Effect of an active fraction isolated from the leaf extract of Leptadenia reticulata on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

作     者：VENKATESAN Natarajan ANTON SMITH Arul Gnana Dhas 

作者机构：Department of Pharmacy Annamalai University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2014年第12卷第6期

页      面：455-460页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the University Grants Commission New Delhi India.UGC-BSR Fellowship-F.4-1/2006(BSR)/7-269/20210 

主　　题：Leptadenia reticulata Blood glucose Lipid profile 

摘      要：AIM: To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats. METHOD: Diabetes was induced by streptozotocin in Wistar rats. Petroleum ether, ethyl acetate, and ethanol extracts of Leptadenia reticulata leaves were administered orally at a dose of 200 mg·kg-1, p.o. Metformin was used as standard anti diabetic drug(50 mg·kg-1, p.o). The extract showing higher antidiabetic activity was subjected to column chromatography and led to the isolation of an active fraction, which was given trivial name Lr-1. Lr-1(100 mg·kg-1, p.o.) was studied for its hypoglycemic and hypolipidemic potential. RESULTS: The ethanol extract was found to lower the FBG level significantly(P 0.05) in diabetic rats. Lr-1 caused a significant(P 0.05) reduction in FBG level, and additionally it caused reduction in cholesterol, triglyceride levels, and an improvement in the HDL level in diabetic rats. CONCLUSION: Reduction in the FBG, cholesterol, triglyceride levels, and an improvement in the HDL by Lr-1 indicates that Lr-1 has antidiabetic activity, along with cardioprotective potential, and provides a scientific rationale for the use as an antidiabetic agent.