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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nunes Pamela Castro-e-Souza Anselmo Alves de Oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and SciELO.Randomized controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were included.Independent reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) evaluations.Total body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for meta-analysis.Results:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were included.RT groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to CG.However,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to CG.Conclusion:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass lipid profile Menopause Strength training

Vitamin C and E supplementation and high intensity interval training induced changes in lipid profile and haematological variables of young males

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Sports Medicine and Health Science 2023年第2期5卷 137-145页

作者： Surojit Sarkar Swapan Kr Dey Gouriprosad Datta Amit Bandyopadhyay Department of Physiology Rammohan College1021Raja Ram Mohan SaraniBaithakkhanaKolkata700009West BengalIndia Department of Sports Science University of CalcuttaUniversity Colleges of Science and Technology92A.P.C.RoadKolkata700009West BengalIndia Sports and Exercise Physiology Laboratory Department of PhysiologyUniversity of CalcuttaUniversity Colleges of Science and Technology92A.P.C.RoadKolkata700009West BengalIndia

High intensity interval training(HIIT)causes oxidative stress and haematological alteration.Present study was aimed to evaluate the effect of 8 weeks’supplementation of vitamin C and E on HIIT induced changes in lipid profile parameters and haematological variables.Hundred six male adolescent players were randomly assigned into five age-matched groups,i.e.,Control(no exercise+placebo),HIIT(placebo),HIIT+vitamin-C(1000mg/day),HIIT+vitamin-E 400 IU/day)and combined HIIT+vitamin C and E.Morning and evening sessions(90min)of HIIT included 4 phases(15min each)with 3 sets(4min each).Each 4min HIIT set consisted of 2min intense sprint workout(90%–95%of heart rate maximum[HRmax])followed by 1min active recovery(60%–70%HRmax)followed by 1min of complete rest(1:1 work-rest ratio).lipid profile parameters,haematological variables,endurance capacity and vertical jump were evaluated by standard protocols.Significant decrease in body weight,fat%,total cholesterol,triglyceride,Total Cholesterol/High Density Lipoprotein-Cholesterol and significant increase in High Density Lipoprotein-Cholesterol,maximal oxygen consumption,vertical jump were observed for all four intervention groups.White blood cell count,red blood cell count,haemoglobin percentage and haematocrit values were significantly decreased while platelet count and platelet-to-leukocyte ratio(PLR)ratio were increased significantly only for HIIT group.Blood level of tocopherol and ascorbic acid was significantly increased(values were within the normal range)in all the respective vitamin supplemented groups.Supplementation of vitamin C and E secures health protection with suppressed haemolysis and improved inflammatory blood variables with enhanced explosive leg strength and lipid profile parameters without any concomitant change in endurance capacity.

关键词： Sprint interval training lipid profile Haematological indices Haemolysis Athletes

Assessment of post-myocardial infarction lipid levels and management:Results from a tertiary care hospital of Pakistan

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World Journal of Cardiology 2024年第5期16卷 282-292页

作者： Rubina Rauf Muhammad Ismail Soomro Muhamman Nauman Khan Mukesh Kumar Najia Aslam Soomro Khawar Abbas Kazmi Department of Preventive Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan Department of Adult Cardiology National Institute of Cardiovascular DiseasesKarachi 75510Pakistan Department of Cardiology Liaquat National HospitalKarachi 74800Pakistan

BACKGROUND lipid treatment practices and levels in post-acute myocardial infarction(AMI)patients,which are crucial for secondary prevention.AIM To evaluate the lipid treatment practices and lipid levels in post-myocardial infarction(MI)patients at a tertiary care hospital in Pakistan.METHODS In this cross-sectional study,we analyzed patients who had experienced their first AMI event in the past 3 years.We assessed fasting and non-fasting lipid profiles,reviewed statin therapy prescriptions,and examined patient compliance.The recommended dose was defined as rosuvastatin≥20 mg or atorvastatin≥40 mg,with target total cholesterol levels set atlipid profile testing after AMI,88.7% of patients were on the recommended statin therapy,and 91.8% of patients were compliant with statin therapy.Only 11.5% had LDL-C within the target range and 71.7% had total cholesterol within the target range.Hospital admission in the past 12 months was reported by 14.4%,and the readmission rate was significantly higher among non-compliant patients(37.5%vs 5.6%).Subsequent AMI event rate was also significantly higher among non-compliant patients(43.8%vs 11.7%).CONCLUSION Our study highlights that while most post-AMI patients received the recommended minimum statin therapy dose,the inadequate practice of lipid assessment may compromise therapy optimization and raise the risk of subsequent events.

