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Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun Zhang Guangqiang Wang Zhiqiang Xiong Zhuan Liao Yangyan Qian Xin Song Li Sui Lianzhong Ai Yongjun Xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal *** this study,the effects of lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were *** results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and *** AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root *** further showed that supplementation with *** AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the *** addition,the microbiota analysis of the colon indicated that *** AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain *** total,*** AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity Dorsal root ganglia Tryptase Microbiota

Impact of Dietary lactobacillus plantarum Postbiotics on the Performance of Layer Hens under Heat Stress Conditions

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Open Journal of Veterinary Medicine 2024年第3期14卷 39-55页

作者： Mohamad Farran Bouchra El Masry Zeinab Kaouk Houssam Shaib Department of Agriculture Faculty of Agricultural and Food Sciences American University of Beirut Beirut Lebanon

This experiment was conducted to determine the performance of heat-stressed layers fed a diet containing the probiotic lactobacillus plantarum RS5 or its products of fermentation (postbiotics). Twenty-week-old Isa White layers, were subdivided into six treatments of 32 individually caged birds. Half of the birds were reared under regular temperature conditions, while the other half was subjected to cyclic daily heat stress. Layers were offered one of three diets: 1) Control;2) Control + lactobacillus plantarum RS5 probiotic;3) Control + lactobacillus plantarum RS5 postbiotics. Birds were tested for performance and visceral organ development for 5 months. Heat stress negatively affected the birds’ feed intake, egg weight, shell weight percentage, Haugh unit, shell thickness, yolk color, body weight and spleen weight percentage. Postbiotics significantly increased egg production (p < 0.05) in comparison to the control and the probiotic fed group (94.8% vs 92.6% vs 93.1%, respectively). Birds under probiotic or postbiotic diet showed a significantly higher (p < 0.05) feed intake and egg weight, although the probiotic had a more pronounced and gradual effect. Specific gravity, yolk weight percentage and shell thickness didn’t show differences among dietary groups. The Haugh Unit was significantly higher (p < 0.05) in probiotic group which also showed a significantly lower yolk color index (p < 0.05). The different feed treatments did not impact the bird’s viscera weight percentage, except for the ileum that was significantly lower (p < 0.05) under postbiotic supplementation. Both probiotics and postbiotics could be used as a potential growth promoters and might alleviate heat stress impact in poultry industry.

关键词： lactobacillus plantarum Layers Heat Stress Postbiotic Probiotics Performance

lactobacillus plantarum KLDS1.0386 with antioxidant capacity ameliorates the lipopolysaccharide-induced acute liver injury in mice by NF-κB and Nrf2 pathway

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Food Bioscience 2022年第3期47卷 184-196页

作者： Jiahuan Dong Lijun Ping Qinggang Xie Deyu Liu Li Zhao Smith Etareri Evivie Zhongjiang Wang Bailiang Li Guicheng Huo Key Laboratory of Dairy Science Ministry of EducationNortheast Agricultural UniversityHarbin150030China Food College Northeast Agricultural UniversityHarbin150030China Heilongjiang Feihe Dairy Co. LtdQiqihaer164800China Department of Food Science and Human Nutrition Faculty of AgricultureUniversity of BeninBenin City300001Nigeria Department of Animal Science Faculty of AgricultureUniversity of BeninBenin City300001Nigeria

The lactobacillus is of great interest as a natural antioxidant to ameliorate liver injury for its antioxidant *** a previous experiment,lactobacillus plantarum KLDS 1.0386 was excellent in adhesion and *** research assessed the antioxidant capacity of *** KLDS 1.0386 and how it ameliorates the LPS-induced acute liver *** vitro results showed that *** KLDS 1.0386 had potential antioxidant capacity with 27 genes,and it had better capacities in hydroxyl radicals scavenging and lipid antioxidant than the reference strain *** WCFS1 (P < 0.05).In vivo results,*** KLDS 1.0386 significantly reduced hepatic tissue injury,pro-inflammatory cytokines (TNF-α,IL-6),myeloperoxidase (MPO) activities and biochemical indicators of hepatotoxicity (ALT,AST,ALP) (P < 0.05),compared with the LPS-treated ***,*** KLDS 1.0386 increased the relative abundance of the genera,including Lachnospiraceae_NK4A136_group,Muribaculaceae and Alistipes,which significantly increased the level of acetic acid and butyric acid (P < 0.05).The results also showed *** KLDS 1.0386 significantly adjusted the expression of HO-1,NQO1,CAT,NF-κB,TLR4 and IκB-α in the liver (P < 0.05).Overall,these results indicated that *** KLDS 1.0386 had great functionality in reducing LPS-induced acute liver injury.

