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Apoferritin nanoparticle based dual-antigen influenza conjugate vaccine with potential cross-protective efficacy against heterosubtypic influenza virus

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Particuology 2022年第5期20卷 56-64页

作者： Yanan Sheng Jiangxue Wei Zhengjun Li Zhiguo Su Guanghui Ma Songping Zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Ferritin nanoparticles with self-assembling properties have been widely explored as vaccine carrier by displaying foreign antigens through genetic fusion strategy.In the present work,an apoferritin(AFt)nanoparticle was tested as Influenza vaccine carrier by chemically conjugating a matrix protein 2 ectodomain(M2e)antigen peptide or/and the full-length hemagglutinin(HA)antigen on the outer surface of the AFt,with heterobifunctional sSMCC or SM(PEG)_(24) containing PEG chain as linkers.To each AFt nanoparticle,about 30-32 M2e or 1.8 HA antigen could be coupled.The AFt-(PEG)24-M2e,in which the M2e was coupled through SM(PEG)_(24) containing PEG chain,conferred higher protective efficacy in immunized mice than AFt-M2e did,but was less effective than AFt-(PEG)_(24)-HA.When both M2e and HA were coupled,the synthesized dual-antigen vaccine candidate AFt-(PEG)_(24)-M2e/HA elicited high level of M2e and HA antigen-specific antibodies and conferred 100%protection against lethal infection of homologous PR8 HI N1 virus strain and 70%protection against a heterologous A/FM/1/47(FM1,H1N1)strain,which was more effective than the M2e or HA single antigen vaccine candidates.The potential cross-protective effect of the dual-antigen vaccine was further demonstrated by significant specific hemagglutination inhibition(HAI)titers in serum of the immunized mice against three other heterologous viral strains including A/Singapore/GPl908/2015(IVR-180)H1N1,A/Anhui/1/2005 H5N1,and A/Hong Kong H3N2.

关键词： Influenza vaccine Apoferritin nanoparticle Hemagglutinin M2e Conjugate vaccine

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Adherence to Advisory Committee on Immunization Practices in diabetes mellitus patients in Saudi Arabia:A multicenter retrospective study

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World Journal of Diabetes 2024年第3期15卷 440-454页

作者： Saleh Fahad Alqifari Aya K Esmail Dalal M Alarifi Ghalya Y Alsuliman Maram M Alhati May R Mutlaq Mohammed Aldhaeefi Shaden A Alshuaibi Palanisamy Amirthalingam Abrar Abdallah Afaf S Wasel Heba R Hamad Shoroq Alamin Tasneem H Atia Tariq Alqahtani Department of Pharmacy Practice University of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi UniversityQassim 52726Saudi Arabia Department of Family Medicine International Medical CenterJeddah 23214Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Pharmacology King Saud Bin Abdulaziz University for Health SciencesKing Abdullah International Medical Research CenterRiyadh 11481Saudi Arabia

BACKGROUND Patients with diabetes mellitus(DM)are predisposed to an increased risk of infection signifying the importance of vaccination to protect against its potentially severe complications.The Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices(CDC/ACIP)issued immunization recommendations to protect this patient population.AIM To assess the adherence of patients with DM to the CDC/ACIP immunization recommendations in Saudi Arabia and to identify the factors associated with the vaccine adherence rate.METHODS An observational retrospective study conducted in 2023 was used to collect data on the vaccination records from 13 diabetes care centers in Saudi Arabia with 1000 eligible patients in phase I with data collected through chart review and 709 patients in phase II through online survey.RESULTS Among participants,10.01%(n=71)had never received any vaccine,while 85.89%(n=609)received at least one dose of the coronavirus disease 2019(COVID-19)vaccine,and 34.83%(n=247)had received the annual Influenza vaccine.Only 2.96%(n=21),2.11%(n=15),and 1.12%(n=8)received herpes zoster,tetanus,diphtheria,and pertussis(Tdap),and human papillomavirus(HPV)vaccines,respectively.For patients with DM in Saudi Arabia,the rate of vaccination for annual influenza and COVID-19 vaccines was higher compared to other vaccinations such as herpes zoster,Tdap,pneumococcal,and HPV.Factors such as vaccine recommendations provided by family physicians or specialists,site of care,income level,DM-related hospitalization history,residency site,hemoglobin A1c(HbA1c)level,and health sector type can significantly influence the vaccination rate in patients with DM.Among non-vaccinated patients with DM,the most reported barriers were lack of knowledge and fear of side effects.This signifies the need for large-scale research in this area to identify additional factors that might facilitate adherence to CDC/ACIP vaccine recommendations in patients with DM.CONCLUSION In Saudi Arabia,patients with DM showed higher vacci

