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Effect of Traditional Chinese Medicine combined with Western Medicine on blood lipid levels and inflammatory factors in patients with angina pectoris in coronary heart disease identified as intermingled phlegm and blood stasis syndrome:a network Meta-anal

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Journal of Traditional Chinese Medicine 2023年第4期43卷 640-649页

作者： WANG Chao WU Qiong LI Ping WANG Zhigang LOU Xusheng LI Yuanyuan ZHANG Lin Postdoctoral Mobile Station of Chinese Academy of Traditional Chinese medicine Beijing 100700China China Academy of Chinese Medical Sciences Beijing 100700China Zang-xiang Teaching and Research Department the Institute of Basic Theory for Chinese MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Cardiovascular Medicine Beijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029China Shandong College of Traditional Chinese Medicine Yantai 264199China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China

OBJECTIVE:To evaluate the clinical efficacy of Traditional Chinese Medicine prescriptions for resolving phlegm in the treatment of angina pectoris of phlegmstasis coronary heart disease by a network ***:Randomized controlled trials(RCTs)on clinical efficacy of CHD angina pectoris with interaction of phlegm and blood stasis were searched in PubMed,Springer,the Cochrane Library and Chinese-language databases China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Data from their inception to December *** was screened and literature bias risk was assessed by RevMan5.4 *** overall response rate,the duration of angina attack,the levels of serum lipids such as total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),and high density lipoprotein cholesterol(HDL-C),and expression of hypersensitive C-reactive protein(hs-CRP)were selected as outcome indicators for network Meta-analysis and mapped using Stata15.1 ***:Totally,26 RCTs were included,involving 2098 *** were 6 TCM formulas with the effects of dispelling phlegm and removing blood *** conventional Western Medicine as the common intervention measures,the results showed that the overall response improvement rate from high to low was displayed as modified Xiaoxianxiong decoction(小陷胸汤,MXD),Danlou tablet(丹蒌片,DT),modified Gualou Xiebai Banxia decoction(瓜蒌薤白半夏汤,MGXBD),modified Wendan decoction(温胆汤,MWD),modified Zhishi Xiebai Guizhi decoction(枳实薤白桂枝汤,MZXGD),and modified Erchen decoction(二陈汤,MED).The sequence of angina attack duration improvement from high to low was MZXGD,MGXBD,DT,MWD,*** sequence of TC improvement from high to low was MZXGD,MED,DT,and *** of improving TG from high to low was MED,MZXGD,MGXBD,and *** LDL-C improvement,the effect from good to poor was MZXGD,MGXBD,DT,and *** regard to HDL-C improvement,the effect was ranked as MED,MZXGD,MGXBD,and

关键词： coronary disease angina pectoris phlegm and blood stasis interaction blood lipid inflammatory factors medicine traditional Chinese network Meta-analysis randomized controlled trial

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Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis

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World Journal of Gastroenterology 2005年第4期11卷 525-528页