关键词： lipid profile Dyslipidemia Acute myocardial infarction Secondary prevention lipid lowering therapy

Effect of an active fraction isolated from the leaf extract of Leptadenia reticulata on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

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Chinese Journal of Natural Medicines 2014年第6期12卷 455-460页

作者： VENKATESAN Natarajan ANTON SMITH Arul Gnana Dhas Department of Pharmacy Annamalai University

AIM: To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats. METHOD: Diabetes was induced by streptozotocin in Wistar rats. Petroleum ether, ethyl acetate, and ethanol extracts of Leptadenia reticulata leaves were administered orally at a dose of 200 mg·kg-1, p.o. Metformin was used as standard anti diabetic drug(50 mg·kg-1, p.o). The extract showing higher antidiabetic activity was subjected to column chromatography and led to the isolation of an active fraction, which was given trivial name Lr-1. Lr-1(100 mg·kg-1, p.o.) was studied for its hypoglycemic and hypolipidemic potential. RESULTS: The ethanol extract was found to lower the FBG level significantly(P < 0.05) in diabetic rats. Lr-1 caused a significant(P < 0.05) reduction in FBG level, and additionally it caused reduction in cholesterol, triglyceride levels, and an improvement in the HDL level in diabetic rats. CONCLUSION: Reduction in the FBG, cholesterol, triglyceride levels, and an improvement in the HDL by Lr-1 indicates that Lr-1 has antidiabetic activity, along with cardioprotective potential, and provides a scientific rationale for the use as an antidiabetic agent.

关键词： Leptadenia reticulata Blood glucose lipid profile

High Physical Activity is Associated with an Improved lipid profile and Resting Heart Rate among Healthy Middle-aged Chinese People

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Biomedical and Environmental Sciences 2015年第4期28卷 263-271页

作者： HU Bo LIU Xiao Yu ZHENG Yao FAN Hong Min YIN Su Feng GUO Chun Yue LI Yun WU Shou Ling FENG Fu Min YUAN Ju Xiang School of Public Health and Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry Hebei United University Department of Respiratory Medicine Kailuan General Hospital Hebei United University Department of Cardiology Kailuan General Hospital Hebei United University

Objective To investigate the effects of physical activity （PA） on dyslipidemia and elevated resting heart rate （RHR） in a large-scale cross-sectional study in China. Methods We recruited community-based individuals who were 40-60 years old using a cluster sampling method. The PA levels of the participants were classified as low, moderate, or high, using the International Physical Activity Questionnaire. Dyslipidemia was defined as the detection of abnormalities in lipid indicators, and 4 lipid parameters were evaluated using fasting blood samples. Multivariate logistic regression analyses were used to evaluate the associations of PA with dyslipidemia and RHR. Results A total of 10,321 participants （38.88% men） were included in this study. The percentages of individuals with high, moderate, and low PA levels were 46.5%, 43.9%, and 9.6%, respectively. In both men and women, high PA provided odds ratios of 0.88 [95% confidence interval （CI）： 0.83, 0.94] for dyslipidemia and 0.82 （95% CI： 0.73, 0.92） for elevated RHR, compared to participants with low PA. Conclusion Our data suggested that substantial health benefits （related to dyslipidemia and elevated RHR） occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men.

