检索结果-南通市图书馆

kinetic resolution of 1,2-Diamines via Organocatalyzed Asymmetric Electrophilic Aminations of Anilines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第24期40卷 1674-1680页

作者： Jinglei Xie Zheng Guo Wei Liu Dekun Zhang Yu-Peng He Xiaoyu Yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Petrochemical Catalytic Science and Technology Liaoning Shihua UniversityFushunLiaoning 113001China Universityof Chinese Academy of Sciences Bejing 100049China State Key Laboratory of Fine Chemicals Ningbo Institute of Dalian University of TechnologyNingboZhejiang 315016China

An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,*** removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.

关键词： Asymmetric catalysis 1,2-Diamines kinetic resolution Chiral phosphoric acids Amination

kinetic resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第6期39卷 1606-1610页

作者： Baohua Cai Qingjing Yang Ling Meng Jun(Joelle)Wang Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong 518055China Department of Chemistry Hong Kong Baptist UniversityKowloonHong KongChina

A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via Rh-catalyzed asymmetric hydroarylation has been described for the first time.A variety of arylboronic acids coupled with 2-substituted 1,2-dihydroquinolines under mild reaction *** transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines as well as the recovered chiral 2-aryl-dihydroquinolines were obtained with high yields and excellent enantioselectivities(86%-99% ee,s factor up to 1057).

关键词： kinetic resolution Hydroarylation Tetrahydroquinoline Asymmetric catalysis Transition metal

kinetic resolution of Racemic 4-Substituted Chroman-2-ones Through Asymmetric Lactone Hydrogenation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第10期6卷 2560-2576页

作者： Xiong Wu Hai-Tao Yue Xiao-Dong Zuo Xiao-Hui Yang Pu-Cha Yan Jian-Hua Xie Qi-Lin Zhou State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryFrontiers Science Center for New Organic MatterNankai UniversityTianjin 300071 Zhejiang Jiuzhou Pharmaceutical Co. Ltd.TaizhouZhejiang 318000

Esters are abundant in natural and synthetic products and their conversion into primary alcohols holds great importance in fine chemical ***,achieving asymmetric hydrogenation(AH)of racemic esters with remote stereocenters via kinetic resolution(KR)remains a formidable challenge due to the difficulties associated with discerning spatially distant *** address this issue,we have designed a hydroxy-assisted strategy that introduces a hydroxy group into racemicβ-aryl esters to facilitate hydrogenation and enhance chiral discrimination through a lactone *** employing chiral Ir-SpiroPAP catalysts,we achieved exceptional AH of racemic 4-substituted chroman-2-ones,lactone form of ortho-hydroxylatedβ-aryl esters,via KR,resulting in impressive selectivity factor(s)values of up to *** approach exhibited significant efficacy for racemic chroman-2-ones containingβ-aryl,alkenyl,alkynyl,and alkyl groups,enabling the synthesis of chiralγ-aryl primary alcohols and the recovery of chiralβ-aryl esters or chroman-2-ones,typically difficult to access using existing *** scalability and broad synthetic applications of this method were exemplified by successfully synthesizing chiral drugs(R)-fesoterodine and enrasentan,alongside various chiral intermediates essential for producing chiral drugs and natural *** promising results highlight the potential of this approach as a powerful tool for synthesizing valuable chiral compounds.

关键词： asymmetric hydrogenation chiralγ-aryl primary alcohols hydrogenation of esters iridium catalysts kinetic resolution

Nickel-catalyzed kinetic resolution to achieve P-chiral phosphine oxides and sec-phosphine oxides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第9期66卷 2569-2575页

作者： Xi Zhang Shao-Qiu Wang Shang-Dong Yang State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Pharmaceutical Science Hangzhou Medical CollegeHangzhou 310012China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

P-Chiral phosphines and sec-phosphine oxides(SPO) are found in a diverse range of compounds that play crucial roles in various fields, including asymmetric catalysis, materials, agrochemistry, and pharmaceutical chemistry. Herein, we describe an enantioselective Ni-catalyzed kinetic resolution of racemic sec-phosphine oxides to obtain the corresponding optically pure Pchiral phosphine oxides and sec-phosphine oxides, respectively. These products are versatile chiral phosphine building blocks that can be used to construct an extensive range of P-chiral phosphines.

关键词： P-chiral phosphine oxide kinetic resolution Ni catalysis

同方期刊数据库

(Parallel) kinetic resolution of 3,3-disubstituted indolines via organocatalyzed reactions with azodicarboxylates

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第3期67卷 973-980页

作者： Qianwen Jiang Dekun Zhang Mengyao Tang Hua Liu Xiaoyu Yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

A novel kinetic resolution(KR) method has been developed for 3,3-disubstituted indolines, whose catalytic asymmetric synthesis remains a significant challenge in organic synthesis. The key to the success of this KR protocol lies in the utilization of chiral phosphoric acid-catalyzed triazane formation reaction with azodicarboxylates, which enables the enantioselective synthesis of various substituted indolines bearing C3-quaternary stereocenters with good to high enantioselectivities(with sfactors up to 70). Moreover, an intriguing parallel kinetic resolution(PKR) has been developed by combining triazane formation and dehydrogenation reactions using different azodicarboxylates. Experimental studies have provided insight into the mechanism of this PKR reaction, demonstrating stereoselectivity in both triazane formation and dehydrogenation steps, favoring the opposite enantiomers. The large-scale synthesis and diverse derivatizations of the products, particularly the imine groupcontaining 3H-indoles, demonstrate the value of these(P)KR methods.

