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Reference gene panel for urinary exosome-based molecular diagnostics in patients with kidney disease

World Journal of Nephrology 2024年第3期13卷 62-72页

作者： Deendayal D Mishra Pramod K Maurya Swasti Tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

BACKGROUND kidney disease is a severe complication of diabetes that often leads to end-stage renal *** diagnosis is crucial for prevention or ***,the current diagnostic methods,with their limitations in detecting the disease in its early stages,underscore the urgency and importance of finding new *** encapsulated inside urinary exosomes(UEs)have potential as early biomarkers for kidney *** need for reference miRNAs for accurate interpretation currently limits their translational *** To identify consistently expressing reference miRNAs from UEs of controls and patients with type 2 diabetesmellitus(T2DM)and biopsy-confirmed kidney *** miRNA profiling was performed on UEs from 31 human urine samples using a rigorous and unbiased *** UEs were isolated from urine samples collected from healthy individuals(n=6),patients with T2DM(n=13),and T2DM patients who also had kidney diseases(including diabetic nephropathy,n=5;membranous nephropathy,n=5;and IgA nephropathy,n=2)through differential *** characterizing the UEs,miRNA expression profiling using microarray technology was *** Microarray data analysis identified 14 miRNAs that were consistently expressed in UEs from 31 human samples,representing various kidney conditions:diabetic controls,diabetic nephropathy,membrane nephropathy,IgA nephropathy,and healthy *** in silico analysis,we determined that 10 of these miRNAs had significant potential to serve as reference genes in *** We identified uniformly expressing UE miRNAs that could serve as reference genes kidney disease biomarkers.

关键词： miRNA Microarray Urinary exosomes Diabetic nephropathy Type 2 diabetes mellitus kidney disease

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Clinicopathological and immunological features of new onset kidney disease: a rare event after SARS-CoV-2 vaccination

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National Science Review 2023年第5期10卷 112-123页

作者： Yue-Miao Zhang Xing-Zi Liu Zhao Zhang Tai-Cheng Zhou Xin Zhang Hong-Yu Yang Meng Tan Nan Hu Su-Fang Shi Fang Wang Rong Xu Li-Jun Liu Su-Xia Wang Gang Liu Fu-De Zhou Ming-Hui Zhao Hong Zhang Ji-Cheng Lv Ya-Ping Zhang Zi-Jie Zhang Li Yang Renal Division Department of MedicinePeking University First Hospital Renal Pathology Center Institute of NephrologyPeking University Key Laboratory of Renal disease Ministry of Health of China Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Research Units of Diagnosis and Treatment of Immune-Mediated kidney diseases Chinese Academy of Medical Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of Sciences Central Laboratory and Liver disease Research Center The Affiliated Hospital of Yunnan University Laboratory of Electron Microscopy Pathological CentrePeking University First Hospital State Key Laboratory for Conservation and Utilization of Bio-Resource and School of Life Sciences Yunnan University

The onset of various kidney diseases has been reported after severe acute respiratory syndrome coronavirus2(SARS-CoV-2) ***,detailed clinical and pathological features are *** screened and analyzed patients with newly diagnosed kidney diseases after inactivated SARS-CoV-2 vaccination in Peking University First Hospital from January 2021 to August 2021,and compared them with the reported cases in the *** obtained samples of blood,urine and renal biopsy *** and laboratory information,as well as light microscopy,immunostaining and ultrastructural observations,were *** SARS-CoV-2 spike protein and nucle oprotein were stained using the immunofluorescence technique in the kidney biopsy ***-CoV-2 specific antibodies were tested using magnetic particle chemiluminescence *** study group included 17 patients with a range of conditions including immune-complex-mediated kidney diseases(IgA nephropathy,membranous nephropathy and lupus nephritis),podocytopathy(minimal change disease and focal segmental glomerulosclerosis) and others(antineutrophil-cytoplasmic-antibody-associated vasculitis,anti-glomerular basement membrane nephritis,acute tubulointerstitial nephritis and thrombotic micro angiopathy).Seven patients(41.18%)developed renal disease after the first dose and ten(58.82%) after the second *** kidney disease spectrum as well as clinicopathological features are similar across different types of SARS-CoV-2 *** found no definitive evidence of SARS-CoV-2 spike protein or nucleoprotein deposition in the kidney biopsy *** markers implicated abnormal immune responses in predisposed *** and follow-up(median=86 days) showed that biopsy diagnosis informed treatment and prognosis in all *** conclusion,we observed various kidney diseases following SARS-CoV-2 vaccine administration,which show a high consistency across different types of SARS-CoV-2 vaccin

关键词： kidney disease SARS-CoV-2 vaccination abnormal immune response

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Relationship between Renalase Expression and kidney disease： an Observational Study in 72 Patients Undergoing Renal Biopsy