关键词： Physical activity lipid profile Dyslipidemia Heart rate Unconditional logistic regression

Correlation between Serum CD36 Level and lipid profile in Patients with Type 2 Diabetes Mellitus, Khartoum State, Sudan

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Journal of Diabetes Mellitus 2023年第1期13卷 68-75页

作者： Eglal Elamein Mohammed Ali Abuagla M. Dafalla Yousif Abdelhameed Mohammed Bakri Yousif Mohamed Nour Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan

Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia. DM-related dyslipidemia are associated with complications resulting from progressive damage of various organs. CD36 is 88-kD, class B scavenger receptor, expressed on different types of cells. In diabetic patients, LDL particles are glycated with strong level;this increases CD36 expression, initiates foam cell formation and accelerates atherosclerosis. Objective: This study aimed to determine the correlation between serum CD36 level and lipid profile among patients with type 2 diabetes mellitus in Zeenam Specialized center, Khartoum State, Sudan, in a period between 2019 and 2022. Methodology: Hundred participants at different ages were included in this study;70 were type 2 diabetic patients (cases) and 30 apparently healthy individual (control). 3 ml of venous blood were collected from the participants by using a sterile needle and syringe into a labeled plain container. Each sample was stood until complete clot occurs. Clotted blood sample was then centrifuged to obtain the serum. Then they were used for measurement of total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride and soluble CD36 levels. Total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were measured using Biosystem chemistry analyzer BTS-302. Serum CD36 was measured using Microplate Reader (URIT-660). Results: The results revealed that serum total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels were significantly higher in patients with type 2 diabetes mellitus compared with control (P = 0.03, P = 0.031, P = 0.000, P = 0.000) respectively, while there is no statistically significant differences in serum CD36 level between cases and control (P = 0.129). Also this study showed that there is no statistically significant correlation between serum CD36 level and total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, age and body mass index. Conclusion: This study concluded that there is no st

关键词： Type 2 Diabetes Mellitus Serum CD36 lipid profile Sudan

Prevalence of Dyslipidemia among Patients Received at the Biochemistry Unit of the Charles de Gaulle Pediatric University Hospital in Ouagadougou

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Advances in Biological Chemistry 2024年第1期14卷 16-26页

作者： Fabienne Marie Soudre Arnaud Kouraogo Alice Kiba Ollo Da Mahutin Benoîte Hounhoui Diema Nadia Karama Seraphine Mano Denis Claude Drabo Augustin Kyetega Raoul Karfo Elie Kabre Jean Sakande Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Charles de Gaulle Pediatric University Hospital Ouagadougou Burkina Faso Health Sciences Institute Nazi BONI University Bobo Dioulasso Burkina Faso Biochemistry Unit Sourou Sanou University Hospital Bobo Dioulasso Burkina Faso Tengandogo University Hospital Ouagadougou Burkina Faso Faculty of Health Sciences Saint Thomas d’Aquin University Ouagadougou Burkina Faso Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso National Agency for Environmental Food Labor and Health Product Safety Ouagadougou Burkina Faso

Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.

关键词： Dyslipidemia lipid profile lipid Abnormalities Prevalence Burkina Faso

The Effect of Macronutrient Restrictions on Gut Microbiome and Biochemical Parameters of Wistar Albino Rats

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Journal of Biosciences and Medicines 2024年第6期12卷 286-310页

作者： Blandine Ngum Shu Bernard Tiencheu Fabrice Tonfack Djikeng Deffo Ngongang Flore Tiepma Dibanda Romelle Feumba Yolandia Jamea Nganje Epanty Lyonga Agnes Namondo Mbongo Aduni Ufuan Achidi Department of Public Health and Administration School of Health Sciences Biaka University Institut of Buea Buea Cameroon Department of Biochemistry and Molecular Biology Faculty of Science University of Buea Buea Cameroon

