检索结果-南通市图书馆

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in Ischemic diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang Zhao Shuang Zhao Xueting Yu Runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang Guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin Zhao Zhaoyang Chen Wenbin Zhang Junjie Guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun Zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological angiogenesis.Here,we investigated the occurrence of partial EndMT in ECs under hypoxic/Ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this process.In addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial EndMT.Furthermore,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial EndMT.In vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after Ischemic injury.Collectively,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/Ischemic diseases.

关键词： Ischemic activation GTF

Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in Ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第11期18卷 2383-2384页

作者： Pengyu Zong Cindy X.Li Jianlin Feng Lixia Yue Department of Cell Biology Calhoun Cardiology CenterUConn HealthFarmingtonCTUSA

Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for Ischemic stroke in a small population of eligible patients.However,there is no effective adjunct medication for preventing neuron loss after reperfusion to mitigate longlasting brain injury.Extrasynaptic N-methyl-Daspartate receptors (esNMDARs) are the major cause of Ischemic neuronal death.However,there is no inhibitor selectively ta rgeting esNMDARs without compromising the function of other"beneficial"syna ptic NMDARs.

关键词： aspartate Ischemic medication

δ-Opioid receptor as a potential therapeutic target for Ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第1期15卷 20-24页

作者： Kalpana Subedi Hongmin Wang Division of Basic Biomedical Sciences and Center for Brain and Behavior Research Sanford School of Medicine University of South Dakota

Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for treatment.In this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating Ischemic stroke-caused neuronal injury.Moreover,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on Ischemic stroke caused dementia or Alzheimer’s disease are also discussed.

关键词： agonist AKT amyloid precursor protein BDNF Ischemic stroke neuroprotection δ-opioid receptor p38 MAPK PI3K TrkB

An overview of Ischemic preconditioning in exercise performance:A systematic review

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2019年第4期8卷 355-369页

作者： Maxime Caru Ariane Levesque Francois Lalonde Daniel Cumier Laboratory of Pathophysiology of EXercise(LPEX) School of Kinesiology and Physical Activity SciencesFaculty of MedicineUniversity of MontrealMontrealQuebec H3T1J4Canada Department of Psychology University of Paris-NanterreNanterre 92000France Laboratoire EA 4430-Clinique Psychanalyse Developpement(CliPsyD) University of Paris-NanterreNanterre 92000France CHUSte-Justine Research Center CHUSte-JustineMontreal H3T1C5Canada Department of Psychology McGill UniversityMontrealQuebec H3A 1G1Canada Department of Physical Activity Sciences Faculty of SciencesUniversite du Quebec a MontrealMontrealQuebec H2L 2C4Canada

Ischemic preconditioning(IPC)is an attractive method for athletes owing to its potential to enhance exercise performance.However,the effectiveness of the IPC intervention in the field of sports science remains mitigated.The number of cycles of ischemia and reperfusion,as well as the duration of the cycle,varies from one study to another;Thus,the aim of this systematic review was to provide a comprehensive review examining the IPC literature in sports science.A systematic literature search was performed in PubMed(MEDLINE)(from 1946 to May 2018),Web of Science(sport sciences)(from 1945 to May 2018),and EMBASE(from 1974 to May 2018).We included all studies investigating the effects of IPC on exercise performance in human subjects.To assess scientific evidence for each study,this review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The electronic database search generated 441 potential articles that were screened for eligibility.A total of 52 studies were identified as eligible and valid for this systematic review.The studies included were of high quality,with 48 of the 52 studies having a ran?domized,controlled trial design.Most studied showed that IPC intervention can be beneficial to exercise performance.However,IPC intervention seems to be more beneficial to healthy subjects who wish to enhance their performance in aerobic exercises than athletes.Thus,this systematic review highlights that a better knowledge of the mechanisms generated by the IPC intervention would make it possible to optimize the protocols according to the characteristics of the subjects with the aim of suggesting to the subjects the best possible experience of IPC intervention.

关键词： Exercise Human performance IPC protocols Ischemic preconditioning Sports science

Association of G-protein coupled purinergic receptor P2Y2 with Ischemic stroke in a Han Chinese population of North China

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第3期14卷 506-512页

作者： Li-Ying Yuan Zhi-Yi He Lei Li Yan-Zhe Wang Department of Neurology First Affiliated Hospital of China Medical University

The G-protein-coupled purinergic receptor P2Y2(P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to Ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and Ischemic stroke risk in the northern Han Chinese population. In this study, clinical data and peripheral blood specimens were collected from 378 Ischemic stroke patients and 344 controls. The Ischemic stroke participants were recruited from the First Affiliated Hospital of China Medical University and the First Affiliated Hospital of Liaoning Medical University. The controls were recruited from the Health Check Center at the First Affiliated Hospital of China Medical University. Ischemic stroke patients were divided into two subgroups according to the Trial of ORG 10172 in Acute Stroke Treatment(TOAST) classification: large-artery atherosclerosis(n = 178) and small-artery occlusion(n = 200) strokes. All subjects were genotyped for three single nucleotide polymorphisms(rs4944831, rs1783596, and rs4944832) in the P2RY2 gene using peripheral venous blood samples. The distribution of the dominant rs4944832 phenotype(GG vs. GA+AA) differed significantly between small-artery occlusion patients and control subjects(odds ratio(OR) = 1.720, 95% confidence interval(CI): 1.203–2.458, P Ischemic stroke patients and controls(P Ischemic stroke patients, the frequency of the G-C-G haplotype was significantly higher than in control subjects(P = 0.028), whereas the frequency of the T-C-A haplotype was lower than in control subjects(P = 0.047). These results indicate that the G-C-G haplotype of P2RY2 is a susceptib

关键词： nerve regeneration P2RY2 gene Ischemic stroke single nucleotide polymorphism case-control study haplotype northern Han Chinese population large-artery atherosclerosis small-artery occlusion hypertension candidate gene neural regeneration

The efficacy and safety of nimodipine in acute Ischemic stroke patients with mild cognitive impairment: a double-blind, randomized,placebo-controlled trial

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2019年第2期64卷 101-107页

作者： Huaguang Zheng Yilong Wang Anxin Wang Hao Li David Wang Xingquan Zhao Penglian Wang Haipeng Shen Lijun Zuo Yuesong Pan Zixiao Li Xia Meng Xianwei Wang Weixiong Shi Yi Ju Liping Liu Kehui Dong Chunxue Wang Rubo Sui Rong Xue Xiaoping Pan Xiaoyua Niu Benyan Luo Yi Sui Huali Wang Tao Feng Yongjun Wang Beijing Tiantan Hospital Capital Medical University China National Clinical Research Center for Neurological Diseases OSF Saint Francis Medical Center Peoria Faculty of Business and Economics University of Hong Kong The First Hospital Liao Ning Medical College The General Hospital Tianjin Medical University Guangzhou First People’s Hospital School of Medicine South China University of Technology The First Hospital of Shanxi Medical University The First Hospital Zhejiang Medical University Shenyang First People’s Hospital Shenyang Medical College Dementia Care & Research Center Peking University Institute of Mental Health

Nimodipine might be effective in subcortical vascular dementia(VaD). Its benefit in preventing further cognitive decline in patients with acute Ischemic stroke(AIS) and vascular mild cognitive impairment(VaMCI) remains to be established. In this multicenter, double-blind trial, we randomly assigned 654 eligible patients to nimodipine 30 mg three times a day or placebo. The primary outcome was any cognitive decline defined by the changes on the Mini-Mental State Examination(DMMSE à3) or vascular AD assessment scale cognitive subscale(DADAS-cog ! 4) at 6 months. Secondary outcomes included any distribution shift of DADAS-cog, DMMSE or cognitive improvement defined by DADAS-cog à2, or DMMSE ! 0. The primary outcome in the nimodipine group and placebo group were similar for DMMSE à3(4.18% and 7.22%, respectively, P = 0.15) and DADAS-cog ! 4(8.36% and 8.93% respectively,P = 0.88). The distribution shift of DADAS-cog and DMMSE differed significantly between the two groups(P = 0.03 and P = 0.05 respectively). Cognitive improvement occurred in 55.4% in the nimodipine group and 43.6% in the placebo group measured by DADAS-cog à2(Odds Ratio, 1.54; 95% confidence interval[CI] 1.10–2.14, P < 0.01) or 84.0% and 74.6% respectively by DMMSE ! 0(Odds Ratio, 1.79; 95% CI 1.18–2.70, P < 0.01). Nimodipine was associated with better cognitive function in the memory domain. The adverse events rate was similar in two groups. This study is registered with ClinicalTrials.gov,NCT01220622. Nimodipine did not show benefit to prevent cognitive decline in AIS patients with VaMCI, but improved cognition moderately, especially measured in the memory domain.

关键词： Nimodipine Acute Ischemic stroke Mild cognitive impairment Cognitive decline Prevention

Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of Ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第3期15卷 416-424页

作者： Bei Zhang Kathryn ESaatman Lei Chen College of Public Health Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of PhysiologyUniversity of KentuckyKYUSA

Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmaceuticals for stroke treatment.Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of Ischemic stroke,and highlight potential mechanisms underlying their therapeutic effects.It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways,thereby attenuating multiple aspects of Ischemic pathology.We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.