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Current Medical Science 2018年第2期38卷 268-276页

作者： Yi-sha HUANG Jian-bo LAP Sheng-fa LI Ting WANG Ying-nan LIU Qing-xia ZHANG Shu-yuan ZHANG Chun-han SUN Nan HU Xin-zhou Zhang Department of Nephrology Shenzhen People 's Hospital Second Clinical Medical College of Jinan University Shenzhen 518000 China. Key Renal Laboratory of Shenzhen Shenzhen 518108 China. Department of Gastrointestinal Shenzhen People 's Hospital Second Clinical Medical College of Jinan University Shenzhen 518000 China. Department of Orthopedics Huizhou First Hospital Affiliated Hospital of Guangdong Medical University Huizhou 516000 China. Department of Cell Biology School of Basic Medical Science Southern Medical University Guangzhou 510515 China. Department of Hand Microsurgry Shenzhen People 's Hospital Second Clinical Medical College of Jinan University Shenzhen 518000 China.

The relationship between the levels of renalase and changes in proteinuria, hypertension, renal function, renal tubular epithelial cell apoptosis and B-cell lymphoma-2 （Bcl-2） expression was investigated in patients （chronic nephritis, primary nephrotic syndrome or other kidney disease） that underwent renal biopsy. The study group comprised 72 patients undergoing renal biopsy. Patient profiles and renal function were collected. Concentrations of renalase and Bcl-2 were measured by immunohistochemistry. Tubular injury was detected by periodic acid Schiff staining （PAS） and renal tubular epithelial cell apoptosis was assessed by TUNEL assay. The expression of renalase was significantly lower in renal biopsy specimens than in normal kidney tissues. There was a positive linear relationship between renalase and some serum and cardiac indices; a negative correlation was found between age, eGFR, Ccr and 24-h urinary protein. Renal tubule injury index and tubular epithelial cell apoptosis index showed a negative linear correlation with renalase. The results showed that renalase probably increased the expression of Bel-2. By two independent samples t-test, renalase levels were significantly increased in the non-hypertension group than in the hypertension group. One-way ANOVA showed that renalase expression was higher in samples with Lee＇s grade Ⅲ than in those with Lee＇s grade V. The expression of renalase was significantly decreased in patients who underwent renal biopsy, and was also associated with blood and renal function. The research proved that renalase may reduce renal tubular injury and apoptosis of renal tubular epithelial cells through the mitochondrial apoptosis pathway, finally achieving the purpose of delaying the progress of renal failure.

关键词： renalase kidney disease flavoprotein renal function renal puncture biopsy

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Rare co-occurrence of osteogenesis imperfecta type Ⅰ and autosomal dominant polycystic kidney disease

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世界儿科杂志:英文版 2016年第4期12卷 501-503页

作者： Julia Hoefele Karin Mayer Christoph Marschall Martin Alberer Hanns-Georg Klein Martin Kirschstein Center for Human Genetics and Laboratory Diagnostics Dr.Klein Dr.Rost and ColleaguesMartinsriedGermany Institute of Human Genetics Technische Universitat MünchenMunichGermany Department of Infectious diseases and Tropical Medicine Ludwig-Maximilians UniversityMunichGermany Department of Pediatrics General HospitalCelleGermany

Background:There are several clinical reports about the co-occurrence of autosomal dominant polycystic kidney disease(ADPKD)and connective tissue disorders.A simultaneous occurrence of osteogenesis imperfecta(OI)type I and ADPKD has not been observed so ***:This report presents the first patient with OI type I and ***:Mutational analysis of PKD1 and COL1A1 in the index patient revealed a heterozygous mutation in each of the two *** analysis of the parents indicated the mother as a carrier of the PKD1 mutation and the father as a carrier of the COL1A1 *** simultaneous occurrence of both disorders has an estimated frequency of 3.5:***:In singular cases,ADPKD can occur in combination with other rare disorders,*** tissue disorders.

关键词： kidney disease osteogenesis imperfecta polycystic kidney

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Diabetic kidney disease in pediatric patients: A current review

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World Journal of Diabetes 2022年第8期13卷 587-599页

作者： Carmen Muntean Iuliana Magdalena Starcea Claudia Banescu Department of Pediatrics I “George Emil Palade”University of MedicinePharmacySciences and Technology of Târgu MuresTârgu Mures 540142Romania Department of IVth Pediatrics University of Medicine and Pharmacy“Grigore T.Popa”Iasi 700115Romania Center for Advanced Medical and Pharmaceutical Research University of MedicinePharmacySciences and Technology of Târgu MureșMureșTârgu Mures 540142Romania

