δ-Opioid receptor as a potential therapeutic target for ischemic stroke

作     者：Kalpana Subedi Hongmin Wang Kalpana Subedi;Hongmin Wang

作者机构：Division of Basic Biomedical Sciences and Center for Brain and Behavior Research Sanford School of Medicine University of South Dakota 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第1期

页      面：20-24页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Institute of Neurological Disorders and Stroke under research grant NS088084(to HW) 

主　　题：agonist AKT amyloid precursor protein BDNF ischemic stroke neuroprotection δ-opioid receptor p38 MAPK PI3K TrkB 

摘      要：Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood vessels.Despite having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for treatment.In this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury.Moreover,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed.