiao Xu Yang-Bo Zhu Qiang Wei Bin Zhou Xiao-Yong Shen Qi Ling Hai-Yang Xie Jian Wu Wei-Lin Wang Shu-Sen Zheng 

作者机构：Division of Hepatobiliary and Pancreatic SurgeryDepartment of Surgery Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University School of Medicine Department of General SurgeryThe Second Hospital of Ningbo City Department of RadiologyZhejiang University School of Medicine Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthFirst Affiliated Hospital Zhejiang University School of Medicine 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2014年第13卷第3期

页      面：259-263页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by grants from the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(81121002) Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents(2012-236) Zhejiang Provincial Education Department Project(Y201018972) Zhejiang Provincial Natural Science Foundation of China(LQ12H03002) 

主　　题：living donor liver transplantation intra-operative liver imaging liver function hepatectomy 

摘      要：BACKGROUND: Living donor liver transplantation(LDLT)has been widely accepted over the past decade, and hepatic dysfunction often occurs in the donor in the early stage after liver donation. The present study aimed to evaluate the effect of intraoperative cholangiography(IOC) and parenchymal resection on liver function of donors in LDLT, and to assess the role of IOC in influencing the biliary complications and improving the overall outcome.METHODS: Data from 40 patients who had donated their right lobes for LDLT were analyzed. Total bilirubin(TB), alanine aminotransferase(ALT), aspartate aminotransferase(AST),alkaline phosphatase(ALP) and γ-glutamyl transpeptidase(GGT)at different time points were compared, and the follow-up data and the biliary complications were also analyzed.RESULTS: The ALT and AST values were significantly increased after IOC(P0.05) or parenchymal resection(P0.05). The biochemical changes caused by IOC or parenchymal resection were not correlated with the degree of post-operative liver injury or the recovery of liver function. The liver functions of the donors after operation were stable, and none of the donors suffered from biliary stenosis or leakage during the follow-up.CONCLUSIONS: IOC and parenchymal resection may induce a transient increase in liver enzymes of donors in LDLT, but do not affect the recovery of liver function after operation. Moreover,the routine IOC is helpful to clarify the division line of the hepatic duct, thus reducing the biliary complication rate.