Influence of Tuina plus oxiracetam on serum inflammatory factors and oxidative stress in mild vascular dementia patients

作     者：GU Nan FAN Yuexian ZHOU Ling ZHANG Yan BAI Weijie LI Yanfeng YANG Liyun LI Jinlong HONG Jue 谷楠;范月先;周玲;张岩;白卫杰;李延峰;杨丽芸;李进龙;洪珏(翻译)

作者机构：Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Province Special Care HospitalShijiazhuang 050000China The Third Hospital of ShijiazhuangHebei ProvinceShijiazhuang 050011China 不详 

出 版 物：《Journal of Acupuncture and Tuina Science》 (针灸推拿医学（英文版）)

年 卷 期：2022年第20卷第4期

页      面：273-280页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：河北省中医药管理局项目 No.2017002 

主　　题：Tuina Massage Cognitive Dysfunction Dementia,Vascular Activities of Daily Living Oxidative Stress Inflammatory Factors 

摘      要：Objective To observe the clinical efficacy of Tuina(Chinese therapeutic massage)plus oxiracetam in treating mild vascular dementia(VD)and seek its underlying *** Ninety-six patients with mild VD were randomized into an observation group and a control group,with 47 cases in the observation group and 49 cases in the control *** control group received oral oxiracetam capsules for treatment,and the observation group was given additional Tuina *** and after treatment,the mini-mental state examination(MMSE)was adopted to assess the patient’s cognitive function;the activities of daily living(ADL)scale was used to evaluate their ability to conduct daily activities;changes in the serum inflammatory factors and oxidative stress indicators were also *** After treatment,the serum content of malondialdehyde(MDA)decreased in both groups(P0.05)and was lower in the observation group than in the control group(P0.05);the serum contents of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)increased in both groups(P0.05)and were higher in the observation group than in the control group(P0.05);the serum contents of interleukin(IL)-1,tumor necrosis factor(TNF)-α,IL-6,and IL-8 declined in both groups(P0.05)and were lower in the observation group than in the control group(P0.05).After the intervention,the levels of systolic velocity(Vs)and mean velocity(Vm)of the middle cerebral artery elevated,and the pulsatility index(PI)dropped in patients in the two groups,showing significant intra-group differences(P0.05);the levels of Vs and Vm in the observation group were higher than those in the control group,and the PI was lower in the observation group than in the control group,showing significant between-group differences(P0.05).The MMSE and ADL scores increased in both groups after the intervention(P0.05)and were higher in the observation group than in the control group(P0.05).Conclusion In the treatment of mild VD,Tuina plus oxi