作者： YongMeng Qing-YongMa Xiao-PingKou JunXu DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To observe the effect of resveratrol on nuclear factor Kappa-B (NF-κB) activation and the inflammatory response in sodium taurocholate-induced pancreatitis in rats. METHODS: Seventy-two male SD rats were randomly divided into three groups: sham operation group (control), severe acute pancreatitis (SAP) group, and severe acute pancreatitis group treated with resveratrol (RES). A SAP model was established by injecting 4% sodium taurocholate 1 mL/kg through puncturing the pancreatic duct. In Res group, Res was given at 30 mg/kg b.m. intraperitoneally after the SAP model was successfully established. Eight animals from each group were sacrificed at 3, 6 and 12 h after modeling. The expression of NF-κB activation of pancreas was detected by irnmunohistochemical staining, whereas the levels of TNF-α and IL-8 in pancreatic tissues were estimated by radioimrnunoassay. The pathological changes of pancreas and lungs were examined microscopically. RESULTS: Much less hyperemia, edema, dust-colored necrotic focus and soaps were noticed in pancreas in RES group than in SAP group. In RES group, hemorrhage, exudates and infiltration of inflammatory cells in pancreas and interstitial edema, destruction of alveolar wall in lung were significantly less than in SAP group. In the SAP group, the activation of NF-κB in pancreatic tissues was enhanced significantly at any measure point compared with control group (64.23±10.72% vs 2.56±0.65%, 55.86±11.34% vs 2.32±0.42%, 36.23±2.30% vs 2.40±0.36%,P<0.01), TNF-α, IL-8 were also increased and reached their peak at 6 h and then declined. The activation of NF-κB and the levels of TNF-α and IL-8 in RES group were significantly lower than those in SAP group (P<0.01): activation (52.63±9.45% vs 64.23±10.72%, 40.52±8.40% vs 55.86±11.34%, 29.83±5.37% vs 36.23±2.30%), TNF-α (132.76±15.68 pg/mL vs 158.36±12.58 pg/mL, 220.32±23.57 pg/mL vs 247.67± 11.62 pg/mL, 175.68±18.43 pg/mL vs 197.35±12.57 pg/mL) and IL-8 (0.62±0.21 μg/L vs 0.83±0.10 μg/L, 1.1

关键词： Acute pancreatitis Resveratrol NF-κB inflammatory factors

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Assessing myocardial indices and inflammatory factors to determine anxiety and depression severity in patients with chronic heart failure

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World Journal of Psychiatry 2024年第1期14卷 53-62页

作者： Li Zhang Qiang Wang Hong-Sheng Cui Yuan-Yuan Luo Department of Cardiology Jingzhou HospitalYangtze UniversityJingzhou 434020Hubei ProvinceChina Department of Intensive Care Unit The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Patients with chronic heart failure(CHF)have a progressive disease that is associated with poor quality of life and high *** patients experience anxiety and depression(A&D)symptoms,which can further accelerate disease *** hypothesized that indicators of myocardial function and inflammatory stress may reflect the severity of A&D symptoms in patients with *** in these biomarkers could potentially predict whether A&D symptoms will deteriorate further in these *** To measure changes in cardiac and inflammatory markers in patients with CHF to determine A&D severity and predict *** We retrospectively analyzed 233 patients with CHF treated at the Jingzhou Hospital,Yangtze University between 2018-2022 and grouped them according to Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)*** compared clinical data in the no-A&D,mild-A&D,moderate-A&D,and severe-A&D groups,the SAS and SDS scores with the New York Heart Association(NYHA)functional classification,and cardiac markers and inflammatory factors between the no/mild-A&D and moderate/severe-A&D *** analysis was performed on the markers with P0.05).In addition,we found that higher NYHA classes were associated with higher the SAS and SDS scores(Pfactors for A&D severity(P<0.05).Among them,NT-pr

关键词： Chronic heart failure Anxiety Depression Cardiac markers inflammatory factors Prediction

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Correlation of preoperative inflammatory factors and emotional disorders with postoperative delirium in patients with craniocerebral trauma

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World Journal of Psychiatry 2024年第7期14卷 1043-1052页

作者： Peng Cao Zhe-Yong Jia Tao Zheng Tao Mei Department of Neurosurgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415003Hunan ProvinceChina

BACKGROUND Traumatic brain injury(TBI)imposes a substantial societal and familial burden due to its high disability and fatality rates,rendering it a serious public health *** patients with TBI have poor treatment outcomes and are prone to postoperative delirium(POD),which affects their quality of *** has been linked to increased POD incidence in some studies,while others have found no *** To investigate the correlation of POD risk factors,preoperative inflammatory factors,and mood disorders in patients with *** We retrospectively collected data on the treatment of 80 patients with TBI from November 2021 to September *** were grouped as POD and non-POD,according to their POD status,and the general data of the two groups were *** factor levels were detected preoperatively,and the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used to investigate the risk factors associated with POD in these *** regression was used to identify the independent risk *** Twenty-one patients(26.25%)developed POD,including 7,10,and 4 cases of the excitatory,inhibitory,and mixed types,*** were 59 cases(73.75%)in the non-POD *** with the non-POD group,the POD group had a significantly higher proportion of patients with low Glasgow Coma Scale(GCS)scores before admission,unilateral mydriasis,preoperative hemorrhagic shock,intraventricular hemorrhage(IVH),and postoperative hyperglycemic hyperosmolar disease(Pfactors for POD in patients with TBI(Pinflammatory indicators,anxiety,and depress

关键词： inflammatory factors Mood disorders Traumatic brain injury Postoperative delirium Relevance Risk factor

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Effects of serum inflammatory factors,health index and disease activity scores on ankylosing spondylitis patients with sleep disorder

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World Journal of Psychiatry 2024年第6期14卷 866-875页

作者： Hui Wang Jia-Ying Sun Yue Zhang Department of Rheumatology and Immunology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Patients with ankylosing spondylitis(AS)frequently suffer from comorbid sleep disorders,exacerbating the burden of the disease and affecting their quality of *** To investigate the clinical significance of serum inflammatory factors,health index and disease activity scores in patients with AS complicated by sleep *** A total of 106 AS patients with comorbid sleep disorders were included in the *** patients were grouped into the desirable and undesirable prognosis groups in accordance with their clinical *** serum levels of inflammatory factors,including C-reactive protein,erythrocyte sedimentation rate,interleukin(IL)-6,tumour necrosis factor-αand IL-1β,were *** activity scores,such as the Bath AS functional index,Bath AS disease activity index,Bath AS metrology index and AS disease activity score,were *** health index was obtained through the Short Form-36 *** The study found significant associations amongst serum inflammatory factors,health index and disease activity scores in AS patients with comorbid sleep *** correlations were found between serum inflammatory factors and disease activity scores,indicating the influence of heightened systemic inflammation on disease severity and functional ***,negative correlations were found between disease activity scores and health index parameters,highlighting the effect of disease activity on various aspects of healthrelated quality of *** regression analysis further confirmed the predictive value of these factors on patient outcomes,underscoring their potential utility in risk assessment and *** The findings demonstrate the intricate interplay amongst disease activity,systemic inflammation and patientreported health outcomes in AS patients complicated by sleep *** results emphasise the need for comprehensive care strategies that address the diverse needs and challe

关键词： inflammatory factors Disease activity scores Health index Ankylosing spondylitis Sleep disorders

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Shizhenqing granule stimulates the hypothalamic-pituitary-adrenal axis and reduces serum pro-inflammatory factors in a rat model with chronic eczema

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Journal of Traditional Chinese Medical Sciences 2020年第4期7卷 386-392页

作者： Jinrui Lu Xiaoyan Liu Yao Xiao Shuran Ma Department of Pharmacy Qiannan Medical College for NationalitiesDuyun558013China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming650500China Ward Two Department of NephroendocrinologyDongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Objective:In this study,we examined the effects of Shizhenqing granule(SZQG)on hypothalamicpituitary-adrenal(HPA)axis and serum inflammatory factors in a rat model of chronic eczema,in order to explore the mechanism of action of SZQG in treatment of this ***:Sixty SpragueeDawley male rats were randomly divided into six groups(with 10 rats per group):blank group;model group;positive control group(prednisone);and the low-,medium-,and high-dose SZQG *** for the blank group,rats in all other groups were treated with 2,4-dinitrochlorobenzene to induce chronic *** rats were administered prednisone or SZQG for 7 consecutive days after successful establishment of the chronic eczema model,and samples were collected 12 h after the last *** degree of skin lesions and the changes in serum levels of corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH),cortisol(CORT),interleukin(IL)-4,interferon(IFN)-g,IL-25,and IL-31 among the groups were ***:SZQG effectively increased the levels of CRH,ACTH,and CORT,which decreased in the serum of rats with chronic eczema,stimulated the function of the HPA axis,and promoted the expression of *** reduced the serum levels of inflammatory factors including IL-4,IL-25 and IL-31,which were overexpressed in rats with chronic eczema,and increased those of anti-inflammatory factor IFN-g,thereby alleviating the inflammatory symptoms and itching,and ameliorating the clinical symptoms of chronic ***:SZQG effectively alleviates skin lesions in the chronic eczema rat model by stimulating the function of the HPA axis.

关键词： Shizhenqing granule Chronic eczema Hypothalamic-pituitary-adrenal axis inflammatory factors

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Depression and anxiety,peripheral blood inflammatory factors,and stress levels on therapeutic outcomes in patients with chronic wounds

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World Journal of Psychiatry 2024年第12期14卷 1836-1844页

作者： Bo Li Cha Li Xian-Jiang Zhong Xiang-Rong Xu Department of Burns and Plastic Surgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Pediatric Intensive Care Unit Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Psychiatry The First People’s Hospital of XiantaoXiantao 433099Hubei ProvinceChina

BACKGROUND The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our *** addition,as the disease spectrum evolves,chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic *** To investigate how depression,anxiety,peripheral blood inflammatory factors,and stress levels affect therapeutic outcomes in patients with chronic *** Retrospectively collected clinical data from 110 patients with chronic wounds treated at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)between January 2021 and December 2023,categorizing them into effective and ineffective groups based on treatment *** between both groups were analyzed using univariate analysis,independent risk factors identified via logistic regression,and their predictive value assessed through receiver operating characteristic *** Following treatment,95 cases were classified as the effective group(cured or improved),while 15 cases with improvement formed the ineffective *** differences between both groups were noted in wound area,infection status,daily bed time,Hamilton Anxiety Rating Scale(HAMA)scores,Hamilton Depression Rating Scale(HAMD)scores,and levels of interleukin-6,tumor necrosis factor-alpha,and superoxide dismutase(Pfactors for ineffective treatment in patients with chronic wounds(Pfactors influencing the therapeutic outcomes in patients with chronic wounds that require careful attention,alongside the d

关键词： Chronic wound Depression Anxiety inflammatory factors Stress level Clinical effect

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Mendelian Randomization Study of Causal Relationship between inflammatory factors and Vascular Dementia and Chinese Herbal Medicines Screening for Prevention and Treatment

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Journal of Biosciences and Medicines 2024年第10期12卷 270-284页

作者： Jinzhi Zhang Wei Chen Guifeng Zhuo Chun Yao Mingyang Su Bingmao Yuan Xiaomin Zhu Zizhen Zhou Fengyi Lei Yulan Fu Lin Wu Department of Neurology The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning China The First Clinical College of Medicine Guangxi University of Chinese Medicine Nanning China Graduate School Guangxi University of Chinese Medicine Nanning China

Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their c

关键词： inflammatory factors Vascular Dementia Mendelian Randomization Study Causal Association Chinese Medicine Prediction Medicine and Food Homology

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Effects of Mo-Rubbing abdomen manipulation on glucose metabolism and inflammatory factors in rats with type 2 diabetes mellitus

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Journal of Acupuncture and Tuina Science 2022年第5期20卷 354-362页

作者： XIE Zhouyu XU Jingsong KONG Xintian WU Yunchuan YANG Yanping School of Acupuncture Moxibustion and TuinaNanjing University of Chinese MedicineNanjing 210023China 不详

