Immunogenicity and Efficacy of Liposome-encapsulated Influenza Split Vaccine in BALB/c Mice

作     者：QI Feng-chun WANG Chun-yi WANG Ya-jun HANG Xue-mei ZHANG Yan SUI Bo LI Xiao-bo SHENG Jun 

作者机构：College of Life Science Jilin University Changchun 130012 P. R. China Changchun Institute of Biological Products Changchun 130062 P. R. China College of Public Health Jilin University Changchun 130012 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第3期

页      面：314-318页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0703[理学-化学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Innovation Fund for Technology Based Firms of China(No06C26212200804) 

主　　题：Liposome Immune effect Influenza vaccine 

摘      要：The cellular immunity of current influenza split vaccine is relatively low. It is necessary to develop a novel vaccine to improve the cellular immunity. The authors of this study prepared liposome-encapsulated influenza split vaccine and tested it in BALB/c mice. The mice were immunized once with 4 μg of haemagglutinin of monovalent A/ New Caledonia/20/99 （H1N1 ） encapsulated with liposomes or the split virus vaccine only through intrastomach injection. In a comparative study, it was observed that the liposome-encapsulated vaccine elicited a higher neutralizing antibedy response, more effectively stimulated spleen cell proliferation, increased cell subsets like CD^4＋ and CD^4＋/ CD8^＋ , and triggered IL-4 and IFN-γ production.