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intracranial infection accompanied sweet’s syndrome in a patient with anti-interferon-γautoantibodies:A case report

World Journal of Clinical Cases 2023年第32期11卷 7926-7934页

作者： Jun-Hui Zheng Dan Wu Xiao-Yun Guo General Internal Medicine Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Intensive Care Unit Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Several reports of adult-onset immunodeficiency syndrome have been associated with anti-interferon-gamma(IFN-γ)autoantibodies(AIGAs).However,it is rare to find AIGAs with intracranial *** SUMMARY In this case study,we report a case of an AIGAs with intracranial infection and hand rashes considered Sweet’s *** patient presented to our hospital with a persistent cough,a fever that had been going on for 6 mo,and a rash that had been going on for a *** patient started losing consciousness gradually on the fourth day after admission,with neck stiffness and weakened limb *** upper lobe of the left lung had a high-density mass with no atypia and a few inflammatory cells in the *** magnetic resonance imaging and cerebrospinal fluid suggest intracranial *** pathology of the skin damage on the right upper extremity revealed an infectious lesion that was susceptible to Sweet’s *** has an anti-IFN-γautoantibody titer of 1:*** was given empirical anti-non-tuberculous mycobacterial and antifungal *** patient had no fever,obvious cough,headache,or rash on the *** got out of bed and took care of herself following hospitalization and discharge with *** Adults with severe and recurrent infections of several organs should be considered for AIGAs if no other known risk factors *** are susceptible to subsequent intracranial infections and Sweet’s syndrome.

关键词： Adult-onset immunodeficiency syndrome Anti-interferon-gamma autoantibodies intracranial infection Sweet disease Case report

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Long-term control of melanoma brain metastases with co-occurring intracranial infection and involuntary drug reduction during COVID- 19 pandemic: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2373-2379页

作者： Yang Wang Bin Lian Chuan-Liang Cui Department of Renal Cancer and Melanoma Peking University Cancer Hospital&InstituteBeijing 100142China

BACKGROUND Melanoma brain metastasis is a common cause of death in melanoma patients andis associated with a poor prognosis. There are relatively few reports onintracranial infections after brain metastasis *** SUMMARY Here we report a case of melanoma brain metastases in a patient harboring aBRAF V600E mutation, who experienced intracranial tumor progression despiteprevious combined treatment with a programmed death (PD)-1 inhibitor, axitinib,and vemurafenib. She repeatedly underwent local therapy, including stereotacticradiosurgery and intracranial surgery, and developed central nervous systeminfection. Treatment with vemurafenib combined with cobimetinib resulted in anintracranial progression-free survival of 10 mo. During the coronavirus disease2019 (COVID-19) pandemic, the patient did not visit the hospital for regularvemurafenib treatment, and experienced intracranial progression afterinvoluntary drug reduction for 1 mo. The patient subsequently received varioussystemic treatments including vemurafenib, PD-1 inhibitor, and chemotherapy,with an overall survival of 29 mo as of September *** We report the first case of melanoma brain metastases with co-occurringintracranial infection and unintended drug reduction during the COVID-19outbreak. Long-term control of the intracranial lesions was achieved withsystemic and local therapies.

关键词： Melanoma intracranial infection Brain metastases COVID-19 Local therapy Case report

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Successful treatment of invasive liver abscess syndrome caused by Klebsiella variicola with intracranial infection and septic shock:A case report

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2938-2944页

作者： Pin-Jie Zhang Zhong-Hua Lu Li-Jun Cao Hu Chen Yun Sun The First Department of Critical Care Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina

BACKGROUND Klebsiella variicola(***)is a member of the Klebsiella genus and is often misidentied as Klebsiella *** this report,we present a rare case of invasive liver abscess caused by *** SUMMARY We report a rare case of liver abscess due to ***.A 57-year-old female patient presented with back pain for a *** developed a high-grade fever associated with chills,and went into a coma and developed *** clinical examinations and tests after admission confirmed a diagnosis of primary liver abscess caused by *** complicated by intracranial infection and septic *** patient successfully recovered following early percutaneous drainage of the abscess,prompt appropriate antibiotic administration,and timely open surgical *** This is a case of successful treatment of invasive liver abscess syndrome caused by ***,which has rarely been *** findings of this report point to the need for further study of this disease.