Macronutrients serve as a source of energy for both gut microbiota and its host. An increase or decrease in macronutrients can either increase or decrease the composition of gut microbiota, leading to gut dysbiosis which has been implicated in many diseases state including non-communicable diseases. To achieve this, seven diets were formulated by restricting 60% of each macronutrient. These diets were fed on 42 albino rats (Wistar), divided into 7 groups of 6 rats each. Group 1 was fed on a normal laboratory chow diet (ND), group 2 received a fat-restricted diet (FRD), group 3 received a protein-restricted diet, (PFD), group 4 received a carbohydrate-restricted diet (CRD), group 5 received a protein and fat-restricted diet (PFRD), group 6 re-ceived a carbohydrate and fat-restricted diet (CFRD) and group 7 received a carbohydrate and protein-restricted diet (CPRD). Feed and water intake were given ad libitum and daily weight and food intake were recorded. The experiment went on for 4 weeks after which animals were sacrificed and intestinal content and blood were collected for analysis (gut microbial composition, glucose, insulin levels, serum lipid, and enzyme). Compared to the control group results showed a decrease in Bacteroides (40.50 - 14.00 CFU), HDL (68.20 - 40.40 mg/dl), and AST (66.62 - 64.74 U/L) in FRD. An increase in AST (66.6 - 69.43 U/L), Bifidobacterial (59.50 - 92.00 CFU) and decreased Bacteroides (40.5 - 19.5 CFU) for PRD was also recorded. CRD reduced Lactobacillus (73 - 33.5 CFU), total bacterial count (129 - 48 CFU), HDL (68.2 - 30.8 mg/dl), and cholesterol (121.44 - 88.65 mg/dl) whereas intestinal composition of E. coli (30.5 - 51.5 CFU) increased. PFRD increased Lactobacillus (73.00 - 102.5 CFU), Bifidobacterial (59.5 - 100 CFU), HDL (68.2 - 74.7 mg/dl), and Triglyceride (111.67 - 146.67 mg/dl) concentration. Meanwhile, a reduction in Bifidobacterial (59.5 - 41.5 CFU), and an increasing of AST (66.62 - 70.30 U/l) were recorded for CFRD. However, Bacteroides (40.5 69.5 CFU), LDL (30.95 - 41.98

关键词： Diets Dysbiosis Gut Microbiome lipid profile Serum Enzymes Non-Communicable Disease Gut Microbiota Gut Dysbiosis Restricted Diet

lipid profile of Coronary Heart Disease Patients: A Prospective Observational Study

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World Journal of Cardiovascular Surgery 2021年第11期11卷 114-124页

作者： Md. Rezaul Alam Md. Bashir Uddin Md. Mojib Uddin Mahbubur Rahman Sougata Mitra Department of Cardiology M. Abdur Rahim Medical College Dinajpur Bangladesh Department of Cardiology Kushtia Medical College Kushtia Bangladesh Department of Pharmacology Rajshahi Medical College Rajshahi Bangladesh Department of Cardiology Rangpur Medical College & Hospital Rangpur Bangladesh Department of Pharmacology and Therapeutics Pabna Medical College Pabna Bangladesh

Background: Coronary heart disease (CHD) remains the major cause of mortality and morbidity in the entire world population despite therapeutic advances that control many risk factors. Lipid profile is regarded as an important factor in the development of coronary heart disease. There have been numerous studies confirming the association of hyperlipidemias with coronary heart disease in most of the Western as well as Asian countries of the world. But we have very little data on the relation between CHD and lipid profile. Aim of the Study: The aim of this study was to assess abnormal lipid levels and their association with coronary heart disease. Methods: This comparative observational study was conducted at the Department of Cardiology in M. Abdur Rahim Medical College, Dinajpur, Bangladesh from January 2019 to December 2019. Properly written consent was taken from all the participants before starting the main part of the investigation. Obeying inclusion and exclusion criteria of the study, a total of 131 participants were finalized as the study population. Among them, the Case Group was formed with 90 patients who had CHD, and with 41 healthy people, the Control Group was formed. All necessary data were collected, analyzed, and disseminated by several programs of MS-Office and SPSS version 23. Result: The study was conducted with 90 case group participants and 41 control group participants. Among the case group, 78% were male and 22% were f

关键词： lipid profile Coronary Heart Disease CHD Cardiology