Objective To observe the effect of Mo-Rubbing abdomen manipulation on glucose metabolism and inflammatory factors in rats with type 2 diabetes mellitus(T2DM).Methods Sixty Sprague-Dawley rats were randomly divided into a normal group(n=10)and a group for modeling(n=50)using the random number table *** in the group for modeling were induced to form T2DM models by a high-sugar and high-fat diet combined with intraperitoneal injection of *** successfully modeled rats were randomly divided into a model group,a Mo-Rubbing abdomen group,and a metformin group,with 10 rats in each *** in the normal group and the model group received no intervention,those in the Mo-Rubbing abdomen group received Mo-Rubbing abdomen manipulation,and those in the metformin group received metformin by *** 8-week intervention,fasting insulin(FINS),fasting plasma glucose(FPG),homeostasis model assessment for insulin resistance(HOMA-IR)and area under the curve at the oral glucose tolerance test(AUC-OGTT),as well as serum inflammatory factors interleukin(IL)-1β,IL-6,and tumor necrosis factor(TNF)-αwere detected,and the morphological changes of the pancreas were also *** After the 8-week intervention,the levels of FINS,FPG,HOMA-IR,and AUC-OGTT of rats in the Mo-Rubbing abdomen group were significantly lower than those in the model group(P<0.05);the pancreatic injury degree in the Mo-Rubbing abdomen group and the metformin group was lower than that in the model *** with the model group,the serum IL-1β,IL-6,and TNF-αlevels of rats in the Mo-Rubbing abdomen group were significantly decreased(P<0.05),and the serum IL-1βand TNF-αlevels of the metformin group showed a downward trend;the serum IL-6 and TNF-αlevels in the Mo-Rubbing abdomen group were significantly lower than those in the metformin group(P<0.01).There was a significant positive correlation between FPG with IL-1β,IL-6,and TNF-αin the T2DM rats(P<0.01).Conclusion Mo-Rubbing abdo

关键词： Tuina Massage Mo-Rubbing Manipulation Diabetes Mellitus,Type 2 inflammatory factors Carbohydrate Metabolism

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Influence of Tuina plus oxiracetam on serum inflammatory factors and oxidative stress in mild vascular dementia patients

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Journal of Acupuncture and Tuina Science 2022年第4期20卷 273-280页

作者： GU Nan FAN Yuexian ZHOU Ling ZHANG Yan BAI Weijie LI Yanfeng YANG Liyun LI Jinlong HONG Jue Hebei University of Chinese Medicine Shijiazhuang 050200China Hebei Province Special Care Hospital Shijiazhuang 050000China The Third Hospital of Shijiazhuang Hebei ProvinceShijiazhuang 050011China 不详

Objective To observe the clinical efficacy of Tuina(Chinese therapeutic massage)plus oxiracetam in treating mild vascular dementia(VD)and seek its underlying *** Ninety-six patients with mild VD were randomized into an observation group and a control group,with 47 cases in the observation group and 49 cases in the control *** control group received oral oxiracetam capsules for treatment,and the observation group was given additional Tuina *** and after treatment,the mini-mental state examination(MMSE)was adopted to assess the patient’s cognitive function;the activities of daily living(ADL)scale was used to evaluate their ability to conduct daily activities;changes in the serum inflammatory factors and oxidative stress indicators were also *** After treatment,the serum content of malondialdehyde(MDA)decreased in both groups(P<0.05)and was lower in the observation group than in the control group(P<0.05);the serum contents of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)increased in both groups(P<0.05)and were higher in the observation group than in the control group(P<0.05);the serum contents of interleukin(IL)-1,tumor necrosis factor(TNF)-α,IL-6,and IL-8 declined in both groups(P<0.05)and were lower in the observation group than in the control group(P<0.05).After the intervention,the levels of systolic velocity(Vs)and mean velocity(Vm)of the middle cerebral artery elevated,and the pulsatility index(PI)dropped in patients in the two groups,showing significant intra-group differences(P<0.05);the levels of Vs and Vm in the observation group were higher than those in the control group,and the PI was lower in the observation group than in the control group,showing significant between-group differences(P<0.05).The MMSE and ADL scores increased in both groups after the intervention(P<0.05)and were higher in the observation group than in the control group(P<0.05).Conclusion In the treatment of mild VD,Tuina plus oxi

关键词： Tuina Massage Cognitive Dysfunction Dementia,Vascular Activities of Daily Living Oxidative Stress inflammatory factors

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