关键词： Diabetes mellitus vaccine recommendation COVID-19 vaccine Influenza vaccine Pneumococcal vaccine Immunization Retrospective study

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Immunogenicity and Efficacy of Liposome-encapsulated influenza Split vaccine in BALB/c Mice

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Chemical Research in Chinese Universities 2007年第3期23卷 314-318页

作者： QI Feng-chun WANG Chun-yi WANG Ya-jun HANG Xue-mei ZHANG Yan SUI Bo LI Xiao-bo SHENG Jun College of Life Science Jilin University Changchun 130012 P. R. China Changchun Institute of Biological Products Changchun 130062 P. R. China College of Public Health Jilin University Changchun 130012 P. R. China

The cellular immunity of current influenza split vaccine is relatively low. It is necessary to develop a novel vaccine to improve the cellular immunity. The authors of this study prepared liposome-encapsulated influenza split vaccine and tested it in BALB/c mice. The mice were immunized once with 4 μg of haemagglutinin of monovalent A/ New Caledonia/20/99 （H1N1 ） encapsulated with liposomes or the split virus vaccine only through intrastomach injection. In a comparative study, it was observed that the liposome-encapsulated vaccine elicited a higher neutralizing antibedy response, more effectively stimulated spleen cell proliferation, increased cell subsets like CD^4＋ and CD^4＋/ CD8^＋ , and triggered IL-4 and IFN-γ production.

关键词： Liposome Immune effect Influenza vaccine

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The effect of adjuvants on vaccine-induced antibody response against influenza in aged mice

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Frontiers in Biology 2014年第2期9卷 89-94页

作者： Mark A. CONCANNON Jiu JIANG Department of Biology Drexel University Philadelphia PA 19104 USA

While influenza remains a major threat to public health, researchers continue to search for a universal solution to improving the efficacy of the Influenza vaccine. Even though influenza affects people of all different ages, it can be extremely hazardous to people of 65 years of age or older since that is the population that makes up the high majority of the death toll caused by influenza-related diseases. Elderly individuals suffer the effects of immunosenescence as they age, which is the diminishing of the overall immune response. Immunosenescence occurs by specifically affecting the adaptive immune response which controls the establishment of immunity after vaccination or infection. There are many studies under way that are trying to find a resolution to the problem of the Influenza vaccine not providing enough protection in the elderly population. One of the possible strategies is to seek the use of an optimal adjuvant, an immunological agent that can enhance immune responses, with the current vaccine formulation. Here, we used the murine model to review the effects of adjuvants on the antibody response to Influenza vaccines in aged mice. Since adjuvants can enhance the production of important inflammatory cytokines and activation of dendritic cells, the stimulation of these cells are boosted to increase the effectiveness of the Influenza vaccine in aged mice which would hopefully translate to the elderly.

