A kinetic resolution accompanied chirality transformation process for asymmetric synthesis of chiral phenol,oxaziridine,andα-hydroxyl cyclic ketone

作     者：Pengxin Wang Xiaoyong Zhang Lingqing Wang Rui Wang Dongxu Yang 

作者机构：Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of SciencesGreat Bay UniversityDongguan 523000China Institute of Systems and Physical BiologyShenzhen Bay LaboratoryShenzhen 518055China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第9期

页      面：2989-2997页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-074,2021-I2M-1-026,2021-I2M-3-001) the Fundamental Research Funds for the Central Universities(lzujbky-2022-ey11,lzujbky-2022-40) the Funds for Fundamental Research Creative Groups of Gansu Province(20JR5RA310) 

主　　题：chirality transformation kinetic resolution accompanied axially chiral phenols chiral oxaziridines 

摘      要：Chirality transformation is a basic,attractive,and important strategy for obtaining enantioenriched products with desired chiral *** reported chirality conversion reaction often involves the process from one type of chirality to another *** better utilize the chirality transformation strategy for obtaining two or more products with different chiral elements in a single reaction,a new method of kinetic resolution accompanied by a chirality transformation protocol is proposed and successfully realized in this *** process is used for the asymmetric oxidation of phenol compounds along with the kinetic resolution of oxaziridines.A wide scope of products,including axially chiral phenols,oxaziridines,andα-hydroxyl cyclic ketones were smoothly obtained in high levels of yields and enantioselectivities in the developed *** products can be readily used for the synthesis of various types of chiral ligands,which are potential choices for other catalytic asymmetric reactions.