Rh-Catalyzed Kinetic Resolution-Based Enantioselective[4+2]-Cydoaddition-lsomerization of Allene-1,3-dienes

作     者：Anni Qin Qian Zhang Hui Qian Yulin Han Shengming Ma Anni Qin;Qian Zhang;Hui Qian;Yulin Han;Shengming Ma

作者机构：Research Center for Molecular Recognition ond SynthesisDeportment of ChemistryFudan University220 Handan LuShanghai 200433China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling inShanghai 200032China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第3期

页      面：559-565页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Founda-tion of China(Grant No.21690063 for S.Ma and Grant No.21801041 for H.Qian)is greatly appreciated.We thank Mr.Feng Jiang in this group for reproducing the results of(3aS 7aS E)-3h (3aS 7aS E)-3I and(3aR 7aR E)-3n presented in this study 

主　　题：Rhodium Cycloaddition Kinetic resolution Allenes Isomerization 

摘      要：Main observation and conclusion The first example of Rh-catalyzed kinetic resolution of 1,3-disubstituted allene-1,3-dienes involving intramolecular[4+2]-cycloaddition has been *** by C=C isomerization,the reaction finally afforded aza-[4.3.0]bicyclic compounds with a very high en-antio-and *** mechanism has been unveiled by careful control *** synthetic potentials of highly enanti-oenriched bicyclic products have also been demonstrated.