关键词： adjuvant Influenza vaccine aged mice

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Bioengineered pseudovirus nanoparticles displaying the HA1 antigens of influenza viruses for enhanced immunogenicity

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Nano Research 2022年第5期15卷 4181-4190页

作者： Ming Xia Md Rejaul Hoq Pengwei Huang Wen Jiang Xi Jiang Ming Tan Division of Infectious Diseases Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA Department of Biological Sciences Purdue Cryo-EM FacilityPurdue UniversityIN 47907USA Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229USA

Even with implementation of current Influenza vaccines,influenza still claims up to 500,000 lives worldwide annually,indicating a need for a better vaccine strategy.We have developed a technology to generate unique S_(60)-HA1 pseudovirus nanoparticles(PVNPs)that display the receptor-binding HA1 domains of influenza viruses.Each self-assembled S_(60)-HA1 PVNP consists of a T=1 icosahedral S_(60) nanoparticle that resembles the inner shell of norovirus capsid and 60 surface-displayed HA1 antigens that are excellent vaccine targets.Soluble S_(60)-HA1 PVNPs presenting HA1 antigens of H7N9 influenza virus subtypes have been produced efficiently in large amount.Their three-dimensional(3D)structures have been solved by cryogenic electron microscopy.The PVNP-displayed HA1 antigens react with HA-specific antibody,and retain authentic sialic acid binding specificity and hemagglutinate human erythrocytes.The PVNPs are highly immunogenic,eliciting high titers of HA1-specific antibodies in mice and the mouse sera strongly inhibited hemagglutinations of homologous and heterologous influenza virus HA proteins.Therefore,the S_(60)-HA1 PVNPs may provide useful reagents to study influenza viruses and offer a potential new vaccine tactic to fight the deadly influenza disease.

关键词： S_(60)nanoparticle pseudovirus nanoparticle influenza virus Influenza vaccine hemagglutinin norovirus

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Association between influenza vaccination and SARS-CoV-2 infection and its outcomes: systematic review and meta-analysis

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Chinese Medical Journal 2022年第19期135卷 2282-2293页

作者： Binshan Jiang Qiangru Huang Mengmeng Jia Xinai Xue Qing Wang Weizhong Yang Luzhao Feng School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBejing 100730China Department of Medical Records Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China.

Background:World Health Organization recommends that Influenza vaccines should benefit as much of the population as possible,especially where resources are limited.Corona virus disease 2019(COVID-19)has become one of the greatest threats to health systems worldwide.The present study aimed to extend the evidence of the association between influenza vaccination and COVID-19 to promote the former.Methods:In this systematic review,four electronic databases,including the Cochrane Library,PubMed,Embase,and Web of Science,were searched for related studies published up to May 2022.All odds ratios(ORs)with 95%confidence intervals(CIs)were pooled by meta-analysis.Results:A total of 36 studies,encompassing 55,996,841 subjects,were included in this study.The meta-analysis for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection provided an OR of 0.80(95%CI:0.73–0.87).The statistically significant estimates for clinical outcomes were 0.83(95%CI:0.72–0.96)for intensive care unit admission,0.69(95%CI:0.57–0.84)for ventilator support,and 0.69(95%CI:0.52–0.93)for fatal infection,while no effect seen in hospitalization with an OR of 0.87(95%CI:0.68–1.10).Conclusion:influenza vaccination helps limit SARS-CoV-2 infection and severe outcomes,but further studies are needed.Registration:PROSPERO,CRD42022333747.

关键词： Influenza vaccine COVID-19 Infection Outcomes Prevention

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Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly influenza Vaccination in an Elderly Population

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World Journal of vaccines 2022年第2期12卷 11-19页

作者： Satoko Kitamura Naoki Komatsu Masahide Matsushita Hiromi Seo Seisho Takeuchi Department of General Medicine Kochi Medical School Hospital Nankoku Japan Kochi General Rehabilitation Hospital Kochi Japan