关键词： lactobacillus plantarum Genomic analysis Lipid antioxidant Hydroxyl radical scavenging Gut microbiota SCFAs

lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism

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Animal Diseases 2023年第4期3卷 299-316页

作者： Songkang Qin Yingli Wang Mengjie Yang Pengpeng Wang Mudassar Iqbal Jinquan Li Yaoqin Shen College of Veterinary Medicine Huazhong Agricultural UniversityWuhan430070People's Republic of China Faculty of Veterinary and Animal Sciences The Islamia University of BahawalpurBahawalpur 63100Pakistan Key Laboratory of Environment Correlative Dietology Interdisciplinary Sciences InstituteCollege of Food Science and TechnologyHuazhong Agricultural UniversityWuhanChina State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanChina

Antibiotics are widely used to treat various ***,growing evidence indicates that antibiotic therapy in human life increases the incidence of inflammatory bowel disease(IBD).Therefore,we need appropriate methods to reduce the incidence or symptoms of *** this study,we used lincomycin hydrochloride to construct a gut micro-bial dysbiosis model in mice,and then,constructed an ulcerative colitis(UC)***,we used lactobacillus plantarum A3 from equine to treat UC in mice with gut microbial *** results showed that lincomycin hydro-chloride had little effect on the small gut microbiota in mice,but had a more destructive effect on the large *** plantarum A3 alleviated the symptoms of UC in mice,which was reflected in its significantly reduced spleen index and disease activity index(DAl)(plactobacillus plan-tarum A3 has the potential to regulate UC in mice with gut microbial dysbiosis.

关键词： Antibiotics Gut microbiota lactobacillus plantarum DSS Ulcerative colitis Untargeted metabolomics

Evaluation of probiotic yoghurt by the mixed culture with lactobacillus plantarum A3

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Food Science and Human Wellness 2022年第2期11卷 323-331页

作者： Fengxuan Lang Jianzhu Wen Zhen Wu Daodong Pan Linjun Wang Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang School of Food and Pharmaceutical SciencesNingbo UniversityNingbo 315211China School of Food Science&Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210097China Qingyunshan Pharmaceutical GuangdongGuangzhou 512000China

Lactic acid bacteria(LAB)fermentation is the simplest and safest way of food preservation,and the use of probiotics in yoghurt could provide dairy products with unique flavors,textures and health *** this study,lactobacillus bulgaricus,Streptococcus thermophilus,*** DSMZ 8533 and the potential probiotic strain *** A3 were used for the milk *** found the texture properties such as hardness,consistency,and viscosity of the yoghurt were enhanced in the mixed culture ***,components like amino acid(leucine),vanilla(vanillin),C;(unsaturated fatty acids)were also accumulated in *** A3 fermented yoghut,which leads to the significant sensory profiling difference compared with the former plain *** these results proved *** A3 is a potential probiotic stom winch could enhance the sensory and nutrition profiling of the fermented *** work still needs to be done on the synergistic interaction between the traditional strains and the probiotics during the fermentation process.

关键词： lactobacillus plantarum Flavor profiles Volatile organic compounds Sensory profiles Fatty acid

Immobilization of lactobacillus plantarum NCIMB 8826 ameliorates Citrobacter rodentium induced lesions and enhances the gut inflammatory response in C57BL/6 weanling mice

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Food Production, Processing and Nutrition 2022年第1期4卷 447-458页

作者： Emmanuel Kyereh Diana Coulon Ingeborg Langohr Anne Raggio Michael Keenan Subramaniam Sathivel School of Nutrition and Food Sciences Louisiana State University Agriculture Center220 H.D.Wilson LaboratoriesLSU Agricultural CenterBaton RougeLA 70803USA Bioassay Core Laboratory Agricultural CenterLouisiana State UniversityBaton RougeLAUSA Department of Pathobiological Sciences Louisiana State UniversityBaton RougeLAUSA Department of Biological and Agriculture Engineering Louisiana State UniversityBaton RougeLAUSA

Infectious diarrhea is a major cause of infant mortality in most developing countries. In this research, we evaluated the potential of immobilized lactobacillus plantarum NCIMB 8826 on weanimix infant cereal and its effectiveness in reducing the severity of Citrobacter rodentium-induced diarrhea in weanling mice. Thirty-six C57BL/6 weanling mice were placed into four groups (n = 9 each;negative, positive, prevention and cure). Mice received either L. plantarum (109 CFU/g) immobilized on weanimix infant cereal 3 days before C. rodentium (109 CFU/ ml) infection (Prevention) or 3 days after C. rodentium infection (Cure). A positive control group was infected with C. rodentium only, while a nega-tive control group received neither L. plantarum nor C. rodentium. Positive control mice showed colonic mucosal and submucosal inflammation, erosion, and mucosal epithelia hyperplasia with the C. rodentium infection. Mice in the prevention and cure groups had less severe histologic alterations in the colon. Some beneficial effect of L. plantarum was observed in cecal short-chain fatty acid concentrations, which stimulates water and electrolytes absorption to reduce diarrhea. Our findings demonstrated that L. plantarum NCIMB 8826 could be immobilized on weanimix infant cereal to help reduce diarrhea during weaning.