In the last decades,a significant increase in the incidence of diabetic kidney disease(DKD)was observed concomitant with rising diabetes mellitus(DM)*** disease associated with DM in children and adolescents is represented by persistent albuminuria,arterial hypertension,progressive decline in estimated glomerular filtration rate to end-stage renal disease and increased cardiovascular and all-cause morbidity and mortality of these *** medical practice,the common and still the“gold standard”marker for prediction and detection of diabetic kidney involvement in pediatric diabetes is represented by microalbuminuria screening even if it has low specificity to detect early stages of *** are some known limitations in albuminuria value as a predictor biomarker for DKD,as not all diabetic children with microalbuminuria or macroalbuminuria will develop end-stage renal *** tubular damage occurs before the glomerular injury,tubular biomarkers are superior to the glomerular ***,they may serve for early detection of DKD in both type 1 DM and type 2 *** and new biomarkers to identify diabetic children and adolescents at risk of renal complications at an early stage as well as renoprotective strategies are necessary to delay the progression of kidney disease to end-stage kidney *** biomarkers and therapeutic strategies are discussed as timely diagnosis and therapy are critical in the pediatric diabetic population.

关键词： Diabetes kidney disease Biomarkers Microalbuminuria Therapy Children

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Biochemical composition of the glomerular extracellular matrix in patients with diabetic kidney disease

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World Journal of Diabetes 2022年第7期13卷 498-520页

作者： María M Adeva-Andany Natalia Carneiro-Freire Nephrology Hospital Juan CardonaFerrol 15406Spain

In the glomeruli,mesangial cells produce mesangial matrix while podocytes wrap glomerular capillaries with cellular extensions named foot processes and tether the glomerular basement membrane(GBM).The turnover of the mature GBM and the ability of adult podocytes to repair injured GBM are *** actin cytoskeleton is a major cytoplasmic component of podocyte foot processes and links the cell to the *** components of the normal glomerular extracellular matrix(ECM)include glycosaminoglycans,proteoglycans,laminins,fibronectin-1,and several types of *** patients with diabetes,multiorgan composition of extracellular tissues is anomalous,including the kidney,so that the constitution and arrangement of glomerular ECM is profoundly *** patients with diabetic kidney disease(DKD),the global quantity of glomerular ECM is *** level of sulfated proteoglycans is reduced while hyaluronic acid is augmented,compared to control *** concentration of mesangial fibronectin-1 varies depending on the stage of *** type III collagen is abundant in patients with DKD,unlike normal *** amount of type V and type VI collagens is higher in DKD and increases with the progression of the *** GBM contains lower amount of type IV collagen in DKD compared to normal ***,genetic variants in theα3 chain of type IV collagen may modulate susceptibility to DKD and end-stage kidney *** cellular models of glomerular cells,analyses of human glomerular proteome,and improved microscopy procedures have been developed to investigate the molecular composition and organization of the human glomerular ECM.

关键词： Diabetes kidney disease Glycosaminoglycans Factor H Sialic acid Laminin Collagen Fibronectin-1 Extracellular matrix

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kidney disease in China： recent progress and prospects

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Chinese Medical Journal 2009年第17期122卷 2048-2053页

作者： YU Xue-qing WEI Jia-li Department of Nephrology First Affiliated Hospital of Sun Yat-senUniversity Guangzhou Guangdong 510080 China

kidney disease is a worldwide public health *** prevalence of end-stage renal disease （ESRD）, a final outcome of kidney disease, has increased progressively in the past decades and has emerged as a great burden to the healthcare system in China. Glomerulonephritis is still the most common cause of ESRD in China. However, the prevalence of diabetes and hypertension are increasing dramatically. There are modifiable risk factors for the development of progressive renal dysfunction. The challenge is to identify the disease and deliver effective therapies at the right time with the right tools. In the last two years,

关键词： kidney disease progress China

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Applying Customized Convolutional Neural Network to kidney Image Volumes for kidney disease Detection

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Computer Systems Science & Engineering 2023年第11期47卷 2119-2134页

作者： Ali Altalbe Abdul Rehman Javed Department of Computer Science Prince Sattam Bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia Faculty of Computing and Information Technology King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Electrical and Computer Engineering Lebanese American UniversityByblosLebanon

kidney infection is a severe medical issue affecting individuals worldwide and increasing mortality *** kidney disease(CKD)is treatable during its initial phases but can become irreversible and cause renal *** the various diseases,the most prevalent kidney conditions affecting kidney function are cyst growth,kidney tumors,and *** significant challenge for the medical community is the immediate diagnosis and treatment of kidney *** failure could result from kidney disorders like tumors,stones,and cysts if not often identified and ***-assisted diagnostics are necessary to support clinicians’and specialists’medical assessments due to the rising prevalence of chronic renal illness,the lack of experts,and the rising rates of assessment and monitoring,mainly in developing *** Intelligence(AI)approaches such as machine,and deep learning has been used in literature for kidney disease detection;however,they still lack *** paper implements a deep learning-based Convolutional Neural Network(CNN)model for the classification and prognosis of kidney *** use a benchmark Computed Tomography(CT)kidney dataset for *** data is pre-processed,and then CNN extracts the features from the *** reveal that the proposed approach accurately classifies kidney disease with a considerable accuracy of 0.992%,0.994%precision,0.982%recall,and 0.987%*** study suggests using the proposed fine-tuned CNN model for kidney disease detection.