关键词： Klebsiella variicola Invasive liver abscess syndrome intracranial infection Case report

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Prevention of postoperative intracranial infection in patients with cerebrospinal fluid rhinorrhea

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Chinese Medical Journal 2011年第24期124卷 4189-4192页

作者： YANG Zhi-jun ZHONG Hong-liang WANG Zhen-min ZHAO Fu LIU Pi-nan Department of Neurosurgery Beijing Tiantan Hospital CapitalMedical University Beijing 100050 China Beiji-ng Neurosurgical Institution of Capital Medical University Beijing 100050 China

Background intracranial infection is a common postoperative complication of neurosurgery. This study aimed to identify risk factors of postoperative intracranial infection in patients with cerebrospinal fluid rhinorrhea and to suggest proposals for the prevention. Methods A total of 167 patients （113 males and 54 males, average age of 34.4 years） with cerebrospinal fluid rhinorrhea operated on by the senior author were retrospectively reviewed. The data collected included etiology, previous history, clinical manifestation, site of bone defect, operative approach, and postoperative complications. Risk factor（s） for postoperative infection were analyzed using the stepwise multiple Logistic regression. Results Eighteen （10.8%） patients were infected post-operatively. The independent risk factors for infection were the site of defect （RR=0.508, 95% Cl 0.306-0.843, P=0.009） and historical meningitis （RR=0.290, 95% Cl 0.094-0.893, P=0.031）. Patients with multiple defects and saddle floor defects had a higher infection rate. The germiculture was positive in 11 patients, and vancomycin was sensitive to all the pathogenesis. Nine infected patients needed lumbar drainage. Ten patients had hyponatremia, and hydrocephalus occurred in two patients with serious trauma. Conclusions To prevent the infection, we should pay closer attention to the high-risk patients pre-operation. During the operation, the methods those can improve wound healing, such as using blood-supply materials, reliable fixation, and eliminating dead space are all helpful. Conducting lumbar drainage and choosing effective prophylactic antibiotics in the early postoperative stage for the high-risk patients are methods of postoperative management.

关键词： cerebrospinal fluid rhinorrhea prevention postoperative intracranial infection

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Clinical Analysis of Lumbar Pool Drainage Combined with Antibiotics in the Treatment of intracranial infection

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Journal of Biosciences and Medicines 2022年第11期10卷 64-68页

作者： Liangzhen Shi Shijie Chen The First Affiliated Hospital of Yangtze University Jingzhou China

Objective: To explore the clinical effect of lumbar pool drainage combined with antibiotics in the treatment of patients with intracranial infections, and to provide a reference basis for clinical treatment. Methods: To collect and select patients admitted to the First People’s Hospital of Jingzhou City for craniotomy from January 2016 to June 2022, the infected were 20 cases, and continuous drainage of the lumbar pool was used under the premise of systemic application of sensitive antibiotics. Results: Twenty cases in this group were discharged cured. Conclusion: Lumbar pool placement drainage combined with systemic application of antibiotics for intracranial infection is a safe and effective treatment method.

关键词： Cranial Surgery intracranial infection Continuous External Lumbar Pool Drainage Intrathecal Injection

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Monitoring and analysis of prevention and treatment of intracranial infection during perioperative period of endoscopic transsphenoidal surgery

Monitoring and analysis of prevention and treatment of intra...