关键词： Probiotics Citrobacter rodentium lactobacillus plantarum Inflammation Weanimix

lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis:A Randomized,Double-Blind,Placebo-Controlled,Pilot Clinical Trial

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Engineering 2021年第3期7卷 376-385页

作者： Yang Liu Xinjie Yu Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Long Qian Qun Wang Zhengqing Xue Qixiao Zhai Wei Chen State Key Laboratory of Food Science and Technology Jjiangnan UniversityWixi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China Hwa Chong Institution(College) Singapore 269734Singapore International Joint Research Laborutory for Probiotics Jiangnan University Wuxi 214122 China National Engineering Research Center for Functional Food Jjiangnan UniversityWuxdi 214122China Wiuxi Translational Medicine Research Center and Jiangsu Translatianal Medicine Research Institute Wuxi Branch Wixi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China The Tinghu People's Hospital Yancheng 224002China Beijing Advanced Innnovation Center for Food Nutrition and Human Health Beijing Technology and Rasiness Univesity(BTBU)Bejing 100048China

Irritable bowel syndrome with diarrhea(IBS-D)is chronic intestinal dysfunction with diarrhea and othercomplicated clinical symptoms,and it has a great impact on the daily life and mental state of *** studies have reported that ingestion of probiotics can significantly alleviate a variety of *** pupose of this study was to investigate the IBS-D-alleviating effects of a probiotic strain,lactobacillus plantarum(***)CCFM8610,with multiple health-promoting *** studywas a 12-week,randomized,double-blind,placebo-controlled,pilot clinical ***-five patientswere randomly assigned to receive the placebo,oligosaccharides,or *** CCFM8610(1×10^(10) colony-forming units(CFU)per day),with a 2-week run-in period,an 8-week intervention period,anda 2-week follow-up observation *** patients'clinical symptoms and quality of life were exam-ined by the IBS symptom severity scale(IBS-SsS)and the IlBS quality of life scale(IBS-QOL).Changes ingut microbiota composition and diversity were measured at the end of the intervention *** oraladministration of *** CCFM8610 significantly decreased the IBS-SSS and IBS-QOL scores,reduced IBS-D symptom severity,recovered gut microbiota diversity,decreased the relative abundanceof bloating-related genus Methanobrevibacter,and increased the relative abundance of butyric acid-producing genera,including Anaerostipes,Anaerotruncus,Bifidobacterium,Butyricimonas,*** findings suggest that ingestion of *** CCFM8610 can significantly alleviate clinical symptoms and gut microbiota dysbiosis in IBS-D *** IBS-D-alleviating effect of ***-tarum CCFM8610 may be related to theincrease in the relative abundance of butyric acid-producing genera in the intestine.

关键词： lactobacillus plantarum Irritable bowelsyndrome Gut microbiota Butyric acid Clinical trial

Potential role of lactobacillus plantarum in colitis induced by dextran sulfate sodium through altering gut microbiota and host metabolism in murine model

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Science China(Life Sciences) 2021年第11期64卷 1906-1916页

作者： Sujuan Ding Wenxin Yan Jun Fang Hongmei Jiang Gang Liu College of Bioscience and Biotechnology Hunan Agricultural UniversityHunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and PoultryChangsha 410128China

Inflammatory bowel disease(IBD) is a chronic lifelong disease characterized by inflammation of the gastrointestinal *** more and more treatment options serve IBD, there is still no cure. It is important to find an effective treatment for *** study aims to investigate whether lactobacillus plantarum(L. plantarum) could alleviate colitis induced by dextran sulfate sodium(DSS). Following the DSS challenge, L. plantarum on DSS-mediated inflammatory colon lesions in mice, and *** therapy heightened the relative abundance of the colon-resident Actinobacteria. Analysis of serum metabolomics also indicated that the content of MG(18:4(6 Z, 9 Z, 12 Z, 15 Z)/0:0/0:0) was increased in response to L. plantarum therapy, and this was also the case for indolepyruvate and 1-hydroxyibuprofen. However, 13-oxooctadecadienoic acid(13-oxo ODE) and indolylacryloylglycine content fell following the DSS challenge. Based on these results, the study elucidates the mitigatory effects of L. plantarum in colitis, which depend on its regulation of the colonic microbial community and its modification of serum metabolites. The results revealed that L. plantarum mitigated inflammatory colon lesions, reprogrammed the microbial community and altered the level of serum metabolites in a murine model challenged with DSS. The study may present a potential therapeutic strategy for colitis.

关键词： lactobacillus plantarum colitis DSS microbiota metabolism

Probiotic Paenibacillus polymyxa 10 and lactobacillus plantarum 16 enhance growth performance of broilers by improving the intestinal health

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Animal Nutrition 2021年第3期7卷 829-840页

作者： Baikui Wang Li Gong Yuanhao Zhou Li Tang Zihan Zeng Qi Wang Peng Zou Dongyou Yu Weifen Li Key Laboratory of Molecular Animal Nutrition of the Ministry of Education Key Laboratory of Animal Nutrition and Feed Science(Eastern of China)of the Ministry of AgricultureKey Laboratory of Animal Feed and Nutrition of Zhejiang ProvinceInstitute of Animal Nutrition and Feed SciencesCollege of Animal SciencesZhejiang University310058HangzhouChina Hainan Institute Zhejiang UniversitySanya 572000China

With the ever-growing strict prohibitions on antibiotic growth promoters(AGP)in animal production,in-feed probiotics are becoming attractive alternatives to antibiotics in the poultry *** investigate the effects of Paenibacillus polymyxa 10 and lactobacillus plantarum 16 on the growth performance and intestinal health of broilers,540 male Cobb 500 broilers of 1 d old were randomly divided into 3 groups with 6 replicates per group and 30 chicks per *** were fed with either a basal diet or basal diets supplemented with 1×108 colony-forming units(CFU)/kg *** 10(BSC10)or *** 16(Lac16)for 42 *** showed that Lac16 treatment improved(P0.05)the growth performance of the starter phase *** increased villus height(P<0.05)at d 14,21 and 42 and villus height to crypt depth ratio(P<0.05)at d 14 and 21 were observed in the ileum of the 2 probiotic ***,transmission electron microscopy results showed that the 2 probiotics enhanced the intestinal epithelial *** probiotic treatments up-regulated(P<0.05)the mRNA expression of fatty acid binding protein 1(FABP1)and sodium-dependent glucose transporters-1(SGLT-1)in the ileal mucosa of broilers at d *** addition,BSC10 and Lac16 treatments significantly(P<0.05)increased the relative abundance of short-chain fatty acids-producing bacteria,such as Butyricicoccus pullicaecorum,Faecalibacterium prausnitzii,Lachnospira and Cop-rococcu,and significantly(P<0.05)decreased the relative abundance of enteric pathogens(Escherichia coli,Bacteroides fragilis and Shigella sonnei).Furthermore,the 2 probiotic treatments also increased the positive connection among the intestinal microbes and the carbohydrate metabolism-related pathways of the intes-tinal bacteria(P<0.05),with decreasing(P<0.05)nucleotides biosynthesis-related pathways of the intesti

关键词： Paenibacillus polymyxa lactobacillus plantarum Growth performance Intestinal health Broiler

In vitro screening of probiotic properties of lactobacillus plantarum isolated from fermented milk product

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Food Quality and Safety 2020年第4期4卷 213-223页

作者： Soumitra Nath Jibalok Sikidar Monisha Roy Bibhas Deb Department of Biotechnology Gurucharan CollegeSilcharIndia Institutional Biotech Hub Gurucharan CollegeSilcharIndia

Objectives:The screening of traditional fermented products is essential for the assessment of safety,security,and further development of functional foods for the well-being of human *** aim of the present study was to isolate and identify bacteria from fermented raw milk samples that exhibit health benefits upon ***:In order to confirm the isolates as probiotics,several in vitro assays were conducted to assess the probiotic properties of isolated *** initial screening includes tolerance to acid,bile,pancreatin,and *** cell surface properties demonstrate their interaction with mucosal epithelium,which includes hydrophobicity and auto-aggregation *** assessment was done by performing haemolytic test and antibiotic susceptibility *** antagonistic activity of probiotic strain was further evaluated against some pathogenic ***:lactobacillus plantarum(***)isolated from fermented raw milk was preliminarily identified by biochemical tests and further confirmed using 16S rRNA *** isolate designated as *** strain GCC_19M1 demonstrated significant tolerance to low pH,0.3%bile,0.5%pancreatin,and 5%*** the presence of simulated gastric juice(at pH 3),the isolate exhibited a survival rate of 93.48-96.97%.Furthermore,the development of ecological niches in the human gut and their successful accumulation have been revealed by auto-aggregation and hydrophobicity *** of haemolytic activity ensures the non-virulent nature of the *** plantarum strain GCC_19M1 showed susceptibility towards gentamicin,tetracycline,kanamycin,meropenem,and ceftriaxone and exhibited an antagonistic effect on pathogenic ***:The obtained results conveyed that *** strain GCC_19M1 has strong probiotic potential,and its presence in the fermented raw milk products may serve as a potent functional probiotic food.

关键词： raw milk probiotic lactobacillus plantarum gastric juice auto-aggregation hydrophobicity