Dynamic monitoring of serum liver function indexes in patients with COVID-19

作     者：Hao Lin Ling-Jie Wu Shun-Qi Guo Rui-Lie Chen Jing-Ru Fan Bin Ke Ze-Qun Pan 

作者机构：Department of GastroenterologyShantou Central HospitalShantou 515000Guangdong ProvinceChina Department of Infectious DiseaseShantou Central HospitalShantou 515000Guangdong ProvinceChina Department of EmergencyShantou Central HospitalShantou 515000Guangdong ProvinceChina Department of UltrasonographyShantou Central HospitalShantou 515000Guangdong ProvinceChina Department of PediatricsShantou Central HospitalShantou 515000Guangdong ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第7期

页      面：1554-1562页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Shantou Science and Technology Bureau 1st Fund of the Prevention and Treatment of New Coronavirus Pneumonia No.2020-1-35 

主　　题：COVID-19 Liver function Dynamic monitoring Disease severity Kidney disease Index 

摘      要：BACKGROUND Some patients with the novel 2019 coronavirus disease(COVID-19)display elevated liver *** antiviral drugs that can be used against COVID-19 are associated with a risk of *** To analyze the clinical significance of the dynamic monitoring of the liver function of patients with *** This was a retrospective study of patients diagnosed with COVID-19 in January and February 2020 at the Department of Infection,Shantou Central *** exclusion criteria for all patients were:(1)History of chronic liver disease;(2)History of kidney disease;(3)History of coronary heart disease;(4)History of malignancy;or(5)History of *** serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyltransferase,and total bilirubin of patients with COVID-19 were measured on days 1,3,7 and 14 after admission,and compared to non-COVID-19 *** Twelve patients with COVID-19(seven men and five women)and twelve controls(eight men and four women)were *** were one,two,and nine patients with severe,mild,and moderate COVID-19,*** were no differences in age and sex between the two groups(both P0.05).No significant differences were found in albumin,ALT,AST,γ-glutamyltransferase,or total bilirubin between the controls and the patients with COVID-19 on day 1 of hospitalization(all P0.05).Serum albumin showed a decreasing trend from days 0 to 7 of hospitalization,reaching the lowest level on day *** bilirubin was higher on day 3 than on day ***,AST,andγ-glutamyltransferase did not change significantly over *** severe patient was observed to have ALT levels of 67 U/L and AST levels of 75 U/L on day 7,ALT of 71 U/L and AST of 35 U/L on day 14,and ALT of 210 U/L and AST of 123 U/L on day *** Changes in serum liver function indicators are not obvious in the early stage of COVID-19,but clinically significant changes might be observed in severe COVID-19.