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第十五届中国医师协会神经外科医师年会

作者： Xiaofeng Wang Lijun Heng Weinan Central Hospital Tangdu Hospital Air Force Medical University

Objective:to summarize and analyze the prevention and control methods of intracranial infection in perioperative period of endoscopic transsphenoidal surgery,especially through the diagnosis and treatment of intracranial infection cases,and summarize how to better avoid,diagnose,treat and monitor intracranial *** the same time,attention should be paid to the evaluation of infection monitoring indicators of intracranial infection and related ***:the cases of intracranial infection after transsphenoidal surgery in Tangdu Hospital during 2018 were analyzed,and the prevention and control methods of infection before,during and after operation were summarized and *** the same time,its effectiveness was evaluated and ***:the incidence of intracranial infection after transsphenoidal surgery was basically consistent with that reported in the *** the same time,it was analyzed that intracranial infection was easy to occur under the conditions of long operation time,improper cleaning of nasal hair before operation,more bleeding in China and intracranial gas accumulation after *** and treatment of lumbar cistern drainage tube is not recommended after infection,but it is suggested that lumbar puncture and cerebrospinal fluid release should be performed daily and routine,biochemical and culture should be carried *** the same time,attention should be paid to the monitoring of blood routine and blood glucose at the same time,and the therapeutic effect of anti-infection should be monitored and *** the same time,antibiotics were treated according to the results of drug sensitivity ***:continuous monitoring of blood routine,white blood cells and neutrophils should be paid attention to in patients with postoperative hyperthermia,lumbar puncture test should be performed in time,cerebrospinal fluid should be cultured and diagnosed clearly,and broad-spectrum antibiotics should be used empirically

关键词： transsphenoidal surgery intracranial infection prevention and treatment strategy

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Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

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Military Medical Research 2020年第4期7卷 497-502页

作者： Li Zhong Xue-Zhi Shi Lei Su Zhi-Feng Liu Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510515China Department of Critical Care Medicine the First Affiliated Hospital of Guizhou University of Chinese MedicineGuiyang 550001China Department of Critical Care Medicine General Hospital of Southern Theater Command of PLAGuangzhou 510010China Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA General Hospital of Southern Theater Command of PLAGuangzhou 510010China

Background:intracranial infection after craniotomy is one of the most serious postoperative complications,especially multidrug-resistant(MDR)or extensively drug-resistant(XDR)bacterial meningitis,and strongly affects the prognosis of *** treatment experience regarding these infections is *** presentation:We report a case of severe intracranial infection of XDR Acinetobacter baumannii(***)that was treated by intravenous(IV)injection,sequential intraventricular(IVT)injection of tigecycline and polymyxin B,and other anti-infective *** results were obtained,and the patient was eventually discharged from the *** case is characterized by intracranial ***:The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR *** tigecycline IVT pathway is also a safe treatment option.

关键词： Intraventricular injection of tigecycline Polymyxin B intracranial infection Acinetobacter baumannii

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Report of Haemophilus Influenzae serotype a intracranial infections in older children

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Pediatric Investigation 2023年第2期7卷 132-136页

作者： Varvara Probst Fadi Shahoud Aaron Fletcher Osborne Ana Alvarez Nizar Maraqa Ayesha Mirza Department of Pediatrics University of Florida College of Medicine-JacksonvilleJacksonvilleFloridaUSA Department of Pediatrics Division of Infectious Diseases and ImmunologyUniversity of Florida College of Medicine-JacksonvilleJacksonvilleFloridaUSA

Introduction:Haemophilus influenzae(Hi)is subdivided into typeable(a-f)and non-typeable *** serotype b(Hib)has historically been one of the important pathogens responsible for invasive ***,after widespread Hib vaccination,the emergence of other Hi serotypes,specifically Hi serotype a(Hia),was noted during the last few decades,mostly in children younger than 5 years of *** presentation:We present two cases of severe intracranial infections with detected Hia in patients>5 years of age within a short time frame and within the same geographic ***:Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of *** can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.