关键词： asymmetric organocatalysis kinetic resolution 3 3-disubstituted indolines azodicarboxylate triazanes

A kinetic resolution accompanied chirality transformation process for asymmetric synthesis of chiral phenol,oxaziridine,andα-hydroxyl cyclic ketone

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第9期67卷 2989-2997页

作者： Pengxin Wang Xiaoyong Zhang Lingqing Wang Rui Wang Dongxu Yang Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of Sciences Great Bay UniversityDongguan 523000China Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518055China

Chirality transformation is a basic,attractive,and important strategy for obtaining enantioenriched products with desired chiral *** reported chirality conversion reaction often involves the process from one type of chirality to another *** better utilize the chirality transformation strategy for obtaining two or more products with different chiral elements in a single reaction,a new method of kinetic resolution accompanied by a chirality transformation protocol is proposed and successfully realized in this *** process is used for the asymmetric oxidation of phenol compounds along with the kinetic resolution of oxaziridines.A wide scope of products,including axially chiral phenols,oxaziridines,andα-hydroxyl cyclic ketones were smoothly obtained in high levels of yields and enantioselectivities in the developed *** products can be readily used for the synthesis of various types of chiral ligands,which are potential choices for other catalytic asymmetric reactions.

关键词： chirality transformation kinetic resolution accompanied axially chiral phenols chiral oxaziridines

Asymmetric synthesis of binaphthyls through photocatalytic crosscoupling and organocatalytic kinetic resolution

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2022年第6期65卷 1142-1148页

作者： Heng-Hui Li Jia-Yan Zhang Shaoyu Li Yong-Bin Wang Jun Kee Cheng Shao-Hua Xiang Bin Tan School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin150001China Shenzhen Grubbs Institute Department of Chemistry and Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen518055China

By capitalizing on the capability of photoredox catalysis to generate reactive radical intermediate under mild conditions, we established a photocatalytic cross-coupling protocol that could deliver both derivatives from 1-bromo-2-naphthols in combination with 2-naphthols or 2-naphthylamines. This distinct activation mode could overcome structural or electronic limitation associated with conventional coupling pathways. Additionally, a novel kinetic resolution protocol of unprotected BINOLs has been established with azodicarboxylates via chiral phosphoric acid(CPA) catalysis. Selectivity factor of up to 175 could be achieved and delivered to both enantiomers in atropisomerically enriched form after a simple work-up.

关键词： 1 1′-bi-2-naphthols 2-amino-2′-hydroxy-1 1′-binaphthyls chiral phosphoric acid kinetic resolution photocatalysis

同方期刊数据库

Atroposelective sp3 C—H Coupling for kinetic resolution of Thioanilide Atropisomers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第12期39卷 3269-3276页

作者： Hua-Jie Jiang Rui-Long Geng Jia-Hui Wei Liu-Zhu Gong Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry University of Science and Technology of ChinaHefeiAnhui 230026China Center for Excellence in Molecular Synthesis of CAS HefeiAnhui 230026China

A highly efficient kinetic resolution of racemic thioanilide atropisomers via C(sp^(3))-H arylation has been achieved by a hybrid palladium catalyst bearing an anionic chiral Co^(Ⅲ)-complex and a phosphoramidite ligand,leading to both enantioenriched atropisomeric arylation thioanilides(up to 99%ee)and N-Me atropisomeric thioanilides(up to 99%ee),*** remained enantioenriched substrates can be arylated again by using an achiral anionic ligand to give the enantiomer with the opposite configuration.

关键词： kinetic resolution C—H activation Atropisomerism Chiral Co^(Ⅲ)-complex Phosphoramidite

Rh-Catalyzed kinetic resolution-Based Enantioselective[4+2]-Cydoaddition-lsomerization of Allene-1,3-dienes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第3期39卷 559-565页

作者： Anni Qin Qian Zhang Hui Qian Yulin Han Shengming Ma Research Center for Molecular Recognition ond Synthesis Deportment of ChemistryFudan University220 Handan LuShanghai 200433China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling inShanghai 200032China

Main observation and conclusion The first example of Rh-catalyzed kinetic resolution of 1,3-disubstituted allene-1,3-dienes involving intramolecular[4+2]-cycloaddition has been *** by C=C isomerization,the reaction finally afforded aza-[4.3.0]bicyclic compounds with a very high en-antio-and *** mechanism has been unveiled by careful control *** synthetic potentials of highly enanti-oenriched bicyclic products have also been demonstrated.

关键词： Rhodium Cycloaddition kinetic resolution Allenes Isomerization