Annual vaccination is necessary to maintain humoral immunity in the elderly population. However, the factors influencing the response to influenza vaccination have not been completely identified. The aim of this study was to explore the factors that influenced antibody responses to repeated vaccination using measures that were both objective and quantitative. A total of 111 volunteers aged > 61 years were vaccinated subcutaneously with one dose of Influenza vaccine from the 2005-2006 season through the 2009-2010 season. The factors that influenced antibody responses after vaccination were evaluated. The seroprotection rates (PRs) were significantly higher in responders (subjects with a higher antibody titer in the 2005-2006 season) than in nonresponders only in the 2006-2007 and 2007-2008 seasons. PRs after vaccination were significantly higher in seropositive individuals (subjects with a higher prevaccination antibody titer in the 2006-2007 season) than in seronegative individuals for all three virus strains in almost all of the 5 years. Age, gender, and vaccination in the 2004-2005 season did not influence the response. These results suggest that an immune response at a certain time point would predict immune responses only in the near future. However, prevaccination antibody titer in the following season is the ideal predictor for future responses that last over several influenza seasons.

关键词： Influenza vaccine Elderly Persons Repeated Vaccination Seroprotection Rate

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Adjuvanted vaccines against influenza in the elderly

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Frontiers in Biology 2012年第3期7卷 221-226页

作者： Erin M. FISHER Jiu JIANG Department of Biology Drexel University Philadelphia PA 19104 USA

influenza is an important public health issue, especially with the aging of the population, since the most serious consequences of the illness affect the elderly. Between 1979 and 2001, approximately 41000 annual deaths have been attributed to influenza in the United States （Dushoff, 2005）. Annual vaccination is a key strategy employed to combat this illness, and while it is very effective in healthy young adults, it is much less successful in the elderly. The impaired immune system with aging may contribute to this diminished ability of the vaccine to afford protection. Strategies to improve vaccine efficacy, particularly for the aged population, are necessary. One potential strategy is the inclusion of adjuvants in the vaccine formulations to enhance the immune response. Adjuvants have been shown to improve antibody production, allow dose-sparing, and potentially increase cross-reactivity. These benefits are important in combating both seasonal influenza and pandemic influenza, as current seasonal vaccine effectiveness depends on close matching to the circulating virus, and fast production of pandemic vaccines are key to their effectiveness. While much is still unknown about adjuvants, especially their mechanisms of action, their potential at improving the efficacy of Influenza vaccines has been well recognized, particularly in the elderly.

关键词： Influenza vaccine elderly adjuvant

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Analysis of 472,688 Severe Cases of COVID-19 in Brazil Showed Lower Mortality in Those Vaccinated against influenza

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World Journal of vaccines 2021年第3期11卷 28-32页

作者： Daniele Melo Sardinha Diana da Costa Lobato Ana Lú cia da Silva Ferreira Karla Valé ria Batista Lima Ricardo José de Paula Souza e Guimarã es Luana Nepomuceno Gondim Costa Lima Post-graduate Program in Epidemiology and Health Surveillance of the Instituto Evandro Chagas (PPGEVS/IEC) Ananindeua Par&#225 Brazil State Coordinator of the Reference Center for Special Immunobiologicals from the Pará State Public Health Department (CRIE/SESPA) Bel&#233 m Par&#225 Brazil Post-Graduation Program in Parasite Biology in the Amazon University of state of Par&#225 Instituto Evandro Chagas (PPGBPA/UEPA/IEC) Bel&#233 m Par&#225 Brazil

Objective: To analyze the severe cases of COVID-19 in Brazil in 2020 and compare those vaccinated and unvaccinated against influenza in invasive ventilation, admission in Intensive Care Unit (ICU) and deaths. Method: Cross-sectional study with public data from the OpenDataSUS platform, regarding confirmed severe cases for COVID-19 in Brazil in the year 2020. Data were analyzed by SPSS, from the chi-square test of independence and binary logistic regression. Results: The population was 472,688 cases and 177,640 deaths, with a lethality of 37.58% in severe cases. The test of independence was highly significant in vaccinated survivors (influenza vaccination as an adjuvant in combating the COVID-19 pandemic in Brazil.

关键词： COVID-19 Pandemic Brazil Influenza vaccine

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