关键词： Haemophilus influenzae serotype b intracranial infection vaccine epidemiology

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Preliminary exploration of the development of a collagenous artificial dura mater for sustained antibiotic release

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Chinese Medical Journal 2013年第17期126卷 3329-3333页

作者： WANG Hao DONG Hui KANG Cheng-gui LIN Cheng YE Xun ZHAO Yuan-li Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Beijing TianXinFu Medical Appliance Company Ltd. China

Background intracranial infection is one of the most common complications of open craniocerebral injury and of conventional craniotomy in neurosurgery. The presence of blood-brain barrier leads to lower drug concentrations in the cerebrospinal fluid than in the venous blood. Increasing the intravenous dosage or frequency carries the risk of systemic adverse reactions or infections in other parts of the body. Developing an artificial dura mater （ADM） for sustained antibiotic release for use during neurosurgery can solve the problems perfectly. Methods Three types of drug-loaded ADMs made of collagen and containing cefuroxime sodium, ceftriaxone sodium, or norvancomycin were prepared. The antibacterial activity and sustained release characteristics of the ADMs were examined using bacteriostatic and release tests. Results Single-layered collagen based ADMs （40 mm×50 mm×5 mm） containing 18 mg cefuroxime sodium or ceftriaxone sodium were not suitable for continued development because of drug preservation and stability issues. Using smaller ADMs （20 mm30 mm×7 mm）, containing 4.86 mg of norvancomycin, with increased collagen density and a three-layered film with two outer drug-free films above and below the antibiotic layer resulted in sustained cumulative release of 2.91 mg （59.9%） of norvancomycin over 72 hours. The similar factor （f2） comparison method proved that products from a same batch were statistically significant similar （f2 〉50）. Conclusions Artificial ADMs made of collagen can be processed to provide a mature dural repair material for the sustained release of norvancomycin. This system may provide a basis for developing sustained release materials for other drugs.

关键词： intracranial infection drug release antibiotics artificial dura mater

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Advantages of using a prophylactic epidural closed drain and non-watertight dura suture in a craniotomy near the“parietal site”

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Chinese Neurosurgical Journal 2021年第3期7卷 196-203页

作者： Xin Li Jing Li Jianfei Sui Tuerdialimu Niyazi Naibijiang Yalikun Shuo Wang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China Department of Operating Room Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China Depatment of Neurosurgery Hetian District HospitalNo.103 Wenhua RoadHetian DistrictHetian City 848000Xinjiang Uygur Autonomous RegionChina.

Background:In neurosurgery,the necessity of having a drainage tube is *** fluid collection(SFC)often occurs,especially in a craniotomy near the“parietal site”.This study aimed to reassess the benefit of using a prophylactic epidural drainage(ED)and non-watertight dura suture in a craniotomy near the parietal ***:A retrospective review was conducted on 63 consecutive patients who underwent a craniotomy near the parietal *** patients were divided into two groups according to different *** deal group received ED and a non-watertight dura suture(drain group,DG),the control group that did not(non-drain group,NDG).Complications and patient recovery were evaluated and ***:Three patients(11.5%,26)in DG and 20 patients(54.1%,37)in NDG presented with SFC(p0.05).Six developed an infection in NDG(four intracranial infections,one abscess,one pulmonary infection),while none in DG(p>0.05)developed ***(11.5%)cases in DG and one(2.7%)case in NDG had muscle strength that improved postoperatively(p>0.05).Fifteen(57.7%)in DG and 14(37.8%)in NDG had epileptic seizures less frequently postoperatively(p0.05),the maximum temperature(37.9°C vs 38.1°C,p>0.05)on 3 PODs,the postoperative hospital stay day(7.5 days vs 8.0 days,p>0.05),and the postoperative medicine fee(¥29762.0 vs¥28321.0,p>0.05)were ***:In patients who undergo a craniotomy near the parietal site,the prophylactic use of ED and a nonwatertight dura suture helps reduce SFC,infection,and control epilepsy.

关键词： Craniotomy Epidural drainage Suction drainage Complication Subdural tensile hydrops Subgaleal fluid collection Wound infection intracranial infection

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