关键词： kidney disease convolutional neural network computed tomography feature extraction deep learning machine learning

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Prevalence of risk factors for cardiovascular and kidney disease in Brazilian healthy preschool children

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World Journal of Nephrology 2016年第6期5卷 507-516页

作者： Adriana Candida da Silva Marcelo de Sousa Tavares Maria Goretti Moreira Guimaraes Penido Post-graduation Program-Master in Health Sciences Child and Adolescent HealthSchool of MedicineFederal University of Minas GeraisSanta EfigeniaBelo HorizonteCEP 30130-100Minas GeraisBrazil Pediatric Nephrology Unit School of MedicineFederal University of Minas GeraisBelo HorizonteCEP 30130-100Minas GeraisBrazil Pediatric Nephrology Unit Center of NephrologySanta Casa de Belo Horizonte HospitalBelo HorizonteCEP 30150-320Minas GeraisBrazil

AIM To investigate the prevalence of nutritional parameters of risk for cardiovascular disease(CVD) and kidney diseases in healthy preschool *** This is an observational cross-sectional study with 60 healthy children, of both genders, aged two to six years old and 56 mothers, in Belo Horizonte, Minas Gerais, Brazil. Preschool children and their families with regular activities at public schools were invited to paticipate in the study. The following characteristics were assessed: Socio-demographic condictions, clinical health, anthropometric, biochemical, lifestyle and data on food consumption. The 56 healthy children were divided into two groups, overweight(C1) and non-overweight(C2), as well as their mothers, respectively, in overweight(M1) and non-overweight(M2). Nutritional status was defined according to results obtained through the Anthro? Software for nutritional analysis. RESULTS Thirty-five children were male, with mean age of 4.44 ± 1.0 years old. Eighty-nine percent of them were eutrophic, 86.7% were sedentary and they had five meals a day. Body mass index(BMI) for age and total cholesterol(TC) was higher on C1(P = 0.0001) and high density lipoprotein cholesterol(HDL-c) was higher on C2. Mothers were 32.5 ± 7.1 years old, mostly married and employed. Eighty-six percent of them were sedentary and 62.5% were overweight with BMI = 26.38 ± 5.07 kg/m2. Eighteen percent of the overweight mothers had isolated total hypercholesterolemia(TC levels elevated) and 12.5% had low HDL-c levels. The present study showed an association between overweight and obesity during the preschool years and the correspondent mothers' nutritional status of overweight and obesity(OR = 4.96; 95%CI: 0.558-44.17). There was a positive correlation between the food risk associated with CVD by children and mothers when their consumption was 4 times/wk(P = 0.049; r = 0.516) or daily(P = 0.000008; r = 0.892).CONCLUSION Analyzed children showed high rates of physical inactivity, hi

关键词： Cardiovascular disease kidney disease Preschool children Food habits Lifestyle

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Liposoluble vitamins A and E in kidney disease

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World Journal of Nephrology 2022年第3期11卷 96-104页

作者： Maria Helena Rojo-Trejo Ma Ludivina Robles-Osorio Ernesto Sabath Nutrition School Universidad Autónoma de QuerétaroQuerétaro 76910Mexico Department of Renal Medicine Nutrition SchoolUniversidad Autónoma de QuerétaroQuerétaro 76090Mexico

kidney disease(KD)is characterized by the presence of elevated oxidative stress,and this is postulated as contributing to the high cardiovascular morbidity and mortality in these *** KD(CKD)is related to high grade inflammatory condition and pro-oxidative state that aggravates the progression of the disease by damaging primary *** vitamins(vitamin A and E)are potent dietary antioxidants that have also anti-inflammatory and antiapoptotic *** deficits in CKD patients are a common issue,and multiple causes are related to them:Anorexia,dietary restrictions,food cooking methods,dialysis losses,gastrointestinal malabsorption,*** potential benefit of retinoic acid(RA)and α-tocopherol have been described in animal models and in some human clinical *** review provides an overview of RA andαtocopherol in KD.

关键词： Retinoic acid α-Tocopherol Oxidative stress kidney disease Podocyte Cardiovascular disease

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