关键词： cell death herbal compound immune response Ischemic stroke therapy neuroplasticity neuroprotection oxidative damage traditional Chinese medicine

Association between PPARG genetic polymorphisms and Ischemic stroke risk in a northern Chinese Han population: a case-control study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第11期14卷 1986-1993页

作者： Yan-Zhe Wang He-Yu Zhang Fang Liu Lei Li Shu-Min Deng Zhi-Yi He Department of Neurology the First Hospital of China Medical University

Two common polymorphisms of the peroxisome proliferator-activated receptor gamma(PPARG) gene, rs1801282 and rs3856806, may be important candidate gene loci affecting the susceptibility to Ischemic stroke. This case-control study sought to identify the relationship between these two single-nucleotide polymorphisms and Ischemic stroke risk in a northern Chinese Han population. A total of 910 Ischemic stroke participants were recruited from the First Hospital of China Medical University, Shenyang, China as a case group, of whom 895 completed the study. The 883 healthy controls were recruited from the Health Check Center of the First Hospital of China Medical University, Shenyang, China. All participants or family members provided informed consent. The study protocol was approved by the Ethics Committee of the First Hospital of China Medical University, China on February 20, 2012(approval No. 2012-38-1). The protocol was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR-COC-17013559). Plasma genomic DNA was extracted from all participants and analyzed for rs1801282 and rs3856806 single nucleotide polymorphisms using a SNaPshot Multiplex sequencing assay. Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated using unconditional logistic regression to estimate the association between Ischemic stroke and a particular genotype. Results demonstrated that the G allele frequency of the PPARG gene rs1801282 locus was significantly higher in the case group than in the control group(P Ischemic stroke(OR = 1.844, 95% CI: 1.286–2.645, P Ischemic stroke(OR = 1.366, 95% CI: 1.077–1.733, P = 0.010). The distribution frequencies of the PPARG gene haplotypes rs1801282-rs3856806 in the control and case groups were determined. The frequency of distribution in the G-T haplotype case group was significantly higher than that in the

关键词： nerve regeneration stroke cerebral ischemia Ischemic stroke peroxisome proliferator-activated receptor γ single-nucleotide polymorphism haplotype analysis interaction case-control study Chinese Han population neural regeneration

Differences in brain-derived neurotrophic factor gene polymorphisms between acute Ischemic stroke patients and healthy controls in the Han population of southwest China

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第8期14卷 1404-1411页

作者： Jie Zhou Meng-Meng Ma Jing-Huan Fang Lei Zhao Mu-Ke Zhou Jian Guo Li He Department of Neurology West China Hospital Sichuan University

Single-nucleotide polymorphisms in the brain-derived neurotrophic factor gene may affect the secretion and function of brain-derived neurotrophic factor, thereby affecting the occurrence, severity and prognosis of Ischemic stroke. This case-control study included 778 patients (475 males and 303 females, mean age of 64.0 ± 12.6 years) in the acute phase of Ischemic stroke and 865 control subjects (438 males and 427 females, mean age of 51.7 ± 14.7 years) from the Department of Neurology, Wes: China Hospital, Sichuan University, China between September 2011 and December 2014. The patients' severities of neurological defici:s in the acute phase were assessed using the National Institutes of Health Stroke Scale immediately after admission to hospital. The Ischemic stroke patients were divided into different subtypes according to the Trial of Org 10172 in Acute Stroke Treatment classification. Early prognosis was evaluated using the Modified Rankin Scale when the patients were discharged. Genomic DNA was extracted from peripheral blood of participants. Genotyping of rs7124442 and rs6265 was performed using Kompetitive Allele Specific polymerase chain reaction genotyping technology. Our results demonstrated that patients who carried the C allele of the rs7124442 locus had a lower risk of poor prognosis than the T allele carriers (odds ratio [OR]= 0.67;95% confidence interval [CI]: 0.45-1.00;P = 0.048). The patients with the CC or TC genotype also exhibited lower risk than TT carriers (OR = 0.65;95% CI: 0.42-1.00;P = 0.049). The AA genotype at the rs6265 locus was associated with the occurrence of Ischemic stroke in patients with large-artery atherosclerosis (OR = 0.5& 95% CI: 0.37-0.90;P = 0.015). We found that the C allele (CC and TC genotypes) at the rs7124442 locus may be protective for the prognosis of Ischemic stroke. The AA genotype at the rs6265 locus is likely a protective factor against the occurrence of Ischemic stroke in patients with large-artery atherosclerosis. The study protocol was approved by the Ethic

关键词： nerve regeneration Ischemic stroke brain-derived neurotrophic factor single-nucleotide polymorphism risk stroke severity prognosis rs6265 rs7124442 neural regeneration